{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T04:30:38Z","timestamp":1750307438862,"version":"3.41.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,18]]},"DOI":"10.7759\/cureus.86273","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T11:48:11Z","timestamp":1750247291000},"source":"Crossref","is-referenced-by-count":0,"title":["Breakthrough Seizures in Children Receiving Valproate Therapy"],"prefix":"10.7759","author":[{"given":"Arunima","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaradhana","family":"Aaradhana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"World Health Organization. Epilepsy. (2023). Accessed: April 5, 2023: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/epilepsy."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200608020-00004","article-title":"Valproate as a mainstay of therapy for pediatric epilepsy","volume":"8","author":"Guerrini R","year":"2006","unstructured":"Guerrini R. Valproate as a mainstay of therapy for pediatric epilepsy. Paediatr Drugs. 2006, 8:113-29. 10.2165\/00148581-200608020-00004","journal-title":"Paediatr Drugs"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000057","article-title":"Therapeutic drug monitoring of antiepileptic drugs in a tertiary care hospital in India","volume":"38","author":"Harivenkatesh N","year":"2015","unstructured":"Harivenkatesh N, Haribalaji N, David DC, Kumar CM. Therapeutic drug monitoring of antiepileptic drugs in a tertiary care hospital in India. Clin Neuropharmacol. 2015, 38:1-5. 10.1097\/WNF.0000000000000057","journal-title":"Clin Neuropharmacol"},{"key":"ref4","article-title":"Correlation between breakthrough seizures and serum level of phenytoin and valproate in Indian patients","volume":"12","author":"Katoch N","year":"2021","unstructured":"Katoch N, Bhardwaj A, Suchal K, Sharma S. Correlation between breakthrough seizures and serum level of phenytoin and valproate in Indian patients. J Pharmacol Pharmacother. 2021, 12:73-8.","journal-title":"J Pharmacol Pharmacother"},{"key":"ref5","article-title":"Factors precipitating breakthrough seizures in well-controlled epilepsy","volume":"42","author":"Kumar S","year":"2005","unstructured":"Kumar S. Factors precipitating breakthrough seizures in well-controlled epilepsy. Indian Pediatr. 2005, 42:182-83.","journal-title":"Indian Pediatr"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2009.5167","article-title":"Therapeutic drug monitoring of valproic acid in patients with monotherapy at steady state","volume":"12","author":"Forooghipour M","year":"2009","unstructured":"Forooghipour M, Mohammadpour AHH, Mashhadian NV, et al.. Therapeutic drug monitoring of valproic acid in patients with monotherapy at steady state. Iran J Basic Med Sci. 2009, 12:146-9. 10.22038\/ijbms.2009.5167","journal-title":"Iran J Basic Med Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-021-2307-2","article-title":"Antiseizure drug levels in children aged 2-12 years presenting with breakthrough seizures: A single center cross-sectional study","volume":"58","author":"Garg R","year":"2021","unstructured":"Garg R, Aggarwal A, Sharma S, et al.. Antiseizure drug levels in children aged 2-12 years presenting with breakthrough seizures: A single center cross-sectional study. Indian Pediatr. 2021, 58:850-2. 10.1007\/s13312-021-2307-2","journal-title":"Indian Pediatr"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e31817fd85f","article-title":"Therapeutic drug monitoring: appropriateness and clinical utility in neuropsychiatry practice","volume":"16","author":"Sharma S","year":"2009","unstructured":"Sharma S, Joshi S, Mukherji S, et al.. Therapeutic drug monitoring: appropriateness and clinical utility in neuropsychiatry practice. Am J Ther. 2009, 16:11-6. 10.1097\/MJT.0b013e31817fd85f","journal-title":"Am J Ther"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.01.004","article-title":"Seizure precipitants in children with intractable epilepsy","volume":"30","author":"Fang PC","year":"2008","unstructured":"Fang PC, Chen YJ, Lee IC. Seizure precipitants in children with intractable epilepsy. Brain Dev. 2008, 30:527-32. 10.1016\/j.braindev.2008.01.004","journal-title":"Brain Dev"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.14581\/jer.23003","article-title":"The frequency and precipitating factors for breakthrough seizures in children with epilepsy","volume":"13","author":"Aldosari AN","year":"2023","unstructured":"Aldosari AN, Alghamdi A, Alharthi A, et al.. The frequency and precipitating factors for breakthrough seizures in children with epilepsy. J Epilepsy Res. 2023, 13:13-8. 10.14581\/jer.23003","journal-title":"J Epilepsy Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2515\/therapie\/2015024","article-title":"Suivi th\u00e9rapeutique de l\u2019acide valpro\u00efque chez l\u2019enfant : \u00e9tude prospective de l\u2019effet de l\u2019observance et du niveau \u00e9conomique sur les concentrations plasmatiques r\u00e9siduelles et les crises \u00e9pileptiques","volume":"70","author":"Charfi R","year":"2015","unstructured":"Charfi R, Lakhal M, Klouz A, et al.. Suivi th\u00e9rapeutique de l\u2019acide valpro\u00efque chez l\u2019enfant : \u00e9tude prospective de l\u2019effet de l\u2019observance et du niveau \u00e9conomique sur les concentrations plasmatiques r\u00e9siduelles et les crises \u00e9pileptiques. Therapie. 2015, 70:415-24. 10.2515\/therapie\/2015024","journal-title":"Therapie"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.12.036","article-title":"Parent health literacy and adherence-related outcomes in children with epilepsy","volume":"56","author":"Paschal AM","year":"2016","unstructured":"Paschal AM, Mitchell QP, Wilroy JD, et al.. Parent health literacy and adherence-related outcomes in children with epilepsy. Epilepsy Behav. 2016, 56:73-82. 10.1016\/j.yebeh.2015.12.036","journal-title":"Epilepsy Behav"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2022.08.009","article-title":"The profile of epilepsy and its characteristics in children with cerebral palsy","volume":"101","author":"K A","year":"2022","unstructured":"K A, Saini L, Gunasekaran PK, et al.. The profile of epilepsy and its characteristics in children with cerebral palsy. Seizure. 2022, 101:190-6. 10.1016\/j.seizure.2022.08.009","journal-title":"Seizure"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01561.x","article-title":"Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies","volume":"49","author":"Patsalos PN","year":"2008","unstructured":"Patsalos PN, Berry DJ, Bourgeois BF, et al.. Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia. 2008, 49:1239-76. 10.1111\/j.1528-1167.2008.01561.x","journal-title":"Epilepsia"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00144.x","article-title":"A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy","volume":"41","author":"Jannuzzi G","year":"2000","unstructured":"Jannuzzi G, Cian P, Fattore C, et al.. A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy. Epilepsia. 2000, 41:222-30. 10.1111\/j.1528-1157.2000.tb00144.x","journal-title":"Epilepsia"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/364084-breakthrough-seizures-in-children-receiving-valproate-therapy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T11:48:13Z","timestamp":1750247293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/364084-breakthrough-seizures-in-children-receiving-valproate-therapy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.86273","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,18]]}}}