{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T10:10:07Z","timestamp":1751451007221,"version":"3.41.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,2]]},"DOI":"10.7759\/cureus.87151","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T09:46:15Z","timestamp":1751449575000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Vancomycin Powder for Surgical Site Prophylaxis in Orthopedic Surgeries: A Comparative Study"],"prefix":"10.7759","author":[{"given":"Ahmed S","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M","family":"Abdelhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awatif","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Alghazali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eltayeb","family":"Hamza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Hajalhasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.39465","article-title":"Prevalence and risk factors of surgical site infections in a Teaching Medical College in the Trichy district of India","volume":"15","author":"Mohan N","year":"2023","unstructured":"Mohan N, Gnanasekar D, Tk S, Ignatious A. Prevalence and risk factors of surgical site infections in a Teaching Medical College in the Trichy district of India. Cureus. 2023, 15:e39465. 10.7759\/cureus.39465","journal-title":"Cureus"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.42493","article-title":"Healthcare cost and outcomes associated with surgical site infection and patient outcomes in low- and middle-income countries","volume":"15","author":"Costabella F","year":"2023","unstructured":"Costabella F, Patel KB, Adepoju AV, et al.. Healthcare cost and outcomes associated with surgical site infection and patient outcomes in low- and middle-income countries. Cureus. 2023, 15:e42493. 10.7759\/cureus.42493","journal-title":"Cureus"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2009.10.001","article-title":"National Healthcare Safety Network (NHSN) report: data summary for 2006 through 2008, issued December 2009","volume":"37","author":"Edwards JR","year":"2009","unstructured":"Edwards JR, Peterson KD, Mu Y, et al.. National Healthcare Safety Network (NHSN) report: data summary for 2006 through 2008, issued December 2009. Am J Infect Control. 2009, 37:783-805. 10.1016\/j.ajic.2009.10.001","journal-title":"Am J Infect Control"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13037-020-00272-4","article-title":"Incidence and root causes of surgical site infections after gastrointestinal surgery at a public teaching hospital in Sudan","volume":"14","author":"Hassan RS","year":"2020","unstructured":"Hassan RS, Osman SO, Aabdeen MA, Mohamed WE, Hassan RS, Mohamed SO. Incidence and root causes of surgical site infections after gastrointestinal surgery at a public teaching hospital in Sudan. Patient Saf Surg. 2020, 14:45. 10.1186\/s13037-020-00272-4","journal-title":"Patient Saf Surg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011426.pub2","article-title":"Topical antibiotics for preventing surgical site infection in wounds healing by primary intention","volume":"11","author":"Heal CF","year":"2016","unstructured":"Heal CF, Banks JL, Lepper PD, Kontopantelis E, van Driel ML. Topical antibiotics for preventing surgical site infection in wounds healing by primary intention. Cochrane Database Syst Rev. 2016, 11:CD011426. 10.1002\/14651858.CD011426.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref6","article-title":"The efficacy and risks of using povidone-iodine irrigation to prevent surgical site infection: an evidence-based review","volume":"50","author":"Chundamala J","year":"2007","unstructured":"Chundamala J, Wright JG. The efficacy and risks of using povidone-iodine irrigation to prevent surgical site infection: an evidence-based review. Can J Surg. 2007, 50:473-81.","journal-title":"Can J Surg"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1135","article-title":"Local antimicrobial administration for prophylaxis of surgical site infections","volume":"32","author":"Huiras P","year":"2012","unstructured":"Huiras P, Logan JK, Papadopoulos S, Whitney D. Local antimicrobial administration for prophylaxis of surgical site infections. Pharmacotherapy. 2012, 32:1006-19. 10.1002\/phar.1135","journal-title":"Pharmacotherapy"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181ff2cb1","article-title":"Intrawound application of vancomycin for prophylaxis in instrumented thoracolumbar fusions: efficacy, drug levels, and patient outcomes","volume":"36","author":"Sweet FA","year":"2011","unstructured":"Sweet FA, Roh M, Sliva C. Intrawound application of vancomycin for prophylaxis in instrumented thoracolumbar fusions: efficacy, drug levels, and patient outcomes. Spine. 