{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T20:21:48Z","timestamp":1774642908821,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,7]]},"DOI":"10.7759\/cureus.83635","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T08:09:38Z","timestamp":1746605378000},"source":"Crossref","is-referenced-by-count":1,"title":["Severity of Locomotive Syndrome Increases the Risk of Mortality: A Retrospective Study of Patients With Osteoporosis"],"prefix":"10.7759","author":[{"given":"Ryoma","family":"Asahi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Maruya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell O","year":"2006","unstructured":"Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006, 17:1726-33. 10.1007\/s00198-006-0172-4","journal-title":"Osteoporos Int"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-3909-3","article-title":"Worldwide prevalence and incidence of osteoporotic vertebral fractures","volume":"28","author":"Ballane G","year":"2017","unstructured":"Ballane G, Cauley JA, Luckey MM, El-Hajj Fuleihan G. Worldwide prevalence and incidence of osteoporotic vertebral fractures. Osteoporos Int. 2017, 28:1531-42. 10.1007\/s00198-017-3909-3","journal-title":"Osteoporos Int"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-022-01352-4","article-title":"Trends in osteoporosis prevalence over a 10-year period in Japan: the ROAD study 2005-2015","volume":"40","author":"Yoshimura N","year":"2022","unstructured":"Yoshimura N, Iidaka T, Horii C, et al.. Trends in osteoporosis prevalence over a 10-year period in Japan: the ROAD study 2005-2015. J Bone Miner Metab. 2022, 40:829-38. 10.1007\/s00774-022-01352-4","journal-title":"J Bone Miner Metab"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3464-8","article-title":"Hip fracture incidence in Japan: estimates of new patients in 2012 and 25-year trends","volume":"27","author":"Orimo H","year":"2016","unstructured":"Orimo H, Yaegashi Y, Hosoi T, Fukushima Y, Onoda T, Hashimoto T, Sakata K. Hip fracture incidence in Japan: estimates of new patients in 2012 and 25-year trends. Osteoporos Int. 2016, 27:1777-84. 10.1007\/s00198-015-3464-8","journal-title":"Osteoporos Int"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/230949901001800204","article-title":"Mortality after vertebral fractures in a Japanese population","volume":"18","author":"Ikeda Y","year":"2010","unstructured":"Ikeda Y, Sudo A, Yamada T, Uchida A. Mortality after vertebral fractures in a Japanese population. J Orthop Surg (Hong Kong). 2010, 18:148-52. 10.1177\/230949901001800204","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1412-5","article-title":"Incident vertebral fractures and mortality in older women: a prospective study","volume":"14","author":"Kado DM","year":"2003","unstructured":"Kado DM, Duong T, Stone KL, Ensrud KE, Nevitt MC, Greendale GA, Cummings SR. Incident vertebral fractures and mortality in older women: a prospective study. Osteoporos Int. 2003, 14:589-94. 10.1007\/s00198-003-1412-5","journal-title":"Osteoporos Int"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.89B4.18552","article-title":"Mortality and mobility after hip fracture in Japan: a ten-year follow-up","volume":"89","author":"Tsuboi M","year":"2007","unstructured":"Tsuboi M, Hasegawa Y, Suzuki S, Wingstrand H, Thorngren KG. Mortality and mobility after hip fracture in Japan: a ten-year follow-up. J Bone Joint Surg Br. 2007, 89:461-6. 10.1302\/0301-620X.89B4.18552","journal-title":"J Bone Joint Surg Br"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00033.2015","article-title":"Estrogens and androgens in skeletal physiology and pathophysiology","volume":"97","author":"Almeida M","year":"2017","unstructured":"Almeida M, Laurent MR, Dubois V, et al.. Estrogens and androgens in skeletal physiology and pathophysiology. Physiol Rev. 2017, 97:135-87. 10.1152\/physrev.00033.2015","journal-title":"Physiol Rev"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4184-z","article-title":"Comparison of spinal alignment, muscular strength, and quality of life between women with postmenopausal osteoporosis and healthy volunteers","volume":"28","author":"Miyakoshi N","year":"2017","unstructured":"Miyakoshi N, Kudo D, Hongo M, Kasukawa Y, Ishikawa Y, Shimada Y. Comparison of spinal alignment, muscular strength, and quality of life between women with postmenopausal osteoporosis and healthy volunteers. Osteoporos Int. 2017, 28:3153-60. 10.1007\/s00198-017-4184-z","journal-title":"Osteoporos Int"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-021-00918-5","article-title":"Association between BMI variability and risk of fracture among Korean men and women: a population based study","volume":"16","author":"Cho Y","year":"2021","unstructured":"Cho Y, Choi S, Yun YH, Cho B, Choi JY, Park SM. Association between BMI variability and risk of fracture among Korean men and women: a population based study. Arch Osteoporos. 2021, 16:67. 10.1007\/s11657-021-00918-5","journal-title":"Arch Osteoporos"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-0970-6","article-title":"Low bone mineral density at femoral neck is a predictor of increased mortality in elderly Japanese women","volume":"21","author":"Suzuki T","year":"2010","unstructured":"Suzuki T, Yoshida H. Low bone mineral density at femoral neck is a predictor of increased mortality in elderly Japanese women. Osteoporos Int. 2010, 21:71-9. 