{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:00:28Z","timestamp":1787731228094,"version":"build-2784847793"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,19]]},"DOI":"10.7759\/cureus.88280","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T07:55:21Z","timestamp":1752911721000},"source":"Crossref","is-referenced-by-count":1,"title":["Impact of Early Rehabilitation Initiation on Walking Recovery in Critically Ill Patients"],"prefix":"10.7759","author":[{"given":"Ryuji","family":"Yoshinaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Kozu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4612-0","article-title":"The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review","volume":"43","author":"Tipping CJ","year":"2017","unstructured":"Tipping CJ, Harrold M, Holland A, Romero L, Nisbet T, Hodgson CL. The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review. Intensive Care Med. 2017, 43:171-83. 10.1007\/s00134-016-4612-0","journal-title":"Intensive Care Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201610-2075ST","article-title":"An official American Thoracic Society\/American College of Chest Physicians clinical practice guideline: liberation from mechanical ventilation in critically ill adults. Rehabilitation protocols, ventilator Liberation protocols, and cuff leak tests","volume":"195","author":"Girard TD","year":"2017","unstructured":"Girard TD, Alhazzani W, Kress JP, et al.. An official American Thoracic Society\/American College of Chest Physicians clinical practice guideline: liberation from mechanical ventilation in critically ill adults. Rehabilitation protocols, ventilator Liberation protocols, and cuff leak tests. Am J Respir Crit Care Med. 2017, 195:120-33. 10.1164\/rccm.201610-2075ST","journal-title":"Am J Respir Crit Care Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a38937","article-title":"Early exercise in critically ill patients enhances short-term functional recovery","volume":"37","author":"Burtin C","year":"2009","unstructured":"Burtin C, Clerckx B, Robbeets C, et al.. Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med. 2009, 37:2499-505. 10.1097\/CCM.0b013e3181a38937","journal-title":"Crit Care Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130722","article-title":"Effect of early rehabilitation during intensive care unit stay on functional status: systematic review and meta-analysis","volume":"10","author":"Castro-Avila AC","year":"2015","unstructured":"Castro-Avila AC, Ser\u00f3n P, Fan E, Gaete M, Mickan S. Effect of early rehabilitation during intensive care unit stay on functional status: systematic review and meta-analysis. PLoS One. 2015, 10:e0130722. 10.1371\/journal.pone.0130722","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.11777","article-title":"Pre-admission predictors of walking independence in critically ill patients","volume":"69","author":"Yoshinaga R","year":"2024","unstructured":"Yoshinaga R, Yamada N, Hanada M, Ishimatsu Y, Kozu R. Pre-admission predictors of walking independence in critically ill patients. Respir Care. 2024, 69:1314-22. 10.4187\/respcare.11777","journal-title":"Respir Care"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-019-0404-2","article-title":"Determinants of gait independence after mechanical ventilation in the intensive care unit: a Japanese multicenter retrospective exploratory cohort study","volume":"7","author":"Watanabe S","year":"2019","unstructured":"Watanabe S, Kotani T, Taito S, et al.. Determinants of gait independence after mechanical ventilation in the intensive care unit: a Japanese multicenter retrospective exploratory cohort study. J Intensive Care. 2019, 7:53. 10.1186\/s40560-019-0404-2","journal-title":"J Intensive Care"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318232da75","article-title":"Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference","volume":"40","author":"Needham DM","year":"2012","unstructured":"Needham DM, Davidson J, Cohen H, et al.. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med. 2012, 40:502-9. 10.1097\/CCM.0b013e318232da75","journal-title":"Crit Care Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2018.07.006","article-title":"A multimodal rehabilitation program for patients with ICU acquired weakness improves ventilator weaning and discharge home","volume":"47","author":"Verceles AC","year":"2018","unstructured":"Verceles AC, Wells CL, Sorkin JD, Terrin ML, Beans J, Jenkins T, Goldberg AP. A multimodal rehabilitation program for patients with ICU acquired weakness improves ventilator weaning and discharge home. J Crit Care. 2018, 47:204-10. 10.1016\/j.jcrc.2018.07.006","journal-title":"J Crit Care"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002927","article-title":"Long-term return to functional baseline after mechanical ventilation in the ICU","volume":"46","author":"Wilson ME","year":"2018","unstructured":"Wilson ME, Barwise A, Heise KJ, et al.. Long-term return to functional baseline after mechanical ventilation in the ICU. Crit Care Med. 2018, 46:562-9. 10.1097\/CCM.0000000000002927","journal-title":"Crit Care Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201606-455OC","article-title":"Recovery from dysphagia symptoms after oral endotracheal intubation in acute respiratory distress syndrome survivors. A 5-year longitudinal study","volume":"14","author":"Brodsky MB","year":"2017","unstructured":"Brodsky MB, Huang M, Shanholtz C, Mendez-Tellez PA, Palmer JB, Colantuoni E, Needham DM. Recovery from dysphagia symptoms after oral endotracheal intubation in acute respiratory distress syndrome survivors. A 5-year longitudinal study. Ann Am Thorac Soc. 2017, 14:376-83. 