{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:40:20Z","timestamp":1789508420626,"version":"build-2803163510"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,24]]},"DOI":"10.7759\/cureus.86641","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T08:10:09Z","timestamp":1750752609000},"source":"Crossref","is-referenced-by-count":1,"title":["Associations Between Myeloid-Derived Suppressor Cells, TIM-3+ T Cells, and Clinical Factors During the Post-transplant Neutropenia Period in Patients With Multiple Myeloma"],"prefix":"10.7759","author":[{"given":"Egor","family":"Batorov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Tyrinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Aristova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Denisova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariya","family":"Batorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Sizikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Ushakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandr","family":"Ostanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Chernykh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.3.579","article-title":"Early lymphocyte recovery predicts superior survival after autologous hematopoietic stem cell transplantation in multiple myeloma or non-Hodgkin lymphoma","volume":"98","author":"Porrata LF","year":"2001","unstructured":"Porrata LF, Gertz MA, Inwards DJ, et al.. Early lymphocyte recovery predicts superior survival after autologous hematopoietic stem cell transplantation in multiple myeloma or non-Hodgkin lymphoma. Blood. 2001, 98:579-85. 10.1182\/blood.v98.3.579","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.1003057","article-title":"Absolute lymphocyte count as predictor of overall survival for patients with multiple myeloma treated with single autologous stem cell transplant","volume":"56","author":"Jimenez-Zepeda VH","year":"2015","unstructured":"Jimenez-Zepeda VH, Reece DE, Trudel S, et al.. Absolute lymphocyte count as predictor of overall survival for patients with multiple myeloma treated with single autologous stem cell transplant. Leuk Lymphoma. 2015, 56:2668-73. 10.3109\/10428194.2014.1003057","journal-title":"Leuk Lymphoma"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.03.007","article-title":"Lymphocyte subset recovery and outcome after autologous hematopoietic stem cell transplantation for plasma cell myeloma","volume":"20","author":"Rueff J","year":"2014","unstructured":"Rueff J, Medinger M, Heim D, Passweg J, Stern M. Lymphocyte subset recovery and outcome after autologous hematopoietic stem cell transplantation for plasma cell myeloma. Biol Blood Marrow Transplant. 2014, 20:896-9. 10.1016\/j.bbmt.2014.03.007","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.748207","article-title":"NK cell reconstitution after autologous hematopoietic stem cell transplantation: association between NK cell maturation stage and outcome in multiple myeloma","volume":"12","author":"Orrantia A","year":"2021","unstructured":"Orrantia A, Terr\u00e9n I, Astarloa-Pando G, et al.. NK cell reconstitution after autologous hematopoietic stem cell transplantation: association between NK cell maturation stage and outcome in multiple myeloma. Front Immunol. 2021, 12:748207. 10.3389\/fimmu.2021.748207","journal-title":"Front Immunol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.01.003","article-title":"Monocyte subpopulation recovery as predictors of hematopoietic cell transplantation outcomes","volume":"25","author":"Turcotte LM","year":"2019","unstructured":"Turcotte LM, Cao Q, Cooley SA, et al.. Monocyte subpopulation recovery as predictors of hematopoietic cell transplantation outcomes. Biol Blood Marrow Transplant. 2019, 25:883-90. 10.1016\/j.bbmt.2019.01.003","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0055","article-title":"T-cell exhaustion in multiple myeloma relapse after autotransplant: optimal timing of immunotherapy","volume":"4","author":"Chung DJ","year":"2016","unstructured":"Chung DJ, Pronschinske KB, Shyer JA, et al.. T-cell exhaustion in multiple myeloma relapse after autotransplant: optimal timing of immunotherapy. Cancer Immunol Res. 2016, 4:61-71. 