{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T04:04:05Z","timestamp":1746504245679,"version":"3.40.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,5]]},"DOI":"10.7759\/cureus.83511","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T14:11:01Z","timestamp":1746454261000},"source":"Crossref","is-referenced-by-count":0,"title":["Reirradiation of Large or Multifocal High-Grade Gliomas With Gyroscopic Radiosurgery in Combination With Modulated Electro-Hyperthermia"],"prefix":"10.7759","author":[{"given":"Morena","family":"Sallabanda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth Estefan\u00eda","family":"Arrojo \u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borja","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lucrecia","family":"Ruiz Echevarr\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Huertas Mod\u00e9jar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kita","family":"Sallabanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v12.i9.767","article-title":"Re-irradiation for high-grade gliomas: has anything changed?","volume":"12","author":"Garc\u00eda-Cabezas S","year":"2021","unstructured":"Garc\u00eda-Cabezas S, Rivin Del Campo E, Solivera-Vela J, Palacios-Eito A. Re-irradiation for high-grade gliomas: has anything changed?. World J Clin Oncol. 2021, 12:767-86. 10.5306\/wjco.v12.i9.767","journal-title":"World J Clin Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12040416","article-title":"Relapsing high-grade glioma from peritumoral zone: critical review of radiotherapy treatment options","volume":"12","author":"Lo Greco MC","year":"2022","unstructured":"Lo Greco MC, Milazzotto R, Liardo RL, et al.. Relapsing high-grade glioma from peritumoral zone: critical review of radiotherapy treatment options. Brain Sci. 2022, 12:416. 10.3390\/brainsci12040416","journal-title":"Brain Sci"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1108587","article-title":"Comparative dosimetric study of radiotherapy in high-grade gliomas based on the guidelines of EORTC and NRG-2019 target delineation","volume":"13","author":"Yan O","year":"2023","unstructured":"Yan O, Teng H, Jiang C, et al.. Comparative dosimetric study of radiotherapy in high-grade gliomas based on the guidelines of EORTC and NRG-2019 target delineation. Front Oncol. 2023, 13:1108587. 10.3389\/fonc.2023.1108587","journal-title":"Front Oncol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab120","article-title":"The 2021 WHO classification of tumors of the central nervous system: clinical implications","volume":"23","author":"Wen PY","year":"2021","unstructured":"Wen PY, Packer RJ. The 2021 WHO classification of tumors of the central nervous system: clinical implications. Neuro Oncol. 2021, 23:1215-7. 10.1093\/neuonc\/noab120","journal-title":"Neuro Oncol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.04.053","article-title":"Recurrence pattern analysis of primary glioblastoma","volume":"103","author":"Rapp M","year":"2017","unstructured":"Rapp M, Baernreuther J, Turowski B, Steiger HJ, Sabel M, Kamp MA. Recurrence pattern analysis of primary glioblastoma. World Neurosurg. 2017, 103:733-40. 10.1016\/j.wneu.2017.04.053","journal-title":"World Neurosurg"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-021-01767-9","article-title":"Current status and recent advances in reirradiation of glioblastoma","volume":"16","author":"Minniti G","year":"2021","unstructured":"Minniti G, Niyazi M, Alongi F, Navarria P, Belka C. Current status and recent advances in reirradiation of glioblastoma. Radiat Oncol. 2021, 16:36. 10.1186\/s13014-021-01767-9","journal-title":"Radiat Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.18480","article-title":"Stereotactic radiosurgery for recurrent glioblastoma multiforme: a retrospective multi-institutional experience","volume":"13","author":"Lovo EE","year":"2021","unstructured":"Lovo EE, Moreira A, Barahona KC, et al.. Stereotactic radiosurgery for recurrent glioblastoma multiforme: a retrospective multi-institutional experience. Cureus. 2021, 13:e18480. 