{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:05Z","timestamp":1784764805313,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,29]]},"DOI":"10.7759\/cureus.85054","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:12:21Z","timestamp":1748563941000},"source":"Crossref","is-referenced-by-count":0,"title":["Fecal Microbiota Transplantation (FMT) in Clostridium difficile Infection: A Paradigm Shift in Gastrointestinal Microbiome Modulation"],"prefix":"10.7759","author":[{"given":"Muhammad","family":"Hamza Saeed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundas","family":"Qamar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Ishtiaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qudsia","family":"Umaira khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Atta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Atta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hifza","family":"Ishtiaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marriam","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Rawal","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.4c00578","article-title":"Unraveling cecal alterations in Clostridioides difficile colonized mice through comprehensive metabolic profiling","volume":"23","author":"Deda O","year":"2024","unstructured":"Deda O, Armitage EG, Mouskeftara T, et al.. Unraveling cecal alterations in Clostridioides difficile colonized mice through comprehensive metabolic profiling. J Proteome Res. 2024, 23:5462-75. 10.1021\/acs.jproteome.4c00578","journal-title":"J Proteome Res"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae467","article-title":"A randomized controlled trial of efficacy and safety of fecal microbiota transplant for preventing recurrent Clostridioides difficile infection","volume":"80","author":"Drekonja DM","year":"2025","unstructured":"Drekonja DM, Shaukat A, Huang Y, et al.. A randomized controlled trial of efficacy and safety of fecal microbiota transplant for preventing recurrent Clostridioides difficile infection. Clin Infect Dis. 2025, 80:52-60. 10.1093\/cid\/ciae467","journal-title":"Clin Infect Dis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0311731","article-title":"Safety and efficacy of fecal microbiota transplantation for viral diseases: a systematic review of clinical trials","volume":"19","author":"Ebrahimi R","year":"2024","unstructured":"Ebrahimi R, Masouri MM, Salehi Amniyeh Khozani AA, Ramadhan Hussein D, Nejadghaderi SA. Safety and efficacy of fecal microbiota transplantation for viral diseases: a systematic review of clinical trials. PLoS One. 2024, 19:e0311731. 10.1371\/journal.pone.0311731","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2423026","article-title":"Faecal (or intestinal) microbiota transplant: a tool for repairing the gut microbiome","volume":"16","author":"Ghani R","year":"2024","unstructured":"Ghani R, Chrysostomou D, Roberts LA, Pandiaraja M, Marchesi JR, Mullish BH. Faecal (or intestinal) microbiota transplant: a tool for repairing the gut microbiome. Gut Microbes. 2024, 16:2423026. 10.1080\/19490976.2024.2423026","journal-title":"Gut Microbes"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2024.2401460","article-title":"'Does this fecal microbiota transplant work?' Quality assurance of capsule based fecal microbiota transplant production","volume":"59","author":"Jochumsen EA","year":"2024","unstructured":"Jochumsen EA, Kragsnaes MS, Nilsson AC, et al.. 'Does this fecal microbiota transplant work?' Quality assurance of capsule based fecal microbiota transplant production. Scand J Gastroenterol. 2024, 59:1234-9. 10.1080\/00365521.2024.2401460","journal-title":"Scand J Gastroenterol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.23736\/S0031-0808.24.05111-5","article-title":"Microbiota restoration for recurrent Clostridioides difficile infection","volume":"66","author":"Khanna S","year":"2024","unstructured":"Khanna S. Microbiota restoration for recurrent Clostridioides difficile infection. Panminerva Med. 2024, 66:417-26. 10.23736\/S0031-0808.24.05111-5","journal-title":"Panminerva Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2412376","article-title":"Gut microbiome therapy: fecal microbiota transplantation vs live biotherapeutic products","volume":"16","author":"Kim DY","year":"2024","unstructured":"Kim DY, Lee SY, Lee JY, Whon TW, Lee JY, Jeon CO, Bae JW. Gut microbiome therapy: fecal microbiota transplantation vs live biotherapeutic products. Gut Microbes. 2024, 16:2412376. 10.1080\/19490976.2024.2412376","journal-title":"Gut Microbes"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-024-00184-3","article-title":"Fecal microbiota transplantation: indications, methods, and challenges","volume":"62","author":"Lee JY","year":"2024","unstructured":"Lee JY, Kim Y, Kim J, Kim JK. Fecal microbiota transplantation: indications, methods, and challenges. J Microbiol. 2024, 62:1057-74. 10.1007\/s12275-024-00184-3","journal-title":"J Microbiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000039219","article-title":"Clinical and economic outcomes associated with fidaxomicin in comparison to vancomycin, metronidazole, and FMT: a systematic literature review","volume":"103","author":"Li Q","year":"2024","unstructured":"Li Q, Obi E, Marciniak A, Newman R, Whittle I, Kufakwaro J. Clinical and economic outcomes associated with fidaxomicin in comparison to vancomycin, metronidazole, and FMT: a systematic literature review. Medicine (Baltimore). 