{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:02:54Z","timestamp":1750219374410,"version":"3.41.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,17]]},"DOI":"10.7759\/cureus.86183","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T07:23:21Z","timestamp":1750145001000},"source":"Crossref","is-referenced-by-count":0,"title":["Neonatal Hypoglycemia and Long-Term Pediatric Neurodevelopmental Outcomes: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Rasha Fawzy","family":"Abdelmonem Mahrous","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally Hassan","family":"Ali Hassanin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raheeq Elssammani","family":"Elemam Elbashir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hind","family":"Gasm Elseed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarra Elnour","family":"Ahmed Elnour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nojoud Noureldayim","family":"Elsayid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.3683","article-title":"Transitional neonatal hypoglycemia and adverse neurodevelopment in midchildhood","volume":"7","author":"Roeper M","year":"2024","unstructured":"Roeper M, Hoermann H, K\u00f6rner LM, Sobottka M, Mayatepek E, Kummer S, Meissner T. Transitional neonatal hypoglycemia and adverse neurodevelopment in midchildhood. JAMA Netw Open. 2024, 7:e243683. 10.1001\/jamanetworkopen.2024.3683","journal-title":"JAMA Netw Open"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-05405-2","article-title":"Neonatal hypoglycemia and neurodevelopmental outcomes: yesterday, today, tomorrow","volume":"183","author":"De Rose DU","year":"2024","unstructured":"De Rose DU, Perri A, Maggio L, Salvatori G, Dotta A, Vento G, Gallini F. Neonatal hypoglycemia and neurodevelopmental outcomes: yesterday, today, tomorrow. Eur J Pediatr. 2024, 183:1113-19. 10.1007\/s00431-023-05405-2","journal-title":"Eur J Pediatr"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.21037\/tp.2017.10.06","article-title":"Hypoglycemia in the preterm neonate: etiopathogenesis, diagnosis, management and long-term outcomes","volume":"6","author":"Sharma A","year":"2017","unstructured":"Sharma A, Davis A, Shekhawat PS. Hypoglycemia in the preterm neonate: etiopathogenesis, diagnosis, management and long-term outcomes. Transl Pediatr. 2017, 6:335-48. 10.21037\/tp.2017.10.06","journal-title":"Transl Pediatr"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/life14121618","article-title":"Neonatal hypoglycemia and neurodevelopmental outcomes-an updated systematic review and meta-analysis","volume":"14","author":"Diggikar S","year":"2024","unstructured":"Diggikar S, Trif P, Mudura D, et al.. Neonatal hypoglycemia and neurodevelopmental outcomes-an updated systematic review and meta-analysis. Life (Basel). 2024, 14:10.3390\/life14121618","journal-title":"Life (Basel)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000492859","article-title":"Neonatal glycaemia and neurodevelopmental outcomes: a systematic review and meta-analysis","volume":"115","author":"Shah R","year":"2019","unstructured":"Shah R, Harding J, Brown J, McKinlay C. Neonatal glycaemia and neurodevelopmental outcomes: a systematic review and meta-analysis. Neonatology. 2019, 115:116-26. 10.1159\/000492859","journal-title":"Neonatology"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-024-03411-0","article-title":"Neonatal dysglycemia: a review of dysglycemia in relation to brain health and neurodevelopmental outcomes","volume":"96","author":"Lagac\u00e9 M","year":"2024","unstructured":"Lagac\u00e9 M, Tam EW. Neonatal dysglycemia: a review of dysglycemia in relation to brain health and neurodevelopmental outcomes. Pediatr Res. 2024, 96:1429-37. 10.1038\/s41390-024-03411-0","journal-title":"Pediatr Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-025-06082-z","article-title":"Exploring the long-term impacts of neonatal hypoglycemia to determine a safe threshold for glucose concentrations","volume":"184","author":"Garg M","year":"2025","unstructured":"Garg M, Devaskar SU. Exploring the long-term impacts of neonatal hypoglycemia to determine a safe threshold for glucose concentrations. Eur J Pediatr. 2025, 184:263. 10.1007\/s00431-025-06082-z","journal-title":"Eur J Pediatr"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref9","article-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses","author":"GA Wells","year":"2000","unstructured":"GA Wells, Shea B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hosp Res Inst. 2000,","journal-title":"Ottawa Hosp Res Inst"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.039412","article-title":"Neurodevelopmental outcome of hypoglycaemia in healthy, large for gestational age, term newborns","volume":"90","author":"Brand PL","year":"2005","unstructured":"Brand PL, Molenaar NL, Kaaijk C, Wierenga WS. Neurodevelopmental outcome of hypoglycaemia in healthy, large for gestational age, term newborns. Arch Dis Child. 