{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:25:05Z","timestamp":1754151905664,"version":"3.41.2"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,21]]},"DOI":"10.7759\/cureus.88401","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T08:24:29Z","timestamp":1753086269000},"source":"Crossref","is-referenced-by-count":0,"title":["Platelet and Red Cell Indices: A Potential Biomarker for Predicting Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease (COPD) Patients"],"prefix":"10.7759","author":[{"given":"Kishore","family":"Kanna S","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanabur","family":"Thirthashree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Bhuvaneswari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Parinita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Baburao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashika","family":"Adinarayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.1995","article-title":"Airway and systemic inflammation and decline in lung function in patients with COPD","volume":"128","author":"Donaldson GC","year":"2005","unstructured":"Donaldson GC, Seemungal TA, Patel IS, et al.. Airway and systemic inflammation and decline in lung function in patients with COPD. Chest. 2005, 128:1995-2004. 10.1378\/chest.128.4.1995","journal-title":"Chest"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"385","author":"GBD 2013 Mortality and Causes of Death Collaborators","year":"2015","unstructured":"GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015, 385:117-71. 10.1016\/S0140-6736(14)61682-2","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00879-2022","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"61","author":"Humbert M","year":"2023","unstructured":"Humbert M, Kovacs G, Hoeper MM, et al.. 2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J. 2023, 61:2200879. 10.1183\/13993003.00879-2022","journal-title":"Eur Respir J"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2021.1898578","article-title":"Platelet count and platelet indices in patients with stable and acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis","volume":"18","author":"Zinellu A","year":"2021","unstructured":"Zinellu A, Paliogiannis P, Sotgiu E, Mellino S, Fois AG, Carru C, Mangoni AA. Platelet count and platelet indices in patients with stable and acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis. COPD. 2021, 18:231-45. 10.1080\/15412555.2021.1898578","journal-title":"COPD"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.05.009","article-title":"Categorization and impact of pulmonary hypertension in patients with advanced COPD","volume":"104","author":"Cuttica MJ","year":"2010","unstructured":"Cuttica MJ, Kalhan R, Shlobin OA, et al.. Categorization and impact of pulmonary hypertension in patients with advanced COPD. Respir Med. 2010, 104:1877-82. 10.1016\/j.rmed.2010.05.009","journal-title":"Respir Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S176413","article-title":"Mean platelet volume as a predictor of pulmonary hypertension in patients with stable COPD","volume":"14","author":"Mohamed MF","year":"2019","unstructured":"Mohamed MF, Ali A, Abbas A, Awad MS, Gouda M, Sediq AM. Mean platelet volume as a predictor of pulmonary hypertension in patients with stable COPD. Int J Chron Obstruct Pulmon Dis. 2019, 14:1099-108. 10.2147\/COPD.S176413","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00007913","article-title":"The vascular bed in COPD: pulmonary hypertension and pulmonary vascular alterations","volume":"23","author":"Sakao S","year":"2014","unstructured":"Sakao S, Voelkel NF, Tatsumi K. The vascular bed in COPD: pulmonary hypertension and pulmonary vascular alterations. Eur Respir Rev. 2014, 23:350-5. 10.1183\/09059180.00007913","journal-title":"Eur Respir Rev"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2013.814835","article-title":"Platelet activation as a novel mechanism of atherothrombotic risk in chronic obstructive pulmonary disease","volume":"6","author":"Malerba M","year":"2013","unstructured":"Malerba M, Clini E, Malagola M, Avanzi GC. Platelet activation as a novel mechanism of atherothrombotic risk in chronic obstructive pulmonary disease. Expert Rev Hematol. 2013, 6:475-83. 10.1586\/17474086.2013.814835","journal-title":"Expert Rev Hematol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/thx.46.7.504","article-title":"Increased platelet aggregate formation in patients with chronic airflow obstruction and hypoxaemia","volume":"46","author":"Wedzicha JA","year":"1991","unstructured":"Wedzicha JA, Syndercombe-Court D, Tan KC. Increased platelet aggregate formation in patients with chronic airflow obstruction and hypoxaemia. Thorax. 1991, 46:504-7. 