{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T05:07:46Z","timestamp":1763183266616,"version":"3.41.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,21]]},"DOI":"10.7759\/cureus.84574","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T19:27:17Z","timestamp":1747855637000},"source":"Crossref","is-referenced-by-count":1,"title":["Pan-Cancer Analysis Reveals Ribonuclease K (RNASEK) as a Potential Prognostic Biomarker in Pancreatic Cancer and a Diagnostic Indicator Across Multiple Human Cancers"],"prefix":"10.7759","author":[{"given":"Nahla Abdalla","family":"Hassan Elsheikh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidal  A","family":"A. Abaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majdh  F","family":"Almrshoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadwa  A","family":"A. Abdalfadil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Alfaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung H","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, et al.. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021, 71:209-49.","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-019-0264-y","article-title":"The importance of exosomal PDL1 in tumour immune evasion","volume":"20","author":"Daassi D","year":"2020","unstructured":"Daassi D, Mahoney KM, Freeman GJ. The importance of exosomal PDL1 in tumour immune evasion. Nat Rev Immunol. 2020, 20:209-15.","journal-title":"Nat Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1038\/cdd.2015.53","article-title":"TP53: an oncogene in disguise","volume":"22","author":"Soussi T","year":"2015","unstructured":"Soussi T, Wiman KG. TP53: an oncogene in disguise. Cell Death Differ. 2015, 22:1239-49.","journal-title":"Cell Death Differ"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1973220","article-title":"A pan-cancer analysis of the prognostic and immunological role of \u03b2-actin (ACTB) in human cancers","volume":"12","author":"Gu Y","year":"2021","unstructured":"Gu Y, Tang S, Wang Z, Cai L, Lian H, Shen Y, Zhou Y. A pan-cancer analysis of the prognostic and immunological role of \u03b2-actin (ACTB) in human cancers. Bioengineered. 2021, 12:6166-85. 10.1080\/21655979.2021.1973220","journal-title":"Bioengineered"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2019.06.010","article-title":"Identification of novel alternative transcripts of the human Ribonuclease \u03ba (RNASEK) gene using 3' RACE and high-throughput sequencing approaches","volume":"112","author":"Adamopoulos PG","year":"2020","unstructured":"Adamopoulos PG, Kontos CK, Scorilas A, Sideris DC. Identification of novel alternative transcripts of the human Ribonuclease \u03ba (RNASEK) gene using 3' RACE and high-throughput sequencing approaches. Genomics. 2020, 112:943-51. 10.1016\/j.ygeno.2019.06.010","journal-title":"Genomics"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm718","article-title":"Molecular cloning and characterization of the human RNase kappa, an ortholog of Cc RNase","volume":"35","author":"Economopoulou MA","year":"2007","unstructured":"Economopoulou MA, Fragoulis EG, Sideris DC. Molecular cloning and characterization of the human RNase kappa, an ortholog of Cc RNase. Nucleic Acids Res. 2007, 35:6389-98. 10.1093\/nar\/gkm718","journal-title":"Nucleic Acids Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0129","article-title":"ACTIBIND, a T2 RNase, competes with angiogenin and inhibits human melanoma growth, angiogenesis, and metastasis","volume":"67","author":"Schwartz B","year":"2007","unstructured":"Schwartz B, Shoseyov O, Melnikova VO, et al.. ACTIBIND, a T2 RNase, competes with angiogenin and inhibits human melanoma growth, angiogenesis, and metastasis. Cancer Res. 2007, 67:5258-66. 10.1158\/0008-5472.CAN-07-0129","journal-title":"Cancer Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2332allergolint.O-06-442","article-title":"Serum concentrations of eosinophil cationic protein and eosinophils of patients with Kimura\u2019s disease","volume":"56","author":"Ohta N","year":"2007","unstructured":"Ohta N, Okazaki S, Fukase S, et al.. Serum concentrations of eosinophil cationic protein and eosinophils of patients with Kimura\u2019s disease. Allergol Int. 2007, 56:45-9. 10.2332allergolint.O-06-442","journal-title":"Allergol Int"},{"key":"ref9","article-title":"Ribonucleases in tumor growth","volume":"31","author":"Shlyakhovenko VA","year":"2009","unstructured":"Shlyakhovenko VA. Ribonucleases in tumor growth. Exp Oncol. 