10.1158\/2326-6066.CIR-15-0055","journal-title":"Cancer Immunol Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-01-825240","article-title":"Myeloma escape after stem cell transplantation is a consequence of T-cell exhaustion and is prevented by TIGIT blockade","volume":"132","author":"Minnie SA","year":"2018","unstructured":"Minnie SA, Kuns RD, Gartlan KH, et al.. Myeloma escape after stem cell transplantation is a consequence of T-cell exhaustion and is prevented by TIGIT blockade. Blood. 2018, 132:1675-88. 10.1182\/blood-2018-01-825240","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108093","article-title":"Highly proliferative and functional PD-1(+) and TIM-3(+) T cells are transiently increased in multiple myeloma following autologous hematopoietic stem cell transplantation","volume":"100","author":"Batorov EV","year":"2021","unstructured":"Batorov EV, Aristova TA, Pronkina NV, et al.. Highly proliferative and functional PD-1(+) and TIM-3(+) T cells are transiently increased in multiple myeloma following autologous hematopoietic stem cell transplantation. Int Immunopharmacol. 2021, 100:108093. 10.1016\/j.intimp.2021.108093","journal-title":"Int Immunopharmacol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01034","article-title":"Dynamics of expression of programmed cell death protein-1 (PD-1) on T cells after allogeneic hematopoietic stem cell transplantation","volume":"10","author":"Simonetta F","year":"2019","unstructured":"Simonetta F, Pradier A, Bosshard C, et al.. Dynamics of expression of programmed cell death protein-1 (PD-1) on T cells after allogeneic hematopoietic stem cell transplantation. Front Immunol. 2019, 10:1034. 10.3389\/fimmu.2019.01034","journal-title":"Front Immunol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2015.1.215","article-title":"Immune reconstitution following stem cell transplantation","volume":"2015","author":"van den Brink MR","year":"2015","unstructured":"van den Brink MR, Velardi E, Perales MA. Immune reconstitution following stem cell transplantation. Hematology Am Soc Hematol Educ Program. 2015, 2015:215-9. 10.1182\/asheducation-2015.1.215","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e26362","article-title":"Decreased circulating myeloid-derived suppressor cell count at the engraftment is one of the risk factors for multiple myeloma relapse after autologous hematopoietic stem cell transplantation","volume":"10","author":"Tyrinova T","year":"2024","unstructured":"Tyrinova T, Batorov E, Aristova T, Ushakova G, Sizikova S, Denisova V, Chernykh E. Decreased circulating myeloid-derived suppressor cell count at the engraftment is one of the risk factors for multiple myeloma relapse after autologous hematopoietic stem cell transplantation. Heliyon. 2024, 10:e26362. 10.1016\/j.heliyon.2024.e26362","journal-title":"Heliyon"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80005","article-title":"Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected","volume":"125","author":"Marvel D","year":"2015","unstructured":"Marvel D, Gabrilovich DI. Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. J Clin Invest. 2015, 125:3356-64. 10.1172\/JCI80005","journal-title":"J Clin Invest"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.15211","article-title":"Day 100 natural killer cell\/CD14+HLA-DR(DIM) ratio and survival in lymphoma post-autologous peripheral blood hematopoietic stem cell transplantation","volume":"38","author":"Porrata LF","year":"2024","unstructured":"Porrata LF, Ansell SM, Micallef IN, et al.. Day 100 natural killer cell\/CD14+HLA-DR(DIM) ratio and survival in lymphoma post-autologous peripheral blood hematopoietic stem cell transplantation. Clin Transplant. 2024, 38:e15211. 10.1111\/ctr.15211","journal-title":"Clin Transplant"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U","article-title":"A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival","volume":"36","author":"Durie BG","year":"1975","unstructured":"Durie BG, Salmon SE. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer. 1975, 36:842-54.","journal-title":"Cancer"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04355.x","article-title":"Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group","volume":"121","author":"International Myeloma Working Group","year":"2003","unstructured":"International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 2003, 121:749-57. 