{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:36:14Z","timestamp":1790728574601,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,8]]},"DOI":"10.7759\/cureus.87520","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T09:52:51Z","timestamp":1751968371000},"source":"Crossref","is-referenced-by-count":1,"title":["Ethanol Extract From the Stem Bark of Adansonia digitata L. (Baobab) Displays Therapeutic Potential Against Klebsiella pneumoniae Infection"],"prefix":"10.7759","author":[{"given":"Germaine  T","family":"Matsuete","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Tangue Talom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lacmata Tamekou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine Odelonne","family":"Kenfack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-De-Dieu","family":"Tamokou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1367422","article-title":"Animal models of Klebsiella pneumoniae mucosal infections","volume":"15","author":"Assoni L","year":"2024","unstructured":"Assoni L, Couto AJ, Vieira B, Milani B, Lima AS, Converso TR, Darrieux M. Animal models of Klebsiella pneumoniae mucosal infections. Front Microbiol. 2024, 15:1367422. 10.3389\/fmicb.2024.1367422","journal-title":"Front Microbiol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76895-5","article-title":"Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo","volume":"10","author":"Tan S","year":"2020","unstructured":"Tan S, Gao J, Li Q, et al.. Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo. Sci Rep. 2020, 10:20013. 10.1038\/s41598-020-76895-5","journal-title":"Sci Rep"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0315-1","article-title":"Population genomics of Klebsiella pneumoniae","volume":"18","author":"Wyres KL","year":"2020","unstructured":"Wyres KL, Lam MM, Holt KE. Population genomics of Klebsiella pneumoniae. Nat Rev Microbiol. 2020, 18:344-59. 10.1038\/s41579-019-0315-1","journal-title":"Nat Rev Microbiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2019.10.014","article-title":"A systematic review and meta-analysis of treatment outcomes following antibiotic therapy among patients with carbapenem-resistant Klebsiella pneumoniae infections","volume":"55","author":"Agyeman AA","year":"2020","unstructured":"Agyeman AA, Bergen PJ, Rao GG, Nation RL, Landersdorfer CB. A systematic review and meta-analysis of treatment outcomes following antibiotic therapy among patients with carbapenem-resistant Klebsiella pneumoniae infections. Int J Antimicrob Agents. 2020, 55:105833. 10.1016\/j.ijantimicag.2019.10.014","journal-title":"Int J Antimicrob Agents"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/nu15092170","article-title":"Adansonia digitata L. (baobab) bioactive compounds, biological activities, and the potential effect on glycemia: a narrative review","volume":"15","author":"Silva ML","year":"2023","unstructured":"Silva ML, Rita K, Bernardo MA, Mesquita MF, Pint\u00e3o AM, Moncada M. Adansonia digitata L. (baobab) bioactive compounds, biological activities, and the potential effect on glycemia: a narrative review. Nutrients. 2023, 15:10.3390\/nu15092170","journal-title":"Nutrients"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2020.1824135","article-title":"Antimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment","volume":"83","author":"Vasconcelos NG","year":"2020","unstructured":"Vasconcelos NG, Vaz MS, Radai JA, et al.. Antimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment. J Toxicol Environ Health A. 2020, 83:719-29. 10.1080\/15287394.2020.1824135","journal-title":"J Toxicol Environ Health A"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2291-9","article-title":"Antibacterial activity evaluation of selected essential oils in liquid and vapor phase on respiratory tract pathogens","volume":"18","author":"\u00c1cs K","year":"2018","unstructured":"\u00c1cs K, Bal\u00e1zs VL, Kocsis B, Bencsik T, B\u00f6sz\u00f6rm\u00e9nyi A, Horv\u00e1th G. Antibacterial activity evaluation of selected essential oils in liquid and vapor phase on respiratory tract pathogens. BMC Complement Altern Med. 2018, 18:227. 10.1186\/s12906-018-2291-9","journal-title":"BMC Complement Altern Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.86251","article-title":"Phytochemical composition, biological activities, and mechanisms of antibacterial action of selected Cameroonian medicinal plants","volume":"17","author":"Matsuete TG","year":"2025","unstructured":"Matsuete TG, Talom TB, Tamokou JD. Phytochemical composition, biological activities, and mechanisms of antibacterial action of selected Cameroonian medicinal plants. Cureus. 2025, 17:e86251. 10.7759\/cureus.86251","journal-title":"Cureus"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.5897\/AJB2005.000-3127","article-title":"Phytochemical constituents of some Nigerian medicinal plants","volume":"4","author":"Edeoga HO","year":"2005","unstructured":"Edeoga HO, Okwu DE, Mbaebie BO. Phytochemical constituents of some Nigerian medicinal plants. Afr J Biotechnol. 2005, 4:685-8. 