10.1513\/AnnalsATS.201606-455OC","journal-title":"Ann Am Thorac Soc"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.00956","article-title":"Functional recovery following physical training in tracheotomized and chronically ventilated patients","volume":"56","author":"Clini EM","year":"2011","unstructured":"Clini EM, Crisafulli E, Antoni FD, et al.. Functional recovery following physical training in tracheotomized and chronically ventilated patients. Respir Care. 2011, 56:306-13. 10.4187\/respcare.00956","journal-title":"Respir Care"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201512-2343OC","article-title":"The RECOVER program: disability risk groups and 1-year outcome after 7 or more days of mechanical ventilation","volume":"194","author":"Herridge MS","year":"2016","unstructured":"Herridge MS, Chu LM, Matte A, et al.. The RECOVER program: disability risk groups and 1-year outcome after 7 or more days of mechanical ventilation. Am J Respir Crit Care Med. 2016, 194:831-44. 10.1164\/rccm.201512-2343OC","journal-title":"Am J Respir Crit Care Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-2606","article-title":"Effect of physiotherapy on regaining independent walking in patients with intensive-care-unit-acquired muscle weakness: a cohort study","volume":"51","author":"Thomas S","year":"2019","unstructured":"Thomas S, Mehrholz J, Bodechtel U, Elsner B. Effect of physiotherapy on regaining independent walking in patients with intensive-care-unit-acquired muscle weakness: a cohort study. J Rehabil Med. 2019, 51:797-804. 10.2340\/16501977-2606","journal-title":"J Rehabil Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0829-5","article-title":"Functional outcomes in ICU - what should we be using? - an observational study","volume":"19","author":"Parry SM","year":"2015","unstructured":"Parry SM, Denehy L, Beach LJ, Berney S, Williamson HC, Granger CL. Functional outcomes in ICU - what should we be using? - an observational study. Crit Care. 2015, 19:127. 10.1186\/s13054-015-0829-5","journal-title":"Crit Care"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/nicc.12438","article-title":"PROtocol-based MObilizaTION on intensive care units: stepped-wedge, cluster-randomized pilot study (Pro-Motion)","volume":"25","author":"Nydahl P","year":"2020","unstructured":"Nydahl P, G\u00fcnther U, Diers A, et al.. PROtocol-based MObilizaTION on intensive care units: stepped-wedge, cluster-randomized pilot study (Pro-Motion). Nurs Crit Care. 2020, 25:368-75. 10.1111\/nicc.12438","journal-title":"Nurs Crit Care"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson ME","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987, 40:373-83. 10.1016\/0021-9681(87)90171-8","journal-title":"J Chronic Dis"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751","article-title":"The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine","volume":"22","author":"Vincent JL","year":"1996","unstructured":"Vincent JL, Moreno R, Takala J, et al.. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996, 22:707-10. 10.1007\/BF01709751","journal-title":"Intensive Care Med"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus WA","year":"1985","unstructured":"Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985, 13:818-29.","journal-title":"Crit Care Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.22.2983","article-title":"Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS)","volume":"289","author":"Ely EW","year":"2003","unstructured":"Ely EW, Truman B, Shintani A, et al.. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA. 2003, 289:2983-91. 10.1001\/jama.289.22.2983","journal-title":"JAMA"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw353","article-title":"Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society","volume":"63","author":"Kalil AC","year":"2016","unstructured":"Kalil AC, Metersky ML, Klompas M, et al.. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016, 63:e61-e111. 10.1093\/cid\/ciw353","journal-title":"Clin Infect Dis"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810625","article-title":"Intensive versus conventional glucose control in critically ill patients","volume":"360","author":"Finfer S","year":"2009","unstructured":"Finfer S, Chittock DR, Su SY, et al.. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009, 360:1283-97. 10.1056\/NEJMoa0810625","journal-title":"N Engl J Med"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-008828","article-title":"First results about recovery of walking function in patients with intensive care unit-acquired muscle weakness from the General Weakness Syndrome Therapy (GymNAST) cohort study","volume":"5","author":"Mehrholz J","year":"2015","unstructured":"Mehrholz J, M\u00fcckel S, Oehmichen F, Pohl M. First results about recovery of walking function in patients with intensive care unit-acquired muscle weakness from the General Weakness Syndrome Therapy (GymNAST) cohort study. BMJ Open. 2015, 5:e008828. 10.1136\/bmjopen-2015-008828","journal-title":"BMJ Open"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/64.1.35","article-title":"Clinical gait assessment in the neurologically impaired. Reliability and meaningfulness","volume":"64","author":"Holden MK","year":"1984","unstructured":"Holden MK, Gill KM, Magliozzi MR, Nathan J, Piehl-Baker L. Clinical gait assessment in the neurologically impaired. Reliability and meaningfulness. Phys Ther. 1984, 64:35-40. 10.1093\/ptj\/64.1.35","journal-title":"Phys Ther"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Kanda Y","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant. 2013, 48:452-8. 10.1038\/bmt.2012.244","journal-title":"Bone Marrow Transplant"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000586","article-title":"Functional recovery in patients with and without intensive care unit-acquired weakness","volume":"96","author":"Dettling-Ihnenfeldt DS","year":"2017","unstructured":"Dettling-Ihnenfeldt DS, Wieske L, Horn J, Nollet F, van der Schaaf M. Functional recovery in patients with and without intensive care unit-acquired weakness. Am J Phys Med Rehabil. 