10.1136\/thx.46.7.504","journal-title":"Thorax"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S152660","article-title":"Impact of acute exacerbations on platelet reactivity in chronic obstructive pulmonary disease patients","volume":"13","author":"Mu\u00f1oz-Esquerre M","year":"2018","unstructured":"Mu\u00f1oz-Esquerre M, Ferreiro JL, Huertas D, et al.. Impact of acute exacerbations on platelet reactivity in chronic obstructive pulmonary disease patients. Int J Chron Obstruct Pulmon Dis. 2018, 13:141-8. 10.2147\/COPD.S152660","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308581","article-title":"Activity of the kynurenine pathway and its interplay with immunity in patients with pulmonary arterial hypertension","volume":"102","author":"Jasiewicz M","year":"2016","unstructured":"Jasiewicz M, Moniuszko M, Pawlak D, et al.. Activity of the kynurenine pathway and its interplay with immunity in patients with pulmonary arterial hypertension. Heart. 2016, 102:230-7. 10.1136\/heartjnl-2015-308581","journal-title":"Heart"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.06.018","article-title":"Enhanced IL-6 trans-signaling in pulmonary arterial hypertension and its potential role in disease-related systemic damage","volume":"76","author":"Jasiewicz M","year":"2015","unstructured":"Jasiewicz M, Knapp M, Waszkiewicz E, et al.. Enhanced IL-6 trans-signaling in pulmonary arterial hypertension and its potential role in disease-related systemic damage. Cytokine. 2015, 76:187-92. 10.1016\/j.cyto.2015.06.018","journal-title":"Cytokine"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.5.7735624","article-title":"Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension","volume":"151","author":"Humbert M","year":"1995","unstructured":"Humbert M, Monti G, Brenot F, et al.. Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med. 1995, 151:1628-31. 10.1164\/ajrccm.151.5.7735624","journal-title":"Am J Respir Crit Care Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3853454","article-title":"Red blood cell distribution width predicts pulmonary hypertension secondary to chronic obstructive pulmonary disease","volume":"2019","author":"Yang J","year":"2019","unstructured":"Yang J, Liu C, Li L, Tu X, Lu Z. Red blood cell distribution width predicts pulmonary hypertension secondary to chronic obstructive pulmonary disease. Can Respir J. 2019, 2019:3853454. 10.1155\/2019\/3853454","journal-title":"Can Respir J"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-23328","article-title":"Red cell distribution width as a novel prognostic marker in multiple clinical studies","volume":"24","author":"Yousefi B","year":"2020","unstructured":"Yousefi B, Sanaie S, Ghamari AA, Soleimanpour H, Karimian A, Mahmoodpoor A. Red cell distribution width as a novel prognostic marker in multiple clinical studies. Indian J Crit Care Med. 2020, 24:49-54. 10.5005\/jp-journals-10071-23328","journal-title":"Indian J Crit Care Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.067","article-title":"Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank","volume":"50","author":"Felker GM","year":"2007","unstructured":"Felker GM, Allen LA, Pocock SJ, et al.. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol. 2007, 50:40-7. 10.1016\/j.jacc.2007.02.067","journal-title":"J Am Coll Cardiol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.05.003","article-title":"Congestive hepatopathy and hypoxic hepatitis in heart failure: a cardiologist's point of view","volume":"166","author":"Kavoliuniene A","year":"2013","unstructured":"Kavoliuniene A, Vaitiekiene A, Cesnaite G. Congestive hepatopathy and hypoxic hepatitis in heart failure: a cardiologist's point of view. Int J Cardiol. 2013, 166:554-8. 10.1016\/j.ijcard.2012.05.003","journal-title":"Int J Cardiol"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1309\/LMZ1GKY9LQTVFBL7","article-title":"Red cell distribution width, revisited","volume":"44","author":"Constantino BT","year":"2013","unstructured":"Constantino BT. Red cell distribution width, revisited.  Lab Med. 2013, 44:2-9.","journal-title":"Lab Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_159_21","article-title":"Prevalence of chronic obstructive pulmonary disease in India: a systematic review and meta-analysis","volume":"38","author":"Daniel RA","year":"2021","unstructured":"Daniel RA, Aggarwal P, Kalaivani M, Gupta SK. Prevalence of chronic obstructive pulmonary disease in India: a systematic review and meta-analysis. Lung India. 2021, 38:506-13. 10.4103\/lungindia.lungindia_159_21","journal-title":"Lung India"},{"key":"ref20","unstructured":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. (2025). Accessed. July 15, 2025: https:\/\/goldcopd.org\/wp-content\/uploads\/2024\/11\/GOLD-2025-Report-v1.0-15Nov2024_WMV.pdf."