10.5897\/AJB2005.000-3127","journal-title":"Afr J Biotechnol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11627-023-10333-9","article-title":"Micropropagation and GC-MS analysis of bioactive compounds in bulbs and callus of white squill","volume":"59","author":"El-Naggar HM","year":"2023","unstructured":"El-Naggar HM, Shehata AM, Morsi MAA. Micropropagation and GC-MS analysis of bioactive compounds in bulbs and callus of white squill.  In Vitro Cell Dev Biol-Plant. 2023, 59:154-66. 10.1007\/s11627-023-10333-9","journal-title":"In Vitro Cell Dev Biol-Plant"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0660-1","article-title":"Antimicrobial and antioxidant flavonoids from the leaves of Oncoba spinosa Forssk (Salicaceae)","volume":"15","author":"Djouossi MG","year":"2015","unstructured":"Djouossi MG, Tamokou JD, Ngnokam D, Kuiate JR, Tapondjou LA, Harakat D, Voutquenne-Nazabadioko L. Antimicrobial and antioxidant flavonoids from the leaves of Oncoba spinosa Forssk (Salicaceae). BMC Complement Altern Med. 2015, 15:134. 10.1186\/s12906-015-0660-1","journal-title":"BMC Complement Altern Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2975909","article-title":"Triterpene and steroids from Ludwigia abyssinica A. Rich (Onagraceae) displayed antimicrobial activities and synergistic effects with conventional antibiotics","volume":"2023","author":"Meli Sonkoue A","year":"2023","unstructured":"Meli Sonkoue A, Kengne IC, Tamekou Lacmata S, et al.. Triterpene and steroids from Ludwigia abyssinica A. Rich (Onagraceae) displayed antimicrobial activities and synergistic effects with conventional antibiotics. Evid Based Complement Alternat Med. 2023, 2023:2975909. 10.1155\/2023\/2975909","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803620-4.00005-0","article-title":"Acute, Subacute, Subchronic, and Chronic General Toxicity Testing for Preclinical Drug Development","author":"Denny KH","year":"2017","unstructured":"Denny KH, Stewart CW. Acute, Subacute, Subchronic, and Chronic General Toxicity Testing for Preclinical Drug Development. A Comprehensive Guide to Toxicology in Nonclinical Drug Development (Second Edition). Faqi AS (ed): Academic Press, Cambridge; 2017. 109-27. 10.1016\/B978-0-12-803620-4.00005-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5702159","article-title":"Acute and subacute toxicity of methanol extract of Syzygium guineense leaves on the histology of the liver and kidney and biochemical compositions of blood in rats","volume":"2019","author":"Loha M","year":"2019","unstructured":"Loha M, Mulu A, Abay SM, Ergete W, Geleta B. Acute and subacute toxicity of methanol extract of Syzygium guineense leaves on the histology of the liver and kidney and biochemical compositions of blood in rats. Evid Based Complement Alternat Med. 2019, 2019:5702159. 10.1155\/2019\/5702159","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071552","article-title":"An improved scalable synthesis of \u03b1- and \u03b2-amyrin","volume":"23","author":"Serbian I","year":"2018","unstructured":"Serbian I, Csuk R. An improved scalable synthesis of \u03b1- and \u03b2-amyrin. Molecules. 2018, 23:10.3390\/molecules23071552","journal-title":"Molecules"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s42269-022-00818-9","article-title":"GC-MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts","volume":"46","author":"Chirumamilla P","year":"2022","unstructured":"Chirumamilla P, Dharavath SB, Taduri S. GC-MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts. Bull Natl Res Cent. 2022, 46:127. 10.1186\/s42269-022-00818-9","journal-title":"Bull Natl Res Cent"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2024.13162","article-title":"Pharmacological activity of capsaicin: mechanisms and controversies (Review)","volume":"29","author":"Zhang W","year":"2024","unstructured":"Zhang W, Zhang Y, Fan J, Feng Z, Song X. Pharmacological activity of capsaicin: mechanisms and controversies (Review). Mol Med Rep. 2024, 29:10.3892\/mmr.2024.13162","journal-title":"Mol Med Rep"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-809286-6.00008-X","article-title":"Antimicrobial Activities of African Medicinal Spices and Vegetables","author":"Tamokou JD","year":"2017","unstructured":"Tamokou JD, Mbaveng TA, Kuete V. Antimicrobial Activities of African Medicinal Spices and Vegetables. Medicinal Spices and Vegetables from Africa: Therapeutic Potential Against Metabolic, Inflammatory, Infectious and Systemic Diseases (1st ed.). Kuete V (ed): Academic Press, London, England; 2017. 207-37. 10.1016\/B978-0-12-809286-6.00008-X"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4303902","article-title":"Antibacterial and therapeutic potentials of the Capsicum annuum extract against infected wound in a rat model with its mechanisms of antibacterial action","volume":"2021","author":"Ekom SE","year":"2021","unstructured":"Ekom SE, Tamokou JD, Kuete V. Antibacterial and therapeutic potentials of the Capsicum annuum extract against infected wound in a rat model with its mechanisms of antibacterial action. Biomed Res Int. 2021, 2021:4303902. 