{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:11:43Z","timestamp":1745986303084,"version":"3.40.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,29]]},"DOI":"10.7759\/cureus.83162","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T08:10:08Z","timestamp":1745914208000},"source":"Crossref","is-referenced-by-count":0,"title":["Role of Novel Target Molecules (\u03b2-Catenin and Retinoblastoma Protein) in the Spectrum of Inflammatory Bowel Disease"],"prefix":"10.7759","author":[{"given":"Manali V","family":"Bharambe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeti R","family":"Doshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachana R","family":"Lakhe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purva S","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reena P","family":"Bharadwaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Rosai and Ackerman\u2019s Surgical Pathology. 11th Edition","author":"Goldblum JR","year":"2018","unstructured":"Goldblum JR, Lamps LW, McKenny J, et al.. Rosai and Ackerman\u2019s Surgical Pathology. 11th Edition. Elsevier, Cambridge, MA; 2018."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.32074\/1591-951X-235","article-title":"Histopathology of IBD Colitis. A practical approach from the pathologists of the Italian Group for the study of the gastrointestinal tract (GIPAD)","volume":"113","author":"Villanacci V","year":"2021","unstructured":"Villanacci V, Reggiani-Bonetti L, Salviato T, et al.. Histopathology of IBD Colitis. A practical approach from the pathologists of the Italian Group for the study of the gastrointestinal tract (GIPAD). Pathologica. 2021, 113:39-53. 10.32074\/1591-951X-235","journal-title":"Pathologica"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070786","article-title":"Immunohistochemical analysis of retinoblastoma and \u03b2-catenin as an assistant tool in the differential diagnosis between Crohn's disease and ulcerative colitis","volume":"8","author":"Soletti RC","year":"2013","unstructured":"Soletti RC, Rodrigues NA, Biasoli D, Luiz RR, de Souza HS, Borges HL. Immunohistochemical analysis of retinoblastoma and \u03b2-catenin as an assistant tool in the differential diagnosis between Crohn's disease and ulcerative colitis. PLoS One. 2013, 8:e70786. 10.1371\/journal.pone.0070786","journal-title":"PLoS One"},{"key":"ref4","article-title":"Robbins & Cotran Pathologic Basis of Disease. 10th Edition","author":"Kumar V","year":"2021","unstructured":"Kumar V, Abbas AK, Aster JC. Robbins & Cotran Pathologic Basis of Disease. 10th Edition. Kumar V, Abbas AK, Aster JC (ed): Elsevier, Cambridge, MA; 2021."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.150","article-title":"The many faces and functions of \u03b2-catenin","volume":"31","author":"Valenta T","year":"2012","unstructured":"Valenta T, Hausmann G, Basler K. The many faces and functions of \u03b2-catenin. EMBO J. 2012, 31:2714-36. 10.1038\/emboj.2012.150","journal-title":"EMBO J"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1358","article-title":"Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation","volume":"65","author":"Ying L","year":"2005","unstructured":"Ying L, Marino J, Hussain SP, et al.. Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation. Cancer Res. 2005, 65:9132-6. 10.1158\/0008-5472.CAN-05-1358","journal-title":"Cancer Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4103\/ijpm.ijpm_739_21","article-title":"Role of Immunohistochemistry and serology in subclassifying the Inflammatory Bowel Disease cases diagnosed as Inflammatory Bowel Diseases---unclassified on colonic biopsies","volume":"65","author":"Paridhi","year":"2022","unstructured":"Paridhi, Singh K, Kumar V, Tewari S, Misra V, Misra SP, Dwivedi M. Role of Immunohistochemistry and serology in subclassifying the Inflammatory Bowel Disease cases diagnosed as Inflammatory Bowel Diseases---unclassified on colonic biopsies. Indian J Pathol Microbiol. 2022, 65:558-64. 10.4103\/ijpm.ijpm_739_21","journal-title":"Indian J Pathol Microbiol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/his.12263","article-title":"Ulcerative colitis or Crohn's disease? Pitfalls and problems","volume":"64","author":"Feakins RM","year":"2014","unstructured":"Feakins RM. Ulcerative colitis or Crohn's disease? Pitfalls and problems. Histopathology. 2014, 64:317-35. 10.1111\/his.12263","journal-title":"Histopathology"},{"key":"ref9","article-title":"Diagnosis and treatment of inflammatory bowel disease","volume":"260","author":"Taylor S","year":"2016","unstructured":"Taylor S, Lobo AJ. Diagnosis and treatment of inflammatory bowel disease. Practitioner. 