{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:40:04Z","timestamp":1792172404114,"version":"4.4.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,4]]},"DOI":"10.7759\/cureus.83440","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T07:40:14Z","timestamp":1746344414000},"source":"Crossref","is-referenced-by-count":2,"title":["Mesenchymal Stromal Cell Treatment Alleviates Autism Spectrum Disorder Symptoms: A Case Report"],"prefix":"10.7759","author":[{"given":"Benjamin","family":"Gesundheit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Hochbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Fetyukhina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasily","family":"Vorobyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay","family":"Vorobyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S120509","article-title":"Epilepsy in patients with autism: links, risks and treatment challenges","volume":"14","author":"Besag FM","year":"2018","unstructured":"Besag FM. Epilepsy in patients with autism: links, risks and treatment challenges. Neuropsychiatr Dis Treat. 2018, 14:1-10. 10.2147\/NDT.S120509","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/02646830500381930","article-title":"Immunity, neuroglia and neuroinflammation in autism","volume":"17","author":"Pardo CA","year":"2005","unstructured":"Pardo CA, Vargas DL, Zimmerman AW. Immunity, neuroglia and neuroinflammation in autism. Int Rev Psychiatry. 2005, 17:485-95. 10.1080\/02646830500381930","journal-title":"Int Rev Psychiatry"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.05.005","article-title":"Immunological and autoimmune considerations of autism spectrum disorders","volume":"44","author":"Gesundheit B","year":"2013","unstructured":"Gesundheit B, Rosenzweig JP, Naor D, et al.. Immunological and autoimmune considerations of autism spectrum disorders. J Autoimmun. 2013, 44:1-7. 10.1016\/j.jaut.2013.05.005","journal-title":"J Autoimmun"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.50","article-title":"Autism-specific maternal autoantibodies recognize critical proteins in developing brain","volume":"3","author":"Braunschweig D","year":"2013","unstructured":"Braunschweig D, Krakowiak P, Duncanson P, et al.. Autism-specific maternal autoantibodies recognize critical proteins in developing brain. Transl Psychiatry. 2013, 3:e277. 10.1038\/tp.2013.50","journal-title":"Transl Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.272","article-title":"Microglial activation in young adults with autism spectrum disorder","volume":"70","author":"Suzuki K","year":"2013","unstructured":"Suzuki K, Sugihara G, Ouchi Y, et al.. Microglial activation in young adults with autism spectrum disorder. JAMA Psychiatry. 2013, 70:49-58. 10.1001\/jamapsychiatry.2013.272","journal-title":"JAMA Psychiatry"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.12.002","article-title":"Elevated immune response in the brain of autistic patients","volume":"207","author":"Li X","year":"2009","unstructured":"Li X, Chauhan A, Sheikh AM, et al.. Elevated immune response in the brain of autistic patients. J Neuroimmunol. 2009, 207:111-6. 10.1016\/j.jneuroim.2008.12.002","journal-title":"J Neuroimmunol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.08.003","article-title":"Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome","volume":"25","author":"Ashwood P","year":"2011","unstructured":"Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun. 2011, 25:40-5. 10.1016\/j.bbi.2010.08.003","journal-title":"Brain Behav Immun"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2014.12.016","article-title":"Therapeutic properties of mesenchymal stem cells for autism spectrum disorders","volume":"84","author":"Gesundheit B","year":"2015","unstructured":"Gesundheit B, Ashwood P, Keating A, Naor D, Melamed M, Rosenzweig JP. Therapeutic properties of mesenchymal stem cells for autism spectrum disorders. Med Hypotheses. 2015, 84:169-77. 10.1016\/j.mehy.2014.12.016","journal-title":"Med Hypotheses"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01855-9","article-title":"Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress","volume":"11","author":"Wu X","year":"2020","unstructured":"Wu X, Jiang J, Gu Z, Zhang J, Chen Y, Liu X. Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress. Stem Cell Res Ther. 2020, 11:345. 10.1186\/s13287-020-01855-9","journal-title":"Stem Cell Res Ther"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF01531713","article-title":"A validity analysis of selected instruments used to assess autism","volume":"16","author":"Teal MB","year":"1986","unstructured":"Teal MB, Wiebe MJ. A validity analysis of selected instruments used to assess autism. J Autism Dev Disord. 1986, 16:485-94. 10.1007\/BF01531713","journal-title":"J Autism Dev Disord"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025014929212","article-title":"Validation of a brief quantitative measure of autistic traits: comparison of the Social Responsiveness Scale with the Autism Diagnostic Interview-Revised","volume":"33","author":"Constantino JN","year":"2003","unstructured":"Constantino JN, Davis SA, Todd RD, et al.. Validation of a brief quantitative measure of autistic traits: comparison of the Social Responsiveness Scale with the Autism Diagnostic Interview-Revised. J Autism Dev Disord. 2003, 33:427-33. 10.1023\/A:1025014929212","journal-title":"J Autism Dev Disord"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2445","article-title":"Association of family history of autoimmune diseases and autism spectrum disorders","volume":"124","author":"Atlad\u00f3ttir HO","year":"2009","unstructured":"Atlad\u00f3ttir HO, Pedersen MG, Thorsen P, Mortensen PB, Deleuran B, Eaton WW, Parner ET. Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics. 2009, 124:687-94. 10.1542\/peds.2008-2445","journal-title":"Pediatrics"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.967954","article-title":"Autism spectrum disorder diagnosis using a new panel of immune- and inflammatory-related serum biomarkers: a case-control multicenter study","volume":"11","author":"Gesundheit B","year":"2023","unstructured":"Gesundheit B, Zisman PD, Hochbaum L, et al.. Autism spectrum disorder diagnosis using a new panel of immune- and inflammatory-related serum biomarkers: a case-control multicenter study. Front Pediatr. 2023, 11:967954. 10.3389\/fped.2023.967954","journal-title":"Front Pediatr"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.18-0090","article-title":"Electrophysiological biomarkers predict clinical improvement in an open-label trial assessing efficacy of autologous umbilical cord blood for treatment of autism","volume":"7","author":"Murias M","year":"2018","unstructured":"Murias M, Major S, Compton S, Buttinger J, Sun JM, Kurtzberg J, Dawson G. Electrophysiological biomarkers predict clinical improvement in an open-label trial assessing efficacy of autologous umbilical cord blood for treatment of autism. Stem Cells Transl Med. 2018, 7:783-91. 10.1002\/sctm.18-0090","journal-title":"Stem Cells Transl Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2029","article-title":"Concise review: prospects of bone marrow mononuclear cells and mesenchymal stem cells for treating status epilepticus and chronic epilepsy","volume":"33","author":"Agadi S","year":"2015","unstructured":"Agadi S, Shetty AK. Concise review: prospects of bone marrow mononuclear cells and mesenchymal stem cells for treating status epilepticus and chronic epilepsy. Stem Cells. 2015, 33:2093-103. 10.1002\/stem.2029","journal-title":"Stem Cells"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001282","article-title":"Feeding disorders in children with autism spectrum disorders are associated with eosinophilic esophagitis","volume":"63","author":"Heifert TA","year":"2016","unstructured":"Heifert TA, Susi A, Hisle-Gorman E, Erdie-Lalena CR, Gorman G, Min SB, Nylund CM. Feeding disorders in children with autism spectrum disorders are associated with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2016, 63:e69-73. 10.1097\/MPG.0000000000001282","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.05.038","article-title":"Phenotypic characterization of eosinophilic esophagitis in a large multicenter patient population from the Consortium for Food Allergy Research","volume":"6","author":"Chehade M","year":"2018","unstructured":"Chehade M, Jones SM, Pesek RD, et al.. Phenotypic characterization of eosinophilic esophagitis in a large multicenter patient population from the Consortium for Food Allergy Research. J Allergy Clin Immunol Pract. 