{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T21:07:43Z","timestamp":1784408863269,"version":"3.55.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,14]]},"DOI":"10.7759\/cureus.86023","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T01:13:09Z","timestamp":1749949989000},"source":"Crossref","is-referenced-by-count":1,"title":["Two Consecutive Days of Low-Dose Methotrexate Toxicity: A Diagnostic Challenge"],"prefix":"10.7759","author":[{"given":"Hridya","family":"Harimohan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quynh","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Yasonova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Moosavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Khamlong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Garcia Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0164","article-title":"Preventing and managing toxicities of high-dose methotrexate","volume":"21","author":"Howard SC","year":"2016","unstructured":"Howard SC, McCormick J, Pui CH, Buddington RK, Harvey RD. Preventing and managing toxicities of high-dose methotrexate. Oncologist. 2016, 21:1471-82. 10.1634\/theoncologist.2015-0164","journal-title":"Oncologist"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2174\/1389200220666190806140844","article-title":"Methotrexate overdose in clinical practice","volume":"20","author":"Pannu AK","year":"2019","unstructured":"Pannu AK. Methotrexate overdose in clinical practice. Curr Drug Metab. 2019, 20:714-9. 10.2174\/1389200220666190806140844","journal-title":"Curr Drug Metab"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-3043-5","article-title":"Methotrexate-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses","volume":"78","author":"Campbell JM","year":"2016","unstructured":"Campbell JM, Bateman E, Stephenson MD, Bowen JM, Keefe DM, Peters MD. Methotrexate-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses. Cancer Chemother Pharmacol. 2016, 78:27-39. 10.1007\/s00280-016-3043-5","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.09.027","article-title":"Side effects of methotrexate therapy for rheumatoid arthritis: a\u00a0systematic review","volume":"158","author":"Wang W","year":"2018","unstructured":"Wang W, Zhou H, Liu L. Side effects of methotrexate therapy for rheumatoid arthritis: a\u00a0systematic review. Eur J Med Chem. 2018, 158:502-16. 10.1016\/j.ejmech.2018.09.027","journal-title":"Eur J Med Chem"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.16096","article-title":"Navigating methotrexate toxicity: examining the therapeutic roles of folinic acid and glucarpidase","volume":"91","author":"Chan BS","year":"2025","unstructured":"Chan BS, Bosco AA, Buckley NA. Navigating methotrexate toxicity: examining the therapeutic roles of folinic acid and glucarpidase. Br J Clin Pharmacol. 2025, 91:628-35. 10.1111\/bcp.16096","journal-title":"Br J Clin Pharmacol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2023.2203482","article-title":"Association between methotrexate-induced Stevens-Johnson syndrome\/toxic epidermal necrolysis and furosemide: a real-world disproportionality analysis","volume":"23","author":"Zhuo S","year":"2024","unstructured":"Zhuo S, Dong T, Yue Z, Qian Y, Liu X, Liu W. Association between methotrexate-induced Stevens-Johnson syndrome\/toxic epidermal necrolysis and furosemide: a real-world disproportionality analysis. Expert Opin Drug Saf. 2024, 23:137-44. 10.1080\/14740338.2023.2203482","journal-title":"Expert Opin Drug Saf"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2021-0165","article-title":"Methotrexate related cutaneous adverse drug reactions: a systematic literature review","volume":"33","author":"Zuber M","year":"2022","unstructured":"Zuber M, Harikrishna, Vidhyashree, Chhabra M, Venkataraman R, Kumar S, Rashid M. Methotrexate related cutaneous adverse drug reactions: a systematic literature review. J Basic Clin Physiol Pharmacol. 2022, 33:549-65. 10.1515\/jbcpp-2021-0165","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15945","article-title":"Fatal low-dose methotrexate toxicity: a case report and literature review","volume":"35","author":"Ouellette S","year":"2022","unstructured":"Ouellette S, Shah R, Razi S, Ashforth G, Wassef C. Fatal low-dose methotrexate toxicity: a case report and literature review. Dermatol Ther. 2022, 35:e15945. 10.1111\/dth.15945","journal-title":"Dermatol Ther"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(83)70079-4","article-title":"Methotrexate-induced necrolysis","volume":"8","author":"Reed KM","year":"1983","unstructured":"Reed KM, Sober AJ. Methotrexate-induced necrolysis. J Am Acad Dermatol. 1983, 8:10.1016\/s0190-9622(83)70079-4","journal-title":"J Am Acad Dermatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/10781552221076456","article-title":"Unexpected severe hepatic and skin toxicities during high dose methotrexate course for osteosarcoma","volume":"28","author":"Sala\u00fcn H","year":"2022","unstructured":"Sala\u00fcn H, Le Nail LR, Simon C, Narciso B, De Pinieux G, Vegas H, Vinceneux A. Unexpected severe hepatic and skin toxicities during high dose methotrexate course for osteosarcoma. J Oncol Pharm Pract. 2022, 28:1458-64. 10.1177\/10781552221076456","journal-title":"J Oncol Pharm Pract"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2021.11.003","article-title":"Undiagnosed and rare diseases in critical care: severe mucocutaneous medication reactions","volume":"38","author":"Shields BE","year":"2022","unstructured":"Shields BE, Wanat KA, Chiu YE. Undiagnosed and rare diseases in critical care: severe mucocutaneous medication reactions. Crit Care Clin. 2022, 38:243-69. 10.1016\/j.ccc.2021.11.003","journal-title":"Crit Care Clin"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/371174-two-consecutive-days-of-low-dose-methotrexate-toxicity-a-diagnostic-challenge","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T01:13:09Z","timestamp":1749949989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/371174-two-consecutive-days-of-low-dose-methotrexate-toxicity-a-diagnostic-challenge"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,14]]},"references-count":11,"URL":"https:\/\/doi.org\/10.7759\/cureus.86023","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,14]]}}}