{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T18:40:11Z","timestamp":1747852811701,"version":"3.41.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,21]]},"DOI":"10.7759\/cureus.84569","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T18:04:01Z","timestamp":1747850641000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of a Triad of Norepinephrine, Tranexamic Acid, and Endo-Cutter Staplers on the Reduction of Blood Loss and Operative Duration in Patients Undergoing Open Radical Cystectomy"],"prefix":"10.7759","author":[{"given":"Harkirat  S","family":"Talwar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudheer Kumar","family":"Devana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Panwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranav","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shrawan  K","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics, 2013","volume":"63","author":"Siegel R","year":"2013","unstructured":"Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013, 63:11-30. 10.3322\/caac.21166","journal-title":"CA Cancer J Clin"},{"key":"ref2","unstructured":"American Cancer Society. Global Cancer Facts & Figures; Atlanta. American Cancer Society. (2011). Accessed: May 18, 2025: https:\/\/www.cancer.org\/research\/cancer-facts-statistics\/all-cancer-facts-figures\/cancer-facts-figures-2011.html."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)56073-5","article-title":"Complications of radical cystectomy for carcinoma of the bladder","volume":"123","author":"Skinner DG","year":"1980","unstructured":"Skinner DG, Crawford ED, Kaufman JJ. Complications of radical cystectomy for carcinoma of the bladder. J Urol. 1980, 123:640-3. 10.1016\/s0022-5347(17)56073-5","journal-title":"J Urol"},{"key":"ref4","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-5347(05)65292-5","article-title":"A multicenter study of the morbidity of radical cystectomy in select elderly patients with bladder cancer","volume":"167","author":"Souli\u00e9 M","year":"2002","unstructured":"Souli\u00e9 M, Straub M, Gam\u00e9 X, Seguin P, De Petriconi R, Plante P, Hautmann RE. A multicenter study of the morbidity of radical cystectomy in select elderly patients with bladder cancer. J Urol. 2002, 167:1325-8.","journal-title":"J Urol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/00365590310020060","article-title":"Early and late treatment-related morbidity following radical cystectomy","volume":"38","author":"Knap MM","year":"2004","unstructured":"Knap MM, Lundbeck F, Overgaard J. Early and late treatment-related morbidity following radical cystectomy. Scand J Urol Nephrol. 2004, 38:153-60. 10.1080\/00365590310020060","journal-title":"Scand J Urol Nephrol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000051372.67213.ca","article-title":"Decreasing blood loss in patients treated with radical cystectomy: a prospective randomizes trial using a new stapling device","volume":"169","author":"Chang SS","year":"2003","unstructured":"Chang SS, Smith JA Jr, Cookson MS. Decreasing blood loss in patients treated with radical cystectomy: a prospective randomizes trial using a new stapling device. J Urol. 2003, 169:951-4. 10.1097\/01.ju.0000051372.67213.ca","journal-title":"J Urol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001886.pub3","article-title":"Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion","author":"Henry DA","year":"2011","unstructured":"Henry DA, Carless PA, Moxey AJ, O'Connell D, Stokes BJ, Fergusson DA, Ker K. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. 2011, CD001886. 10.1002\/14651858.CD001886.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0049-3848(00)00353-4","article-title":"Epinephrine induced platelet aggregation in rat platelet-rich plasma","volume":"100","author":"Yun-Choi HS","year":"2000","unstructured":"Yun-Choi HS, Park KM, Pyo MK. Epinephrine induced platelet aggregation in rat platelet-rich plasma. Thromb Res. 2000, 100:511-18. 