{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:12:35Z","timestamp":1754143955481,"version":"3.41.2"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,14]]},"DOI":"10.7759\/cureus.87946","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:50:47Z","timestamp":1752551447000},"source":"Crossref","is-referenced-by-count":0,"title":["Autoimmune Acquired Factor V Deficiency in a Patient With Pancreatic Cancer Complicated by Cholangitis: A Rare Coagulopathy With a Favorable Course"],"prefix":"10.7759","author":[{"given":"Tsuyoshi","family":"Ueda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Miyagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Tsukada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-029850","article-title":"Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation","volume":"109","author":"Collins PW","year":"2007","unstructured":"Collins PW, Hirsch S, Baglin TP, et al.. Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation. Blood. 2007, 109:1870-7. 10.1182\/blood-2006-06-029850","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1740149","article-title":"A review of coagulation abnormalities of autoimmune acquired factor V deficiency with a focus on Japan","volume":"48","author":"Ichinose A","year":"2022","unstructured":"Ichinose A, Osaki T, Souri M. A review of coagulation abnormalities of autoimmune acquired factor V deficiency with a focus on Japan. Semin Thromb Hemost. 2022, 48:206-18. 10.1055\/s-0041-1740149","journal-title":"Semin Thromb Hemost"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1787188","article-title":"Diagnosis and treatment of autoimmune acquired coagulation factor deficiencies: an evidence-based review of Japanese practice","volume":"51","author":"Ichinose A","year":"2025","unstructured":"Ichinose A, Osaki T, Souri M. Diagnosis and treatment of autoimmune acquired coagulation factor deficiencies: an evidence-based review of Japanese practice. Semin Thromb Hemost. 2025, 51:491-505. 10.1055\/s-0044-1787188","journal-title":"Semin Thromb Hemost"},{"key":"ref4","article-title":"Acquired factor V inhibitor. A problem-based systematic review","volume":"101","author":"Ang AL","year":"2009","unstructured":"Ang AL, Kuperan P, Ng CH, Ng HJ. Acquired factor V inhibitor. A problem-based systematic review. Thromb Haemost. 2009, 101:852-9.","journal-title":"Thromb Haemost"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-010-0529-6","article-title":"Acquired factor V inhibitors: a systematic review","volume":"31","author":"Franchini M","year":"2011","unstructured":"Franchini M, Lippi G. Acquired factor V inhibitors: a systematic review. J Thromb Thrombolysis. 2011, 31:449-57. 10.1007\/s11239-010-0529-6","journal-title":"J Thromb Thrombolysis"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.076232","article-title":"Acquired factor V inhibitor associated with valproic acid use in a cirrhotic patient","volume":"55","author":"Godart B","year":"2006","unstructured":"Godart B, Boinot C, Remblier C, Hajjar A, Beauchant M. Acquired factor V inhibitor associated with valproic acid use in a cirrhotic patient. Gut. 2006, 55:134-5. 10.1136\/gut.2005.076232","journal-title":"Gut"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s0950-3536(98)80050-4","article-title":"Acquired factor V inhibitors","volume":"11","author":"Kn\u00f6bl P","year":"1998","unstructured":"Kn\u00f6bl P, Lechner K. Acquired factor V inhibitors. Baillieres Clin Haematol. 1998, 11:305-18. 10.1016\/s0950-3536(98)80050-4","journal-title":"Baillieres Clin Haematol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.509","article-title":"Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis","volume":"25","author":"Miura F","year":"2018","unstructured":"Miura F, Okamoto K, Takada T, et al.. Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis. J Hepatobiliary Pancreat Sci. 2018, 25:31-40. 10.1002\/jhbp.509","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"ref9","article-title":"Acquired factor V inhibitors: a review of the literature","volume":"4","author":"Boland F","year":"2017","unstructured":"Boland F, Shreenivas AV. Acquired factor V inhibitors: a review of the literature. Ann Hematol Oncol. 2017, 4:1168.","journal-title":"Ann Hematol Oncol"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V60.1.59.59","article-title":"Radioimmunoassay of factor V in human plasma and platelets","volume":"60","author":"Tracy PB","year":"1982","unstructured":"Tracy PB, Eide LL, Bowie EJ, Mann KG. Radioimmunoassay of factor V in human plasma and platelets.  Blood. 1982, 60:59-63.","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13114","article-title":"Acquired factor V inhibitor after exposure to topical human thrombin related to an otorhinolaryngological procedure","volume":"13","author":"Donohoe K","year":"2015","unstructured":"Donohoe K, Levine R. Acquired factor V inhibitor after exposure to topical human thrombin related to an otorhinolaryngological procedure. J Thromb Haemost. 