{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:40:28Z","timestamp":1780605628038,"version":"3.54.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,30]]},"DOI":"10.7759\/cureus.87032","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T14:29:32Z","timestamp":1751293772000},"source":"Crossref","is-referenced-by-count":1,"title":["A Case Report of Clozapine-Induced Cardiomyopathy"],"prefix":"10.7759","author":[{"given":"Gourav","family":"Gourisaria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Sumanasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goksu","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thejas Swaroop","family":"Konduru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Karunakaran Thozhuthumparambil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/schizbullopen\/sgac042","article-title":"Patients\u2019 experiences of clozapine for treatment-resistant schizophrenia: a systematic review","volume":"3","author":"Parkes S","year":"2022","unstructured":"Parkes S, Mantell B, Oloyede E, Blackman G. Patients\u2019 experiences of clozapine for treatment-resistant schizophrenia: a systematic review. Schizophr Bull Open. 2022, 3:sgac042. 10.1093\/schizbullopen\/sgac042","journal-title":"Schizophr Bull Open"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.029868","article-title":"Clozapine in drug induced psychosis in Parkinson's disease: a randomised, placebo controlled study with open follow up","volume":"75","author":"Pollak P","year":"2004","unstructured":"Pollak P, Tison F, Rascol O, et al.. Clozapine in drug induced psychosis in Parkinson's disease: a randomised, placebo controlled study with open follow up. J Neurol Neurosurg Psychiatry. 2004, 75:689-95. 10.1136\/jnnp.2003.029868","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/2042098618756261","article-title":"Safety of antipsychotics for the treatment of schizophrenia: a focus on the adverse effects of clozapine","volume":"9","author":"De Berardis D","year":"2018","unstructured":"De Berardis D, Rapini G, Olivieri L, et al.. Safety of antipsychotics for the treatment of schizophrenia: a focus on the adverse effects of clozapine. Ther Adv Drug Saf. 2018, 9:237-56. 10.1177\/2042098618756261","journal-title":"Ther Adv Drug Saf"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby052","article-title":"Clozapine and long-term mortality risk in patients with schizophrenia: a systematic review and meta-analysis of studies lasting 1.1-12.5 years","volume":"45","author":"Vermeulen JM","year":"2019","unstructured":"Vermeulen JM, van Rooijen G, van de Kerkhof MP, Sutterland AL, Correll CU, de Haan L. Clozapine and long-term mortality risk in patients with schizophrenia: a systematic review and meta-analysis of studies lasting 1.1-12.5 years. Schizophr Bull. 2019, 45:315-29. 10.1093\/schbul\/sby052","journal-title":"Schizophr Bull"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/0706743718816058","article-title":"Incidence and management of clozapine-induced myocarditis in a large tertiary hospital","volume":"64","author":"Higgins JM","year":"2019","unstructured":"Higgins JM, San C, Lagnado G, Chua D, Mihic T. Incidence and management of clozapine-induced myocarditis in a large tertiary hospital. Can J Psychiatry. 2019, 64:561-7. 10.1177\/0706743718816058","journal-title":"Can J Psychiatry"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1039856215604480","article-title":"Incidence and risk factors for clozapine-induced myocarditis and cardiomyopathy at a regional mental health service in Australia","volume":"24","author":"Youssef DL","year":"2016","unstructured":"Youssef DL, Narayanan P, Gill N. Incidence and risk factors for clozapine-induced myocarditis and cardiomyopathy at a regional mental health service in Australia. Australas Psychiatry. 2016, 24:176-80. 10.1177\/1039856215604480","journal-title":"Australas Psychiatry"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/j.1440-1614.2004.01481.x","article-title":"Clozapine-related myocarditis and cardiomyopathy in an Australian metropolitan psychiatric service","volume":"38","author":"Reinders J","year":"2004","unstructured":"Reinders J, Parsonage W, Lange D, Potter JM, Plever S. Clozapine-related myocarditis and cardiomyopathy in an Australian metropolitan psychiatric service. Aust N Z J Psychiatry. 2004, 38:915-22. 