10.1016\/s0049-3848(00)00353-4","journal-title":"Thromb Res"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0090-4295(99)00619-6","article-title":"Continent urinary reconstruction versus ileal conduit: a contemporary single institution comparison of perioperative morbidity and mortality","volume":"55","author":"Parekh DJ","year":"2000","unstructured":"Parekh DJ, Gilbert WB, Koch MO, Smith JA Jr. Continent urinary reconstruction versus ileal conduit: a contemporary single institution comparison of perioperative morbidity and mortality. Urology. 2000, 55:852-5. 10.1016\/s0090-4295(99)00619-6","journal-title":"Urology"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/s0090-4295(00)00582-3","article-title":"Radical cystectomy: minimizing operative blood loss with a \u201cstapling technique\u201d","volume":"56","author":"Hanash KA","year":"2000","unstructured":"Hanash KA, Peracha AM, Al-Zahrani HM. Radical cystectomy: minimizing operative blood loss with a \u201cstapling technique\u201d. Urology. 2000, 56:488-91. 10.1016\/s0090-4295(00)00582-3","journal-title":"Urology"},{"key":"ref11","article-title":"Impact of a collaborative care approach to radical cystectomy and urinary reconstruction","volume":"154","author":"Koch MO","year":"1995","unstructured":"Koch MO, Seckin B, Smith JA Jr. Impact of a collaborative care approach to radical cystectomy and urinary reconstruction. J Urol. 1995, 154:996-1001.","journal-title":"J Urol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1997.00122.x","article-title":"Intra-operative autotransfusion in radical cystectomy","volume":"79","author":"Park KI","year":"1997","unstructured":"Park KI, Kojima O, Tomoyoshi T. Intra-operative autotransfusion in radical cystectomy. Br J Urol. 1997, 79:717-21. 10.1046\/j.1464-410x.1997.00122.x","journal-title":"Br J Urol"},{"key":"ref13","article-title":"Modification of the surgical technique in radical cystectomy","volume":"2","author":"Douglas TH","year":"1996","unstructured":"Douglas TH, McLeod DG. Modification of the surgical technique in radical cystectomy. Tech Urol. 1996, 2:73-6.","journal-title":"Tech Urol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)52478-7","article-title":"Controlled hypotensive anesthesia to reduce blood loss in radical cystectomy for bladder cancer","volume":"129","author":"Ahlering TE","year":"1983","unstructured":"Ahlering TE, Henderson JB, Skinner DG. Controlled hypotensive anesthesia to reduce blood loss in radical cystectomy for bladder cancer. J Urol. 1983, 129:953-4. 10.1016\/s0022-5347(17)52478-7","journal-title":"J Urol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.1002","article-title":"Blood transfusion and hemostatic agents used during radical cystectomy","volume":"7","author":"Punjani N","year":"2013","unstructured":"Punjani N, Lavall\u00e9e LT, Momoli F, et al.. Blood transfusion and hemostatic agents used during radical cystectomy. Can Urol Assoc J. 2013, 7:E275-80. 10.5489\/cuaj.1002","journal-title":"Can Urol Assoc J"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5812\/numonthly.40409","article-title":"Local administration of tranexamic acid during prostatectomy surgery: effects on reducing the amount of bleeding","volume":"8","author":"Pourfakhr P","year":"2016","unstructured":"Pourfakhr P, Gatavi E, Gooran S, et al.. Local administration of tranexamic acid during prostatectomy surgery: effects on reducing the amount of bleeding. Nephrourol Mon. 2016, 8:e40409. 10.5812\/numonthly.40409","journal-title":"Nephrourol Mon"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010562.pub2","article-title":"Topical application of tranexamic acid for the reduction of bleeding","volume":"2013","author":"Ker K","year":"2013","unstructured":"Ker K, Beecher D, Roberts I. Topical application of tranexamic acid for the reduction of bleeding. Cochrane Database Syst Rev. 2013, 2013:CD010562. 10.1002\/14651858.CD010562.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.08.046","article-title":"Intraoperative continuous norepinephrine infusion combined with restrictive deferred hydration significantly reduces the need for blood transfusion in patients undergoing open radical cystectomy: results of a prospective randomised trial","volume":"66","author":"Wuethrich PY","year":"2014","unstructured":"Wuethrich PY, Studer UE, Thalmann GN, Burkhard FC. Intraoperative continuous norepinephrine infusion combined with restrictive deferred hydration significantly reduces the need for blood transfusion in patients undergoing open radical cystectomy: results of a prospective randomised trial. Eur Urol. 2014, 66:352-60. 