2009, 31:127-33.","journal-title":"Exp Oncol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06746.x","article-title":"Genomic structure and expression analysis of the RNase kappa family ortholog gene in the insect Ceratitis capitata","volume":"275","author":"Rampias TN","year":"2008","unstructured":"Rampias TN, Fragoulis EG, Sideris DC. Genomic structure and expression analysis of the RNase kappa family ortholog gene in the insect Ceratitis capitata. FEBS J. 2008, 275:6217-27. 10.1111\/j.1742-4658.2008.06746.x","journal-title":"FEBS J"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.06.076","article-title":"Rnasek is a V-ATPase-associated factor required for endocytosis and the replication of rhinovirus, influenza A virus, and dengue virus","volume":"12","author":"Perreira JM","year":"2015","unstructured":"Perreira JM, Aker AM, Savidis G, et al.. Rnasek is a V-ATPase-associated factor required for endocytosis and the replication of rhinovirus, influenza A virus, and dengue virus. Cell Rep. 2015, 12:850-63. 10.1016\/j.celrep.2015.06.076","journal-title":"Cell Rep"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424098112","article-title":"RNASEK is required for internalization of diverse acid-dependent viruses","volume":"112","author":"Hackett BA","year":"2015","unstructured":"Hackett BA, Yasunaga A, Panda D, Tartell MA, Hopkins KC, Hensley SE, Cherry S. RNASEK is required for internalization of diverse acid-dependent viruses. Proc Natl Acad Sci U S A. 2015, 112:7797-802. 10.1073\/pnas.1424098112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0307","article-title":"TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells","volume":"77","author":"Li T","year":"2017","unstructured":"Li T, Fan J, Wang B, et al.. TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 2017, 77:e108-10. 10.1158\/0008-5472.CAN-17-0307","journal-title":"Cancer Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses","volume":"45","author":"Tang Z","year":"2017","unstructured":"Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017, 45:W98-102. 10.1093\/nar\/gkx247","journal-title":"Nucleic Acids Res"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2017.05.002","article-title":"UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses","volume":"19","author":"Chandrashekar DS","year":"2017","unstructured":"Chandrashekar DS, Bashel B, Balasubramanya SA, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BV, Varambally S. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 2017, 19:649-58. 10.1016\/j.neo.2017.05.002","journal-title":"Neoplasia"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2021.07.014","article-title":"Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer","volume":"19","author":"Gy\u0151rffy B","year":"2021","unstructured":"Gy\u0151rffy B. Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer. Comput Struct Biotechnol J. 2021, 19:4101-9. 10.1016\/j.csbj.2021.07.014","journal-title":"Comput Struct Biotechnol J"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami E","year":"2012","unstructured":"Cerami E, Gao J, Dogrusoz U, et al.. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012, 2:401-4. 10.1158\/2159-8290.CD-12-0095","journal-title":"Cancer Discov"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets--update","volume":"41","author":"Barrett T","year":"2013","unstructured":"Barrett T, Wilhite SE, Ledoux P, et al.. NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013, 41:D991-5. 10.1093\/nar\/gks1193","journal-title":"Nucleic Acids Res"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang D","year":"2023","unstructured":"Tang D, Chen M, Huang X, et al.. SRplot: a free online platform for data visualization and graphing. PLoS One. 2023, 18:e0294236. 10.1371\/journal.pone.0294236","journal-title":"PLoS One"},{"key":"ref20","article-title":"The cancer genome atlas pan-cancer analysis project","volume":"45","author":"Cancer Genome Atlas Research Network","year":"2013","unstructured":"Cancer Genome Atlas Research Network, Weinstein JN, Collisson EA, et al.. The cancer genome atlas pan-cancer analysis project.  Nat Gen. 2013, 45:1113-20.","journal-title":"Nat Gen"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.03.023","article-title":"Pan-cancer analyses reveal long intergenic non-coding RNAs relevant to tumor diagnosis, subtyping and prognosis","volume":"7","author":"Ching T","year":"2016","unstructured":"Ching T, Peplowska K, Huang S, et al.. Pan-cancer analyses reveal long intergenic non-coding RNAs relevant to tumor diagnosis, subtyping and prognosis. EBioMedicine. 2016, 7:62-72. 