{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T04:09:56Z","timestamp":1751342996961,"version":"3.41.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,30]]},"DOI":"10.7759\/cureus.87035","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T15:41:01Z","timestamp":1751298061000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical Profile and Outcomes of Patients With Necrotizing Soft Tissue Infections: A Prospective Observational Study"],"prefix":"10.7759","author":[{"given":"Piyush","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Karthik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayank","family":"Badkur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam","family":"Elhence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarika P","family":"Kobade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawan","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Puranik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaishali","family":"Paras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanket","family":"Kevadiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.05.006","article-title":"Moving beyond survival as a measure of success: understanding the patient experience of necrotizing soft-tissue infections","volume":"192","author":"Hakkarainen TW","year":"2014","unstructured":"Hakkarainen TW, Burkette Ikebata N, Bulger E, Evans HL. Moving beyond survival as a measure of success: understanding the patient experience of necrotizing soft-tissue infections. J Surg Res. 2014, 192:143-9. 10.1016\/j.jss.2014.05.006","journal-title":"J Surg Res"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600673","article-title":"Necrotizing Soft-Tissue Infections","volume":"377","author":"Stevens DL","year":"2017","unstructured":"Stevens DL, Bryant AE. Necrotizing Soft-Tissue Infections. N Engl J Med. 2017, 377:2253-65. 10.1056\/NEJMra1600673","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.10.019","article-title":"Factors associated with mortality among patients with necrotizing soft tissue infections: An analysis of 4597 cases using the Diagnosis Procedure Combination Database","volume":"102","author":"Suzuki H","year":"2021","unstructured":"Suzuki H, Muramatsu K, Kubo T, et al.. Factors associated with mortality among patients with necrotizing soft tissue infections: An analysis of 4597 cases using the Diagnosis Procedure Combination Database. Int J Infect Dis. 2021, 102:73-8. 10.1016\/j.ijid.2020.10.019","journal-title":"Int J Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-014-1162-1","article-title":"Predictors of mortality for necrotizing soft-tissue infections: a retrospective analysis of 64 cases","volume":"399","author":"Krieg A","year":"2014","unstructured":"Krieg A, Dizdar L, Verde PE, Knoefel WT. Predictors of mortality for necrotizing soft-tissue infections: a retrospective analysis of 64 cases. Langenbecks Arch Surg. 2014, 399:333-41. 10.1007\/s00423-014-1162-1","journal-title":"Langenbecks Arch Surg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-018-0219-9","article-title":"2018 WSES\/SIS-E consensus conference: recommendations for the management of skin and soft-tissue infections","volume":"13","author":"Sartelli M","year":"2018","unstructured":"Sartelli M, Guirao X, Hardcastle TC, et al.. 2018 WSES\/SIS-E consensus conference: recommendations for the management of skin and soft-tissue infections. World J Emerg Surg. 2018, 13:58. 10.1186\/s13017-018-0219-9","journal-title":"World J Emerg Surg"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211018442","article-title":"Necrotizing soft tissue infection: clinical characteristics, diagnosis, and management of 32 cases in Beijing","volume":"49","author":"Cui Z","year":"2021","unstructured":"Cui Z, Lu S, Bai Y, et al.. Necrotizing soft tissue infection: clinical characteristics, diagnosis, and management of 32 cases in Beijing. J Int Med Res. 2021, 49:3000605211018442. 10.1177\/03000605211018442","journal-title":"J Int Med Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00583-7","article-title":"Necrotising soft-tissue infections","volume":"23","author":"Hua C","year":"2023","unstructured":"Hua C, Urbina T, Bosc R, Parks T, Sriskandan S, de Prost N, Chosidow O. Necrotising soft-tissue infections. Lancet Infect Dis. 2023, 23:e81-94. 10.1016\/S1473-3099(22)00583-7","journal-title":"Lancet Infect Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05730-x","article-title":"Patient's characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study","volume":"45","author":"Madsen MB","year":"2019","unstructured":"Madsen MB, Skrede S, Perner A, et al.. Patient's characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study. Intensive Care Med. 2019, 45:1241-51. 