{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T04:03:00Z","timestamp":1750564980321,"version":"3.41.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,21]]},"DOI":"10.7759\/cureus.86472","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T07:50:43Z","timestamp":1750492243000},"source":"Crossref","is-referenced-by-count":0,"title":["Fatal Duodenal Ulcer Hemorrhage in a Post-Operative Patient of Proximal Femur Fracture Undergoing Carbon Ion Radiotherapy for Locally Advanced Pancreatic Carcinoma: A Case Report"],"prefix":"10.7759","author":[{"given":"Hiroki","family":"Iida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikako","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Mizokami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryu","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20200416","article-title":"Updated trends in cancer in Japan: incidence in 1985-2015 and mortality in 1958-2018-a sign of decrease in cancer incidence","volume":"31","author":"Katanoda K","year":"2021","unstructured":"Katanoda K, Hori M, Saito E, et al.. Updated trends in cancer in Japan: incidence in 1985-2015 and mortality in 1958-2018-a sign of decrease in cancer incidence. J Epidemiol. 2021, 31:426-50. 10.2188\/jea.JE20200416","journal-title":"J Epidemiol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12401","article-title":"Pancreatic cancer","volume":"171","author":"G\u00fcng\u00f6r C","year":"2014","unstructured":"G\u00fcng\u00f6r C, Hofmann BT, Wolters-Eisfeld G, Bockhorn M. Pancreatic cancer. Br J Pharmacol. 2014, 171:849-58. 10.1111\/bph.12401","journal-title":"Br J Pharmacol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.03.059","article-title":"A multicenter phase II trial of S-1 with concurrent radiation therapy for locally advanced pancreatic cancer","volume":"85","author":"Ikeda M","year":"2013","unstructured":"Ikeda M, Ioka T, Ito Y, et al.. A multicenter phase II trial of S-1 with concurrent radiation therapy for locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys. 2013, 85:163-9. 10.1016\/j.ijrobp.2012.03.059","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2016.00023","article-title":"Effects of charged particles on human tumor cells","volume":"6","author":"Held KD","year":"2016","unstructured":"Held KD, Kawamura H, Kaminuma T, et al.. Effects of charged particles on human tumor cells. Front Oncol. 2016, 6:23. 10.3389\/fonc.2016.00023","journal-title":"Front Oncol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-005-0998-1","article-title":"Report on the Japanese Orthopaedic Association's 3-year project observing hip fractures at fixed-point hospitals","volume":"11","author":"Sakamoto K","year":"2006","unstructured":"Sakamoto K, Nakamura T, Hagino H, et al.. Report on the Japanese Orthopaedic Association's 3-year project observing hip fractures at fixed-point hospitals. J Orthop Sci. 2006, 11:127-34. 10.1007\/s00776-005-0998-1","journal-title":"J Orthop Sci"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1583-0","article-title":"Consequences of hip fracture on activities of daily life and residential needs","volume":"15","author":"Osnes EK","year":"2004","unstructured":"Osnes EK, Lofthus CM, Meyer HE, et al.. Consequences of hip fracture on activities of daily life and residential needs. Osteoporos Int. 2004, 15:567-74. 10.1007\/s00198-003-1583-0","journal-title":"Osteoporos Int"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.4318","article-title":"Fracture risk prediction using the fracture risk assessment tool in individuals with cancer","volume":"10","author":"Ye C","year":"2024","unstructured":"Ye C, Leslie WD, Al-Azazi S, et al.. Fracture risk prediction using the fracture risk assessment tool in individuals with cancer. JAMA Oncol. 2024, 10:1554-60. 10.1001\/jamaoncol.2024.4318","journal-title":"JAMA Oncol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(23)00285-4","article-title":"Risk of fractures in half a million survivors of 20 cancers: a population-based matched cohort study using linked English electronic health records","volume":"5","author":"Buzasi E","year":"2024","unstructured":"Buzasi E, Carreira H, Funston G, et al.. Risk of fractures in half a million survivors of 20 cancers: a population-based matched cohort study using linked English electronic health records. Lancet Healthy Longev. 2024, 5:e194-203. 10.1016\/S2666-7568(23)00285-4","journal-title":"Lancet Healthy Longev"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-022-06542-4","article-title":"Fractures and long-term mortality in cancer patients: a population-based cohort study","volume":"33","author":"Ye C","year":"2022","unstructured":"Ye C, Leslie WD, Al-Azazi S, et al.. Fractures and long-term mortality in cancer patients: a population-based cohort study. Osteoporos Int. 2022, 33:2629-35. 10.1007\/s00198-022-06542-4","journal-title":"Osteoporos Int"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.12.362","article-title":"Carbon ion radiation therapy with concurrent gemcitabine for patients with locally advanced pancreatic cancer","volume":"95","author":"Shinoto M","year":"2016","unstructured":"Shinoto M, Yamada S, Terashima K, et al.. Carbon ion radiation therapy with concurrent gemcitabine for patients with locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys. 2016, 95:498-504. 