2005, 90:78-81. 10.1136\/adc.2003.039412","journal-title":"Arch Dis Child"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0079","article-title":"Neonatal morbidities and developmental delay in moderately preterm-born children","volume":"130","author":"Kerstjens JM","year":"2012","unstructured":"Kerstjens JM, Bocca-Tjeertes IF, de Winter AF, Reijneveld SA, Bos AF. Neonatal morbidities and developmental delay in moderately preterm-born children. Pediatrics. 2012, 130:e265-72. 10.1542\/peds.2012-0079","journal-title":"Pediatrics"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.1631","article-title":"Association between transient newborn hypoglycemia and fourth-grade achievement test proficiency: a population-based study","volume":"169","author":"Kaiser JR","year":"2015","unstructured":"Kaiser JR, Bai S, Gibson N, et al.. Association between transient newborn hypoglycemia and fourth-grade achievement test proficiency: a population-based study. JAMA Pediatr. 2015, 169:913-21. 10.1001\/jamapediatrics.2015.1631","journal-title":"JAMA Pediatr"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1424","article-title":"Developmental outcomes of preterm infants with neonatal hypoglycemia","volume":"138","author":"Goode RH","year":"2016","unstructured":"Goode RH, Rettiganti M, Li J, Lyle RE, Whiteside-Mansell L, Barrett KW, Casey PH. Developmental outcomes of preterm infants with neonatal hypoglycemia. Pediatrics. 2016, 138:10.1542\/peds.2016-1424","journal-title":"Pediatrics"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504909","article-title":"Neonatal glycemia and neurodevelopmental outcomes at 2 years","volume":"373","author":"McKinlay CJ","year":"2015","unstructured":"McKinlay CJ, Alsweiler JM, Ansell JM, et al.. Neonatal glycemia and neurodevelopmental outcomes at 2 years. N Engl J Med. 2015, 373:1507-18. 10.1056\/NEJMoa1504909","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2017.05.028","article-title":"Neurodevelopmental outcome of asymptomatic hypoglycemia compared with symptomatic hypoglycemia and euglycemia in high-risk neonates","volume":"74","author":"Mahajan G","year":"2017","unstructured":"Mahajan G, Mukhopadhyay K, Attri S, Kumar P. Neurodevelopmental outcome of asymptomatic hypoglycemia compared with symptomatic hypoglycemia and euglycemia in high-risk neonates. Pediatr Neurol. 2017, 74:74-79. 10.1016\/j.pediatrneurol.2017.05.028","journal-title":"Pediatr Neurol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.1579","article-title":"Association of neonatal glycemia with neurodevelopmental outcomes at 4.5 years","volume":"171","author":"McKinlay CJ","year":"2017","unstructured":"McKinlay CJ, Alsweiler JM, Anstice NS, et al.. Association of neonatal glycemia with neurodevelopmental outcomes at 4.5 years. JAMA Pediatr. 2017, 171:972-83. 10.1001\/jamapediatrics.2017.1579","journal-title":"JAMA Pediatr"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0425-5","article-title":"Moderate neonatal hypoglycemia and adverse neurological development at 2-6\u00a0years of age","volume":"33","author":"Wickstr\u00f6m R","year":"2018","unstructured":"Wickstr\u00f6m R, Ski\u00f6ld B, Petersson G, Stephansson O, Altman M. Moderate neonatal hypoglycemia and adverse neurological development at 2-6\u00a0years of age. Eur J Epidemiol. 2018, 33:1011-20. 10.1007\/s10654-018-0425-5","journal-title":"Eur J Epidemiol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-019-1509-4","article-title":"Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemia","volume":"19","author":"Qiao LX","year":"2019","unstructured":"Qiao LX, Wang J, Yan JH, et al.. Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemia. BMC Pediatr. 2019, 19:133. 10.1186\/s12887-019-1509-4","journal-title":"BMC Pediatr"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03729-x","article-title":"Neurodevelopmental outcomes after moderate to severe neonatal hypoglycemia","volume":"179","author":"Rasmussen AH","year":"2020","unstructured":"Rasmussen AH, Wehberg S, P\u00f8rtner F, Larsen AM, Filipsen K, Christesen HT. Neurodevelopmental outcomes after moderate to severe neonatal hypoglycemia. Eur J Pediatr. 2020, 179:1981-91. 10.1007\/s00431-020-03729-x","journal-title":"Eur J Pediatr"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.35989","article-title":"Neurocognitive outcomes at age 2 years after neonatal hypoglycemia in a cohort of participants from the hPOD randomized trial","volume":"5","author":"Edwards T","year":"2022","unstructured":"Edwards T, Alsweiler JM, Gamble GD, et al.. Neurocognitive outcomes at age 2 years after neonatal hypoglycemia in a cohort of participants from the hPOD randomized trial. JAMA Netw Open. 2022, 5:e2235989. 10.1001\/jamanetworkopen.2022.35989","journal-title":"JAMA Netw Open"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-022-02410-3","article-title":"Neurodevelopmental correlates of caudate volume in children born at risk of neonatal hypoglycaemia","volume":"93","author":"Kennedy E","year":"2023","unstructured":"Kennedy E, Nivins S, Thompson B, McKinlay CJ, Harding J. Neurodevelopmental correlates of caudate volume in children born at risk of neonatal hypoglycaemia. Pediatr Res. 2023, 93:1634-41. 