2015, 13:1787-9. 10.1111\/jth.13114","journal-title":"J Thromb Haemost"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07708.x","article-title":"Advances in understanding the bleeding diathesis in factor V deficiency","volume":"146","author":"Duckers C","year":"2009","unstructured":"Duckers C, Simioni P, Rosing J, Castoldi E. Advances in understanding the bleeding diathesis in factor V deficiency. Br J Haematol. 2009, 146:17-26. 10.1111\/j.1365-2141.2009.07708.x","journal-title":"Br J Haematol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200412000-00003","article-title":"Factor V inhibitors: rare or not so uncommon? A multi-laboratory investigation","volume":"15","author":"Favaloro EJ","year":"2004","unstructured":"Favaloro EJ, Posen J, Ramakrishna R, et al.. Factor V inhibitors: rare or not so uncommon? A multi-laboratory investigation. Blood Coagul Fibrinolysis. 2004, 15:637-47. 10.1097\/00001721-200412000-00003","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10172","article-title":"High-titer acquired factor V inhibitor responsive to corticosteroids and cyclophosphamide in a patient with two malignant tumors","volume":"71","author":"Bayani N","year":"2002","unstructured":"Bayani N, Rugina M, Haddad-Vergnes L, Lelong F. High-titer acquired factor V inhibitor responsive to corticosteroids and cyclophosphamide in a patient with two malignant tumors. Am J Hematol. 2002, 71:33-6. 10.1002\/ajh.10172","journal-title":"Am J Hematol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12245","article-title":"Ruling out lupus anticoagulants with mixing test-specific cutoff assessment and the index of circulating anticoagulant","volume":"3","author":"Kumano O","year":"2019","unstructured":"Kumano O, Moore GW. Ruling out lupus anticoagulants with mixing test-specific cutoff assessment and the index of circulating anticoagulant. Res Pract Thromb Haemost. 2019, 3:695-703. 10.1002\/rth2.12245","journal-title":"Res Pract Thromb Haemost"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3402024","article-title":"A case of acquired factor V deficiency in patient with bleeding","volume":"4","author":"Vetri D","year":"2020","unstructured":"Vetri D, Lumera G, Tarascio S, Scuto S, Marino E, Barcellona G, Signorelli SS. A case of acquired factor V deficiency in patient with bleeding. TH Open. 2020, 4:e77-9. 10.1055\/s-0039-3402024","journal-title":"TH Open"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V56.5.835.835","article-title":"Successful management of bleeding in a patient with factor V inhibitor by platelet transfusions","volume":"56","author":"Chediak J","year":"1980","unstructured":"Chediak J, Ashenhurst JB, Garlick I, Desser RK. Successful management of bleeding in a patient with factor V inhibitor by platelet transfusions. Blood. 1980, 56:835-41.","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3283001d49","article-title":"Adjunctive role for recombinant activated factor VII in the treatment of bleeding secondary to a factor V inhibitor","volume":"19","author":"William BM","year":"2008","unstructured":"William BM. Adjunctive role for recombinant activated factor VII in the treatment of bleeding secondary to a factor V inhibitor. Blood Coagul Fibrinolysis. 2008, 19:327-8. 10.1097\/MBC.0b013e3283001d49","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255442","article-title":"Recombinant activated factor VII: mechanisms of action and current indications","volume":"36","author":"Franchini M","year":"2010","unstructured":"Franchini M, Lippi G. Recombinant activated factor VII: mechanisms of action and current indications. Semin Thromb Hemost. 2010, 36:485-92. 10.1055\/s-0030-1255442","journal-title":"Semin Thromb Hemost"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3283424883","article-title":"Inherited and acquired factor V deficiency","volume":"22","author":"Lippi G","year":"2011","unstructured":"Lippi G, Favaloro EJ, Montagnana M, Manzato F, Guidi GC, Franchini M. Inherited and acquired factor V deficiency. Blood Coagul Fibrinolysis. 2011, 22:160-6. 10.1097\/MBC.0b013e3283424883","journal-title":"Blood Coagul Fibrinolysis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/387187-autoimmune-acquired-factor-v-deficiency-in-a-patient-with-pancreatic-cancer-complicated-by-cholangitis-a-rare-coagulopathy-with-a-favorable-course","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:50:48Z","timestamp":1752551448000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/387187-autoimmune-acquired-factor-v-deficiency-in-a-patient-with-pancreatic-cancer-complicated-by-cholangitis-a-rare-coagulopathy-with-a-favorable-course"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.87946","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,7,14]]}}}