{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:24:43Z","timestamp":1775067883055,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,9]]},"DOI":"10.7759\/cureus.85670","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T05:42:09Z","timestamp":1749534129000},"source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Cardiovascular Outcomes in Childhood Cancer Survivors: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Abdulla","family":"Fahmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fathima","family":"Safa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheza","family":"Mariya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash","family":"Deep","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal  C","family":"S","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adwaith  S","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112607","article-title":"Childhood cancer: occurrence, treatment and risk of second primary malignancies","volume":"13","author":"Zahnreich S","year":"2021","unstructured":"Zahnreich S, Schmidberger H. Childhood cancer: occurrence, treatment and risk of second primary malignancies. Cancers (Basel). 2021, 13:2607. 10.3390\/cancers13112607","journal-title":"Cancers (Basel)"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-10565-3","article-title":"Risk factors of childhood cancer in Armenia: a case-control study","volume":"23","author":"Avagyan M","year":"2023","unstructured":"Avagyan M, Demirchyan A, Abrahamyan L. Risk factors of childhood cancer in Armenia: a case-control study. BMC Cancer. 2023, 23:81. 10.1186\/s12885-023-10565-3","journal-title":"BMC Cancer"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0002530","article-title":"Towards attainment of the 2030 goal for childhood cancer survival for the World Health Organization Global Initiative for Childhood Cancer: an ecological, cross-sectional study","volume":"4","author":"Smith ER","year":"2024","unstructured":"Smith ER, Cotache-Condor C, Leraas H, et al.. Towards attainment of the 2030 goal for childhood cancer survival for the World Health Organization Global Initiative for Childhood Cancer: an ecological, cross-sectional study. PLOS Glob Public Health. 2024, 4:e0002530. 10.1371\/journal.pgph.0002530","journal-title":"PLOS Glob Public Health"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/GO.22.00044","article-title":"Long-term outcomes in survivors of childhood cancer: a 30-year experience from India","volume":"8","author":"Prasad M","year":"2022","unstructured":"Prasad M, Goswami S, Chinnaswamy G, Banavali SD, Kurkure PA. Long-term outcomes in survivors of childhood cancer: a 30-year experience from India. JCO Glob Oncol. 2022, 8:e2200044. 10.1200\/GO.22.00044","journal-title":"JCO Glob Oncol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1288","article-title":"The heart of the world","volume":"19","author":"Di Cesare M","year":"2024","unstructured":"Di Cesare M, Perel P, Taylor S, et al.. The heart of the world. Glob Heart. 2024, 19:11. 10.5334\/gh.1288","journal-title":"Glob Heart"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.3920","article-title":"Cardiovascular disease in survivors of childhood cancer: insights into epidemiology, pathophysiology, and prevention","volume":"36","author":"Armenian SH","year":"2018","unstructured":"Armenian SH, Armstrong GT, Aune G, et al.. Cardiovascular disease in survivors of childhood cancer: insights into epidemiology, pathophysiology, and prevention. J Clin Oncol. 2018, 36:2135-44. 10.1200\/JCO.2017.76.3920","journal-title":"J Clin Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182a88099","article-title":"Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association","volume":"128","author":"Lipshultz SE","year":"2013","unstructured":"Lipshultz SE, Adams MJ, Colan SD, et al.. Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association. Circulation. 2013, 128:1927-95. 10.1161\/CIR.0b013e3182a88099","journal-title":"Circulation"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2020.08.006","article-title":"Cardiac disease in childhood cancer survivors: risk prediction, prevention, and surveillance: JACC CardioOncology state-of-the-art review","volume":"2","author":"Leerink JM","year":"2020","unstructured":"Leerink JM, de Baat EC, Feijen EA, et al.. Cardiac disease in childhood cancer survivors: risk prediction, prevention, and surveillance: JACC CardioOncology state-of-the-art review. JACC CardioOncol. 2020, 2:363-78. 10.1016\/j.jaccao.2020.08.006","journal-title":"JACC CardioOncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-070213-054849","article-title":"Cardiovascular disease in adult survivors of childhood cancer","volume":"66","author":"Lipshultz SE","year":"2015","unstructured":"Lipshultz SE, Franco VI, Miller TL, Colan SD, Sallan SE. Cardiovascular disease in adult survivors of childhood cancer. Annu Rev Med. 2015, 66:161-76. 