{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T15:22:50Z","timestamp":1774192970832,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,8]]},"DOI":"10.7759\/cureus.83753","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T01:50:00Z","timestamp":1746755400000},"source":"Crossref","is-referenced-by-count":1,"title":["Large B-cell Lymphoma With Interferon Regulatory Factor 4 Rearrangement Presenting as a Primary Central Nervous System Lymphoma in the Brain"],"prefix":"10.7759","author":[{"given":"Hannah","family":"Cutshall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay M","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip E","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca A","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Gokden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Large B-cell lymphoma with IRF4 re-arrangement","year":"2024","unstructured":"Large B-cell lymphoma with IRF4 re-arrangement. WHO Classification of Tumours Editorial Board. Haematolymphoid Tumours, 5th\u00a0ed. Oschlies I, Siebert R, Burkhardt B, Schafernak KT, Woessmann W (ed). International Agency for Research on Cancer, Lyon; 2024."},{"key":"ref2","article-title":"Large B-cell lymphoma with IRF4 rearrangement","year":"2017","unstructured":"Large B-cell lymphoma with IRF4 rearrangement. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Pittaluga S, Harris NL, Siebert R, Salaverria I (ed). International Agency for Research on Cancer, Lyon; 2017. 280-1."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15082285","article-title":"Large B-cell lymphomas in the 5th edition of the WHO-classification of haematolymphoid neoplasms-updated classification and new concepts","volume":"15","author":"Kurz KS","year":"2023","unstructured":"Kurz KS, Ott M, Kalmbach S, et al.. Large B-cell lymphomas in the 5th edition of the WHO-classification of haematolymphoid neoplasms-updated classification and new concepts. Cancers (Basel). 2023, 15:10.3390\/cancers15082285","journal-title":"Cancers (Basel)"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851","article-title":"The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee","volume":"140","author":"Campo E","year":"2022","unstructured":"Campo E, Jaffe ES, Cook JR, et al.. The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee. Blood. 2022, 140:1229-53. 10.1182\/blood.2022015851","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16578","article-title":"Experience with provisional WHO-entities large B-cell lymphoma with IRF4-rearrangement and Burkitt-like lymphoma with 11q aberration in paediatric patients of the NHL-BFM group","volume":"190","author":"Au-Yeung RK","year":"2020","unstructured":"Au-Yeung RK, Arias Padilla L, Zimmermann M, et al.. Experience with provisional WHO-entities large B-cell lymphoma with IRF4-rearrangement and Burkitt-like lymphoma with 11q aberration in paediatric patients of the NHL-BFM group. Br J Haematol. 2020, 190:753-63. 10.1111\/bjh.16578","journal-title":"Br J Haematol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-330795","article-title":"Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults","volume":"118","author":"Salaverria I","year":"2011","unstructured":"Salaverria I, Philipp C, Oschlies I, et al.. Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults. Blood. 2011, 118:139-47. 10.1182\/blood-2011-01-330795","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.10.011","article-title":"Large B-cell lymphoma with IRF4 gene rearrangements: differences in clinicopathologic, immunophenotypic and cytogenetic features between pediatric and adult patients","volume":"131","author":"Berg HE","year":"2023","unstructured":"Berg HE, Peterson JF, Lee HE, McPhail ED. Large B-cell lymphoma with IRF4 gene rearrangements: differences in clinicopathologic, immunophenotypic and cytogenetic features between pediatric and adult patients. Hum Pathol. 2023, 131:108-15. 10.1016\/j.humpath.2022.10.011","journal-title":"Hum Pathol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-022-00968-0","article-title":"The dynamic functions of IRF4 in B cell malignancies","volume":"23","author":"Maffei R","year":"2023","unstructured":"Maffei R, Fiorcari S, Atene CG, et al.. The dynamic functions of IRF4 in B cell malignancies. Clin Exp Med. 2023, 23:1171-80. 10.1007\/s10238-022-00968-0","journal-title":"Clin Exp Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpr.2022.300602","article-title":"Large B-cell lymphoma with IRF4 rearrangement and follicular pattern: a differential diagnosis of follicular lymphoma","volume":"27","author":"Kim DH","year":"2022","unstructured":"Kim DH, Li S, Garces S, Xu J. Large B-cell lymphoma with IRF4 rearrangement and follicular pattern: a differential diagnosis of follicular lymphoma. Human Pathol Rep. 2022, 27:300602. 10.1016\/j.hpr.2022.300602","journal-title":"Human Pathol Rep"},{"key":"ref10","article-title":"Recurrent immunoglobulin gene translocations identify distinct molecular subtypes of myeloma","volume":"11 Suppl 1","author":"Chesi M","year":"2000","unstructured":"Chesi M, Kuehl WM, Bergsagel PL. Recurrent immunoglobulin gene translocations identify distinct molecular subtypes of myeloma. Ann Oncol. 