10.7759\/cureus.18480","journal-title":"Cureus"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103540","article-title":"The current landscape of systemic therapy for recurrent glioblastoma: a systematic review of randomized-controlled trials","volume":"169","author":"Fazzari FG","year":"2022","unstructured":"Fazzari FG, Rose F, Pauls M, et al.. The current landscape of systemic therapy for recurrent glioblastoma: a systematic review of randomized-controlled trials. Crit Rev Oncol Hematol. 2022, 169:103540. 10.1016\/j.critrevonc.2021.103540","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-023-04441-0","article-title":"Reirradiation versus systemic therapy versus combination therapy for recurrent high-grade glioma: a systematic review and meta-analysis of survival and toxicity","volume":"164","author":"Marwah R","year":"2023","unstructured":"Marwah R, Xing D, Squire T, Soon YY, Gan HK, Ng SP. Reirradiation versus systemic therapy versus combination therapy for recurrent high-grade glioma: a systematic review and meta-analysis of survival and toxicity. J Neurooncol. 2023, 164:505-24. 10.1007\/s11060-023-04441-0","journal-title":"J Neurooncol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030880","article-title":"Meta-analysis of modulated electro-hyperthermia and tumor treating fields in the treatment of glioblastomas","volume":"15","author":"Szasz AM","year":"2023","unstructured":"Szasz AM, Arrojo Alvarez EE, Fiorentini G, Herold M, Herold Z, Sarti D, Dank M. Meta-analysis of modulated electro-hyperthermia and tumor treating fields in the treatment of glioblastomas. Cancers (Basel). 2023, 15:880. 10.3390\/cancers15030880","journal-title":"Cancers (Basel)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184569","article-title":"The clinical validation of modulated electro-hyperthermia (mEHT)","volume":"15","author":"Lee SY","year":"2023","unstructured":"Lee SY, Lorant G, Grand L, Szasz AM. The clinical validation of modulated electro-hyperthermia (mEHT). Cancers (Basel). 2023, 15:4569. 10.3390\/cancers15184569","journal-title":"Cancers (Basel)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000036421","article-title":"Efficacy of tumour-treating fields therapy in recurrent glioblastoma: a narrative review of current evidence","volume":"102","author":"Olatunji G","year":"2023","unstructured":"Olatunji G, Aderinto N, Adefusi T, et al.. Efficacy of tumour-treating fields therapy in recurrent glioblastoma: a narrative review of current evidence. Medicine (Baltimore). 2023, 102:e36421. 10.1097\/MD.0000000000036421","journal-title":"Medicine (Baltimore)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/1534735418812691","article-title":"Modulated electrohyperthermia in integrative cancer treatment for relapsed malignant glioblastoma and astrocytoma: retrospective multicenter controlled study","volume":"18","author":"Fiorentini G","year":"2019","unstructured":"Fiorentini G, Sarti D, Milandri C, et al.. Modulated electrohyperthermia in integrative cancer treatment for relapsed malignant glioblastoma and astrocytoma: retrospective multicenter controlled study. Integr Cancer Ther. 2019, 18:1534735418812691. 10.1177\/1534735418812691","journal-title":"Integr Cancer Ther"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2019.05.009","article-title":"Using the common terminology Criteria for Adverse Events (CTCAE - version 5.0) to evaluate the severity of adverse events of anticancer therapies","volume":"112","author":"Freites-Martinez A","year":"2021","unstructured":"Freites-Martinez A, Santana N, Arias-Santiago S, Viera A. Using the common terminology Criteria for Adverse Events (CTCAE - version 5.0) to evaluate the severity of adverse events of anticancer therapies. Actas Dermosifiliogr (Engl Ed). 2021, 112:90-2. 10.1016\/j.ad.2019.05.009","journal-title":"Actas Dermosifiliogr (Engl Ed)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou230","article-title":"Delayed contrast extravasation MRI: a new paradigm in neuro-oncology","volume":"17","author":"Zach L","year":"2015","unstructured":"Zach L, Guez D, Last D, et al.. Delayed contrast extravasation MRI: a new paradigm in neuro-oncology. Neuro Oncol. 