10.1146\/annurev-med-070213-054849","journal-title":"Annu Rev Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.4730","article-title":"High risk of symptomatic cardiac events in childhood cancer survivors","volume":"30","author":"van der Pal HJ","year":"2012","unstructured":"van der Pal HJ, van Dalen EC, van Delden E, et al.. High risk of symptomatic cardiac events in childhood cancer survivors. J Clin Oncol. 2012, 30:1429-37. 10.1200\/JCO.2010.33.4730","journal-title":"J Clin Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.013","article-title":"Comprehensive echocardiographic detection of treatment-related cardiac\u00a0dysfunction in adult survivors of\u00a0childhood cancer: results from the St. Jude Lifetime Cohort Study","volume":"65","author":"Armstrong GT","year":"2015","unstructured":"Armstrong GT, Joshi VM, Ness KK, et al.. Comprehensive echocardiographic detection of treatment-related cardiac\u00a0dysfunction in adult survivors of\u00a0childhood cancer: results from the St. Jude Lifetime Cohort Study. J Am Coll Cardiol. 2015, 65:2511-22. 10.1016\/j.jacc.2015.04.013","journal-title":"J Am Coll Cardiol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7326\/M15-0424","article-title":"Cardiac outcomes in adult survivors of childhood cancer exposed to cardiotoxic therapy: a cross-sectional study","volume":"164","author":"Mulrooney DA","year":"2016","unstructured":"Mulrooney DA, Armstrong GT, Huang S, et al.. Cardiac outcomes in adult survivors of childhood cancer exposed to cardiotoxic therapy: a cross-sectional study. Ann Intern Med. 2016, 164:93-101. 10.7326\/M15-0424","journal-title":"Ann Intern Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.59497","article-title":"Racial and socioeconomic determinants of cardiovascular health: a comprehensive review","volume":"16","author":"Borkowski P","year":"2024","unstructured":"Borkowski P, Borkowska N, Mangeshkar S, Adal BH, Singh N. Racial and socioeconomic determinants of cardiovascular health: a comprehensive review. Cureus. 2024, 16:e59497. 10.7759\/cureus.59497","journal-title":"Cureus"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-024-01368-2","article-title":"Major cardiovascular events in long-term multiple myeloma survivors: a Korean case-control study (the CAREMM-2105 study)","volume":"24","author":"Ha J","year":"2024","unstructured":"Ha J, Choi S, Moon S, et al.. Major cardiovascular events in long-term multiple myeloma survivors: a Korean case-control study (the CAREMM-2105 study). Clin Exp Med. 2024, 24:125. 10.1007\/s10238-024-01368-2","journal-title":"Clin Exp Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78493-x","article-title":"Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia","volume":"10","author":"Morel S","year":"2020","unstructured":"Morel S, L\u00e9veill\u00e9 P, Samoilenko M, et al.. Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia. Sci Rep. 2020, 10:21507. 10.1038\/s41598-020-78493-x","journal-title":"Sci Rep"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33974","article-title":"Late health outcomes after dexrazoxane treatment: a report from the Children's Oncology Group","volume":"128","author":"Chow EJ","year":"2022","unstructured":"Chow EJ, Aplenc R, Vrooman LM, et al.. Late health outcomes after dexrazoxane treatment: a report from the Children's Oncology Group. Cancer. 2022, 128:788-96. 10.1002\/cncr.33974","journal-title":"Cancer"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081046","article-title":"A retrospective evaluation of risk of peripartum cardiac dysfunction in survivors of childhood, adolescent and young adult malignancies","volume":"11","author":"Chait-Rubinek L","year":"2019","unstructured":"Chait-Rubinek L, Mariani JA, Goroncy N, et al.. A retrospective evaluation of risk of peripartum cardiac dysfunction in survivors of childhood, adolescent and young adult malignancies. Cancers (Basel). 2019, 11:1046. 10.3390\/cancers11081046","journal-title":"Cancers (Basel)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1754","article-title":"Incidence of cardiovascular disease up to 13\u00a0year after cancer diagnosis: a matched cohort study among 32\u00a0757 cancer survivors","volume":"7","author":"Schoormans D","year":"2018","unstructured":"Schoormans D, Vissers PA, van Herk-Sukel MP, et al.. Incidence of cardiovascular disease up to 13\u00a0year after cancer diagnosis: a matched cohort study among 32\u00a0757 cancer survivors. Cancer Med. 2018, 7:4952-63. 