2018, 6:1534-1544.e5. 10.1016\/j.jaip.2018.05.038","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19-0434","article-title":"Infusion of human umbilical cord tissue mesenchymal stromal cells in children with autism spectrum disorder","volume":"9","author":"Sun JM","year":"2020","unstructured":"Sun JM, Dawson G, Franz L, et al.. Infusion of human umbilical cord tissue mesenchymal stromal cells in children with autism spectrum disorder. Stem Cells Transl Med. 2020, 9:1137-46. 10.1002\/sctm.19-0434","journal-title":"Stem Cells Transl Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.16-0474","article-title":"Autologous cord blood infusions are safe and feasible in young children with autism spectrum disorder: results of a single-center phase I open-label trial","volume":"6","author":"Dawson G","year":"2017","unstructured":"Dawson G, Sun JM, Davlantis KS, et al.. Autologous cord blood infusions are safe and feasible in young children with autism spectrum disorder: results of a single-center phase I open-label trial. Stem Cells Transl Med. 2017, 6:1332-9. 10.1002\/sctm.16-0474","journal-title":"Stem Cells Transl Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67474-9","article-title":"Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature","volume":"10","author":"Simhal AK","year":"2020","unstructured":"Simhal AK, Carpenter KL, Nadeem S, et al.. Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature. Sci Rep. 2020, 10:10819. 10.1038\/s41598-020-67474-9","journal-title":"Sci Rep"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.03.011","article-title":"A phase II randomized clinical trial of the safety and efficacy of intravenous umbilical cord blood infusion for treatment of children with autism spectrum disorder","volume":"222","author":"Dawson G","year":"2020","unstructured":"Dawson G, Sun JM, Baker J, et al.. A phase II randomized clinical trial of the safety and efficacy of intravenous umbilical cord blood infusion for treatment of children with autism spectrum disorder. J Pediatr. 2020, 222:164-173.e5. 10.1016\/j.jpeds.2020.03.011","journal-title":"J Pediatr"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03381-w","article-title":"MSCs' conditioned media cytokine and growth factor profiles and their impact on macrophage polarization","volume":"14","author":"Peshkova M","year":"2023","unstructured":"Peshkova M, Korneev A, Suleimanov S, Vlasova II, Svistunov A, Kosheleva N, Timashev P. MSCs' conditioned media cytokine and growth factor profiles and their impact on macrophage polarization. Stem Cell Res Ther. 2023, 14:142. 10.1186\/s13287-023-03381-w","journal-title":"Stem Cell Res Ther"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c00831","article-title":"Mesenchymal stem cell-derived exosomes for treatment of autism spectrum disorder","volume":"3","author":"Liang Y","year":"2020","unstructured":"Liang Y, Duan L, Xu X, et al.. Mesenchymal stem cell-derived exosomes for treatment of autism spectrum disorder. ACS Appl Bio Mater. 2020, 3:6384-93. 10.1021\/acsabm.0c00831","journal-title":"ACS Appl Bio Mater"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17030944","article-title":"Stem cell-derived exosomes in autism spectrum disorder","volume":"17","author":"Alessio N","year":"2020","unstructured":"Alessio N, Brigida AL, Peluso G, Antonucci N, Galderisi U, Siniscalco D. Stem cell-derived exosomes in autism spectrum disorder. Int J Environ Res Public Health. 2020, 17:944. 10.3390\/ijerph17030944","journal-title":"Int J Environ Res Public Health"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/319211-mesenchymal-stromal-cell-treatment-alleviates-autism-spectrum-disorder-symptoms-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T07:40:14Z","timestamp":1746344414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/319211-mesenchymal-stromal-cell-treatment-alleviates-autism-spectrum-disorder-symptoms-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,4]]},"references-count":24,"URL":"https:\/\/doi.org\/10.7759\/cureus.83440","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,4]]}}}