{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:06:14Z","timestamp":1745985974618,"version":"3.40.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,28]]},"DOI":"10.7759\/cureus.83155","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T05:11:19Z","timestamp":1745903479000},"source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the Silent Threat: The Rise of \u0392-Lactamase Enzymes in Gram-Negative Bacterial Isolates Identified From Sterile Body Fluids in an Indian Healthcare Institution"],"prefix":"10.7759","author":[{"given":"Rounak","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satyajeet","family":"Pawar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kailash","family":"Wagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashanth K","family":"Guddeti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhawani S","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita S","family":"Mundhe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaishnavi B","family":"Shevale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11070986","article-title":"\u03b2-lactamases: sequence, structure, function, and inhibition","volume":"11","author":"Oelschlaeger P","year":"2021","unstructured":"Oelschlaeger P. \u03b2-lactamases: sequence, structure, function, and inhibition. Biomolecules. 2021, 11:986. 10.3390\/biom11070986","journal-title":"Biomolecules"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025239","article-title":"\u03b2-lactamases: a focus on current challenges","volume":"7","author":"Bonomo RA","year":"2017","unstructured":"Bonomo RA. \u03b2-lactamases: a focus on current challenges. Cold Spring Harb Perspect Med. 2017, 7:10.1101\/cshperspect.a025239","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.15171\/ijep.2017.20","article-title":"Prevalence of extended spectrum \u03b2-lactamase, AmpC \u03b2-lactamase and Metallo-\u03b2-lactamase among gram negative bacilli recovered from clinical specimens in Benin City, Nigeria","volume":"5","author":"Ibadin EE","year":"2017","unstructured":"Ibadin EE, Omoregie R, Anogie NA, Igbarumah IO, Ogefere HO. Prevalence of extended spectrum \u03b2-lactamase, AmpC \u03b2-lactamase and Metallo-\u03b2-lactamase among gram negative bacilli recovered from clinical specimens in Benin City, Nigeria. Int J Enteric Pathog. 2017, 5:85-91. 10.15171\/ijep.2017.20","journal-title":"Int J Enteric Pathog"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.14442","article-title":"Are there any completely sterile organs or tissues in the human body? Is there any sacred place?","volume":"17","author":"Mich\u00e1n-Do\u00f1a A","year":"2024","unstructured":"Mich\u00e1n-Do\u00f1a A, V\u00e1zquez-Borrego MC, Mich\u00e1n C. Are there any completely sterile organs or tissues in the human body? Is there any sacred place?. Microb Biotechnol. 2024, 17:e14442. 10.1111\/1751-7915.14442","journal-title":"Microb Biotechnol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.9734\/mrji\/2019\/v28i130123","article-title":"Aerobic bacteriological profile and antimicrobial sensitivity pattern of bacteria isolated from sterile body fluids: a study from a tertiary care hospital in North India","volume":"28","author":"Rouf M","year":"2019","unstructured":"Rouf M, Nazir A. Aerobic bacteriological profile and antimicrobial sensitivity pattern of bacteria isolated from sterile body fluids: a study from a tertiary care hospital in North India. Microbiol Res J Int. 2019, 28:1-10. 10.9734\/mrji\/2019\/v28i130123","journal-title":"Microbiol Res J Int"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.32322\/jhsm.981918","article-title":"Distribution of clinical isolates obtained from sterile body fluids: a four-year retrospective data","volume":"4","author":"Duran A\u00c7","year":"2021","unstructured":"Duran A\u00c7, Atik TK, \u00d6zen N, Sig AK, Irmak O. Distribution of clinical isolates obtained from sterile body fluids: a four-year retrospective data. J Health Sci Med. 2021, 4:907-11. 10.32322\/jhsm.981918","journal-title":"J Health Sci Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1590\/s1413-86702006000600002","article-title":"Enrichment methodology to increase the positivity of cultures from body fluids","volume":"10","author":"Daur AV","year":"2006","unstructured":"Daur AV, Klimak F Jr, Cogo LL, Bot\u00e3o GD, Monteiro CL, Dalla Costa LM. Enrichment methodology to increase the positivity of cultures from body fluids. Braz J Infect Dis. 2006, 10:372-3. 10.1590\/s1413-86702006000600002","journal-title":"Braz J Infect Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.33314\/jnhrc.v0i0.1656","article-title":"Bacteriological profile and antimicrobial susceptibility pattern among isolates obtained from body fluids","volume":"17","author":"Shrestha LB","year":"2019","unstructured":"Shrestha LB, Bhattarai NR, Khanal B. Bacteriological profile and antimicrobial susceptibility pattern among isolates obtained from body fluids. J Nepal Health Res Counc. 2019, 17:173-7. 