10.1046\/j.1365-2141.2003.04355.x","journal-title":"Br J Haematol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0491-y","article-title":"Different role of circulating myeloid-derived suppressor cells in patients with multiple myeloma undergoing autologous stem cell transplantation","volume":"7","author":"Lee SE","year":"2019","unstructured":"Lee SE, Lim JY, Kim TW, et al.. Different role of circulating myeloid-derived suppressor cells in patients with multiple myeloma undergoing autologous stem cell transplantation. J Immunother Cancer. 2019, 7:35. 10.1186\/s40425-018-0491-y","journal-title":"J Immunother Cancer"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.15789\/1563-0625-ATO-2760","article-title":"Attempt to assess direct interactions between tumor burden, myeloid-derived suppressor cells and PD-1- and TIM-3-expressing T cells in multiple myeloma patients","volume":"25","author":"Batorov EV","year":"2023","unstructured":"Batorov EV, Aristova TA, Pronkina NV, Denisova VV, Sizikova SA. Ushakova GYu. Attempt to assess direct interactions between tumor burden, myeloid-derived suppressor cells and PD-1- and TIM-3-expressing T cells in multiple myeloma patients. Medical Immunology (Russia). 2023, 25:1151-8. 10.15789\/1563-0625-ATO-2760","journal-title":"Medical Immunology (Russia)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-02517-1","article-title":"Integrating histopathology, immune biomarkers, and molecular subgroups in solid cancer: the next step in precision oncology","volume":"474","author":"Giraldo NA","year":"2019","unstructured":"Giraldo NA, Peske JD, Saut\u00e8s-Fridman C, Fridman WH. Integrating histopathology, immune biomarkers, and molecular subgroups in solid cancer: the next step in precision oncology. Virchows Arch. 2019, 474:463-74. 10.1007\/s00428-018-02517-1","journal-title":"Virchows Arch"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11897","article-title":"CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation","volume":"93","author":"Atanackovic D","year":"2008","unstructured":"Atanackovic D, Cao Y, Luetkens T, et al.. CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation. Haematologica. 2008, 93:423-30. 10.3324\/haematol.11897","journal-title":"Haematologica"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0958-9","article-title":"Reconstitution of regulatory T cells after autologous transplantation in multiple myeloma","volume":"94","author":"Ganeshan P","year":"2011","unstructured":"Ganeshan P, Gupta R, Hakim M, Kumar L, Bhaskar A, Sharma A. Reconstitution of regulatory T cells after autologous transplantation in multiple myeloma. Int J Hematol. 2011, 94:578-9. 10.1007\/s12185-011-0958-9","journal-title":"Int J Hematol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.10.6738","article-title":"The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands","volume":"181","author":"Kinter AL","year":"2008","unstructured":"Kinter AL, Godbout EJ, McNally JP, Sereti I, Roby GA, O'Shea MA, Fauci AS. The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J Immunol. 2008, 181:6738-46. 10.4049\/jimmunol.181.10.6738","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102609","article-title":"Antigen-independent induction of TIM-3 expression on human T cells by the common \u03b3-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway","volume":"188","author":"Mujib S","year":"2012","unstructured":"Mujib S, Jones RB, Lo C, et al.. Antigen-independent induction of TIM-3 expression on human T cells by the common \u03b3-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway. J Immunol. 2012, 188:3745-56. 10.4049\/jimmunol.1102609","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00783","article-title":"Targeting myeloid-derived suppressor cell, a promising strategy to overcome resistance to immune checkpoint inhibitors","volume":"11","author":"Hou A","year":"2020","unstructured":"Hou A, Hou K, Huang Q, Lei Y, Chen W. Targeting myeloid-derived suppressor cell, a promising strategy to overcome resistance to immune checkpoint inhibitors. Front Immunol. 2020, 11:783. 10.3389\/fimmu.2020.00783","journal-title":"Front Immunol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-023-00793-1","article-title":"Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer","volume":"14","author":"He ZN","year":"2023","unstructured":"He ZN, Zhang CY, Zhao YW, et al.. Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer. Discov Oncol. 2023, 14:185. 