2016, 260:19-23.","journal-title":"Practitioner"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.5.445","article-title":"Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes","volume":"10","author":"Lawrance IC","year":"2001","unstructured":"Lawrance IC, Fiocchi C, Chakravarti S. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Hum Mol Genet. 2001, 10:445-56. 10.1093\/hmg\/10.5.445","journal-title":"Hum Mol Genet"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7451946","article-title":"Diagnostic markers for nonspecific inflammatory bowel diseases","volume":"2018","author":"Derkacz A","year":"2018","unstructured":"Derkacz A, Olczyk P, Komosinska-Vassev K. Diagnostic markers for nonspecific inflammatory bowel diseases. Dis Markers. 2018, 2018:7451946. 10.1155\/2018\/7451946","journal-title":"Dis Markers"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.11613\/bm.2013.006","article-title":"Serological markers of inflammatory bowel disease","volume":"23","author":"Kuna AT","year":"2013","unstructured":"Kuna AT. Serological markers of inflammatory bowel disease. Biochem Med (Zagreb). 2013, 23:28-42. 10.11613\/bm.2013.006","journal-title":"Biochem Med (Zagreb)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1102942","article-title":"Ulcerative colitis","volume":"365","author":"Danese S","year":"2011","unstructured":"Danese S, Fiocchi C. Ulcerative colitis. N Engl J Med. 2011, 365:1713-25. 10.1056\/NEJMra1102942","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020831","article-title":"Inflammatory bowel disease","volume":"347","author":"Podolsky DK","year":"2002","unstructured":"Podolsky DK. Inflammatory bowel disease. N Engl J Med. 2002, 347:417-29. 10.1056\/NEJMra020831","journal-title":"N Engl J Med"},{"key":"ref15","article-title":"Diagnosis and management of Crohn's disease","volume":"84","author":"Wilkins T","year":"2011","unstructured":"Wilkins T, Jarvis K, Patel J. Diagnosis and management of Crohn's disease. Am Fam Physician. 2011, 84:1365-75.","journal-title":"Am Fam Physician"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2010.07.2184","article-title":"Serologic markers: impact on early diagnosis and disease stratification in inflammatory bowel disease","volume":"122","author":"Arai R","year":"2010","unstructured":"Arai R. Serologic markers: impact on early diagnosis and disease stratification in inflammatory bowel disease. Postgrad Med. 2010, 122:177-85. 10.3810\/pgm.2010.07.2184","journal-title":"Postgrad Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory bowel disease","volume":"361","author":"Abraham C","year":"2009","unstructured":"Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med. 2009, 361:2066-78. 10.1056\/NEJMra0804647","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.032","article-title":"The genetics of inflammatory bowel disease","volume":"133","author":"Cho JH","year":"2007","unstructured":"Cho JH, Weaver CT. The genetics of inflammatory bowel disease. Gastroenterology. 2007, 133:1327-39. 10.1053\/j.gastro.2007.08.032","journal-title":"Gastroenterology"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/nri2161","article-title":"Unveiling the roles of autophagy in innate and adaptive immunity","volume":"7","author":"Levine B","year":"2007","unstructured":"Levine B, Deretic V. Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol. 2007, 7:767-77. 10.1038\/nri2161","journal-title":"Nat Rev Immunol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02248.x","article-title":"Diagnostic difficulties in inflammatory bowel disease pathology","volume":"48","author":"Yantiss RK","year":"2006","unstructured":"Yantiss RK, Odze RD. Diagnostic difficulties in inflammatory bowel disease pathology. Histopathology. 2006, 48:116-32. 10.1111\/j.1365-2559.2005.02248.x","journal-title":"Histopathology"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/348505-role-of-novel-target-molecules--catenin-and-retinoblastoma-protein-in-the-spectrum-of-inflammatory-bowel-disease","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T08:10:10Z","timestamp":1745914210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/348505-role-of-novel-target-molecules--catenin-and-retinoblastoma-protein-in-the-spectrum-of-inflammatory-bowel-disease"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.83162","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,29]]}}}