{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T04:02:06Z","timestamp":1750910526250,"version":"3.41.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,24]]},"DOI":"10.7759\/cureus.86697","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T04:15:18Z","timestamp":1750824918000},"source":"Crossref","is-referenced-by-count":0,"title":["Voluntary Exercise-Induced Skeletal Muscle Responses in Young and Aged Mice on a High-Fat Diet"],"prefix":"10.7759","author":[{"given":"Yuji","family":"Kanazawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Miyahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Miyachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiaki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Ikeda-Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158451","article-title":"Metabolic changes in aging humans: current evidence and therapeutic strategies","volume":"132","author":"Palmer AK","year":"2022","unstructured":"Palmer AK, Jensen MD. Metabolic changes in aging humans: current evidence and therapeutic strategies. J Clin Invest. 2022, 132:14-6. 10.1172\/JCI158451","journal-title":"J Clin Invest"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa161","article-title":"The relationship between intermuscular fat and physical performance is moderated by muscle area in older adults","volume":"76","author":"Farsijani S","year":"2021","unstructured":"Farsijani S, Santanasto AJ, Miljkovic I, Boudreau RM, Goodpaster BH, Kritchevsky SB, Newman AB. The relationship between intermuscular fat and physical performance is moderated by muscle area in older adults. J Gerontol A Biol Sci Med Sci. 2021, 76:115-22. 10.1093\/gerona\/glaa161","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1113\/JP287056","article-title":"Adverse effects of high-fat diet consumption on contractile mechanics of isolated mouse skeletal muscle are reduced when supplemented with resveratrol","volume":"603","author":"Shelley SP","year":"2025","unstructured":"Shelley SP, James RS, Eustace SJ, Turner MC, Brett R, Eyre EL, Tallis J. Adverse effects of high-fat diet consumption on contractile mechanics of isolated mouse skeletal muscle are reduced when supplemented with resveratrol. J Physiol. 2025, 603:2675-98. 10.1113\/JP287056","journal-title":"J Physiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2011.20598","article-title":"Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?","volume":"7","author":"Seneff S","year":"2011","unstructured":"Seneff S, Wainwright G, Mascitelli L. Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?. Arch Med Sci. 2011, 7:8-20. 10.5114\/aoms.2011.20598","journal-title":"Arch Med Sci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.16.17102","article-title":"Antagonistic control of muscle cell size by AMPK and mTORC1","volume":"10","author":"Mounier R","year":"2011","unstructured":"Mounier R, Lantier L, Leclerc J, Sotiropoulos A, Foretz M, Viollet B. Antagonistic control of muscle cell size by AMPK and mTORC1. Cell Cycle. 2011, 10:2640-6. 10.4161\/cc.10.16.17102","journal-title":"Cell Cycle"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080079","article-title":"Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function","volume":"88","author":"Hilton TN","year":"2008","unstructured":"Hilton TN, Tuttle LJ, Bohnert KL, Mueller MJ, Sinacore DR. Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function. Phys Ther. 2008, 88:1336-44. 10.2522\/ptj.20080079","journal-title":"Phys Ther"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12263","article-title":"Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2\u03b1 activation","volume":"13","author":"Tardif N","year":"2014","unstructured":"Tardif N, Salles J, Guillet C, et al.. Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2\u03b1 activation. Aging Cell. 2014, 13:1001-11. 10.1111\/acel.12263","journal-title":"Aging Cell"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-15-0533","article-title":"Insulin resistance and sarcopenia: mechanistic links between common co-morbidities","volume":"229","author":"Cleasby ME","year":"2016","unstructured":"Cleasby ME, Jamieson PM, Atherton PJ. Insulin resistance and sarcopenia: mechanistic links between common co-morbidities. J Endocrinol. 2016, 229:R67-81. 10.1530\/JOE-15-0533","journal-title":"J Endocrinol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81037-6","article-title":"Methionine restriction plus overload improves skeletal muscle and metabolic health in old mice on a high fat diet","volume":"11","author":"Swaminathan A","year":"2021","unstructured":"Swaminathan A, Fokin A, Venck\u016bnas T, Degens H. Methionine restriction plus overload improves skeletal muscle and metabolic health in old mice on a high fat diet. Sci Rep. 2021, 11:1260. 