{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:25:06Z","timestamp":1754151906430,"version":"3.41.2"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,21]]},"DOI":"10.7759\/cureus.88405","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T08:45:51Z","timestamp":1753087551000},"source":"Crossref","is-referenced-by-count":0,"title":["Serum High-sensitive C-Reactive Protein, Interleukin-6 and Malondialdehyde Levels in Acne Vulgaris and Their Correlation With Disease Severity: A Cross-Sectional Study"],"prefix":"10.7759","author":[{"given":"Sumitra","family":"Bhoi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuldip","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purnima","family":"Meher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharati","family":"Panda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhusmita","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DibyaPrakash","family":"Barik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamata","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14586","article-title":"Gut microbiota alterations in moderate to severe acne vulgaris patients","volume":"45","author":"Yan HM","year":"2018","unstructured":"Yan HM, Zhao HJ, Guo DY, Zhu PQ, Zhang CL, Jiang W. Gut microbiota alterations in moderate to severe acne vulgaris patients. J Dermatol. 2018, 45:1166-71. 10.1111\/1346-8138.14586","journal-title":"J Dermatol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14475","article-title":"Acne prevalence and associations with lifestyle: a cross-sectional online survey of adolescents\/young adults in 7 European countries","volume":"32","author":"Wolkenstein P","year":"2018","unstructured":"Wolkenstein P, Machovcov\u00e1 A, Szepietowski JC, Tennstedt D, Veraldi S, Delarue A. Acne prevalence and associations with lifestyle: a cross-sectional online survey of adolescents\/young adults in 7 European countries. J Eur Acad Dermatol Venereol. 2018, 32:298-306. 10.1111\/jdv.14475","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref3","article-title":"A comprehensive review of acne vulgaris","volume":"6","author":"Mohiuddin AK","year":"2019","unstructured":"Mohiuddin AK. A comprehensive review of acne vulgaris. Clin Res Dermatol Open Access. 2019, 6:1-34.","journal-title":"Clin Res Dermatol Open Access"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2009.08.010","article-title":"Multimodal treatment of acne, acne scars and pigmentation","volume":"27","author":"Shamban AT","year":"2009","unstructured":"Shamban AT, Narurkar VA. Multimodal treatment of acne, acne scars and pigmentation. Dermatologic Clin. 2009, 27:459-71. 10.1016\/j.det.2009.08.010","journal-title":"Dermatologic Clin"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161162","article-title":"Comparison of vitamin D levels in patients with and without acne: a case-control study combined with a randomized controlled trial","volume":"11","author":"Lim SK","year":"2016","unstructured":"Lim SK, Ha JM, Lee YH, et al.. Comparison of vitamin D levels in patients with and without acne: a case-control study combined with a randomized controlled trial. PLoS One. 2016, 11:e0161162. 10.1371\/journal.pone.0161162","journal-title":"PLoS One"},{"key":"ref6","article-title":"Biochemistry of free radicals and antioxidants","volume":"2","author":"Sisein EA","year":"2014","unstructured":"Sisein EA. Biochemistry of free radicals and antioxidants. Scholars Academic Journal of Biosciences. 2014, 2:110-8.","journal-title":"Scholars Academic Journal of Biosciences"},{"key":"ref7","article-title":"Polymorphism in the IL-8 gene promoter and the risk of acne vulgaris in a Pakistani population","volume":"14","author":"Hussain S","year":"2015","unstructured":"Hussain S, Iqbal T, Sadiq I, Feroz S, Shafique-Satti H. Polymorphism in the IL-8 gene promoter and the risk of acne vulgaris in a Pakistani population. Iran J Allergy Asthma Immunol. 2015, 14:443-9.","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840120517","article-title":"Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6","volume":"12","author":"Castell JV","year":"1990","unstructured":"Castell JV, G\u00f3mez-Lech\u00f3n MJ, David M, Fabra R, Trullenque R, Heinrich PC. Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6. Hepatology. 1990, 12:1179-86. 10.1002\/hep.1840120517","journal-title":"Hepatology"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8070987","article-title":"Potential role of the microbiome in acne: a comprehensive review","volume":"8","author":"Lee YB","year":"2019","unstructured":"Lee YB, Byun EJ, Kim HS. Potential role of the microbiome in acne: a comprehensive review. J Clin Med. 2019, 8:987. 10.3390\/jcm8070987","journal-title":"J Clin Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.07.050","article-title":"Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk","volume":"43","author":"Meier-Ewert HK","year":"2004","unstructured":"Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol. 2004, 43:678-83. 10.1016\/j.jacc.2003.07.050","journal-title":"J Am Coll Cardiol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03505.x","article-title":"Oxidative stress in acne vulgaris","volume":"24","author":"Sarici G","year":"2010","unstructured":"Sarici G, Cinar S, Armutcu F, Altinyazar C, Koca R, Tekin NS. Oxidative stress in acne vulgaris. J Eur Acad Dermatol Venereol. 