{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T04:09:16Z","timestamp":1749787756051,"version":"3.41.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,12]]},"DOI":"10.7759\/cureus.85864","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T18:56:48Z","timestamp":1749754608000},"source":"Crossref","is-referenced-by-count":0,"title":["Genetic Abnormalities in the Diagnosis and Treatment of Childhood Acute Myeloid Leukemia: A Prospective Study at Hue Central Hospital, Vietnam"],"prefix":"10.7759","author":[{"given":"Hoa Thi Kim","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao Kiem","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viet Hung","family":"Phan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Son Binh Bao","family":"Bui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.1034","article-title":"The leukemias: a half-century of discovery","volume":"32","author":"Freireich EJ","year":"2014","unstructured":"Freireich EJ, Wiernik PH, Steensma DP. The leukemias: a half-century of discovery. J Clin Oncol. 2014, 32:3463-9. 10.1200\/JCO.2014.57.1034","journal-title":"J Clin Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62187-4","article-title":"Acute lymphoblastic leukaemia","volume":"381","author":"Inaba H","year":"2013","unstructured":"Inaba H, Greaves M, Mullighan CG. Acute lymphoblastic leukaemia. Lancet. 2013, 381:1943-55. 10.1016\/S0140-6736(12)62187-4","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.8289","article-title":"Collaborative efforts driving progress in pediatric acute myeloid leukemia","volume":"33","author":"Zwaan CM","year":"2015","unstructured":"Zwaan CM, Kolb EA, Reinhardt D, et al.. Collaborative efforts driving progress in pediatric acute myeloid leukemia. J Clin Oncol. 2015, 33:2949-62. 10.1200\/JCO.2015.62.8289","journal-title":"J Clin Oncol"},{"key":"ref4","article-title":"A comprehensive analysis of cytogenetics, molecular profile, and survival among pediatric acute myeloid leukemia: a prospective study from a tertiary referral center","volume":"12","author":"Meena JP","year":"2022","unstructured":"Meena JP, Makkar H, Gupta AK, et al.. A comprehensive analysis of cytogenetics, molecular profile, and survival among pediatric acute myeloid leukemia: a prospective study from a tertiary referral center. Am J Blood Res. 2022, 12:177-89.","journal-title":"Am J Blood Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic\u00a0neoplasms","volume":"36","author":"Khoury JD","year":"2022","unstructured":"Khoury JD, Solary E, Abla O, et al.. The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic\u00a0neoplasms. Leukemia. 2022, 36:1703-19. 10.1038\/s41375-022-01613-1","journal-title":"Leukemia"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4328\/ACAM.21847","article-title":"Research of genetic abnormalities in diagnosis and treatment of childhood acute lymphoblastic leukemia at Hue Central Hospital","volume":"15","author":"Tran HK","year":"2024","unstructured":"Tran HK, Nguyen HTK, Phan VH. Research of genetic abnormalities in diagnosis and treatment of childhood acute lymphoblastic leukemia at Hue Central Hospital. Ann Clin Anal Med. 2024, 15:21-4. 10.4328\/ACAM.21847","journal-title":"Ann Clin Anal Med"},{"key":"ref7","article-title":"Clinical presentations of acute leukemia","volume":"24","author":"Shahab F","year":"2014","unstructured":"Shahab F, Raziq F. Clinical presentations of acute leukemia. J Coll Physicians Surg Pak. 2014, 24:472-6.","journal-title":"J Coll Physicians Surg Pak"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/genes12060924","article-title":"Cytogenetics of pediatric acute myeloid leukemia: a review of the current knowledge","volume":"12","author":"Quessada J","year":"2021","unstructured":"Quessada J, Cuccuini W, Saultier P, Loosveld M, Harrison CJ, Lafage-Pochitaloff M. Cytogenetics of pediatric acute myeloid leukemia: a review of the current knowledge. Genes (Basel). 2021, 12:924. 10.3390\/genes12060924","journal-title":"Genes (Basel)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-172007","article-title":"Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry","volume":"113","author":"Juliusson G","year":"2009","unstructured":"Juliusson G, Antunovic P, Derolf A, et al.. Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry. Blood. 2009, 113:4179-87. 10.1182\/blood-2008-07-172007","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22233","article-title":"Acute myeloid leukemia: epidemiology and etiology","volume":"107","author":"Deschler B","year":"2006","unstructured":"Deschler B, L\u00fcbbert M. Acute myeloid leukemia: epidemiology and etiology. Cancer. 2006, 107:2099-107. 