2015, 17:457-65. 10.1093\/neuonc\/nou230","journal-title":"Neuro Oncol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052008","article-title":"Delayed contrast extravasation MRI for depicting tumor and non-tumoral tissues in primary and metastatic brain tumors","volume":"7","author":"Zach L","year":"2012","unstructured":"Zach L, Guez D, Last D, et al.. Delayed contrast extravasation MRI for depicting tumor and non-tumoral tissues in primary and metastatic brain tumors. PLoS One. 2012, 7:e52008. 10.1371\/journal.pone.0052008","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2023.100697","article-title":"Re-irradiation of recurrent IDH-wildtype glioblastoma in the bevacizumab and immunotherapy era: target delineation, outcomes and patterns of recurrence","volume":"44","author":"Christ SM","year":"2024","unstructured":"Christ SM, Youssef G, Tanguturi SK, et al.. Re-irradiation of recurrent IDH-wildtype glioblastoma in the bevacizumab and immunotherapy era: target delineation, outcomes and patterns of recurrence. Clin Transl Radiat Oncol. 2024, 44:100697. 10.1016\/j.ctro.2023.100697","journal-title":"Clin Transl Radiat Oncol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.13972","article-title":"Characterization of the ZAP-X\u00ae peripheral dose fall-off","volume":"13","author":"Weidlich GA","year":"2021","unstructured":"Weidlich GA, Chung W, Kolli S, Thirunarayanan I, Loysel T. Characterization of the ZAP-X\u00ae peripheral dose fall-off. Cureus. 2021, 13:e13972. 10.7759\/cureus.13972","journal-title":"Cureus"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000519862","article-title":"ZAP-X gyroscopic radiosurgery system: a preliminary analysis of clinical applications within a retrospective case series","volume":"100","author":"Hendricks BK","year":"2022","unstructured":"Hendricks BK, DiDomenico JD, Barani IJ, Barranco FD. ZAP-X gyroscopic radiosurgery system: a preliminary analysis of clinical applications within a retrospective case series. Stereotact Funct Neurosurg. 2022, 100:99-107. 10.1159\/000519862","journal-title":"Stereotact Funct Neurosurg"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8324","article-title":"ZAP-X: a novel radiosurgical device for the treatment of trigeminal neuralgia","volume":"12","author":"Romanelli P","year":"2020","unstructured":"Romanelli P, Chuang C, Meola A, Bodduluri RM, Adler JR Jr. ZAP-X: a novel radiosurgical device for the treatment of trigeminal neuralgia. Cureus. 2020, 12:e8324. 10.7759\/cureus.8324","journal-title":"Cureus"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14740","article-title":"Treatment planning system and beam data validation for the ZAP-X: a novel self-shielded stereotactic radiosurgery system","volume":"48","author":"Srivastava SP","year":"2021","unstructured":"Srivastava SP, Jani SS, Pinnaduwage DS, et al.. Treatment planning system and beam data validation for the ZAP-X: a novel self-shielded stereotactic radiosurgery system. Med Phys. 2021, 48:2494-510. 10.1002\/mp.14740","journal-title":"Med Phys"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.103184","article-title":"Local treatment for relapsing glioblastoma: a decision-making tree for choosing between reirradiation and second surgery","volume":"157","author":"Scoccianti S","year":"2021","unstructured":"Scoccianti S, Perna M, Olmetto E, et al.. Local treatment for relapsing glioblastoma: a decision-making tree for choosing between reirradiation and second surgery. Crit Rev Oncol Hematol. 2021, 157:103184. 10.1016\/j.critrevonc.2020.103184","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-023-04364-w","article-title":"Correction to: re-irradiation for recurrent high-grade glioma: an analysis of prognostic factors for survival and predictors of radiation necrosis","volume":"163","author":"Moore-Palhares D","year":"2023","unstructured":"Moore-Palhares D, Chen H, Keith J, et al.. Correction to: re-irradiation for recurrent high-grade glioma: an analysis of prognostic factors for survival and predictors of radiation necrosis. J Neurooncol. 2023, 163:553. 