10.1007\/s00134-019-05730-x","journal-title":"Intensive Care Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.121978","article-title":"Necrotizing fasciitis","volume":"46","author":"Sadasivan J","year":"2013","unstructured":"Sadasivan J, Maroju NK, Balasubramaniam A. Necrotizing fasciitis. Indian J Plast Surg. 2013, 46:472-8. 10.4103\/0970-0358.121978","journal-title":"Indian J Plast Surg"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-020-02268-x","article-title":"Necrotising soft tissue infection in the twenty-first century\u2014a clinical and microbiological spectrum analysis","volume":"83","author":"Menon B","year":"2021","unstructured":"Menon B, Krishna M, Galagali A, Mehrotra S. Necrotising soft tissue infection in the twenty-first century\u2014a clinical and microbiological spectrum analysis. Indian J Surg.  2021, 83:66-71. 10.1007\/s12262-020-02268-x","journal-title":"Indian J Surg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000129486.35458.7d","article-title":"The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections","volume":"32","author":"Wong CH","year":"2004","unstructured":"Wong CH, Khin LW, Heng KS, Tan KC, Low CO. The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit Care Med. 2004, 32:1535-41. 10.1097\/01.ccm.0000129486.35458.7d","journal-title":"Crit Care Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-019-05061-4","article-title":"The  SIARI score: A novel decision support tool outperforms LRINEC score in necrotizing fasciitis","volume":"43","author":"Cribb BI","year":"2019","unstructured":"Cribb BI, Wang MT, Kulasegaran S, Gamble GD, MacCormick AD. The  SIARI score: A novel decision support tool outperforms LRINEC score in necrotizing fasciitis. World J Surg. 2019, 43:2393-400. 10.1007\/s00268-019-05061-4","journal-title":"World J Surg"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus WA","year":"1985","unstructured":"Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985, 13:818-29.","journal-title":"Crit Care Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(77)90283-5","article-title":"Bacteriology of necrotizing fasciitis","volume":"134","author":"Giuliano A","year":"1977","unstructured":"Giuliano A, Lewis F Jr, Hadley K, Blaisdell FW. Bacteriology of necrotizing fasciitis. Am J Surg. 1977, 134:52-7. 10.1016\/0002-9610(77)90283-5","journal-title":"Am J Surg"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2017.05.011","article-title":"Evaluation and management of necrotizing soft tissue infections","volume":"31","author":"Bonne SL","year":"2017","unstructured":"Bonne SL, Kadri SS. Evaluation and management of necrotizing soft tissue infections. Infect Dis Clin North Am. 2017, 31:497-511. 10.1016\/j.idc.2017.05.011","journal-title":"Infect Dis Clin North Am"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-57616-5_5","article-title":"Microbiological etiology of necrotizing soft tissue infections","volume":"1294","author":"Skrede S","year":"2020","unstructured":"Skrede S, Bruun T, Rath E, Oppegaard O. Microbiological etiology of necrotizing soft tissue infections. Adv Exp Med Biol. 2020, 1294:53-71. 10.1007\/978-3-030-57616-5_5","journal-title":"Adv Exp Med Biol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-57616-5","article-title":"Necrotizing Soft Tissue Infections: Clinical and Pathogenic Aspects","author":"Norrby-Teglund A","year":"2020","unstructured":"Norrby-Teglund A, Svensson M, Skrede S (eds). Necrotizing Soft Tissue Infections: Clinical and Pathogenic Aspects. Springer, Cham; 2020. 10.1007\/978-3-030-57616-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268815002745","article-title":"Deaths from necrotizing fasciitis in the United States, 2003-2013","volume":"144","author":"Arif N","year":"2016","unstructured":"Arif N, Yousfi S, Vinnard C. Deaths from necrotizing fasciitis in the United States, 2003-2013. Epidemiol Infect. 2016, 144:1338-44. 10.1017\/S0950268815002745","journal-title":"Epidemiol Infect"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2013\/5535.3240","article-title":"Necrotising soft tissue infection-risk factors for mortality","volume":"7","author":"V K","year":"2013","unstructured":"V K, Hiremath BV, V A I. Necrotising soft tissue infection-risk factors for mortality. J Clin Diagn Res. 2013, 7:1662-5. 