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J Neurosurg Spine. 2020, 32:790-8. 10.3171\/2019.11.SPINE191176","journal-title":"J Neurosurg Spine"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200008000-00026","article-title":"Time-dependent astroglial changes after gamma knife radiosurgery in the rat forebrain","volume":"47","author":"Yang T","year":"2000","unstructured":"Yang T, Wu SL, Liang JC, Rao ZR, Ju G. Time-dependent astroglial changes after gamma knife radiosurgery in the rat forebrain. Neurosurgery. 2000, 47:407-15. 10.1097\/00006123-200008000-00026","journal-title":"Neurosurgery"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-1376-9_19","article-title":"Radiosurgery as neuromodulation therapy!","volume":"116","author":"R\u00e9gis J","year":"2013","unstructured":"R\u00e9gis J. Radiosurgery as neuromodulation therapy!. Acta Neurochir Suppl. 2013, 116:121-6. 10.1007\/978-3-7091-1376-9_19","journal-title":"Acta Neurochir Suppl"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2003.09.003","article-title":"The nucleus accumbens: a target for deep brain stimulation in obsessive-compulsive- and anxiety-disorders","volume":"26","author":"Sturm V","year":"2003","unstructured":"Sturm V, Lenartz D, Koulousakis A, Treuer H, Herholz K, Klein JC, Klosterk\u00f6tter J. The nucleus accumbens: a target for deep brain stimulation in obsessive-compulsive- and anxiety-disorders. J Chem Neuroanat. 2003, 26:293-9. 10.1016\/j.jchemneu.2003.09.003","journal-title":"J Chem Neuroanat"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.06.006","article-title":"The different effects of high-frequency stimulation of the nucleus accumbens shell and core on food consumption are possibly associated with different neural responses in the lateral hypothalamic area","volume":"301","author":"Wei N","year":"2015","unstructured":"Wei N, Wang Y, Wang X, et al.. The different effects of high-frequency stimulation of the nucleus accumbens shell and core on food consumption are possibly associated with different neural responses in the lateral hypothalamic area. Neuroscience. 2015, 301:312-22. 10.1016\/j.neuroscience.2015.06.006","journal-title":"Neuroscience"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.06.060","article-title":"Role of lateral hypothalamic orexin neurons in reward processing and addiction","volume":"56","author":"Aston-Jones G","year":"2009","unstructured":"Aston-Jones G, Smith RJ, Moorman DE, Richardson KA. Role of lateral hypothalamic orexin neurons in reward processing and addiction. 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