2017, 96:236-42. 10.1097\/PHM.0000000000000586","journal-title":"Am J Phys Med Rehabil"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0937-2","article-title":"Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study","volume":"19","author":"Wieske L","year":"2015","unstructured":"Wieske L, Dettling-Ihnenfeldt DS, Verhamme C, et al.. Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study. Crit Care. 2015, 19:196. 10.1186\/s13054-015-0937-2","journal-title":"Crit Care"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0993-7","article-title":"Clinical review: intensive care unit acquired weakness","volume":"19","author":"Hermans G","year":"2015","unstructured":"Hermans G, Van den Berghe G. Clinical review: intensive care unit acquired weakness. Crit Care. 2015, 19:274. 10.1186\/s13054-015-0993-7","journal-title":"Crit Care"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70178-8","article-title":"Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis","volume":"10","author":"Latronico N","year":"2011","unstructured":"Latronico N, Bolton CF. Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. Lancet Neurol. 2011, 10:931-41. 10.1016\/S1474-4422(11)70178-8","journal-title":"Lancet Neurol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.2490\/prm.20180003","article-title":"Effect of early rehabilitation activity time on critically ill patients with intensive care unit-acquired weakness: a Japanese retrospective multicenter study","volume":"3","author":"Watanabe S","year":"2018","unstructured":"Watanabe S, Iida Y, Ito T, Mizutani M, Morita Y, Suzuki S, Nishida O. Effect of early rehabilitation activity time on critically ill patients with intensive care unit-acquired weakness: a Japanese retrospective multicenter study. Prog Rehabil Med. 2018, 3:20180003. 10.2490\/prm.20180003","journal-title":"Prog Rehabil Med"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2023.05.023","article-title":"Trends and outcomes of early rehabilitation in the intensive care unit for patients with cardiovascular disease: a cohort study with propensity score-matched analysis","volume":"32","author":"Hamazaki N","year":"2023","unstructured":"Hamazaki N, Kamiya K, Nozaki K, et al.. Trends and outcomes of early rehabilitation in the intensive care unit for patients with cardiovascular disease: a cohort study with propensity score-matched analysis. Heart Lung Circ. 2023, 32:1240-9. 10.1016\/j.hlc.2023.05.023","journal-title":"Heart Lung Circ"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-054478","article-title":"Effects of evidence-based ICU care on long-term outcomes of patients with sepsis or septic shock (ILOSS): protocol for a multicentre prospective observational cohort study in Japan","volume":"12","author":"Liu K","year":"2022","unstructured":"Liu K, Kotani T, Nakamura K, et al.. Effects of evidence-based ICU care on long-term outcomes of patients with sepsis or septic shock (ILOSS): protocol for a multicentre prospective observational cohort study in Japan. BMJ Open. 2022, 12:e054478. 10.1136\/bmjopen-2021-054478","journal-title":"BMJ Open"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62072-9","article-title":"A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial","volume":"375","author":"Str\u00f8m T","year":"2010","unstructured":"Str\u00f8m T, Martinussen T, Toft P. A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet. 2010, 375:475-80. 10.1016\/S0140-6736(09)62072-9","journal-title":"Lancet"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-024-02460-z","article-title":"A comprehensive assessment tool of acute-phase rehabilitation is associated with clinical outcomes in patients after cardiovascular surgery","volume":"40","author":"Ogura K","year":"2025","unstructured":"Ogura K, Hamazaki N, Kamiya K, et al.. A comprehensive assessment tool of acute-phase rehabilitation is associated with clinical outcomes in patients after cardiovascular surgery. Heart Vessels. 2025, 40:258-66. 10.1007\/s00380-024-02460-z","journal-title":"Heart Vessels"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.5535\/arm.23056","article-title":"Association between mobilization level and activity of daily living independence in critically ill patients","volume":"47","author":"Watanabe S","year":"2023","unstructured":"Watanabe S, Liu K, Kozu R, et al.. Association between mobilization level and activity of daily living independence in critically ill patients. Ann Rehabil Med. 2023, 47:519-27. 10.5535\/arm.23056","journal-title":"Ann Rehabil Med"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-023-00697-w","article-title":"Japanese Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients 2023 (J-ReCIP 2023)","volume":"11","author":"Unoki T","year":"2023","unstructured":"Unoki T, Hayashida K, Kawai Y, et al.. Japanese Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients 2023 (J-ReCIP 2023). J Intensive Care. 2023, 11:47. 10.1186\/s40560-023-00697-w","journal-title":"J Intensive Care"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/369581-impact-of-early-rehabilitation-initiation-on-walking-recovery-in-critically-ill-patients","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T07:55:21Z","timestamp":1752911721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/369581-impact-of-early-rehabilitation-initiation-on-walking-recovery-in-critically-ill-patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,19]]},"references-count":35,"URL":"https:\/\/doi.org\/10.7759\/cureus.88280","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,19]]}}}