{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T04:13:00Z","timestamp":1750824780562,"version":"3.41.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,24]]},"DOI":"10.7759\/cureus.86689","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:23:40Z","timestamp":1750811020000},"source":"Crossref","is-referenced-by-count":0,"title":["Experience of the Pediatric Department at the Mohammed VI University Hospital Center in Oujda on Trisomy 21 and Congenital Heart Defects: What Is the Reality in the Oriental Region of Morocco?"],"prefix":"10.7759","author":[{"given":"Abdeladim","family":"Babakhouya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaymae","family":"Yechouti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaimae","family":"Salhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziza","family":"Elouali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Rkain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"[National Diagnostic and Care Protocol (PNDS) for Down Syndrome] (Book in French)","author":"Sanlaville D","year":"2020","unstructured":"Sanlaville D, Touraine R, De Fr\u00e9minville B. [National Diagnostic and Care Protocol (PNDS) for Down Syndrome] (Book in French). Saint-Etienne University Hospital, Saint-Priest-en-Jarez, France; 2020."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1525","article-title":"Down syndrome and genetics - a case of linked histories","volume":"6","author":"Patterson D","year":"2005","unstructured":"Patterson D, Costa AC. Down syndrome and genetics - a case of linked histories. Nat Rev Genet. 2005, 6:137-47. 10.1038\/nrg1525","journal-title":"Nat Rev Genet"},{"key":"ref3","article-title":"[Item 31: Problems Posed by Genetic Diseases] (Book in French)","author":"French National College of Gynecologists and Obstetricians","year":"2011","unstructured":"French National College of Gynecologists and Obstetricians. [Item 31: Problems Posed by Genetic Diseases] (Book in French). French National College of Gynecologists and Obstetricians, Paris, France; 2011."},{"key":"ref4","article-title":"Observations on an ethnic classification of idiots","volume":"3","author":"Down JL","year":"1866","unstructured":"Down JL. Observations on an ethnic classification of idiots. Lond Hosp Rep. 1866, 3:259\u201162.","journal-title":"Lond Hosp Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320400105","article-title":"Sir A. E. Garrod, congenital heart disease in Down syndrome, and the doctrine of fetal endocarditis","volume":"40","author":"Lubinsky MS","year":"1991","unstructured":"Lubinsky MS. Sir A. E. Garrod, congenital heart disease in Down syndrome, and the doctrine of fetal endocarditis. Am J Med Genet. 1991, 40:27-30. 10.1002\/ajmg.1320400105","journal-title":"Am J Med Genet"},{"key":"ref6","article-title":"[Down syndrome. epidemiology, diagnosis, and progression] (Article in French)","volume":"51","author":"de Parscau L","year":"2001","unstructured":"de Parscau L. [Down syndrome. epidemiology, diagnosis, and progression] (Article in French). Rev Prat. 2001, 51:545\u20119.","journal-title":"Rev Prat"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199407000-00010","article-title":"Congenital heart disease in infants with Down's syndrome","volume":"87","author":"Wells GL","year":"1994","unstructured":"Wells GL, Barker SE, Finley SC, Colvin EV, Finley WH. Congenital heart disease in infants with Down's syndrome. South Med J. 1994, 87:724-7. 10.1097\/00007611-199407000-00010","journal-title":"South Med J"},{"key":"ref8","article-title":"[Study of Congenital Heart Diseases in Down Syndrome: Experience of CHNEAR] (Book in French)","author":"Ndiaye Diop MM","year":"2003","unstructured":"Ndiaye Diop MM. [Study of Congenital Heart Diseases in Down Syndrome: Experience of CHNEAR] (Book in French). Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal; 2003."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.gyobfe.2007.12.003","article-title":"[Prenatal diagnosis and prevalence of Down syndrome in the Parisian population, 2001-2005] (Article in French)","volume":"36","author":"de Vigan C","year":"2008","unstructured":"de Vigan C, Khoshnood B, Cadio E, Vodovar V, Goffinet F. [Prenatal diagnosis and prevalence of Down syndrome in the Parisian population, 2001-2005] (Article in French). Gynecol Obstet Fertil. 2008, 36:146-50. 10.1016\/j.gyobfe.2007.12.003","journal-title":"Gynecol Obstet Fertil"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2009.02.013","article-title":"[Diagnosis of congenital heart disease in a nonselected population in Upper Normandy: retrospective study between 2003 and 2007] (Article in French)","volume":"16","author":"Durand I","year":"2009","unstructured":"Durand I, David N, Blaysat G, Marguet C. [Diagnosis of congenital heart disease in a nonselected population in Upper Normandy: retrospective study between 2003 and 2007] (Article in French). Arch Pediatr. 2009, 16:409-16. 