2011, 36:2084-8. 10.1097\/BRS.0b013e3181ff2cb1","journal-title":"Spine"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7150\/jbji.16649","article-title":"Local intra-wound administration of powdered antibiotics in orthopaedic surgery","volume":"2","author":"Fleischman AN","year":"2017","unstructured":"Fleischman AN, Austin MS. Local intra-wound administration of powdered antibiotics in orthopaedic surgery. J Bone Jt Infect. 2017, 2:23-8. 10.7150\/jbji.16649","journal-title":"J Bone Jt Infect"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1086\/491709","article-title":"Vancomycin: a history","volume":"42 Suppl 1","author":"Levine DP","year":"2006","unstructured":"Levine DP. Vancomycin: a history. Clin Infect Dis. 2006, 42 Suppl 1:S5-12. 10.1086\/491709","journal-title":"Clin Infect Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/BSD.0000000000000516","article-title":"Vancomycin powder regimen for prevention of surgical site infection in complex spine surgeries","volume":"30","author":"Van Hal M","year":"2017","unstructured":"Van Hal M, Lee J, Laudermilch D, Nwasike C, Kang J. Vancomycin powder regimen for prevention of surgical site infection in complex spine surgeries. Clin Spine Surg. 2017, 30:E1062-5. 10.1097\/BSD.0000000000000516","journal-title":"Clin Spine Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000001863","article-title":"Vancomycin powder use in fractures at high risk of surgical site infection","volume":"35","author":"Qadir R","year":"2021","unstructured":"Qadir R, Costales T, Coale M, et al.. Vancomycin powder use in fractures at high risk of surgical site infection. J Orthop Trauma. 2021, 35:23-8. 10.1097\/BOT.0000000000001863","journal-title":"J Orthop Trauma"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5371\/hp.2018.30.1.37","article-title":"Intrawound vancomycin powder in primary total hip arthroplasty increases rate of sterile wound complications","volume":"30","author":"Dial BL","year":"2018","unstructured":"Dial BL, Lampley AJ, Green CL, Hallows R. Intrawound vancomycin powder in primary total hip arthroplasty increases rate of sterile wound complications. Hip Pelvis. 2018, 30:37-44. 10.5371\/hp.2018.30.1.37","journal-title":"Hip Pelvis"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2019.05.592","article-title":"The efficacy of intrawound vancomycin powder and povidone-iodine irrigation to prevent surgical site infections in complex instrumented spine surgery","volume":"19","author":"Lemans JV","year":"2019","unstructured":"Lemans JV, \u00d6ner FC, Wijdicks SP, Ekkelenkamp MB, Vogely HC, Kruyt MC. The efficacy of intrawound vancomycin powder and povidone-iodine irrigation to prevent surgical site infections in complex instrumented spine surgery. Spine J. 2019, 19:1648-56. 10.1016\/j.spinee.2019.05.592","journal-title":"Spine J"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000000015","article-title":"Effects of using intravenous antibiotic only versus local intrawound vancomycin antibiotic powder application in addition to intravenous antibiotics on postoperative infection in spine surgery in 907 patients","volume":"38","author":"Tubaki VR","year":"2013","unstructured":"Tubaki VR, Rajasekaran S, Shetty AP. Effects of using intravenous antibiotic only versus local intrawound vancomycin antibiotic powder application in addition to intravenous antibiotics on postoperative infection in spine surgery in 907 patients. Spine (Phila Pa 1976). 2013, 38:2149-55. 10.1097\/BRS.0000000000000015","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12306-017-0490-z","article-title":"Intrawound application of vancomycin changes the responsible germ in elective spine surgery without significant effect on the rate of infection: a randomized prospective study","volume":"102","author":"Mirzashahi B","year":"2018","unstructured":"Mirzashahi B, Chehrassan M, Mortazavi SM. Intrawound application of vancomycin changes the responsible germ in elective spine surgery without significant effect on the rate of infection: a randomized prospective study. Musculoskelet Surg. 2018, 102:35-9. 10.1007\/s12306-017-0490-z","journal-title":"Musculoskelet Surg"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1086\/646686","article-title":"Nosocomial infections in surgical patients in the United States, January 1986-June 1992. National Nosocomial Infections Surveillance (NNIS) System","volume":"14","author":"Horan TC","year":"1993","unstructured":"Horan TC, Culver DH, Gaynes RP, Jarvis WR, Edwards JR, Reid CR. Nosocomial infections in surgical patients in the United States, January 1986-June 1992. National Nosocomial Infections Surveillance (NNIS) System. Infect Control Hosp Epidemiol. 