10.1002\/cam4.1754","journal-title":"Cancer Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2023.01.011","article-title":"Cardiovascular risk factor disparities in adult survivors of childhood cancer compared with the general population","volume":"5","author":"Noyd DH","year":"2023","unstructured":"Noyd DH, Liu Q, Yasui Y, et al.. Cardiovascular risk factor disparities in adult survivors of childhood cancer compared with the general population. JACC CardioOncol. 2023, 5:489-500. 10.1016\/j.jaccao.2023.01.011","journal-title":"JACC CardioOncol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.12.623","article-title":"Cardiovascular risk factors in survivors of childhood hematopoietic cell transplantation treated with total body irradiation: a longitudinal analysis","volume":"23","author":"Friedman DN","year":"2017","unstructured":"Friedman DN, Hilden P, Moskowitz CS, et al.. Cardiovascular risk factors in survivors of childhood hematopoietic cell transplantation treated with total body irradiation: a longitudinal analysis. Biol Blood Marrow Transplant. 2017, 23:475-82. 10.1016\/j.bbmt.2016.12.623","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-023-02153-7","article-title":"Quality of life after pediatric cancer: comparison of long-term childhood cancer survivors' quality of life with a representative general population sample and associations with physical health and risk indicators","volume":"21","author":"Ernst M","year":"2023","unstructured":"Ernst M, Hinz A, Br\u00e4hler E, Merzenich H, Faber J, Wild PS, Beutel ME. Quality of life after pediatric cancer: comparison of long-term childhood cancer survivors' quality of life with a representative general population sample and associations with physical health and risk indicators. Health Qual Life Outcomes. 2023, 21:65. 10.1186\/s12955-023-02153-7","journal-title":"Health Qual Life Outcomes"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2022.10.029","article-title":"Long-term kidney and cardiovascular complications in pediatric cancer survivors","volume":"255","author":"Hsiao W","year":"2023","unstructured":"Hsiao W, Lapite A, Faig W, et al.. Long-term kidney and cardiovascular complications in pediatric cancer survivors. J Pediatr. 2023, 255:89-97.e1. 10.1016\/j.jpeds.2022.10.029","journal-title":"J Pediatr"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31696","article-title":"Risk of cardiovascular disease among Nordic childhood cancer survivors with diabetes mellitus: a report from adult life after childhood cancer in Scandinavia","volume":"124","author":"Winther JF","year":"2018","unstructured":"Winther JF, Bhatia S, Cederkvist L, et al.. Risk of cardiovascular disease among Nordic childhood cancer survivors with diabetes mellitus: a report from adult life after childhood cancer in Scandinavia. Cancer. 2018, 124:4393-400. 10.1002\/cncr.31696","journal-title":"Cancer"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.49696","article-title":"Recent advances in serum biomarkers for cardiological risk stratification and insight into the cardiac management of the patients with hematological malignancies treated with targeted therapy","volume":"15","author":"Andreescu M","year":"2023","unstructured":"Andreescu M. Recent advances in serum biomarkers for cardiological risk stratification and insight into the cardiac management of the patients with hematological malignancies treated with targeted therapy. Cureus. 2023, 15:e49696. 10.7759\/cureus.49696","journal-title":"Cureus"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s40959-024-00254-w","article-title":"Navigating the crossroads: cardiometabolic risks in cancer survivorship - a comprehensive review","volume":"10","author":"Albulushi A","year":"2024","unstructured":"Albulushi A, Al Balushi A, Shahzad M, Al Bulushi I, Al Lawati H. Navigating the crossroads: cardiometabolic risks in cancer survivorship - a comprehensive review. Cardiooncology. 2024, 10:51. 10.1186\/s40959-024-00254-w","journal-title":"Cardiooncology"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12111797","article-title":"Cardiovascular complications in hematopoietic stem cell transplanted patients","volume":"12","author":"Zhao Y","year":"2022","unstructured":"Zhao Y, He R, Oerther S, Zhou W, Vosough M, Hassan M. Cardiovascular complications in hematopoietic stem cell transplanted patients. J Pers Med. 2022, 12:1797. 10.3390\/jpm12111797","journal-title":"J Pers Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/351957-long-term-cardiovascular-outcomes-in-childhood-cancer-survivors-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T05:42:10Z","timestamp":1749534130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/351957-long-term-cardiovascular-outcomes-in-childhood-cancer-survivors-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.85670","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,9]]}}}