2024, 103:e39219. 10.1097\/MD.0000000000039219","journal-title":"Medicine (Baltimore)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2393766","article-title":"Bile acids impact the microbiota, host, and C. difficile dynamics providing insight into mechanisms of efficacy of FMTs and microbiota-focused therapeutics","volume":"16","author":"McMillan AS","year":"2024","unstructured":"McMillan AS, Theriot CM. Bile acids impact the microbiota, host, and C. difficile dynamics providing insight into mechanisms of efficacy of FMTs and microbiota-focused therapeutics. Gut Microbes. 2024, 16:2393766. 10.1080\/19490976.2024.2393766","journal-title":"Gut Microbes"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00706-24","article-title":"Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent Clostridioides difficile infection","volume":"9","author":"McMillan AS","year":"2024","unstructured":"McMillan AS, Zhang G, Dougherty MK, McGill SK, Gulati AS, Baker ES, Theriot CM. Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent Clostridioides difficile infection. mSphere. 2024, 9:e0070624. 10.1128\/msphere.00706-24","journal-title":"mSphere"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.rgmxen.2024.03.004","article-title":"Fecal microbiota transplantation through colonoscopy in the treatment of recurrent Clostridioides difficile: experience at a university center","volume":"89","author":"Quera R","year":"2024","unstructured":"Quera R, Nu\u00f1ez P, von Muhlenbrock C, Espinoza R. Fecal microbiota transplantation through colonoscopy in the treatment of recurrent Clostridioides difficile: experience at a university center. Rev Gastroenterol Mex (Engl Ed). 2024, 89:513-20. 10.1016\/j.rgmxen.2024.03.004","journal-title":"Rev Gastroenterol Mex (Engl Ed)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2025.2450707","article-title":"Modulating the microbiome in chronic liver diseases-current evidence on the role of fecal microbiota transplantation","volume":"19","author":"Saha S","year":"2025","unstructured":"Saha S, Schnabl B. Modulating the microbiome in chronic liver diseases-current evidence on the role of fecal microbiota transplantation. Expert Rev Gastroenterol Hepatol. 2025, 19:53-64. 10.1080\/17474124.2025.2450707","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.07.023","article-title":"Microbiome modification for personalized treatment of dysbiotic diseases","volume":"32","author":"Sartor RB","year":"2024","unstructured":"Sartor RB. Microbiome modification for personalized treatment of dysbiotic diseases. Cell Host Microbe. 2024, 32:1219-24. 10.1016\/j.chom.2024.07.023","journal-title":"Cell Host Microbe"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2415488","article-title":"Normalization of short-chain fatty acid concentration by bacterial count of stool samples improves discrimination between eubiotic and dysbiotic gut microbiota caused by Clostridioides difficile infection","volume":"16","author":"Sayol-Altarriba A","year":"2024","unstructured":"Sayol-Altarriba A, Aira A, Villasante A, et al.. Normalization of short-chain fatty acid concentration by bacterial count of stool samples improves discrimination between eubiotic and dysbiotic gut microbiota caused by Clostridioides difficile infection. Gut Microbes. 2024, 16:2415488. 10.1080\/19490976.2024.2415488","journal-title":"Gut Microbes"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00734-24","article-title":"Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation","volume":"68","author":"Sintes R","year":"2024","unstructured":"Sintes R, McLellan P, Navelli G, et al.. Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation. Antimicrob Agents Chemother. 2024, 68:e0073424. 10.1128\/aac.00734-24","journal-title":"Antimicrob Agents Chemother"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1055\/a-2303-3368","article-title":"The gastrointestinal microbiome-vision and mission (Article in German)","volume":"150","author":"Stallmach A","year":"2025","unstructured":"Stallmach A. The gastrointestinal microbiome-vision and mission (Article in German). Dtsch Med Wochenschr. 2025, 150:157-62. 10.1055\/a-2303-3368","journal-title":"Dtsch Med Wochenschr"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2446378","article-title":"Nutritional optimization of fecal microbiota transplantation in humans: a scoping review","volume":"17","author":"Teigen LM","year":"2025","unstructured":"Teigen LM, Hoeg A, Zehra H, et al.. Nutritional optimization of fecal microbiota transplantation in humans: a scoping review. Gut Microbes. 2025, 17:2446378. 10.1080\/19490976.2024.2446378","journal-title":"Gut Microbes"}],"updated-by":[{"DOI":"10.7759\/cureus.r206","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"record-id":"71724"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/347883-fecal-microbiota-transplantation-fmt-in-clostridium-difficile-infection-a-paradigm-shift-in-gastrointestinal-microbiome-modulation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:12:22Z","timestamp":1748563942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/347883-fecal-microbiota-transplantation-fmt-in-clostridium-difficile-infection-a-paradigm-shift-in-gastrointestinal-microbiome-modulation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.85054","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,29]]}}}