10.1038\/s41390-022-02410-3","journal-title":"Pediatr Res"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.0992","article-title":"Association of neonatal hypoglycemia with academic performance in mid-childhood","volume":"327","author":"Shah R","year":"2022","unstructured":"Shah R, Dai DW, Alsweiler JM, et al.. Association of neonatal hypoglycemia with academic performance in mid-childhood. JAMA. 2022, 327:1158-70. 10.1001\/jama.2022.0992","journal-title":"JAMA"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6659.1304","article-title":"Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia","volume":"297","author":"Lucas A","year":"1988","unstructured":"Lucas A, Morley R, Cole TJ. Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia. BMJ. 1988, 297:1304-308. 10.1136\/bmj.297.6659.1304","journal-title":"BMJ"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1053\/sp.2000.6361","article-title":"Glucose metabolism in the developing brain","volume":"24","author":"Vannucci RC","year":"2000","unstructured":"Vannucci RC, Vannucci SJ. Glucose metabolism in the developing brain. Semin Perinatol. 2000, 24:107-15. 10.1053\/sp.2000.6361","journal-title":"Semin Perinatol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000069049","article-title":"Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release","volume":"24","author":"Yager JY","year":"2002","unstructured":"Yager JY, Armstrong EA, Miyashita H, Wirrell EC. Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release. Dev Neurosci. 2002, 24:367-81. 10.1159\/000069049","journal-title":"Dev Neurosci"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-010-0481-0","article-title":"Molecular and cellular mechanisms of excitotoxic neuronal death","volume":"15","author":"Wang Y","year":"2010","unstructured":"Wang Y, Qin ZH. Molecular and cellular mechanisms of excitotoxic neuronal death. Apoptosis. 2010, 15:1382-402. 10.1007\/s10495-010-0481-0","journal-title":"Apoptosis"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2013.09.003","article-title":"Defining neonatal hypoglycaemia: a continuing debate","volume":"19","author":"Tin W","year":"2014","unstructured":"Tin W. Defining neonatal hypoglycaemia: a continuing debate. Semin Fetal Neonatal Med. 2014, 19:27-32. 10.1016\/j.siny.2013.09.003","journal-title":"Semin Fetal Neonatal Med"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70294-1","article-title":"Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances","volume":"8","author":"Volpe JJ","year":"2009","unstructured":"Volpe JJ. Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol. 2009, 8:110-24. 10.1016\/S1474-4422(08)70294-1","journal-title":"Lancet Neurol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1975.229.5.1165","article-title":"Induction processes in blood-brain transfer of ketone bodies during starvation","volume":"229","author":"Gjedde A","year":"1975","unstructured":"Gjedde A, Crone C. Induction processes in blood-brain transfer of ketone bodies during starvation. Am J Physiol. 1975, 229:1165-69. 10.1152\/ajplegacy.1975.229.5.1165","journal-title":"Am J Physiol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.03.057","article-title":"Recommendations from the pediatric endocrine society for evaluation and management of persistent hypoglycemia in neonates, infants, and children","volume":"167","author":"Thornton PS","year":"2015","unstructured":"Thornton PS, Stanley CA, De Leon DD, et al.. Recommendations from the pediatric endocrine society for evaluation and management of persistent hypoglycemia in neonates, infants, and children. J Pediatr. 2015, 167:238-45. 10.1016\/j.jpeds.2015.03.057","journal-title":"J Pediatr"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61645-1","article-title":"Dextrose gel for neonatal hypoglycaemia (the Sugar Babies Study): a randomised, double-blind, placebo-controlled trial.","volume":"382","author":"Harris DL","year":"2013","unstructured":"Harris DL, Weston PJ, Signal M, Chase JG, Harding JE. Dextrose gel for neonatal hypoglycaemia (the Sugar Babies Study): a randomised, double-blind, placebo-controlled trial.. The Lancet. 2013, 382:2077-83. 10.1016\/S0140-6736(13)61645-1","journal-title":"The Lancet"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/377386-neonatal-hypoglycemia-and-long-term-pediatric-neurodevelopmental-outcomes-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T07:23:22Z","timestamp":1750145002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/377386-neonatal-hypoglycemia-and-long-term-pediatric-neurodevelopmental-outcomes-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":31,"URL":"https:\/\/doi.org\/10.7759\/cureus.86183","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,17]]}}}