10.7860\/JCDR\/2013\/5535.3240","journal-title":"J Clin Diagn Res"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2016.2.29069","article-title":"Inadequate sensitivity of laboratory risk indicator to rule out necrotizing fasciitis in the emergency department","volume":"17","author":"Burner E","year":"2016","unstructured":"Burner E, Henderson SO, Burke G, Nakashioya J, Hoffman JR. Inadequate sensitivity of laboratory risk indicator to rule out necrotizing fasciitis in the emergency department. West J Emerg Med. 2016, 17:333-6. 10.5811\/westjem.2016.2.29069","journal-title":"West J Emerg Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2019.10.007","article-title":"Accurate and quick predictor of necrotizing soft tissue infection: Usefulness of the LRINEC score and NSTI assessment score","volume":"26","author":"Harasawa T","year":"2020","unstructured":"Harasawa T, Kawai-Kowase K, Tamura J, Nakamura M. Accurate and quick predictor of necrotizing soft tissue infection: Usefulness of the LRINEC score and NSTI assessment score. J Infect Chemother. 2020, 26:331-4. 10.1016\/j.jiac.2019.10.007","journal-title":"J Infect Chemother"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.33545\/surgery.2020.v4.i1f.358","article-title":"Prognostic factors influencing necrotizing soft tissue lesions in North India","volume":"4","author":"Tripathi S","year":"20201","unstructured":"Tripathi S, Tripathi AD, Singh R. Prognostic factors influencing necrotizing soft tissue lesions in North India. Int J Surg Sci. 20201, 4:316-9. 10.33545\/surgery.2020.v4.i1f.358","journal-title":"Int J Surg Sci"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.21614\/chirurgia.2745","article-title":"Clinical diagnosis, management and microbiological profiling of necrotizing soft tissue infections - a prospective study of North India region","volume":"117","author":"Bhalla T","year":"2022","unstructured":"Bhalla T, Nar AS, Singh RP, Jindal R, Bhalla A, Mishra A. Clinical diagnosis, management and microbiological profiling of necrotizing soft tissue infections - a prospective study of North India region. Chirurgia (Bucur). 2022, 117:572-8. 10.21614\/chirurgia.2745","journal-title":"Chirurgia (Bucur)"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu444","article-title":"Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America","volume":"59","author":"Stevens DL","year":"2014","unstructured":"Stevens DL, Bisno AL, Chambers HF, et al.. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014, 59:e10-52. 10.1093\/cid\/ciu444","journal-title":"Clin Infect Dis"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2700.173868","article-title":"Early surgical intervention and its impact on patients presenting with necrotizing soft tissue infections: A single academic center experience","volume":"9","author":"Hadeed GJ","year":"2016","unstructured":"Hadeed GJ, Smith J, O'Keeffe T, et al.. Early surgical intervention and its impact on patients presenting with necrotizing soft tissue infections: A single academic center experience. J Emerg Trauma Shock. 2016, 9:22-7. 10.4103\/0974-2700.173868","journal-title":"J Emerg Trauma Shock"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.4103\/JETS.JETS_17_18","article-title":"Factors affecting mortality following necrotizing soft-tissue infections: randomized prospective study","volume":"12","author":"Barupal SR","year":"2019","unstructured":"Barupal SR, Soni ML, Barupal R. Factors affecting mortality following necrotizing soft-tissue infections: randomized prospective study. J Emerg Trauma Shock. 2019, 12:108-16. 10.4103\/JETS.JETS_17_18","journal-title":"J Emerg Trauma Shock"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4813-1","article-title":"Therapeutic targets in necrotizing soft tissue infections","volume":"43","author":"de Prost N","year":"2017","unstructured":"de Prost N, Lipman J, Mimoz O. Therapeutic targets in necrotizing soft tissue infections. Intensive Care Med. 2017, 43:1717-9. 10.1007\/s00134-017-4813-1","journal-title":"Intensive Care Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/368421-clinical-profile-and-outcomes-of-patients-with-necrotizing-soft-tissue-infections-a-prospective-observational-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T15:41:02Z","timestamp":1751298062000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/368421-clinical-profile-and-outcomes-of-patients-with-necrotizing-soft-tissue-infections-a-prospective-observational-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.87035","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}