10.1016\/j.ebiom.2016.03.023","journal-title":"EBioMedicine"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2012.08526.x","article-title":"Essential cysteine residues for human RNase \u03ba catalytic activity","volume":"279","author":"Kiritsi MN","year":"2012","unstructured":"Kiritsi MN, Fragoulis EG, Sideris DC. Essential cysteine residues for human RNase \u03ba catalytic activity. FEBS J. 2012, 279:1318-26. 10.1111\/j.1742-4658.2012.08526.x","journal-title":"FEBS J"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-017-0467-0","article-title":"DNA methylation profiles in cancer diagnosis and therapeutics","volume":"18","author":"Pan Y","year":"2018","unstructured":"Pan Y, Liu G, Zhou F, Su B, Li Y. DNA methylation profiles in cancer diagnosis and therapeutics. Clin Exp Med. 2018, 18:1-14. 10.1007\/s10238-017-0467-0","journal-title":"Clin Exp Med"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/biology10100957","article-title":"Identification of five hub genes as key prognostic biomarkers in liver cancer via integrated bioinformatics analysis","volume":"10","author":"Nguyen TB","year":"2021","unstructured":"Nguyen TB, Do DN, Nguyen-Thanh T, Tatipamula VB, Nguyen HT. Identification of five hub genes as key prognostic biomarkers in liver cancer via integrated bioinformatics analysis. Biology (Basel). 2021, 10:10.3390\/biology10100957","journal-title":"Biology (Basel)"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.32471\/exp-oncology.2312-8852.vol-44-no-2.17785","article-title":"The changes of NO level and RNase activity in tumor tissue accompanying the progression of prostate cancer","volume":"44","author":"Burlaka AP","year":"2022","unstructured":"Burlaka AP, Virko SV, Grygorenko VM, Samoylenko O\u0410, Verbinenko AV, Shlyakhovenko VO. The changes of NO level and RNase activity in tumor tissue accompanying the progression of prostate cancer. Exp Oncol. 2022, 44:159-62. 10.32471\/exp-oncology.2312-8852.vol-44-no-2.17785","journal-title":"Exp Oncol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.10.002","article-title":"Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAF(v600) mutation-positive melanoma receiving adjuvant vemurafenib","volume":"31","author":"Ascierto PA","year":"2020","unstructured":"Ascierto PA, Lewis KD, Di Giacomo AM, et al.. Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAF(v600) mutation-positive melanoma receiving adjuvant vemurafenib. Ann Oncol. 2020, 31:153-9. 10.1016\/j.annonc.2019.10.002","journal-title":"Ann Oncol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1117-9","article-title":"The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications","volume":"18","author":"Liu X","year":"2019","unstructured":"Liu X, Xu J, Zhang B, et al.. The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications. Mol Cancer. 2019, 18:184. 10.1186\/s12943-019-1117-9","journal-title":"Mol Cancer"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-018-0027-x","article-title":"Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer","volume":"16","author":"Wang SS","year":"2019","unstructured":"Wang SS, Liu W, Ly D, Xu H, Qu L, Zhang L. Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer. Cell Mol Immunol. 2019, 16:6-18. 10.1038\/s41423-018-0027-x","journal-title":"Cell Mol Immunol"},{"key":"ref29","article-title":"Identification of differentially expressed genes using an annealing control primer system in stage III serous ovarian carcinoma","volume":"10","author":"Kim Y-S","year":"2010","unstructured":"Kim Y-S, Hwan JD, Bae S, et al.. Identification of differentially expressed genes using an annealing control primer system in stage III serous ovarian carcinoma. BMC Cancer. 2010, 10:576.","journal-title":"BMC Cancer"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/ac0b7e","article-title":"Temporal order of mutations influences cancer initiation dynamics","volume":"18","author":"Teimouri H","year":"2021","unstructured":"Teimouri H, Kolomeisky AB. Temporal order of mutations influences cancer initiation dynamics. Phys Biol. 2021, 18:10.1088\/1478-3975\/ac0b7e","journal-title":"Phys Biol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/340325-pan-cancer-analysis-reveals-ribonuclease-k-rnasek-as-a-potential-prognostic-biomarker-in-pancreatic-cancer-and-a-diagnostic-indicator-across-multiple-human-cancers","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T19:27:20Z","timestamp":1747855640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/340325-pan-cancer-analysis-reveals-ribonuclease-k-rnasek-as-a-potential-prognostic-biomarker-in-pancreatic-cancer-and-a-diagnostic-indicator-across-multiple-human-cancers"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.84574","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,21]]}}}