10.1016\/j.eururo.2013.08.046","journal-title":"Eur Urol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-005-0050-2","article-title":"Local infusion of norepinephrine reduces blood losses and need of transfusion in total knee arthroplasty","volume":"30","author":"Gasparini G","year":"2006","unstructured":"Gasparini G, Papaleo P, Pola P, Cerciello S, Pola E, Fabbriciani C. Local infusion of norepinephrine reduces blood losses and need of transfusion in total knee arthroplasty. Int Orthop. 2006, 30:253-6. 10.1007\/s00264-005-0050-2","journal-title":"Int Orthop"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095667","article-title":"Laparoscopic versus open radical cystectomy in bladder cancer: a systematic review and meta-analysis of comparative studies","volume":"9","author":"Tang K","year":"2014","unstructured":"Tang K, Li H, Xia D, et al.. Laparoscopic versus open radical cystectomy in bladder cancer: a systematic review and meta-analysis of comparative studies. PLoS One. 2014, 9:e95667. 10.1371\/journal.pone.0095667","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000346755","article-title":"Evaluation of open and laparoscopic radical cystoprostatectomy combined with orthotopic neobladder: a single-surgeon experience","volume":"90","author":"Akin Y","year":"2013","unstructured":"Akin Y, Celik O, Ates M, Nuhoglu B, Erdogru T. Evaluation of open and laparoscopic radical cystoprostatectomy combined with orthotopic neobladder: a single-surgeon experience. Urol Int. 2013, 90:348-53. 10.1159\/000346755","journal-title":"Urol Int"},{"key":"ref22","article-title":"Compare of laparoscopic and open surgery for radical cystectomy with orthotopic ileal neobladder","volume":"46","author":"Huang J","year":"2008","unstructured":"Huang J, Huang H, Lin TX, et al.. Compare of laparoscopic and open surgery for radical cystectomy with orthotopic ileal neobladder. Zhonghua Wai Ke Za Zhi. 2008, 46:1870-4.","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.10.011","article-title":"Radical cystectomy for bladder cancer: morbidity of laparoscopic versus open surgery","volume":"181","author":"Guillotreau J","year":"2009","unstructured":"Guillotreau J, Gam\u00e9 X, Mouzin M, et al.. Radical cystectomy for bladder cancer: morbidity of laparoscopic versus open surgery. J Urol. 2009, 181:554-9; discussion 559. 10.1016\/j.juro.2008.10.011","journal-title":"J Urol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2011.02888.x","article-title":"A dual-centre, cohort comparison of open, laparoscopic and robotic-assisted radical cystectomy","volume":"66","author":"Khan MS","year":"2012","unstructured":"Khan MS, Challacombe B, Elhage O, et al.. A dual-centre, cohort comparison of open, laparoscopic and robotic-assisted radical cystectomy. Int J Clin Pract. 2012, 66:656-62. 10.1111\/j.1742-1241.2011.02888.x","journal-title":"Int J Clin Pract"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000273462","article-title":"Comparison of hand-assisted laparoscopic and open radical cystectomy for bladder cancer","volume":"84","author":"Wang SZ","year":"2010","unstructured":"Wang SZ, Chen LW, Zhang YH, Wang WW, Chen W, Lin HY. Comparison of hand-assisted laparoscopic and open radical cystectomy for bladder cancer. Urol Int. 2010, 84:28-33. 10.1159\/000273462","journal-title":"Urol Int"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/349277-effect-of-a-triad-of-norepinephrine-tranexamic-acid-and-endo-cutter-staplers-on-the-reduction-of-blood-loss-and-operative-duration-in-patients-undergoing-open-radical-cystectomy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T18:04:10Z","timestamp":1747850650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/349277-effect-of-a-triad-of-norepinephrine-tranexamic-acid-and-endo-cutter-staplers-on-the-reduction-of-blood-loss-and-operative-duration-in-patients-undergoing-open-radical-cystectomy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.84569","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,21]]}}}