{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:30:24Z","timestamp":1773178224265,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,28]]},"DOI":"10.7759\/cureus.83154","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T04:50:54Z","timestamp":1745902254000},"source":"Crossref","is-referenced-by-count":1,"title":["Optimal Management of Bleeding and Thrombosis in Total Knee Arthroplasty: Tranexamic Acid With Acetylsalicylic Acid or Low-Molecular-Weight Heparin"],"prefix":"10.7759","author":[{"given":"Zafer","family":"Uzunay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Burak","family":"Satilmis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolgahan","family":"Cengiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed Nadir","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300811","article-title":"The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study","volume":"30","author":"Felson DT","year":"1987","unstructured":"Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1987, 30:914-8. 10.1002\/art.1780300811","journal-title":"Arthritis Rheum"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.F.00222","article-title":"Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030","volume":"89","author":"Kurtz S","year":"2007","unstructured":"Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007, 89:780-5. 10.2106\/JBJS.F.00222","journal-title":"J Bone Joint Surg Am"},{"key":"ref3","article-title":"Primary total knee arthroplasty","author":"Burke D","year":"2001","unstructured":"Burke D, O\u2019Flynn H. Primary total knee arthroplasty. Chapman\u2019s Orthopedic Surgery. Chapman MW (ed): Lippincott Williams & Wilkins, Philadelphia; 2001. 2870-95."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00873","article-title":"Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis","volume":"94","author":"Yang ZG","year":"2012","unstructured":"Yang ZG, Chen WP, Wu LD. Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis. J Bone Joint Surg Am. 2012, 94:1153-9. 10.2106\/JBJS.K.00873","journal-title":"J Bone Joint Surg Am"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-015-3964-2","article-title":"The effects of tourniquet use in total knee arthroplasty: a randomized, controlled trial","volume":"25","author":"Wang K","year":"2017","unstructured":"Wang K, Ni S, Li Z, et al.. The effects of tourniquet use in total knee arthroplasty: a randomized, controlled trial. Knee Surg Sports Traumatol Arthrosc. 2017, 25:2849-57. 10.1007\/s00167-015-3964-2","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.23.00254","article-title":"Tranexamic acid is safe in patients with a history of venous thromboembolism undergoing total joint arthroplasty","volume":"106","author":"Richardson MK","year":"2024","unstructured":"Richardson MK, Liu KC, Mayfield CK, Kistler NM, Lieberman JR, Heckmann ND. Tranexamic acid is safe in patients with a history of venous thromboembolism undergoing total joint arthroplasty. J Bone Joint Surg Am. 2024, 106:30-8. 10.2106\/JBJS.23.00254","journal-title":"J Bone Joint Surg Am"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-15-00760","article-title":"Venous thromboembolism prophylaxis in total hip arthroplasty and total knee arthroplasty patients: from guidelines to practice","volume":"25","author":"Lieberman JR","year":"2017","unstructured":"Lieberman JR, Heckmann N. Venous thromboembolism prophylaxis in total hip arthroplasty and total knee arthroplasty patients: from guidelines to practice. J Am Acad Orthop Surg. 2017, 25:789-98. 10.5435\/JAAOS-D-15-00760","journal-title":"J Am Acad Orthop Surg"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-018-1038-0","article-title":"Blood loss of total knee arthroplasty in osteoarthritis: an analysis of influential factors","volume":"13","author":"Hu Y","year":"2018","unstructured":"Hu Y, Li Q, Wei BG, Zhang XS, Torsha TT, Xiao J, Shi ZJ. Blood loss of total knee arthroplasty in osteoarthritis: an analysis of influential factors. J Orthop Surg Res. 2018, 13:325. 10.1186\/s13018-018-1038-0","journal-title":"J Orthop Surg Res"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2016.02.081","article-title":"The James A. Rand Young Investigator's Award: a randomized controlled trial of oral and intravenous tranexamic acid in total knee arthroplasty: the same efficacy at lower cost?","volume":"31","author":"Fillingham YA","year":"2016","unstructured":"Fillingham YA, Kayupov E, Plummer DR, Moric M, Gerlinger TL, Della Valle CJ. The James A. Rand Young Investigator's Award: a randomized controlled trial of oral and intravenous tranexamic acid in total knee arthroplasty: the same efficacy at lower cost?. J Arthroplasty. 