10.1080\/j.1440-1614.2004.01481.x","journal-title":"Aust N Z J Psychiatry"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.03.006","article-title":"Clozapine-induced cardiomyopathy and myocarditis monitoring: a systematic review","volume":"199","author":"Knoph KN","year":"2018","unstructured":"Knoph KN, Morgan RJ 3rd, Palmer BA, et al.. Clozapine-induced cardiomyopathy and myocarditis monitoring: a systematic review. Schizophr Res. 2018, 199:17-30. 10.1016\/j.schres.2018.03.006","journal-title":"Schizophr Res"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.22m14587","article-title":"The protective effect of clozapine on suicide: a population mortality study of statewide autopsy records in Maryland","volume":"84","author":"Lee BJ","year":"2023","unstructured":"Lee BJ, Cotes RO, Mojtabai R, Margolis RL, Nucifora FC, Nestadt PS. The protective effect of clozapine on suicide: a population mortality study of statewide autopsy records in Maryland. J Clin Psychiatry. 2023, 84:22m14587. 10.4088\/JCP.22m14587","journal-title":"J Clin Psychiatry"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-017-2679-5","article-title":"Clozapine-induced, dilated cardiomyopathy: a case report","volume":"10","author":"Longhi S","year":"2017","unstructured":"Longhi S, Heres S. Clozapine-induced, dilated cardiomyopathy: a case report. BMC Res Notes. 2017, 10:338. 10.1186\/s13104-017-2679-5","journal-title":"BMC Res Notes"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.170135","article-title":"Clozapine, elevated heart rate and QTc prolongation","volume":"43","author":"Kim DD","year":"2018","unstructured":"Kim DD, White RF, Barr AM, Honer WG, Procyshyn RM. Clozapine, elevated heart rate and QTc prolongation. J Psychiatry Neurosci. 2018, 43:71-2. 10.1503\/jpn.170135","journal-title":"J Psychiatry Neurosci"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152628","article-title":"Bioactivation of clozapine by mitochondria of the murine heart: possible cause of cardiotoxicity","volume":"447","author":"Arzuk E","year":"2021","unstructured":"Arzuk E, Karaku\u015f F, Orhan H. Bioactivation of clozapine by mitochondria of the murine heart: possible cause of cardiotoxicity. Toxicology. 2021, 447:152628. 10.1016\/j.tox.2020.152628","journal-title":"Toxicology"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01773.x","article-title":"Low blood selenium concentrations in schizophrenic patients on clozapine","volume":"55","author":"Vaddadi KS","year":"2003","unstructured":"Vaddadi KS, Soosai E, Vaddadi G. Low blood selenium concentrations in schizophrenic patients on clozapine. Br J Clin Pharmacol. 2003, 55:307-9. 10.1046\/j.1365-2125.2003.01773.x","journal-title":"Br J Clin Pharmacol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.2270","article-title":"Routine electrocardiogram screening and cardiovascular disease events in adults","volume":"184","author":"Yagi R","year":"2024","unstructured":"Yagi R, Mori Y, Goto S, Iwami T, Inoue K. Routine electrocardiogram screening and cardiovascular disease events in adults. JAMA Intern Med. 2024, 184:1035-44. 10.1001\/jamainternmed.2024.2270","journal-title":"JAMA Intern Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0b013e31814e5e68","article-title":"Early recognition of clozapine-induced myocarditis","volume":"27","author":"Annamraju S","year":"2007","unstructured":"Annamraju S, Sheitman B, Saik S, Stephenson A. Early recognition of clozapine-induced myocarditis. J Clin Psychopharmacol. 2007, 27:479-83. 10.1097\/jcp.0b013e31814e5e68","journal-title":"J Clin Psychopharmacol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/835952","article-title":"Left ventricular thrombus as a complication of clozapine-induced cardiomyopathy: a case report and brief literature review","volume":"2015","author":"Malik SA","year":"2015","unstructured":"Malik SA, Malik S, Dowsley TF, Singh B. Left ventricular thrombus as a complication of clozapine-induced cardiomyopathy: a case report and brief literature review. Case Rep Cardiol. 2015, 2015:835952. 10.1155\/2015\/835952","journal-title":"Case Rep Cardiol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/369118-a-case-report-of-clozapine-induced-cardiomyopathy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T14:29:32Z","timestamp":1751293772000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/369118-a-case-report-of-clozapine-induced-cardiomyopathy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.87032","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}