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S359873","article-title":"The incidence and prevalence of pulmonary hypertension in the COPD population: a systematic review and meta-analysis","volume":"17","author":"Zhang L","year":"2022","unstructured":"Zhang L, Liu Y, Zhao S, et al.. The incidence and prevalence of pulmonary hypertension in the COPD population: a systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. 2022, 17:1365-79. 10.2147\/COPD.S359873","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.011","article-title":"Inflammatory mechanisms in patients with chronic obstructive pulmonary disease","volume":"138","author":"Barnes PJ","year":"2016","unstructured":"Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016, 138:16-27. 10.1016\/j.jaci.2016.05.011","journal-title":"J Allergy Clin Immunol"},{"key":"ref23","article-title":"Chronic obstructive pulmonary disease and its effect on red blood cell indices","volume":"13","author":"Tariq S","year":"2023","unstructured":"Tariq S, Ismail D, Thapa M, et al.. Chronic obstructive pulmonary disease and its effect on red blood cell indices. Cureus. 2023, 13:15.","journal-title":"Cureus"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2020.201.1_MeetingAbstracts.A3863","article-title":"Red cell distribution width as a marker for pulmonary hypertension in COPD: a systematic review","volume":"201","author":"Ravi D","year":"2020","unstructured":"Ravi D, Sharma N, Ochieng PO. Red cell distribution width as a marker for pulmonary hypertension in COPD: a systematic review. Am J Respir Crit Care Med. 2020, 201:A3863. 10.1164\/ajrccm-conference.2020.201.1_MeetingAbstracts.A3863","journal-title":"Am J Respir Crit Care Med"},{"key":"ref25","article-title":"Prediction of pulmonary hypertension in COPD patients based on red cell distribution width, mean platelet volume, platelet distribution width","volume":"5","author":"Venkatesh M","year":"2023","unstructured":"Venkatesh M, Suresh R, Panackal MSV, Gopinath R, Jegatheesh R. Prediction of pulmonary hypertension in COPD patients based on red cell distribution width, mean platelet volume, platelet distribution width. Int J Acad Med Pharm. 2023, 5:846-50.","journal-title":"Int J Acad Med Pharm"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/bab.2723","article-title":"Prognostic and diagnostic value of platelet distribution width in COPD patients with pulmonary hypertension: a retrospective study. [Online ahead of print]","author":"Xie X","year":"2025","unstructured":"Xie X, Wang Y, Tian S, Cao D. Prognostic and diagnostic value of platelet distribution width in COPD patients with pulmonary hypertension: a retrospective study. [Online ahead of print]. Biotechnol Appl Biochem. 2025, 10.1002\/bab.2723","journal-title":"Biotechnol Appl Biochem"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02686-1","article-title":"Platelet-lymphocyte ratio as a new predictor of in-hospital mortality in cardiac intensive care unit patients","volume":"11","author":"Zhai G","year":"2021","unstructured":"Zhai G, Wang J, Liu Y, Zhou Y. Platelet-lymphocyte ratio as a new predictor of in-hospital mortality in cardiac intensive care unit patients. Sci Rep. 2021, 11:23578. 10.1038\/s41598-021-02686-1","journal-title":"Sci Rep"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20150126","article-title":"Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are predictors of heart failure","volume":"105","author":"Durmus E","year":"2015","unstructured":"Durmus E, Kivrak T, Gerin F, Sunbul M, Sari I, Erdogan O. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are predictors of heart failure. Arq Bras Cardiol. 2015, 105:606-13. 10.5935\/abc.20150126","journal-title":"Arq Bras Cardiol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1177\/14799731211056340","article-title":"Diffusing capacity in chronic obstructive pulmonary disease assessment: a meta-analysis","volume":"18","author":"Ni Y","year":"2021","unstructured":"Ni Y, Yu Y, Dai R, Shi G. Diffusing capacity in chronic obstructive pulmonary disease assessment: a meta-analysis. Chron Respir Dis. 2021, 18:14799731211056340. 10.1177\/14799731211056340","journal-title":"Chron Respir Dis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/389935-platelet-and-red-cell-indices-a-potential-biomarker-for-predicting-pulmonary-hypertension-in-chronic-obstructive-pulmonary-disease-copd-patients","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T08:24:33Z","timestamp":1753086273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/389935-platelet-and-red-cell-indices-a-potential-biomarker-for-predicting-pulmonary-hypertension-in-chronic-obstructive-pulmonary-disease-copd-patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.88401","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,7,21]]}}}