10.1007\/s00198-009-0970-6","journal-title":"Osteoporos Int"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2015.11.003","article-title":"Associations of walking speed, grip strength, and standing balance with total and cause-specific mortality in a general population of Japanese elders","volume":"17","author":"Nofuji Y","year":"2016","unstructured":"Nofuji Y, Shinkai S, Taniguchi Y, et al.. Associations of walking speed, grip strength, and standing balance with total and cause-specific mortality in a general population of Japanese elders. J Am Med Dir Assoc. 2016, 17:184.e1-7. 10.1016\/j.jamda.2015.11.003","journal-title":"J Am Med Dir Assoc"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2188\/jea.je20100180","article-title":"Body mass index and mortality from all causes and major causes in Japanese: results of a pooled analysis of 7 large-scale cohort studies","volume":"21","author":"Sasazuki S","year":"2011","unstructured":"Sasazuki S, Inoue M, Tsuji I, et al.. Body mass index and mortality from all causes and major causes in Japanese: results of a pooled analysis of 7 large-scale cohort studies. J Epidemiol. 2011, 21:417-30. 10.2188\/jea.je20100180","journal-title":"J Epidemiol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1076-7460.2000.80022.x","article-title":"Hypertension in the elderly","volume":"9","author":"Webb-Peploe KM","year":"2000","unstructured":"Webb-Peploe KM, MacGregor GA. Hypertension in the elderly. Am J Geriatr Cardiol. 2000, 9:130-7. 10.1111\/j.1076-7460.2000.80022.x","journal-title":"Am J Geriatr Cardiol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.08.004","article-title":"Heart failure disease management works, but will it succeed?","volume":"25","author":"Rumsfeld JS","year":"2004","unstructured":"Rumsfeld JS, Masoudi FA. Heart failure disease management works, but will it succeed?. Eur Heart J. 2004, 25:1565-7. 10.1016\/j.ehj.2004.08.004","journal-title":"Eur Heart J"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217269109","article-title":"Using distance correlation and SS-ANOVA to assess associations of familial relationships, lifestyle factors, diseases, and mortality","volume":"109","author":"Kong J","year":"2012","unstructured":"Kong J, Klein BE, Klein R, Lee KE, Wahba G. Using distance correlation and SS-ANOVA to assess associations of familial relationships, lifestyle factors, diseases, and mortality. Proc Natl Acad Sci U S A. 2012, 109:20352-7. 10.1073\/pnas.1217269109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac168","article-title":"The relevance of geriatric assessments on the association between chronic kidney disease stages and mortality among older people: a secondary analysis of a multicentre cohort study","volume":"51","author":"Corsonello A","year":"2022","unstructured":"Corsonello A, Soraci L, \u00c4rnl\u00f6v J, et al.. The relevance of geriatric assessments on the association between chronic kidney disease stages and mortality among older people: a secondary analysis of a multicentre cohort study. Age Ageing. 2022, 51:afac168. 10.1093\/ageing\/afac168","journal-title":"Age Ageing"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-080919-112707","article-title":"Advances in chronic obstructive pulmonary disease","volume":"72","author":"Ferrera MC","year":"2021","unstructured":"Ferrera MC, Labaki WW, Han MK. Advances in chronic obstructive pulmonary disease. Annu Rev Med. 2021, 72:119-34. 10.1146\/annurev-med-080919-112707","journal-title":"Annu Rev Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-015-0737-1","article-title":"Development of a screening program to assess motor function in the adult population: a cross-sectional observational study","volume":"20","author":"Ogata T","year":"2015","unstructured":"Ogata T, Muranaga S, Ishibashi H, et al.. Development of a screening program to assess motor function in the adult population: a cross-sectional observational study. J Orthop Sci. 2015, 20:888-95. 10.1007\/s00776-015-0737-1","journal-title":"J Orthop Sci"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-022-01324-8","article-title":"Epidemiology of locomotive syndrome using updated clinical decision limits: 6-year follow-ups of the ROAD study","volume":"40","author":"Yoshimura N","year":"2022","unstructured":"Yoshimura N, Iidaka T, Horii C, et al.. Epidemiology of locomotive syndrome using updated clinical decision limits: 6-year follow-ups of the ROAD study. J Bone Miner Metab. 2022, 40:623-35. 10.1007\/s00774-022-01324-8","journal-title":"J Bone Miner Metab"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.7.1254","article-title":"Association between vertebral fracture and increased mortality in osteoporotic patients","volume":"18","author":"Jalava T","year":"2003","unstructured":"Jalava T, Sarna S, Pylkk\u00e4nen L, et al.. Association between vertebral fracture and increased mortality in osteoporotic patients. J Bone Miner Res. 2003, 18:1254-60. 