10.1155\/2021\/4303902","journal-title":"Biomed Res Int"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1996.tb03560.x","article-title":"A rat model of infection by Salmonella typhimurium or Salm. enteritidis","volume":"81","author":"Naughton PJ","year":"1996","unstructured":"Naughton PJ, Grant G, Spencer RJ, Bardocz S, Pusztai A. A rat model of infection by Salmonella typhimurium or Salm. enteritidis. J Appl Bacteriol. 1996, 81:651-6. 10.1111\/j.1365-2672.1996.tb03560.x","journal-title":"J Appl Bacteriol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.5897\/JPP2013.0291","article-title":"In vivo and in vitro antibacterial activities of Momordica charantia on Salmonella Typhi and its effect on liver function in typhoid-infected rats","volume":"5","author":"Adeyi AO","year":"2013","unstructured":"Adeyi AO, Jinadu AM, Arojojoye OA, Alao OO, Ighodaro OM, Adeyi OE. In vivo and in vitro antibacterial activities of Momordica charantia on Salmonella Typhi and its effect on liver function in typhoid-infected rats. J Pharmacogn Phytotherap. 2013, 5:183-18. 10.5897\/JPP2013.0291","journal-title":"J Pharmacogn Phytotherap"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(93)90081-F","article-title":"Toxic effects of crude root extract of Plumbago rosea (Rakta chitraka) on mice and rats","volume":"38","author":"Emerson SF","year":"1993","unstructured":"Emerson SF, Shadara AC, Uma DP. Toxic effects of crude root extract of Plumbago rosea (Rakta chitraka) on mice and rats. J Ethnopharmacol. 1993, 38:79-84. 10.1016\/0378-8741(93)90081-F","journal-title":"J Ethnopharmacol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.9734\/JAMPS\/2016\/24949","article-title":"Antioxidant effect of aqueous extract of Curcuma longa rhizomes (Zingiberaceae) in the typhoid fever induced in Wistar rats model","volume":"7","author":"Kodjio N","year":"2016","unstructured":"Kodjio N, Atsafack S, Njateng G, Sokoudjou JB, Kuiate JR, Gatsing D. Antioxidant effect of aqueous extract of Curcuma longa rhizomes (Zingiberaceae) in the typhoid fever induced in Wistar rats model. J Adv Med Pharma Sci. 2016, 7:1-13. 10.9734\/JAMPS\/2016\/24949","journal-title":"J Adv Med Pharma Sci"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/864159","article-title":"Management of necrotizing pneumonia and pulmonary gangrene: a case series and review of the literature","volume":"21","author":"Chatha N","year":"2014","unstructured":"Chatha N, Fortin D, Bosma KJ. Management of necrotizing pneumonia and pulmonary gangrene: a case series and review of the literature. Can Respir J. 2014, 21:239-45. 10.1155\/2014\/864159","journal-title":"Can Respir J"},{"key":"ref25","article-title":"Septic\u00e9mie et m\u00e9ningite \u00e0 Klebsiella pneumoniae au depart d'un abc\u00e8s h\u00e9patique chez un patient diab\u00e9tique [Klebsiella pneumoniae septicaemia and meningitis in a diabetic patient with an hepatic abscess]","volume":"28","author":"M\u00e9ric de Bellefon L","year":"2007","unstructured":"M\u00e9ric de Bellefon L, Legrand JC, Codden T, Carlier E, Vanhaeverbeek M. Septic\u00e9mie et m\u00e9ningite \u00e0 Klebsiella pneumoniae au depart d'un abc\u00e8s h\u00e9patique chez un patient diab\u00e9tique [Klebsiella pneumoniae septicaemia and meningitis in a diabetic patient with an hepatic abscess]. Rev Med Brux. 2007, 28:460-3.","journal-title":"Rev Med Brux"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3923\/JPT.2007.373.379","article-title":"The effects of ethanolic extract of Commiphora africana (Burseraceae) on rat liver and kidney functions","volume":"2","author":"Aliyu RR","year":"2007","unstructured":"Aliyu RR, Adebayo JO, Gatsing D, Garba IH. The effects of ethanolic extract of Commiphora africana (Burseraceae) on rat liver and kidney functions. J Pharmacol Toxicol. 2007, 2:373-9. 10.3923\/JPT.2007.373.379","journal-title":"J Pharmacol Toxicol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143080","article-title":"C-reactive protein is an important biomarker for prognosis, tumor recurrence, and treatment response in adult solid tumors: a systematic review","volume":"10","author":"Shrotriya S","year":"2015","unstructured":"Shrotriya S, Walsh D, Bennani-Baiti N, Thomas S, Lorton C. C-reactive protein is an important biomarker for prognosis, tumor recurrence, and treatment response in adult solid tumors: a systematic review. PLoS One. 2015, 10:e0143080. 10.1371\/journal.pone.0143080","journal-title":"PLoS One"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/387719-ethanol-extract-from-the-stem-bark-of-adansonia-digitata-l-baobab-displays-therapeutic-potential-against-klebsiella-pneumoniae-infection","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T09:52:52Z","timestamp":1751968372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/387719-ethanol-extract-from-the-stem-bark-of-adansonia-digitata-l-baobab-displays-therapeutic-potential-against-klebsiella-pneumoniae-infection"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.87520","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,8]]}}}