10.1007\/s12672-023-00793-1","journal-title":"Discov Oncol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00989","article-title":"Myeloid-derived suppressor cells in the context of allogeneic hematopoietic stem cell transplantation","volume":"11","author":"D'Aveni M","year":"2020","unstructured":"D'Aveni M, Notarantonio AB, Bertrand A, Boulang\u00e9 L, Pochon C, Rubio MT. Myeloid-derived suppressor cells in the context of allogeneic hematopoietic stem cell transplantation. Front Immunol. 2020, 11:989. 10.3389\/fimmu.2020.00989","journal-title":"Front Immunol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6662","article-title":"Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression","volume":"7","author":"Pinton L","year":"2016","unstructured":"Pinton L, Solito S, Damuzzo V, et al.. Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression. Oncotarget. 2016, 7:1168-84. 10.18632\/oncotarget.6662","journal-title":"Oncotarget"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00377-3","article-title":"Reprogramming immunosuppressive myeloid cells by activated T cells promotes the response to anti-PD-1 therapy in colorectal cancer","volume":"6","author":"Chen J","year":"2021","unstructured":"Chen J, Sun HW, Yang YY, et al.. Reprogramming immunosuppressive myeloid cells by activated T cells promotes the response to anti-PD-1 therapy in colorectal cancer. Signal Transduct Target Ther. 2021, 6:4. 10.1038\/s41392-020-00377-3","journal-title":"Signal Transduct Target Ther"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.06.001","article-title":"Alteration of the intestinal microbiota by broad-spectrum antibiotic use correlates with the occurrence of intestinal graft-versus-host disease","volume":"25","author":"Lee SE","year":"2019","unstructured":"Lee SE, Lim JY, Ryu DB, et al.. Alteration of the intestinal microbiota by broad-spectrum antibiotic use correlates with the occurrence of intestinal graft-versus-host disease. Biol Blood Marrow Transplant. 2019, 25:1933-43. 10.1016\/j.bbmt.2019.06.001","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006923","article-title":"Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study","volume":"137","author":"Khan N","year":"2021","unstructured":"Khan N, Lindner S, Gomes AL, et al.. Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study. Blood. 2021, 137:1527-37. 10.1182\/blood.2020006923","journal-title":"Blood"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-170792","article-title":"G-CSF use in mobilization and post-hematopoietic stem cell transplant induces regulatory myeloid populations","volume":"140","author":"McCartney E","year":"2022","unstructured":"McCartney E, Snelling S, Denney M, et al.. G-CSF use in mobilization and post-hematopoietic stem cell transplant induces regulatory myeloid populations. Blood. 2022, 140:12659-60. 10.1182\/blood-2022-170792","journal-title":"Blood"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.09.012","article-title":"A prospective, randomized trial examining the use of G-CSF versus no G-CSF in patients post-autologous transplantation","volume":"28","author":"Grosso D","year":"2022","unstructured":"Grosso D, Leiby B, Wilde L, et al.. A prospective, randomized trial examining the use of G-CSF versus no G-CSF in patients post-autologous transplantation. Transplant Cell Ther. 2022, 28:831.e1-7. 10.1016\/j.jtct.2022.09.012","journal-title":"Transplant Cell Ther"},{"key":"ref32","article-title":"Impact of G-CSF administration post-allogeneic hematopoietic stem-cell transplantation on outcomes: a systematic review and meta-analysis","volume":"11","author":"Gupta AK","year":"2021","unstructured":"Gupta AK, Meena JP, Haldar P, Tanwar P, Seth R. Impact of G-CSF administration post-allogeneic hematopoietic stem-cell transplantation on outcomes: a systematic review and meta-analysis. Am J Blood Res. 2021, 11:544-63.","journal-title":"Am J Blood Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/358876-associations-between-myeloid-derived-suppressor-cells-tim-3-t-cells-and-clinical-factors-during-the-post-transplant-neutropenia-period-in-patients-with-multiple-myeloma","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T08:10:10Z","timestamp":1750752610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/358876-associations-between-myeloid-derived-suppressor-cells-tim-3-t-cells-and-clinical-factors-during-the-post-transplant-neutropenia-period-in-patients-with-multiple-myeloma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":32,"URL":"https:\/\/doi.org\/10.7759\/cureus.86641","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}