{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T04:10:21Z","timestamp":1749010221112,"version":"3.41.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,3]]},"DOI":"10.7759\/cureus.85274","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T10:20:27Z","timestamp":1748946027000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Adding Clonidine to Bupivacaine 0.25% Versus Plain Bupivacaine 0.25% Infiltration in Scalp Blocks for Supratentorial Craniotomy"],"prefix":"10.7759","author":[{"given":"Chris Leslie","family":"Lemos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anivesh","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chhavi","family":"Dwivedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradyumna Singh","family":"Kakodia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparna","family":"Tamaskar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.19080\/JAICM.2017.02.555592","article-title":"Our scalp block results in craniotomy cases","volume":"2","author":"Canakci E","year":"2017","unstructured":"Canakci E, Unal D, Yildirim T, Yilmaz A. Our scalp block results in craniotomy cases. J Anesth Inten Care Med. 2017, 2:555592. 10.19080\/JAICM.2017.02.555592","journal-title":"J Anesth Inten Care Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e32831aedb2","article-title":"The effect of scalp block and local infiltration on the haemodynamic and stress response to skull-pin placement for craniotomy","volume":"26","author":"Geze S","year":"2009","unstructured":"Geze S, Yilmaz AA, Tuzuner F. The effect of scalp block and local infiltration on the haemodynamic and stress response to skull-pin placement for craniotomy. Eur J Anaesthesiol. 2009, 26:298-303. 10.1097\/EJA.0b013e32831aedb2","journal-title":"Eur J Anaesthesiol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.174809","article-title":"A prospective, comparative, randomised, double blind study on the efficacy of addition of clonidine to 0.25% bupivacaine in scalp block for supratentorial craniotomies","volume":"60","author":"Wajekar AS","year":"2016","unstructured":"Wajekar AS, Oak SP, Shetty AN, Jain RA. A prospective, comparative, randomised, double blind study on the efficacy of addition of clonidine to 0.25% bupivacaine in scalp block for supratentorial craniotomies. Indian J Anaesth. 2016, 60:39-43. 10.4103\/0019-5049.174809","journal-title":"Indian J Anaesth"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4103\/ija.ija_450_21","article-title":"Comparison of effects of dexmedetomidine added to ropivacaine versus ropivacaine alone infiltration scalp block for attenuation of the haemodynamic response to skull pin placement in neurosurgical procedures: a double-blind, randomised clinical trial","volume":"65","author":"Sahana BN","year":"2021","unstructured":"Sahana BN, Radhapuram SD, Samantaray A, Hemanth N, Pasupuleti H, Mangu HR. Comparison of effects of dexmedetomidine added to ropivacaine versus ropivacaine alone infiltration scalp block for attenuation of the haemodynamic response to skull pin placement in neurosurgical procedures: a double-blind, randomised clinical trial. Indian J Anaesth. 2021, 65:782-8. 10.4103\/ija.ija_450_21","journal-title":"Indian J Anaesth"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00001503-200112000-00024","article-title":"Alpha 2 agonists in regional anesthesia and analgesia","volume":"14","author":"Gabriel JS","year":"2001","unstructured":"Gabriel JS, Gordin V. Alpha 2 agonists in regional anesthesia and analgesia. Curr Opin Anaesthesiol. 2001, 14:751-3. 10.1097\/00001503-200112000-00024","journal-title":"Curr Opin Anaesthesiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182863c22","article-title":"Regional scalp block for postcraniotomy analgesia: a systematic review and meta-analysis","volume":"116","author":"Guilfoyle MR","year":"2013","unstructured":"Guilfoyle MR, Helmy A, Duane D, Hutchinson PJ. Regional scalp block for postcraniotomy analgesia: a systematic review and meta-analysis. Anesth Analg. 2013, 116:1093-102. 10.1213\/ANE.0b013e3182863c22","journal-title":"Anesth Analg"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200111000-00048","article-title":"Scalp nerve blocks decrease the severity of pain after craniotomy","volume":"1","author":"Nguyen A","year":"2001","unstructured":"Nguyen A, Girard F, Boudreault D, et al.. Scalp nerve blocks decrease the severity of pain after craniotomy. Anesth Analg. 2001, 1:1272-6. 10.1097\/00000539-200111000-00048","journal-title":"Anesth Analg"},{"key":"ref8","article-title":"Better hemodynamics and less antihypertensive medication: comparison of scalp block and local infiltration anesthesia for skull-pin placement in awake deep brain stimulation surgery","volume":"1","author":"Krauss P","year":"2018","unstructured":"Krauss P, Marahori NA, Oertel MF, Barth F, Stieglitz LH. Better hemodynamics and less antihypertensive medication: comparison of scalp block and local infiltration anesthesia for skull-pin placement in awake deep brain stimulation surgery. World neurosurgery. 