10.1007\/s11060-023-04364-w","journal-title":"J Neurooncol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180457","article-title":"Modification and optimization of an established prognostic score after re-irradiation of recurrent glioma","volume":"12","author":"Kessel KA","year":"2017","unstructured":"Kessel KA, Hesse J, Straube C, et al.. Modification and optimization of an established prognostic score after re-irradiation of recurrent glioma. PLoS One. 2017, 12:e0180457. 10.1371\/journal.pone.0180457","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2017.06.013","article-title":"Reirradiation with concurrent bevacizumab for recurrent high-grade gliomas in adult patients","volume":"22","author":"Schernberg A","year":"2018","unstructured":"Schernberg A, Dhermain F, Ammari S, et al.. Reirradiation with concurrent bevacizumab for recurrent high-grade gliomas in adult patients. Cancer Radiother. 2018, 22:9-16. 10.1016\/j.canrad.2017.06.013","journal-title":"Cancer Radiother"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-023-04407-2","article-title":"The evolving role of reirradiation in the management of recurrent brain tumors","volume":"164","author":"De Pietro R","year":"2023","unstructured":"De Pietro R, Zaccaro L, Marampon F, Tini P, De Felice F, Minniti G. The evolving role of reirradiation in the management of recurrent brain tumors. J Neurooncol. 2023, 164:271-86. 10.1007\/s11060-023-04407-2","journal-title":"J Neurooncol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2021.01.011","article-title":"High-dose re-irradiation of intracranial lesions - efficacy and safety including dosimetric analysis based on accumulated EQD2Gy dose EQD calculation","volume":"27","author":"Stiefel I","year":"2021","unstructured":"Stiefel I, Schr\u00f6der C, Tanadini-Lang S, et al.. High-dose re-irradiation of intracranial lesions - efficacy and safety including dosimetric analysis based on accumulated EQD2Gy dose EQD calculation. Clin Transl Radiat Oncol. 2021, 27:132-8. 10.1016\/j.ctro.2021.01.011","journal-title":"Clin Transl Radiat Oncol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01012","article-title":"Review of the clinical evidences of modulated electro-hyperthermia (mEHT) method: an update for the practicing oncologist","volume":"9","author":"Szasz AM","year":"2019","unstructured":"Szasz AM, Minnaar CA, Szentm\u00e1rtoni G, Szigeti GP, Dank M. Review of the clinical evidences of modulated electro-hyperthermia (mEHT) method: an update for the practicing oncologist. Front Oncol. 2019, 9:1012. 10.3389\/fonc.2019.01012","journal-title":"Front Oncol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673-5374.2013.29.009","article-title":"Treatment of malignant glioma using hyperthermia","volume":"8","author":"Sun J","year":"2013","unstructured":"Sun J, Guo M, Pang H, Qi J, Zhang J, Ge Y. Treatment of malignant glioma using hyperthermia. Neural Regen Res. 2013, 8:2775-82. 10.3969\/j.issn.1673-5374.2013.29.009","journal-title":"Neural Regen Res"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-014-0617-1","article-title":"DNA fragmentation and caspase-independent programmed cell death by modulated electrohyperthermia","volume":"190","author":"Meggyeshazi N","year":"2014","unstructured":"Meggyeshazi N, Andocs G, Balogh L, et al.. DNA fragmentation and caspase-independent programmed cell death by modulated electrohyperthermia. Strahlenther Onkol. 2014, 190:815-22. 10.1007\/s00066-014-0617-1","journal-title":"Strahlenther Onkol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/350103-reirradiation-of-large-or-multifocal-high-grade-gliomas-with-gyroscopic-radiosurgery-in-combination-with-modulated-electro-hyperthermia","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T14:11:02Z","timestamp":1746454262000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/350103-reirradiation-of-large-or-multifocal-high-grade-gliomas-with-gyroscopic-radiosurgery-in-combination-with-modulated-electro-hyperthermia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,5]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.83511","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,5]]}}}