2016, 31:26-30. 10.1016\/j.arth.2016.02.081","journal-title":"J Arthroplasty"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/ortho.IJOrtho_179_16","article-title":"Is combined administration of tranexamic acid better than both intravenous and topical regimes for total loss, hidden loss and post-operative swelling? A randomized control trial","volume":"52","author":"Prakash J","year":"2018","unstructured":"Prakash J, Seon JK, Song EK, Lee DH, Yang HY, Jin C. Is combined administration of tranexamic acid better than both intravenous and topical regimes for total loss, hidden loss and post-operative swelling? A randomized control trial. Indian J Orthop. 2018, 52:117-23. 10.4103\/ortho.IJOrtho_179_16","journal-title":"Indian J Orthop"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B5.38070","article-title":"Aspirin - have we had the answer all along?","volume":"98-B","author":"Haddad FS","year":"2016","unstructured":"Haddad FS. Aspirin - have we had the answer all along?. Bone Joint J. 2016, 98-B:577-8. 10.1302\/0301-620X.98B5.38070","journal-title":"Bone Joint J"},{"key":"ref12","article-title":"Venous Thromboembolism in Over 16s: Reducing the Risk of Hospital-Acquired Deep Vein Thrombosis or Pulmonary Embolism","author":"National Guideline Centre (UK)","year":"2018","unstructured":"National Guideline Centre (UK). Venous Thromboembolism in Over 16s: Reducing the Risk of Hospital-Acquired Deep Vein Thrombosis or Pulmonary Embolism. National Institute for Health and Care Excellence (NICE), London; 2018."},{"key":"ref13","article-title":"Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update [Internet]","author":"Balk EM","year":"2017","unstructured":"Balk EM, Ellis AG, Di M, et al.. Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update [Internet]. Agency for Healthcare Research and Quality (US), Rockville; 2017."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13566","article-title":"Comparative effectiveness of venous thromboembolism prophylaxis options for the patient undergoing total hip and knee replacement: a network meta-analysis","volume":"15","author":"Kapoor A","year":"2017","unstructured":"Kapoor A, Ellis A, Shaffer N, et al.. Comparative effectiveness of venous thromboembolism prophylaxis options for the patient undergoing total hip and knee replacement: a network meta-analysis. J Thromb Haemost. 2017, 15:284-94. 10.1111\/jth.13566","journal-title":"J Thromb Haemost"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B8.36957","article-title":"Systematic review of aspirin for thromboprophylaxis in modern elective total hip and knee arthroplasty","volume":"98-B","author":"Wilson DG","year":"2016","unstructured":"Wilson DG, Poole WE, Chauhan SK, Rogers BA. Systematic review of aspirin for thromboprophylaxis in modern elective total hip and knee arthroplasty. Bone Joint J. 2016, 98-B:1056-61. 10.1302\/0301-620X.98B8.36957","journal-title":"Bone Joint J"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000121","article-title":"Administering aspirin, rivaroxaban and low-molecular-weight heparin to prevent deep venous thrombosis after total knee arthroplasty","volume":"25","author":"Zou Y","year":"2014","unstructured":"Zou Y, Tian S, Wang Y, Sun K. Administering aspirin, rivaroxaban and low-molecular-weight heparin to prevent deep venous thrombosis after total knee arthroplasty. Blood Coagul Fibrinolysis. 2014, 25:660-4. 10.1097\/MBC.0000000000000121","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177\/1076029618772337","article-title":"Comparison of postoperative bleeding in total hip and knee arthroplasty patients receiving rivaroxaban, enoxaparin, or aspirin for thromboprophylaxis","volume":"24","author":"Lindquist DE","year":"2018","unstructured":"Lindquist DE, Stewart DW, Brewster A, Waldroup C, Odle BL, Burchette JE, El-Bazouni H. Comparison of postoperative bleeding in total hip and knee arthroplasty patients receiving rivaroxaban, enoxaparin, or aspirin for thromboprophylaxis. Clin Appl Thromb Hemost. 2018, 24:1315-21. 10.1177\/1076029618772337","journal-title":"Clin Appl Thromb Hemost"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-017-5394-6","article-title":"Venous thromboembolism prophylaxis after TKA: aspirin, warfarin, enoxaparin, or Factor Xa inhibitors?","volume":"475","author":"Bala A","year":"2017","unstructured":"Bala A, Huddleston JI 3rd, Goodman SB, Maloney WJ, Amanatullah DF. Venous thromboembolism prophylaxis after TKA: aspirin, warfarin, enoxaparin, or Factor Xa inhibitors?. Clin Orthop Relat Res. 2017, 475:2205-13. 