10.1038\/s41598-021-81037-6","journal-title":"Sci Rep"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/metabo14110589","article-title":"Exercise as a therapeutic strategy for obesity: central and peripheral mechanisms","volume":"14","author":"Zhang Y","year":"2024","unstructured":"Zhang Y, Wang R, Liu T, Wang R. Exercise as a therapeutic strategy for obesity: central and peripheral mechanisms. Metabolites. 2024, 14:26-8. 10.3390\/metabo14110589","journal-title":"Metabolites"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/tsm2.70","article-title":"Moderate-intensity aerobic exercise improves skeletal muscle quality in older adults","volume":"2","author":"Brightwell CR","year":"2019","unstructured":"Brightwell CR, Markofski MM, Moro T, Fry CS, Porter C, Volpi E, Rasmussen BB. Moderate-intensity aerobic exercise improves skeletal muscle quality in older adults. Transl Sports Med. 2019, 2:109-19. 10.1002\/tsm2.70","journal-title":"Transl Sports Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000183179.86594.4f","article-title":"Training effects in mice after long-term voluntary exercise","volume":"38","author":"Davidson SR","year":"2006","unstructured":"Davidson SR, Burnett M, Hoffman-Goetz L. Training effects in mice after long-term voluntary exercise. Med Sci Sports Exerc. 2006, 38:250-5. 10.1249\/01.mss.0000183179.86594.4f","journal-title":"Med Sci Sports Exerc"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.5.1900","article-title":"Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse","volume":"90","author":"Allen DL","year":"2001","unstructured":"Allen DL, Harrison BC, Maass A, Bell ML, Byrnes WC, Leinwand LA. Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse. J Appl Physiol (1985). 2001, 90:1900-8. 10.1152\/jappl.2001.90.5.1900","journal-title":"J Appl Physiol (1985)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.5603\/FM.a2019.0131","article-title":"Beneficial effects of voluntary over forced exercise on skeletal muscle structure and myokines' expression","volume":"79","author":"Eldomiaty MA","year":"2020","unstructured":"Eldomiaty MA, Elayat A, Ali S, Algaidi S, Elnaggar M. Beneficial effects of voluntary over forced exercise on skeletal muscle structure and myokines' expression. Folia Morphol (Warsz). 2020, 79:350-8. 10.5603\/FM.a2019.0131","journal-title":"Folia Morphol (Warsz)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s42826-019-0035-8","article-title":"A comparison of the metabolic effects of treadmill and wheel running exercise in mouse model","volume":"36","author":"Kim YJ","year":"2020","unstructured":"Kim YJ, Kim HJ, Lee WJ, Seong JK. A comparison of the metabolic effects of treadmill and wheel running exercise in mouse model. Lab Anim Res. 2020, 36:3. 10.1186\/s42826-019-0035-8","journal-title":"Lab Anim Res"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.166603","article-title":"The effects of 8\u2005weeks voluntary wheel running on the contractile performance of isolated locomotory (soleus) and respiratory (diaphragm) skeletal muscle during early ageing","volume":"220","author":"Tallis J","year":"2017","unstructured":"Tallis J, Higgins MF, Seebacher F, Cox VM, Duncan MJ, James RS. The effects of 8\u2005weeks voluntary wheel running on the contractile performance of isolated locomotory (soleus) and respiratory (diaphragm) skeletal muscle during early ageing. J Exp Biol. 2017, 220:3733-41. 10.1242\/jeb.166603","journal-title":"J Exp Biol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12319","article-title":"Molecular and metabolomic effects of voluntary running wheel activity on skeletal muscle in late middle-aged rats","volume":"3","author":"Garvey SM","year":"2015","unstructured":"Garvey SM, Russ DW, Skelding MB, Dugle JE, Edens NK. Molecular and metabolomic effects of voluntary running wheel activity on skeletal muscle in late middle-aged rats. Physiol Rep. 2015, 3:16-8. 10.14814\/phy2.12319","journal-title":"Physiol Rep"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Kanda Y","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant. 2013, 48:452-8. 10.1038\/bmt.2012.244","journal-title":"Bone Marrow Transplant"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2337\/ds17-0013","article-title":"Role of physical activity for weight loss and weight maintenance","volume":"30","author":"Cox CE","year":"2017","unstructured":"Cox CE. Role of physical activity for weight loss and weight maintenance. Diabetes Spectr. 2017, 30:157-60. 10.2337\/ds17-0013","journal-title":"Diabetes Spectr"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.12.009","article-title":"Increases in physical activity result in diminishing increments in daily energy expenditure in mice","volume":"27","author":"O'Neal TJ","year":"2017","unstructured":"O'Neal TJ, Friend DM, Guo J, Hall KD, Kravitz AV. Increases in physical activity result in diminishing increments in daily energy expenditure in mice. Curr Biol. 2017, 27:423-30. 10.1016\/j.cub.2016.12.009","journal-title":"Curr Biol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1340","article-title":"Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity","volume":"152","author":"Krawczewski Carhuatanta KA","year":"2011","unstructured":"Krawczewski Carhuatanta KA, Demuro G, Tsch\u00f6p MH, Pfluger PT, Benoit SC, Obici S. Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity. Endocrinology. 2011, 152:2655-64. 10.1210\/en.2010-1340","journal-title":"Endocrinology"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2022","article-title":"Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions","volume":"103","author":"Roberts MD","year":"2023","unstructured":"Roberts MD, McCarthy JJ, Hornberger TA, et al.. Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions. Physiol Rev. 2023, 103:2679-757. 10.1152\/physrev.00039.2022","journal-title":"Physiol Rev"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113237","article-title":"Succinate dehydrogenase and ribonucleic acid networks in cancer and other diseases","volume":"12","author":"Moreno C","year":"2020","unstructured":"Moreno C, Santos RM, Burns R, Zhang WC. Succinate dehydrogenase and ribonucleic acid networks in cancer and other diseases. Cancers (Basel). 2020, 12:32-4. 10.3390\/cancers12113237","journal-title":"Cancers (Basel)"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado8549","article-title":"Succinate dehydrogenase-complex II regulates skeletal muscle cellular respiration and contractility but not muscle mass in genetically induced pulmonary emphysema","volume":"10","author":"Balnis J","year":"2024","unstructured":"Balnis J, Tufts A, Jackson EL, et al.. Succinate dehydrogenase-complex II regulates skeletal muscle cellular respiration and contractility but not muscle mass in genetically induced pulmonary emphysema. Sci Adv. 2024, 10:eado8549. 10.1126\/sciadv.ado8549","journal-title":"Sci Adv"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3780156","article-title":"The effect of aerobic exercise on the oxidative capacity of skeletal muscle mitochondria in mice with impaired glucose tolerance","volume":"2022","author":"Wang D","year":"2022","unstructured":"Wang D, Jiang DM, Yu RR, et al.. The effect of aerobic exercise on the oxidative capacity of skeletal muscle mitochondria in mice with impaired glucose tolerance. J Diabetes Res. 2022, 2022:3780156. 10.1155\/2022\/3780156","journal-title":"J Diabetes Res"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.4.1284","article-title":"SDH activity and cross-sectional area of muscle fibers in cat diaphragm","volume":"60","author":"Sieck GC","year":"1986","unstructured":"Sieck GC, Sacks RD, Blanco CE, Edgerton VR. SDH activity and cross-sectional area of muscle fibers in cat diaphragm. J Appl Physiol (1985). 1986, 60:1284-92. 10.1152\/jappl.1986.60.4.1284","journal-title":"J Appl Physiol (1985)"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-016-0118-2","article-title":"A novel method for the quantification of fatty infiltration in skeletal muscle","volume":"7","author":"Biltz NK","year":"2017","unstructured":"Biltz NK, Meyer GA. A novel method for the quantification of fatty infiltration in skeletal muscle. Skelet Muscle. 2017, 7:1. 10.1186\/s13395-016-0118-2","journal-title":"Skelet Muscle"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/srep37278","article-title":"A high-fat high-sucrose diet rapidly alters muscle integrity, inflammation and gut microbiota in male rats","volume":"6","author":"Collins KH","year":"2016","unstructured":"Collins KH, Paul HA, Hart DA, et al.. A high-fat high-sucrose diet rapidly alters muscle integrity, inflammation and gut microbiota in male rats. Sci Rep. 2016, 6:37278. 10.1038\/srep37278","journal-title":"Sci Rep"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.12.8075","article-title":"Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes","volume":"86","author":"Goodpaster BH","year":"2001","unstructured":"Goodpaster BH, He J, Watkins S, Kelley DE. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab. 2001, 86:5755-61. 10.1210\/jcem.86.12.8075","journal-title":"J Clin Endocrinol Metab"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.05.015","article-title":"High-fat diet induces sarcopenic obesity in natural aging rats through the gut-trimethylamine N-oxide-muscle axis","volume":"70","author":"Mo X","year":"2025","unstructured":"Mo X, Cheng R, Shen L, et al.. High-fat diet induces sarcopenic obesity in natural aging rats through the gut-trimethylamine N-oxide-muscle axis. J Adv Res. 2025, 70:405-22. 10.1016\/j.jare.2024.05.015","journal-title":"J Adv Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/380013-voluntary-exercise-induced-skeletal-muscle-responses-in-young-and-aged-mice-on-a-high-fat-diet","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T04:15:19Z","timestamp":1750824919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/380013-voluntary-exercise-induced-skeletal-muscle-responses-in-young-and-aged-mice-on-a-high-fat-diet"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.86697","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}