10.1002\/cncr.22233","journal-title":"Cancer"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506153322407","article-title":"Childhood leukemias","volume":"332","author":"Pui CH","year":"1995","unstructured":"Pui CH. Childhood leukemias. N Engl J Med. 1995, 332:1618-30. 10.1056\/NEJM199506153322407","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000368176","article-title":"BCR-ABL1+ acute myeloid leukemia: clonal selection of a BCR-ABL1- subclone as a cause of refractory disease with nilotinib treatment","volume":"133","author":"Neuendorff NR","year":"2015","unstructured":"Neuendorff NR, Schwarz M, Hemmati P, et al.. BCR-ABL1+ acute myeloid leukemia: clonal selection of a BCR-ABL1- subclone as a cause of refractory disease with nilotinib treatment. Acta Haematol. 2015, 133:237-41. 10.1159\/000368176","journal-title":"Acta Haematol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2015.12.003","article-title":"Co-existence of AML1-ETO and BCR-ABL1 transcripts in a relapsed patient of acute myeloid leukemia with favorable risk group: a coincidence or clonal evolution?","volume":"10","author":"Singh MK","year":"2017","unstructured":"Singh MK, Gupta R, Rahman K, Kumar S, Sharma A, Nityanand S. Co-existence of AML1-ETO and BCR-ABL1 transcripts in a relapsed patient of acute myeloid leukemia with favorable risk group: a coincidence or clonal evolution?. Hematol Oncol Stem Cell Ther. 2017, 10:39-41. 10.1016\/j.hemonc.2015.12.003","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12040","article-title":"Childhood acute myeloid leukaemia","volume":"159","author":"Rubnitz JE","year":"2012","unstructured":"Rubnitz JE, Inaba H. Childhood acute myeloid leukaemia. Br J Haematol. 2012, 159:259-76. 10.1111\/bjh.12040","journal-title":"Br J Haematol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.7405","article-title":"Biology, risk stratification, and therapy of pediatric acute leukemias: an update","volume":"29","author":"Pui CH","year":"2011","unstructured":"Pui CH, Carroll WL, Meshinchi S, Arceci RJ. Biology, risk stratification, and therapy of pediatric acute leukemias: an update. J Clin Oncol. 2011, 29:551-65. 10.1200\/JCO.2010.30.7405","journal-title":"J Clin Oncol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-139189","article-title":"Improved outcome in pediatric AML - the AML-BFM 2012 study","volume":"136","author":"Waack K","year":"2020","unstructured":"Waack K, Schneider M, Walter C, et al.. Improved outcome in pediatric AML - the AML-BFM 2012 study. Blood. 2020, 136:12-4. 10.1182\/blood-2020-139189","journal-title":"Blood"},{"key":"ref17","article-title":"Clinical and treatment outcome of childhood acute myeloid leukemia at Children Hospital's Number 2","volume":"22","author":"Bui HT","year":"2018","unstructured":"Bui HT, Nguyen QH, Nguyen VD. Clinical and treatment outcome of childhood acute myeloid leukemia at Children Hospital's Number 2. Ho Chi Minh Med J. 2018, 22:89-94.","journal-title":"Ho Chi Minh Med J"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030504","article-title":"Pediatric acute myeloid leukemia-past, present, and future","volume":"11","author":"Reinhardt D","year":"2022","unstructured":"Reinhardt D, Antoniou E, Waack K. Pediatric acute myeloid leukemia-past, present, and future. J Clin Med. 2022, 11:504. 10.3390\/jcm11030504","journal-title":"J Clin Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.073189","article-title":"Extramedullary relapse of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcomes","volume":"98","author":"Harris AC","year":"2013","unstructured":"Harris AC, Kitko CL, Couriel DR, et al.. Extramedullary relapse of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcomes. Haematologica. 2013, 98:179-84. 10.3324\/haematol.2012.073189","journal-title":"Haematologica"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2003.18.1.13","article-title":"Prognostic value of AML1\/ETO fusion transcripts in patients with acute myelogenous leukemia","volume":"18","author":"Cho EK","year":"2003","unstructured":"Cho EK, Bang SM, Ahn JY, et al.. Prognostic value of AML1\/ETO fusion transcripts in patients with acute myelogenous leukemia. Korean J Intern Med. 2003, 18:13-20. 10.3904\/kjim.2003.18.1.13","journal-title":"Korean J Intern Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/259488-genetic-abnormalities-in-the-diagnosis-and-treatment-of-childhood-acute-myeloid-leukemia-a-prospective-study-at-hue-central-hospital-vietnam","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T18:56:49Z","timestamp":1749754609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/259488-genetic-abnormalities-in-the-diagnosis-and-treatment-of-childhood-acute-myeloid-leukemia-a-prospective-study-at-hue-central-hospital-vietnam"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,12]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.85864","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,12]]}}}