10.33314\/jnhrc.v0i0.1656","journal-title":"J Nepal Health Res Counc"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2005.10.005","article-title":"Evaluation of the Bactec microbial detection system for culturing miscellaneous sterile body fluids","volume":"157","author":"Akcam FZ","year":"2006","unstructured":"Akcam FZ, Yayli G, Uskun E, Kaya O, Demir C. Evaluation of the Bactec microbial detection system for culturing miscellaneous sterile body fluids. Res Microbiol. 2006, 157:433-6. 10.1016\/j.resmic.2005.10.005","journal-title":"Res Microbiol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.21767\/2576-1412.100001","article-title":"Bacteriological profile and antimicrobial sensitivity pattern in sterile body fluids from a tertiary care hospital","volume":"1","author":"Sharma R","year":"2017","unstructured":"Sharma R, Anuradha ND. Bacteriological profile and antimicrobial sensitivity pattern in sterile body fluids from a tertiary care hospital. J Appl Microbiol Biochem. 2017, 1:1. 10.21767\/2576-1412.100001","journal-title":"J Appl Microbiol Biochem"},{"key":"ref11","article-title":"Mackie & McCartney Practical Medical Microbiology","author":"Collee JG","year":"1996","unstructured":"Collee JG, Mackie TJ, McCartney JE. Mackie & McCartney Practical Medical Microbiology. Collee JG, Fraser AG, Marmion BP, Simmons A (ed): Churchill Livingstone, New York, NY; 1996."},{"key":"ref12","article-title":"Performance standards for antimicrobial susceptibility testing","year":"2025","unstructured":"CLSI M100. Performance Standards for Antimicrobial Susceptibility Testing.  Clinical and Laboratory Standards Institute (CLSI), Malvern, PA; 2025. https:\/\/clsi.org\/standards\/products\/microbiology\/documents\/m100\/."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.4.657-686.2005","article-title":"Extended-spectrum beta-lactamases: a clinical update","volume":"18","author":"Paterson DL","year":"2005","unstructured":"Paterson DL, Bonomo RA. Extended-spectrum beta-lactamases: a clinical update. Clin Microbiol Rev. 2005, 18:657-86. 10.1128\/CMR.18.4.657-686.2005","journal-title":"Clin Microbiol Rev"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2009.50.3.335","article-title":"Metallo-beta-lactamase-producing Pseudomonas spp. in Korea: high prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type","volume":"50","author":"Lee K","year":"2009","unstructured":"Lee K, Park AJ, Kim MY, et al.. Metallo-beta-lactamase-producing Pseudomonas spp. in Korea: high prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type. Yonsei Med J. 2009, 50:335-9. 10.3349\/ymj.2009.50.3.335","journal-title":"Yonsei Med J"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00404-11","article-title":"Practical approach for reliable detection of AmpC beta-lactamase-producing Enterobacteriaceae","volume":"49","author":"Polsfuss S","year":"2011","unstructured":"Polsfuss S, Bloemberg GV, Giger J, Meyer V, B\u00f6ttger EC, Hombach M. Practical approach for reliable detection of AmpC beta-lactamase-producing Enterobacteriaceae. J Clin Microbiol. 2011, 49:2798-803. 10.1128\/JCM.00404-11","journal-title":"J Clin Microbiol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.22207\/JPAM.18.2.17","article-title":"Comparative study of biofilm and non-biofilm producing klebsiella pneumoniae with special reference to metallo-beta-lactamase production","volume":"18","author":"Pawar PS","year":"20241","unstructured":"Pawar PS, Pawar SK, Patil SR, Patil HV, Mane PM. Comparative study of biofilm and non-biofilm producing klebsiella pneumoniae with special reference to metallo-beta-lactamase production. J Pure Appl Microbil. 20241, 18:1025. 10.22207\/JPAM.18.2.17","journal-title":"J Pure Appl Microbil"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S351961","article-title":"Aerobic bacterial profile and their antibiotic susceptibility patterns of sterile body fluids among patients at Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia","volume":"15","author":"Shume T","year":"2022","unstructured":"Shume T, Tesfa T, Mekonnen S, Asmerom H, Tebeje F, Weldegebreal F. Aerobic bacterial profile and their antibiotic susceptibility patterns of sterile body fluids among patients at Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia. Infect Drug Resist. 2022, 15:581-93. 10.2147\/IDR.S351961","journal-title":"Infect Drug Resist"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2023\/66938.18751","article-title":"Bacteriological profile and antibiotic susceptibility pattern in sterile body fluids from a tertiary care hospital in Bhubaneswar, Odisha, India: a cross-sectional study","volume":"17","author":"Tiwari S","year":"2023","unstructured":"Tiwari S, Nanda M, Pattanaik S, et al.. Bacteriological profile and antibiotic susceptibility pattern in sterile body fluids from a tertiary care hospital in Bhubaneswar, Odisha, India: a cross-sectional study. J Clin Diagn Res. 2023, 17:20-3. 10.7860\/JCDR\/2023\/66938.18751","journal-title":"J Clin Diagn Res"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.20546\/ijcmas.2019.808.071","article-title":"An aerobic bacteriological profile and antibiogram of various body fluids from a tertiary care hospital in Telangana, India - a 5 year study","volume":"8","author":"Durga SV","year":"2019","unstructured":"Durga SV, Anuradha B. An aerobic bacteriological profile and antibiogram of various body fluids from a tertiary care hospital in Telangana, India - a 5 year study. Int J Curr Microbiol App Sci. 2019, 8:592-601. 