2000, 11 Suppl 1:131-5.","journal-title":"Ann Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1560-3","article-title":"Peripheral T-cell lymphoma with t(6;14)(p25;q11.2) translocation presenting with massive splenomegaly","volume":"464","author":"Somja J","year":"2014","unstructured":"Somja J, Bisig B, Bonnet C, Herens C, Siebert R, de Leval L. Peripheral T-cell lymphoma with t(6;14)(p25;q11.2) translocation presenting with massive splenomegaly. Virchows Arch. 2014, 464:735-41. 10.1007\/s00428-014-1560-3","journal-title":"Virchows Arch"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.225","article-title":"Specificity of IRF4 translocations for primary cutaneous anaplastic large cell lymphoma: a multicenter study of 204 skin biopsies","volume":"24","author":"Wada DA","year":"2011","unstructured":"Wada DA, Law ME, Hsi ED, et al.. Specificity of IRF4 translocations for primary cutaneous anaplastic large cell lymphoma: a multicenter study of 204 skin biopsies. Mod Pathol. 2011, 24:596-605. 10.1038\/modpathol.2010.225","journal-title":"Mod Pathol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-230641","article-title":"DUSP22-IRF4 rearrangement in AIDS-associated ALK-negative anaplastic large cell lymphoma","volume":"12","author":"Wang M","year":"2019","unstructured":"Wang M, Kibbi N, Ring N, Siddon A, Foss F, Totonchy M. DUSP22-IRF4 rearrangement in AIDS-associated ALK-negative anaplastic large cell lymphoma. BMJ Case Rep. 2019, 12:10.1136\/bcr-2019-230641","journal-title":"BMJ Case Rep"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22994","article-title":"Balanced and unbalanced translocations in a multicentric series of 2843 patients with chronic lymphocytic leukemia","volume":"61","author":"Costa D","year":"2022","unstructured":"Costa D, Granada I, Espinet B, et al.. Balanced and unbalanced translocations in a multicentric series of 2843 patients with chronic lymphocytic leukemia. Genes Chromosomes Cancer. 2022, 61:37-43. 10.1002\/gcc.22994","journal-title":"Genes Chromosomes Cancer"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006034","article-title":"Diffuse large B-cell lymphomas in adults with aberrant coexpression of CD10, BCL6, and MUM1 are enriched in IRF4 rearrangements","volume":"6","author":"Frauenfeld L","year":"2022","unstructured":"Frauenfeld L, Castrejon-de-Anta N, Ramis-Zaldivar JE, et al.. Diffuse large B-cell lymphomas in adults with aberrant coexpression of CD10, BCL6, and MUM1 are enriched in IRF4 rearrangements. Blood Adv. 2022, 6:2361-72. 10.1182\/bloodadvances.2021006034","journal-title":"Blood Adv"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12405","article-title":"Frequency of MYD88 and CD79B mutations, and MGMT methylation in primary central nervous system diffuse large B-cell lymphoma","volume":"37","author":"Zheng M","year":"2017","unstructured":"Zheng M, Perry AM, Bierman P, et al.. Frequency of MYD88 and CD79B mutations, and MGMT methylation in primary central nervous system diffuse large B-cell lymphoma. Neuropathology. 2017, 37:509-16. 10.1111\/neup.12405","journal-title":"Neuropathology"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/his.14885","article-title":"Reclassification of diffuse large B cell lymphoma to large B cell lymphoma with IRF4 rearrangement in an adult population","volume":"82","author":"Hesius EA","year":"2023","unstructured":"Hesius EA, van Laar L, Oosterveld M, et al.. Reclassification of diffuse large B cell lymphoma to large B cell lymphoma with IRF4 rearrangement in an adult population. Histopathology. 2023, 82:1013-20. 10.1111\/his.14885","journal-title":"Histopathology"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/pin.13067","article-title":"B cell lymphoma with IRF4 rearrangement: a clinicopathological study of 13 cases","volume":"71","author":"Zhou L","year":"2021","unstructured":"Zhou L, Gu B, Shen X, et al.. B cell lymphoma with IRF4 rearrangement: a clinicopathological study of 13 cases. Pathol Int. 2021, 71:183-90. 10.1111\/pin.13067","journal-title":"Pathol Int"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-021-00415-0","article-title":"Central nervous system ALK-negative anaplastic large cell lymphoma with IRF4\/DUSP22 rearrangement","volume":"39","author":"Magaki S","year":"2022","unstructured":"Magaki S, Satyadev R, Chen Z, Yung KS, Vinters HV, Kinney MC, Said JW. Central nervous system ALK-negative anaplastic large cell lymphoma with IRF4\/DUSP22 rearrangement. Brain Tumor Pathol. 2022, 39:25-34. 10.1007\/s10014-021-00415-0","journal-title":"Brain Tumor Pathol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002301","article-title":"Clinicopathological and molecular characteristics of rare EBV-associated diffuse large B-cell lymphoma with IRF4 rearrangement","volume":"48","author":"Zhang Y","year":"2024","unstructured":"Zhang Y, Li A, Li Y, et al.. Clinicopathological and molecular characteristics of rare EBV-associated diffuse large B-cell lymphoma with IRF4 rearrangement. Am J Surg Pathol. 2024, 48:1341-8. 10.1097\/PAS.0000000000002301","journal-title":"Am J Surg Pathol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/327889-large-b-cell-lymphoma-with-interferon-regulatory-factor-4-rearrangement-presenting-as-a-primary-central-nervous-system-lymphoma-in-the-brain","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T01:50:01Z","timestamp":1746755401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/327889-large-b-cell-lymphoma-with-interferon-regulatory-factor-4-rearrangement-presenting-as-a-primary-central-nervous-system-lymphoma-in-the-brain"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.83753","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,8]]}}}