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J Clin Med. 2024, 13:4852. 10.3390\/jcm13164852","journal-title":"J Clin Med"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003030","article-title":"Lactate level versus lactate clearance for predicting mortality in patients with septic shock defined by Sepsis-3","volume":"46","author":"Ryoo SM","year":"2018","unstructured":"Ryoo SM, Lee J, Lee YS, et al.. Lactate level versus lactate clearance for predicting mortality in patients with septic shock defined by Sepsis-3. Crit Care Med. 2018, 46:e489-95. 10.1097\/CCM.0000000000003030","journal-title":"Crit Care Med"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3254-2","article-title":"The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial","volume":"20","author":"Hager DN","year":"2019","unstructured":"Hager DN, Hooper MH, Bernard GR, et al.. The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. Trials. 2019, 20:197. 10.1186\/s13063-019-3254-2","journal-title":"Trials"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06191-3","article-title":"Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study","volume":"46","author":"Hwang SY","year":"2020","unstructured":"Hwang SY, Ryoo SM, Park JE, et al.. Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study. Intensive Care Med. 2020, 46:2015-25. 10.1007\/s00134-020-06191-3","journal-title":"Intensive Care Med"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2007.02.007","article-title":"Myths and misconceptions of Wernicke's encephalopathy: what every emergency physician should know","volume":"50","author":"Donnino MW","year":"2007","unstructured":"Donnino MW, Vega J, Miller J, Walsh M. Myths and misconceptions of Wernicke's encephalopathy: what every emergency physician should know. Ann Emerg Med. 2007, 50:715-21. 10.1016\/j.annemergmed.2007.02.007","journal-title":"Ann Emerg Med"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03153.x","article-title":"EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy","volume":"17","author":"Galvin R","year":"2010","unstructured":"Galvin R, Br\u00e5then G, Ivashynka A, Hillbom M, Tanasescu R, Leone MA. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur J Neurol. 2010, 17:1408-18. 10.1111\/j.1468-1331.2010.03153.x","journal-title":"Eur J Neurol"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.815","article-title":"Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review","volume":"301","author":"Annane D","year":"2009","unstructured":"Annane D, Bellissant E, Bollaert PE, et al.. Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review. 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