10.1016\/j.ijrobp.2015.12.362","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.04.057","article-title":"Multi-institutional study of carbon-ion radiotherapy for locally advanced pancreatic cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) study 1403 pancreas","volume":"101","author":"Kawashiro S","year":"2018","unstructured":"Kawashiro S, Yamada S, Okamoto M, et al.. Multi-institutional study of carbon-ion radiotherapy for locally advanced pancreatic cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) study 1403 pancreas. Int J Radiat Oncol Biol Phys. 2018, 101:1212-21. 10.1016\/j.ijrobp.2018.04.057","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.08.026","article-title":"A single institutional experience of combined carbon-ion radiotherapy and chemotherapy for unresectable locally advanced pancreatic cancer","volume":"129","author":"Shinoto M","year":"2018","unstructured":"Shinoto M, Terashima K, Suefuji H, et al.. A single institutional experience of combined carbon-ion radiotherapy and chemotherapy for unresectable locally advanced pancreatic cancer. Radiother Oncol. 2018, 129:333-9. 10.1016\/j.radonc.2018.08.026","journal-title":"Radiother Oncol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07273-2","article-title":"Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis","volume":"5","author":"Huang JQ","year":"2002","unstructured":"Huang JQ, Sridhar S, Hunt RH. Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis. Lancet. 2002, 5:359-14. 10.1016\/S0140-6736(02)07273-2","journal-title":"Lancet"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/art.27412","article-title":"Variability among nonsteroidal antiinflammatory drugs in risk of upper gastrointestinal bleeding","volume":"62","author":"Mass\u00f3 Gonz\u00e1lez EL","year":"2010","unstructured":"Mass\u00f3 Gonz\u00e1lez EL, Patrignani P, Tacconelli S, Garc\u00eda Rodr\u00edguez LA. Variability among nonsteroidal antiinflammatory drugs in risk of upper gastrointestinal bleeding. Arthritis Rheum. 2010, 62:1592-601. 10.1002\/art.27412","journal-title":"Arthritis Rheum"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015368","article-title":"Feasibility of administrative data for studying complications after hip fracture surgery","volume":"7","author":"Sheehan KJ","year":"2017","unstructured":"Sheehan KJ, Sobolev B, Guy P, et al.. Feasibility of administrative data for studying complications after hip fracture surgery. BMJ Open. 2017, 7:e015368. 10.1136\/bmjopen-2016-015368","journal-title":"BMJ Open"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.18.2053","article-title":"Medical complications and outcomes after hip fracture repair","volume":"162","author":"Lawrence VA","year":"2002","unstructured":"Lawrence VA, Hilsenbeck SG, Noveck H, et al.. Medical complications and outcomes after hip fracture repair. Arch Intern Med. 2002, 162:2053-7. 10.1001\/archinte.162.18.2053","journal-title":"Arch Intern Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A028","article-title":"Meta-analysis of proton pump inhibitors in treatment of bleeding peptic ulcers","volume":"35","author":"Zed PJ","year":"2001","unstructured":"Zed PJ, Loewen PS, Slavik RS, Marra CA. Meta-analysis of proton pump inhibitors in treatment of bleeding peptic ulcers. Ann Pharmacother. 2001, 35:1528-34. 10.1345\/aph.1A028","journal-title":"Ann Pharmacother"},{"key":"ref18","article-title":"Long-term follow-up of endoscopic treatment for bleeding gastric and duodenal ulcers","volume":"90","author":"Inadomi J","year":"1995","unstructured":"Inadomi J, Koch J, Cello JP. Long-term follow-up of endoscopic treatment for bleeding gastric and duodenal ulcers. Am J Gastroenterol. 1995, 90:1065-8.","journal-title":"Am J Gastroenterol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-017-0898-z","article-title":"Short- and long-term outcomes of surgical management of peptic ulcer complications in the era of proton pump inhibitors","volume":"44","author":"Hasadia R","year":"2018","unstructured":"Hasadia R, Kopelman Y, Olsha O, et al.. Short- and long-term outcomes of surgical management of peptic ulcer complications in the era of proton pump inhibitors. Eur J Trauma Emerg Surg. 2018, 44:795-801. 10.1007\/s00068-017-0898-z","journal-title":"Eur J Trauma Emerg Surg"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s40792-018-0522-4","article-title":"Conversion surgery for an initially unresectable, locally advanced pancreatic cancer after induction chemotherapy and carbon-ion radiotherapy: a case report","volume":"4","author":"Fujishiro T","year":"2018","unstructured":"Fujishiro T, Mashiko T, Masuoka Y, et al.. Conversion surgery for an initially unresectable, locally advanced pancreatic cancer after induction chemotherapy and carbon-ion radiotherapy: a case report. Surg Case Rep. 2018, 4:112. 10.1186\/s40792-018-0522-4","journal-title":"Surg Case Rep"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/339017-fatal-duodenal-ulcer-hemorrhage-in-a-post-operative-patient-of-proximal-femur-fracture-undergoing-carbon-ion-radiotherapy-for-locally-advanced-pancreatic-carcinoma-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T07:50:43Z","timestamp":1750492243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/339017-fatal-duodenal-ulcer-hemorrhage-in-a-post-operative-patient-of-proximal-femur-fracture-undergoing-carbon-ion-radiotherapy-for-locally-advanced-pancreatic-carcinoma-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,21]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.86472","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,21]]}}}