10.1007\/s11999-017-5394-6","journal-title":"Clin Orthop Relat Res"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1694768","article-title":"Six-dose intravenous tranexamic acid regimen further inhibits postoperative fibrinolysis and reduces hidden blood loss following total knee arthroplasty","volume":"34","author":"Zhang S","year":"2021","unstructured":"Zhang S, Xie J, Cao G, Lei Y, Huang Q, Pei F. Six-dose intravenous tranexamic acid regimen further inhibits postoperative fibrinolysis and reduces hidden blood loss following total knee arthroplasty. J Knee Surg. 2021, 34:224-32. 10.1055\/s-0039-1694768","journal-title":"J Knee Surg"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2017.05.042","article-title":"Comparative effectiveness and safety of drug prophylaxis for prevention of venous thromboembolism after total knee arthroplasty","volume":"32","author":"Cafri G","year":"2017","unstructured":"Cafri G, Paxton EW, Chen Y, et al.. Comparative effectiveness and safety of drug prophylaxis for prevention of venous thromboembolism after total knee arthroplasty. J Arthroplasty. 2017, 32:3524-3528.e1. 10.1016\/j.arth.2017.05.042","journal-title":"J Arthroplasty"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-017-0512-4","article-title":"Comparison of the effectiveness and safety of topical versus intravenous tranexamic acid in primary total knee arthroplasty: a meta-analysis of randomized controlled trials","volume":"12","author":"Chen TP","year":"2017","unstructured":"Chen TP, Chen YM, Jiao JB, et al.. Comparison of the effectiveness and safety of topical versus intravenous tranexamic acid in primary total knee arthroplasty: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2017, 12:11. 10.1186\/s13018-017-0512-4","journal-title":"J Orthop Surg Res"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.04.088","article-title":"Is aspirin as effective as the newer direct oral anticoagulants for venous thromboembolism prophylaxis after total hip and knee arthroplasty? An analysis from the National Joint Registry for England, Wales, Northern Ireland, and the Isle of Man","volume":"35","author":"Matharu GS","year":"2020","unstructured":"Matharu GS, Garriga C, Whitehouse MR, Rangan A, Judge A. Is aspirin as effective as the newer direct oral anticoagulants for venous thromboembolism prophylaxis after total hip and knee arthroplasty? An analysis from the National Joint Registry for England, Wales, Northern Ireland, and the Isle of Man. J Arthroplasty. 2020, 35:2631-2639.e6. 10.1016\/j.arth.2020.04.088","journal-title":"J Arthroplasty"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2015.04.048","article-title":"Direct costs of aspirin versus warfarin for venous thromboembolism prophylaxis after total knee or hip arthroplasty","volume":"30","author":"Gutowski CJ","year":"2015","unstructured":"Gutowski CJ, Zmistowski BM, Lonner JH, Purtill JJ, Parvizi J. Direct costs of aspirin versus warfarin for venous thromboembolism prophylaxis after total knee or hip arthroplasty. J Arthroplasty. 2015, 30:36-8. 10.1016\/j.arth.2015.04.048","journal-title":"J Arthroplasty"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1054\/arth.2003.50024","article-title":"The effect of anticoagulation on the restoration of range of motion after total knee arthroplasty: enoxaparin versus aspirin","volume":"18","author":"Keays AC","year":"2003","unstructured":"Keays AC, Mason M, Keays SL, Newcombe PA. The effect of anticoagulation on the restoration of range of motion after total knee arthroplasty: enoxaparin versus aspirin. J Arthroplasty. 2003, 18:180-5. 10.1054\/arth.2003.50024","journal-title":"J Arthroplasty"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/359612-optimal-management-of-bleeding-and-thrombosis-in-total-knee-arthroplasty-tranexamic-acid-with-acetylsalicylic-acid-or-low-molecular-weight-heparin","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T04:50:55Z","timestamp":1745902255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/359612-optimal-management-of-bleeding-and-thrombosis-in-total-knee-arthroplasty-tranexamic-acid-with-acetylsalicylic-acid-or-low-molecular-weight-heparin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":24,"URL":"https:\/\/doi.org\/10.7759\/cureus.83154","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,28]]}}}