10.1359\/jbmr.2003.18.7.1254","journal-title":"J Bone Miner Res"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2021.07.019","article-title":"Osteoporosis and its association with cardiovascular disease, respiratory disease, and cancer: findings from the UK Biobank prospective cohort study","volume":"97","author":"Rodr\u00edguez-G\u00f3mez I","year":"2022","unstructured":"Rodr\u00edguez-G\u00f3mez I, Gray SR, Ho FK, et al.. Osteoporosis and its association with cardiovascular disease, respiratory disease, and cancer: findings from the UK Biobank prospective cohort study. Mayo Clin Proc. 2022, 97:110-21. 10.1016\/j.mayocp.2021.07.019","journal-title":"Mayo Clin Proc"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.06.005","article-title":"Low bone mineral density, coronary heart disease, and stroke mortality in men and women: the Third National Health and Nutrition Examination Survey","volume":"17","author":"Mussolino ME","year":"2007","unstructured":"Mussolino ME, Armenian HK. Low bone mineral density, coronary heart disease, and stroke mortality in men and women: the Third National Health and Nutrition Examination Survey. Ann Epidemiol. 2007, 17:841-6. 10.1016\/j.annepidem.2007.06.005","journal-title":"Ann Epidemiol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4386-z","article-title":"Nonlinear association between bone mineral density and all-cause mortality: the Dong-gu study","volume":"29","author":"Choi CK","year":"2018","unstructured":"Choi CK, Kweon S-, Lee Y-, et al.. Nonlinear association between bone mineral density and all-cause mortality: the Dong-gu study. Osteoporos Int. 2018, 29:2011-20. 10.1007\/s00198-018-4386-z","journal-title":"Osteoporos Int"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roac101","article-title":"Does locomotive syndrome severity predict future fragility fractures in community-dwelling women with osteoporosis?","volume":"33","author":"Asahi R","year":"2023","unstructured":"Asahi R, Nakamura Y, Koike Y, et al.. Does locomotive syndrome severity predict future fragility fractures in community-dwelling women with osteoporosis?. Mod Rheumatol. 2023, 33:1036-43. 10.1093\/mr\/roac101","journal-title":"Mod Rheumatol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10091896","article-title":"Osteoporosis detection by physical function tests in resident health exams: a Japanese cohort survey randomly sampled from a basic resident registry","volume":"10","author":"Osawa R","year":"2021","unstructured":"Osawa R, Ikegami S, Horiuchi H, Tokida R, Kato H, Takahashi J. Osteoporosis detection by physical function tests in resident health exams: a Japanese cohort survey randomly sampled from a basic resident registry. J Clin Med. 2021, 10:1896. 10.3390\/jcm10091896","journal-title":"J Clin Med"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4467","article-title":"Objectively measured physical capability levels and mortality: systematic review and meta-analysis","volume":"341","author":"Cooper R","year":"2010","unstructured":"Cooper R, Kuh D, Hardy R. Objectively measured physical capability levels and mortality: systematic review and meta-analysis. BMJ. 2010, 341:c4467. 10.1136\/bmj.c4467","journal-title":"BMJ"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-021-05963-x","article-title":"The analysis of osteosarcopenia as a risk factor for fractures, mortality, and falls","volume":"32","author":"Teng Z","year":"2021","unstructured":"Teng Z, Zhu Y, Teng Y, et al.. The analysis of osteosarcopenia as a risk factor for fractures, mortality, and falls. Osteoporos Int. 2021, 32:2173-83. 10.1007\/s00198-021-05963-x","journal-title":"Osteoporos Int"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-019-01012-0","article-title":"Prevalence and co-existence of locomotive syndrome, sarcopenia, and frailty: the third survey of Research on Osteoarthritis\/Osteoporosis Against Disability (ROAD) study","volume":"37","author":"Yoshimura N","year":"2019","unstructured":"Yoshimura N, Muraki S, Iidaka T, et al.. Prevalence and co-existence of locomotive syndrome, sarcopenia, and frailty: the third survey of Research on Osteoarthritis\/Osteoporosis Against Disability (ROAD) study. J Bone Miner Metab. 2019, 37:1058-66. 10.1007\/s00774-019-01012-0","journal-title":"J Bone Miner Metab"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.12965\/jer.2244234.117","article-title":"An analysis study of sarcopenia and locomotive syndrome in the old people using evaluation tool","volume":"18","author":"Kim MC","year":"2022","unstructured":"Kim MC, Park HS, Kim HI, Paik JK, Chung DK. An analysis study of sarcopenia and locomotive syndrome in the old people using evaluation tool. J Exerc Rehabil. 2022, 18:256-63. 10.12965\/jer.2244234.117","journal-title":"J Exerc Rehabil"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/343420-severity-of-locomotive-syndrome-increases-the-risk-of-mortality-a-retrospective-study-of-patients-with-osteoporosis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T08:09:39Z","timestamp":1746605379000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/343420-severity-of-locomotive-syndrome-increases-the-risk-of-mortality-a-retrospective-study-of-patients-with-osteoporosis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,7]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.83635","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,7]]}}}