1993, 14:73-80. 10.1086\/646686","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2014.12.033","article-title":"The use of vancomycin powder in modern spine surgery: systematic review and meta-analysis of the clinical evidence","volume":"83","author":"Bakhsheshian J","year":"2015","unstructured":"Bakhsheshian J, Dahdaleh NS, Lam SK, Savage JW, Smith ZA. The use of vancomycin powder in modern spine surgery: systematic review and meta-analysis of the clinical evidence. World Neurosurg. 2015, 83:816-23. 10.1016\/j.wneu.2014.12.033","journal-title":"World Neurosurg"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbo.2017.12.003","article-title":"Infectious prophylaxis with intrawound vancomycin powder in orthopedic surgeries: systematic review with meta-analysis","volume":"54","author":"Sadigursky D","year":"2019","unstructured":"Sadigursky D, Sousa MD, Caja\u00edba YG, Martins RR, Lob\u00e3o DM. Infectious prophylaxis with intrawound vancomycin powder in orthopedic surgeries: systematic review with meta-analysis. Rev Bras Ortop (Sao Paulo). 2019, 54:617-26. 10.1016\/j.rbo.2017.12.003","journal-title":"Rev Bras Ortop (Sao Paulo)"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2015.10.015","article-title":"Serum and wound vancomycin levels after Intrawound administration in primary total joint arthroplasty","volume":"32","author":"Johnson JD","year":"2017","unstructured":"Johnson JD, Nessler JM, Horazdovsky RD, Vang S, Thomas AJ, Marston SB. Serum and wound vancomycin levels after Intrawound administration in primary total joint arthroplasty. J Arthroplasty. 2017, 32:924-8. 10.1016\/j.arth.2015.10.015","journal-title":"J Arthroplasty"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.119698","article-title":"Vancomycin versus cefazolin prophylaxis for cardiac surgery in the setting of a high prevalence of methicillin-resistant staphylococcal infections","volume":"123","author":"Finkelstein R","year":"2002","unstructured":"Finkelstein R, Rabino G, Mashiah T, et al.. Vancomycin versus cefazolin prophylaxis for cardiac surgery in the setting of a high prevalence of methicillin-resistant staphylococcal infections. J Thorac Cardiovasc Surg. 2002, 123:326-32. 10.1067\/mtc.2002.119698","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3171\/2013.6.SPINE1311","article-title":"Circulatory collapse after topical application of vancomycin powder during spine surgery","volume":"19","author":"Mariappan R","year":"2013","unstructured":"Mariappan R, Manninen P, Massicotte EM, Bhatia A. Circulatory collapse after topical application of vancomycin powder during spine surgery. J Neurosurg Spine. 2013, 19:381-3. 10.3171\/2013.6.SPINE1311","journal-title":"J Neurosurg Spine"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1386754","article-title":"Sterile seroma resulting from multilevel XLIF procedure as possible adverse effect of prophylactic vancomycin powder: a case report","volume":"5","author":"Youssef JA","year":"2014","unstructured":"Youssef JA, Orndorff DG, Scott MA, Ebner RE, Knewitz AP. Sterile seroma resulting from multilevel XLIF procedure as possible adverse effect of prophylactic vancomycin powder: a case report. Evid Based Spine Care J. 2014, 5:127-33. 10.1055\/s-0034-1386754","journal-title":"Evid Based Spine Care J"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-014-2022-z","article-title":"The use of vancomycin powder reduces surgical reoperation in posterior instrumented and noninstrumented spinal surgery","volume":"156","author":"Hill BW","year":"2014","unstructured":"Hill BW, Emohare O, Song B, Davis R, Kang MM. The use of vancomycin powder reduces surgical reoperation in posterior instrumented and noninstrumented spinal surgery. Acta Neurochir (Wien). 2014, 156:749-54. 10.1007\/s00701-014-2022-z","journal-title":"Acta Neurochir (Wien)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/379021-clinical-outcomes-of-vancomycin-powder-for-surgical-site-prophylaxis-in-orthopedic-surgeries-a-comparative-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T09:46:17Z","timestamp":1751449577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/379021-clinical-outcomes-of-vancomycin-powder-for-surgical-site-prophylaxis-in-orthopedic-surgeries-a-comparative-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":24,"URL":"https:\/\/doi.org\/10.7759\/cureus.87151","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,2]]}}}