10.1016\/j.arcped.2009.02.013","journal-title":"Arch Pediatr"},{"key":"ref11","article-title":"[Complex congenital heart diseases: role of the pediatric cardiologist] (Article in French)","volume":"15","author":"Fermont L","year":"2002","unstructured":"Fermont L. [Complex congenital heart diseases: role of the pediatric cardiologist] (Article in French). J P\u00e9diatr Pu\u00e9ricult. 2002, 15:84-6.","journal-title":"J P\u00e9diatr Pu\u00e9ricult"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1977.02120140031003","article-title":"Down syndrome with congenital heart malformation","volume":"131","author":"Park SC","year":"1977","unstructured":"Park SC, Mathews RA, Zuberbuhler JR, Rowe RD, Neches WH, Lenox CC. Down syndrome with congenital heart malformation. Am J Dis Child. 1977, 131:29-33. 10.1001\/archpedi.1977.02120140031003","journal-title":"Am J Dis Child"},{"key":"ref13","article-title":"[Congenital Heart Defects in Children With Trisomy 21] (Book in French)","author":"Belaribi MJ","year":"2020","unstructured":"Belaribi MJ, Bendjedid A, Ghrieb L, Ghomri B. [Congenital Heart Defects in Children With Trisomy 21] (Book in French). University of Abu Bekr Belkaid, Tlemcen, Algeria; 2020."},{"key":"ref14","article-title":"[Diagnosis of congenital heart diseases] (Article in French)","volume":"27","author":"Massin M","year":"2006","unstructured":"Massin M, Malekzadeh-Milani S, Dessy H. [Diagnosis of congenital heart diseases] (Article in French). Rev Med Brux. 2006, 27:78-81.","journal-title":"Rev Med Brux"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2006.01681.x","article-title":"Current treatment options in children with pulmonary arterial hypertension and experiences with oral bosentan","volume":"36","author":"Beghetti M","year":"2006","unstructured":"Beghetti M. Current treatment options in children with pulmonary arterial hypertension and experiences with oral bosentan. Eur J Clin Invest. 2006, 36:16-24. 10.1111\/j.1365-2362.2006.01681.x","journal-title":"Eur J Clin Invest"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.100388","article-title":"Long-term oral bosentan treatment in patients with pulmonary arterial hypertension related to congenital heart disease: a 2-year study","volume":"93","author":"Apostolopoulou SC","year":"2007","unstructured":"Apostolopoulou SC, Manginas A, Cokkinos DV, Rammos S. Long-term oral bosentan treatment in patients with pulmonary arterial hypertension related to congenital heart disease: a 2-year study. Heart. 2007, 93:350-4. 10.1136\/hrt.2006.100388","journal-title":"Heart"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2004.03.007","article-title":"[Management of congenital heart diseases using interventional catheterism] (Article in French)","volume":"11","author":"Rey C","year":"2004","unstructured":"Rey C. [Management of congenital heart diseases using interventional catheterism] (Article in French). Arch Pediatr. 2004, 11:639-41. 10.1016\/j.arcped.2004.03.007","journal-title":"Arch Pediatr"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2004.03.084","article-title":"[Surgery for congenital heart diseases] (Article in French)","volume":"11","author":"Baudet E","year":"2004","unstructured":"Baudet E. [Surgery for congenital heart diseases] (Article in French). Arch Pediatr. 2004, 11:642-4. 10.1016\/j.arcped.2004.03.084","journal-title":"Arch Pediatr"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.gyobfe.2010.01.002","article-title":"[First trimester fetal cardiac scanning for fetuses at higher risk for congenital heart disease] (Article in French)","volume":"38","author":"Rosenblatt J","year":"2010","unstructured":"Rosenblatt J, Fermont L, Saada P, Benifla JL, Jouannic JM. [First trimester fetal cardiac scanning for fetuses at higher risk for congenital heart disease] (Article in French). Gynecol Obstet Fertil. 2010, 38:173-8. 10.1016\/j.gyobfe.2010.01.002","journal-title":"Gynecol Obstet Fertil"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.perped.2021.07.005","article-title":"Congenital heart disease in 2021: update on management and outcome","volume":"4","author":"Ovaert C","year":"2021","unstructured":"Ovaert C, Fouilloux V. Congenital heart disease in 2021: update on management and outcome. Perfection P\u00e9diatr. 2021, 4:236\u201147. 10.1016\/j.perped.2021.07.005","journal-title":"Perfection P\u00e9diatr"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/380938-experience-of-the-pediatric-department-at-the-mohammed-vi-university-hospital-center-in-oujda-on-trisomy-21-and-congenital-heart-defects-what-is-the-reality-in-the-oriental-region-of-morocco","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:23:41Z","timestamp":1750811021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/380938-experience-of-the-pediatric-department-at-the-mohammed-vi-university-hospital-center-in-oujda-on-trisomy-21-and-congenital-heart-defects-what-is-the-reality-in-the-oriental-region-of-morocco"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.86689","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}