10.20546\/ijcmas.2019.808.071","journal-title":"Int J Curr Microbiol App Sci"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5456067","article-title":"Bacterial isolates and drug susceptibility pattern of sterile body fluids from tertiary hospital, northern Ethiopia: a four-year retrospective study","volume":"2019","author":"Tsegay E","year":"2019","unstructured":"Tsegay E, Hailesilassie A, Hailekiros H, Niguse S, Saravanan M, Abdulkader M. Bacterial isolates and drug susceptibility pattern of sterile body fluids from tertiary hospital, northern Ethiopia: a four-year retrospective study. J Pathog. 2019, 2019:5456067. 10.1155\/2019\/5456067","journal-title":"J Pathog"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1260841","article-title":"Bacterial etiologies, antimicrobial susceptibility pattern and associated factors among patients suspected sterile body site infections at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia","volume":"11","author":"Admas D","year":"2024","unstructured":"Admas D, Demeke G, Adugna A, Esmael A. Bacterial etiologies, antimicrobial susceptibility pattern and associated factors among patients suspected sterile body site infections at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia. Front Med (Lausanne). 2024, 11:1260841. 10.3389\/fmed.2024.1260841","journal-title":"Front Med (Lausanne)"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.25259\/IJMS_63_2023","article-title":"Sterile body fluids infections: profile of bacteria and their antimicrobial resistance pattern in a tertiary care hospital from Uttar Pradesh","volume":"75","author":"Singh P","year":"2023","unstructured":"Singh P, Pandey A, Bisht AS. Sterile body fluids infections: profile of bacteria and their antimicrobial resistance pattern in a tertiary care hospital from Uttar Pradesh. Indian J Med Sci. 2023, 75:161-7. 10.25259\/IJMS_63_2023","journal-title":"Indian J Med Sci"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.9734\/jamb\/2022\/v22i830476","article-title":"Bacterial isolates and drug susceptibility pattern of sterile body fluids at a tertiary care hospital in Northern India","volume":"22","author":"Kar M","year":"2022","unstructured":"Kar M, Chaudhary R, Sahu C, Dubey A, Patel SS. Bacterial isolates and drug susceptibility pattern of sterile body fluids at a tertiary care hospital in Northern India. J Adv Microbiol. 2022, 22:6-15. 10.9734\/jamb\/2022\/v22i830476","journal-title":"J Adv Microbiol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/917856","article-title":"Patterns of antimicrobial resistance in the causative organisms of spontaneous bacterial peritonitis: a single centre, six-year experience of 1981 samples","volume":"2014","author":"Sheikhbahaei S","year":"2014","unstructured":"Sheikhbahaei S, Abdollahi A, Hafezi-Nejad N, Zare E. Patterns of antimicrobial resistance in the causative organisms of spontaneous bacterial peritonitis: a single centre, six-year experience of 1981 samples. Int J Hepatol. 2014, 2014:917856. 10.1155\/2014\/917856","journal-title":"Int J Hepatol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1086\/425368","article-title":"Practice guidelines for the management of bacterial meningitis","volume":"39","author":"Tunkel AR","year":"2004","unstructured":"Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004, 39:1267-84. 10.1086\/425368","journal-title":"Clin Infect Dis"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1086\/520682","article-title":"Community-acquired recurrent bacterial meningitis in adults","volume":"45","author":"Adriani KS","year":"2007","unstructured":"Adriani KS, van de Beek D, Brouwer MC, Spanjaard L, de Gans J. Community-acquired recurrent bacterial meningitis in adults. Clin Infect Dis. 2007, 45:e46-51. 10.1086\/520682","journal-title":"Clin Infect Dis"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2012\/5016.2673","article-title":"ESBL, MBL and Ampc \u03b2 lactamases producing superbugs - havoc in the intensive care units of Punjab India","volume":"7","author":"Oberoi L","year":"2013","unstructured":"Oberoi L, Singh N, Sharma P, Aggarwal A. ESBL, MBL and Ampc \u03b2 lactamases producing superbugs - havoc in the intensive care units of Punjab India. J Clin Diagn Res. 2013, 7:70-3. 10.7860\/JCDR\/2012\/5016.2673","journal-title":"J Clin Diagn Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/355073-unveiling-the-silent-threat-the-rise-of--lactamase-enzymes-in-gram-negative-bacterial-isolates-identified-from-sterile-body-fluids-in-an-indian-healthcare-institution","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T05:11:20Z","timestamp":1745903480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/355073-unveiling-the-silent-threat-the-rise-of--lactamase-enzymes-in-gram-negative-bacterial-isolates-identified-from-sterile-body-fluids-in-an-indian-healthcare-institution"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.83155","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,28]]}}}