2018, 1:991-9.","journal-title":"World neurosurgery"},{"key":"ref9","article-title":"Comparison of the effect of scalp block analgesia bupivacaine 0.25% and clonidine 2 \u00b5g\/kg with bupivacaine 0.25% and dexamethasone 8 mg on cortisol levels and numeric rating scale in craniotomy tumour","volume":"1","author":"Maharani ND","year":"2023","unstructured":"Maharani ND, Fuadi A, Halimi RA. Comparison of the effect of scalp block analgesia bupivacaine 0.25% and clonidine 2 \u00b5g\/kg with bupivacaine 0.25% and dexamethasone 8 mg on cortisol levels and numeric rating scale in craniotomy tumour. Med J Malaysia. 2023, 1:809.","journal-title":"Med J Malaysia"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005230","article-title":"Influence of levobupivacaine regional scalp block on hemodynamic stability, intra-and postoperative opioid consumption in supratentorial craniotomies: a randomized controlled trial","volume":"132","author":"Carella M","year":"2021","unstructured":"Carella M, Tran G, Bonhomme VL, Franssen C. Influence of levobupivacaine regional scalp block on hemodynamic stability, intra-and postoperative opioid consumption in supratentorial craniotomies: a randomized controlled trial. Anesth Analg. 2021, 132:500-11. 10.1213\/ANE.0000000000005230","journal-title":"Anesth Analg"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1097\/00000542-199609000-00026","article-title":"\u03b12-Adrenergic agonists for regional anesthesia: a clinical review of clonidine (1984-1995)","author":"Eisenach JC","year":"1996","unstructured":"Eisenach JC, De Kock M, Klimscha W. \u03b12-Adrenergic agonists for regional anesthesia: a clinical review of clonidine (1984-1995). Anesthesiology. 1996, 655-74.","journal-title":"Anesthesiology"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199805000-00017","article-title":"Clonidine premedication decreases hemodynamic responses to pin head-holder application during craniotomy","volume":"86","author":"Costello TG","year":"1998","unstructured":"Costello TG, Cormack JR. Clonidine premedication decreases hemodynamic responses to pin head-holder application during craniotomy. Anesth Analg. 1998, 86:1001-4. 10.1213\/00000539-199805000-00017","journal-title":"Anesth Analg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X9202000312","article-title":"Oral clonidine pretreatment for haemodynamic stability during craniotomy","volume":"20","author":"Chadha R","year":"1992","unstructured":"Chadha R, Padmanabhan V, Joseph A, Mohandas K. Oral clonidine pretreatment for haemodynamic stability during craniotomy. Anaesth Intensive Care. 1992, 20:341-4. 10.1177\/0310057X9202000312","journal-title":"Anaesth Intensive Care"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.67342","article-title":"Comparison of the effect of scalp block with ropivacaine vs. ropivacaine and clonidine on postoperative pain in patients undergoing craniotomy surgery under general anesthesia","volume":"16","author":"Bagle A","year":"2024","unstructured":"Bagle A, Raj A, B U RP, Kale A. Comparison of the effect of scalp block with ropivacaine vs. ropivacaine and clonidine on postoperative pain in patients undergoing craniotomy surgery under general anesthesia. Cureus. 2024, 16:e67342. 10.7759\/cureus.67342","journal-title":"Cureus"},{"key":"ref15","article-title":"Effect of clonidine, by infiltration and by intravenous route, on scalp block for supratentorial craniotomy","volume":"16","author":"Dash SK","year":"2010","unstructured":"Dash SK, Gosav KS, Parikh HG, Kondwilkar B. Effect of clonidine, by infiltration and by intravenous route, on scalp block for supratentorial craniotomy. Southern African Journal of Anaesthesia and Analgesia. 2010, 16:13-21.","journal-title":"Southern African Journal of Anaesthesia and Analgesia"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4103\/jnrp.jnrp_310_17","article-title":"Efficacy of dexmedetomidine as an adjuvant to local anesthetic agent in scalp block and scalp infiltration to control postcraniotomy pain: a double-blind randomized trial","volume":"9","author":"Vallapu S","year":"2018","unstructured":"Vallapu S, Panda NB, Samagh N, Bharti N. Efficacy of dexmedetomidine as an adjuvant to local anesthetic agent in scalp block and scalp infiltration to control postcraniotomy pain: a double-blind randomized trial. J Neurosci Rural Pract. 2018, 9:73-9. 10.4103\/jnrp.jnrp_310_17","journal-title":"J Neurosci Rural Pract"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/373126-efficacy-of-adding-clonidine-to-bupivacaine-025-versus-plain-bupivacaine-025-infiltration-in-scalp-blocks-for-supratentorial-craniotomy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T10:20:28Z","timestamp":1748946028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/373126-efficacy-of-adding-clonidine-to-bupivacaine-025-versus-plain-bupivacaine-025-infiltration-in-scalp-blocks-for-supratentorial-craniotomy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.85274","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,3]]}}}