{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T22:40:04Z","timestamp":1752446404664,"version":"3.41.2"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,13]]},"DOI":"10.7759\/cureus.87852","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T21:59:12Z","timestamp":1752443952000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Cost-Effectiveness of MDM2 Fluorescence In Situ Hybridization (FISH) in Morphologically Atypical Spermatic Cord Lipomas"],"prefix":"10.7759","author":[{"given":"Zobash","family":"Noor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaymaa","family":"Hegazy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Naous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200204000-00018","article-title":"Lipomas of the cord and round ligament","volume":"235","author":"Lilly MC","year":"2002","unstructured":"Lilly MC, Arregui ME. Lipomas of the cord and round ligament. Ann Surg. 2002, 235:586-90. 10.1097\/00000658-200204000-00018","journal-title":"Ann Surg"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.84","article-title":"Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms","volume":"21","author":"Weaver J","year":"2008","unstructured":"Weaver J, Downs-Kelly E, Goldblum JR, et al.. Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms. Mod Pathol. 2008, 21:943-9. 10.1038\/modpathol.2008.84","journal-title":"Mod Pathol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.20471\/acc.2021.60.01.07","article-title":"Liposarcoma of the spermatic cord: diagnostic and therapeutic issue","volume":"60","author":"Jeremi\u0107 D","year":"2021","unstructured":"Jeremi\u0107 D, Maletin M, Vojinov S, Levakov I, Grbi\u0107 D, Laki\u0107 T, Trivuni\u0107 Dajko S. Liposarcoma of the spermatic cord: diagnostic and therapeutic issue. Acta Clin Croat. 2021, 60:50-4. 10.20471\/acc.2021.60.01.07","journal-title":"Acta Clin Croat"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023","article-title":"Atypical lipomatous tumor\/well differentiated liposarcoma and related mimics with updates. When is molecular testing most cost-effective, necessary, and indicated?","volume":"147","author":"Kilpatrick SE","year":"2024","unstructured":"Kilpatrick SE. Atypical lipomatous tumor\/well differentiated liposarcoma and related mimics with updates. When is molecular testing most cost-effective, necessary, and indicated?. Hum Pathol. 2024, 147:82-91. 10.1016\/j.humpath.2023","journal-title":"Hum Pathol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.03.013","article-title":"Reviving the guardian of the genome: small molecule activators of p53","volume":"178","author":"Nguyen D","year":"2017","unstructured":"Nguyen D, Liao W, Zeng SX, Lu H. Reviving the guardian of the genome: small molecule activators of p53. Pharmacol Ther. 2017, 178:92-108. 10.1016\/j.pharmthera.2017.03.013","journal-title":"Pharmacol Ther"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182417330","article-title":"Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors","volume":"36","author":"Thway K","year":"2012","unstructured":"Thway K, Flora R, Shah C, Olmos D, Fisher C. Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors. Am J Surg Pathol. 2012, 36:462-9. 10.1097\/PAS.0b013e3182417330","journal-title":"Am J Surg Pathol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.90","article-title":"Sensitivity of MDM2 amplification and unexpected multiple faint alphoid 12 (alpha 12 satellite sequences) signals in atypical lipomatous tumor","volume":"25","author":"Kashima T","year":"2012","unstructured":"Kashima T, Halai D, Ye H, et al.. Sensitivity of MDM2 amplification and unexpected multiple faint alphoid 12 (alpha 12 satellite sequences) signals in atypical lipomatous tumor. Mod Pathol. 2012, 25:1384-96. 10.1038\/modpathol.2012.90","journal-title":"Mod Pathol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.155039","article-title":"MDM2 FISH testing criteria in adipose tissue tumors with mature adipocytic morphology: a resection case-based study","volume":"253","author":"Li L","year":"2024","unstructured":"Li L, Yue P, Du Q, Zhang H, Song Y. MDM2 FISH testing criteria in adipose tissue tumors with mature adipocytic morphology: a resection case-based study. Pathol Res Pract. 2024, 253:155039. 10.1016\/j.prp.2023.155039","journal-title":"Pathol Res Pract"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24928","article-title":"Differential diagnosis of lipoma and atypical lipomatous tumor\/well-differentiated liposarcoma by cytological analysis","volume":"50","author":"Sugiyama K","year":"2022","unstructured":"Sugiyama K, Washimi K, Sato S, et al.. Differential diagnosis of lipoma and atypical lipomatous tumor\/well-differentiated liposarcoma by cytological analysis. Diagn Cytopathol. 2022, 50:112-22. 10.1002\/dc.24928","journal-title":"Diagn Cytopathol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.62257","article-title":"Fine needle aspiration biopsy diagnosis of dedifferentiated liposarcoma: cytomorphology and MDM2 amplification by FISH","volume":"7","author":"Al-Maghraby HQ","year":"2010","unstructured":"Al-Maghraby HQ, Khalbuss WE, Rao UN, Cieply K, Dacic S, Monaco SE. Fine needle aspiration biopsy diagnosis of dedifferentiated liposarcoma: cytomorphology and MDM2 amplification by FISH. Cytojournal. 2010, 7:5. 10.4103\/1742-6413.62257","journal-title":"Cytojournal"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000468","article-title":"MDM2 amplification in problematic lipomatous tumors: analysis of FISH testing criteria","volume":"39","author":"Clay MR","year":"2015","unstructured":"Clay MR, Martinez AP, Weiss SW, Edgar MA. MDM2 amplification in problematic lipomatous tumors: analysis of FISH testing criteria. Am J Surg Pathol. 2015, 39:1433-9. 10.1097\/PAS.0000000000000468","journal-title":"Am J Surg Pathol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2019.11.004","article-title":"MDM2 inhibition in a subset of sarcoma cell lines increases susceptibility to radiation therapy by inducing senescence in the polyploid cells","volume":"5","author":"Das S","year":"2020","unstructured":"Das S. MDM2 inhibition in a subset of sarcoma cell lines increases susceptibility to radiation therapy by inducing senescence in the polyploid cells. Adv Radiat Oncol. 2020, 5:250-9. 10.1016\/j.adro.2019.11.004","journal-title":"Adv Radiat Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/380582-efficacy-and-cost-effectiveness-of-mdm2-fluorescence-in-situ-hybridization-fish-in-morphologically-atypical-spermatic-cord-lipomas","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T21:59:13Z","timestamp":1752443953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/380582-efficacy-and-cost-effectiveness-of-mdm2-fluorescence-in-situ-hybridization-fish-in-morphologically-atypical-spermatic-cord-lipomas"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,13]]},"references-count":12,"URL":"https:\/\/doi.org\/10.7759\/cureus.87852","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,7,13]]}}}