2010, 24:763-7. 10.1111\/j.1468-3083.2009.03505.x","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref12","article-title":"How to calculate sample size for observational and experimental nursing research studies","volume":"10","author":"Sharma SK","year":"2020","unstructured":"Sharma SK, Mudgal SK, Thakur K, Gaur R. How to calculate sample size for observational and experimental nursing research studies. National Journal of Physiology, Pharmacy and Pharmacology. 2020, 10:1-8.","journal-title":"National Journal of Physiology, Pharmacy and Pharmacology"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00099.x","article-title":"A comparison of current acne grading systems and proposal of a novel system","volume":"36","author":"Doshi A","year":"1997","unstructured":"Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997, 36:416-8. 10.1046\/j.1365-4362.1997.00099.x","journal-title":"Int J Dermatol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.19082\/7224","article-title":"Prevalence and psychological impact of acne vulgaris among female secondary school students in Arar city, Saudi Arabia, in 2018","volume":"10","author":"Alanazi MS","year":"2018","unstructured":"Alanazi MS, Hammad SM, Mohamed AE. Prevalence and psychological impact of acne vulgaris among female secondary school students in Arar city, Saudi Arabia, in 2018. Electron Physician. 2018, 10:7224-9. 10.19082\/7224","journal-title":"Electron Physician"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44089","article-title":"Relationships between disease severity and the C-reactive protein\/albumin ratio and various hematological parameters in patients with acne vulgaris","volume":"15","author":"Pala E","year":"2023","unstructured":"Pala E, Bayraktar M. Relationships between disease severity and the C-reactive protein\/albumin ratio and various hematological parameters in patients with acne vulgaris. Cureus. 2023, 15:e44089. 10.7759\/cureus.44089","journal-title":"Cureus"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04218.x","article-title":"What's new in acne? An analysis of systematic reviews and clinically significant trials published in 2010-11","volume":"36","author":"Simpson RC","year":"2011","unstructured":"Simpson RC, Grindlay DJ, Williams HC. What's new in acne? An analysis of systematic reviews and clinically significant trials published in 2010-11. Clin Exp Dermatol. 2011, 36:840-3. 10.1111\/j.1365-2230.2011.04218.x","journal-title":"Clin Exp Dermatol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2011.00570.x","article-title":"Decrease in glutathione may be involved in pathogenesis of acne vulgaris","volume":"10","author":"Ikeno H","year":"2011","unstructured":"Ikeno H, Tochio T, Tanaka H, Nakata S. Decrease in glutathione may be involved in pathogenesis of acne vulgaris. J Cosmet Dermatol. 2011, 10:240-4. 10.1111\/j.1473-2165.2011.00570.x","journal-title":"J Cosmet Dermatol"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.19100\/jdvi.v5i3.262","article-title":"Plasma malondialdehyde levels related to acne vulgaris severity","volume":"5","author":"Puspita F","year":"2021","unstructured":"Puspita F, Jusuf NK, Yosi A. Plasma malondialdehyde levels related to acne vulgaris severity. Journal of General-Procedural Dermatology and Venereology Indonesia. 2021, 5:Article 3.","journal-title":"Journal of General-Procedural Dermatology and Venereology Indonesia"},{"key":"ref19","article-title":"High-sensitivity C-reactive protein: clinical importance","volume":"29","author":"Bassuk SS","year":"2004","unstructured":"Bassuk SS, Rifai N, Ridker PM. High-sensitivity C-reactive protein: clinical importance. Curr Probl Cardiol. 2004, 29:439-93.","journal-title":"Curr Probl Cardiol"},{"key":"ref20","article-title":"Study of oxidative stress in different clinical severities of acne vulgaris","volume":"34","author":"Garem YF","year":"2014","unstructured":"Garem YF, Ahmed RAM, Ragab MA, Abouzeid AA. Study of oxidative stress in different clinical severities of acne vulgaris. Egypt J Dermatol Venereol. 2014, 34:53-7.","journal-title":"Egypt J Dermatol Venereol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.15562\/bmj.v12i2.4239","article-title":"The correlation between interleukin-6 (IL-6) level and high sensitivity C-reactive protein (hs-CRP) level in acne vulgaris","volume":"12","author":"Nauli A","year":"2023","unstructured":"Nauli A, Putra IB, Jusuf NK. The correlation between interleukin-6 (IL-6) level and high sensitivity C-reactive protein (hs-CRP) level in acne vulgaris. Bali Medical Journal. 2023, 12:1926-9. 10.15562\/bmj.v12i2.4239","journal-title":"Bali Medical Journal"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.1016\/j.it.2012.07.003","article-title":"Interleukin-6 from an inflammatory marker to a target for inflammatory diseases","volume":"33","author":"Rincon M","year":"2012","unstructured":"Rincon M. Interleukin-6 from an inflammatory marker to a target for inflammatory diseases. Trends Immunol. 2012, 33:571-7.","journal-title":"Trends Immunol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105238","article-title":"IL-17\/Th17 pathway is activated in acne lesions","volume":"9","author":"Kelh\u00e4l\u00e4 HL","year":"2014","unstructured":"Kelh\u00e4l\u00e4 HL, Palatsi R, Fyhrquist N, et al.. IL-17\/Th17 pathway is activated in acne lesions. PLoS One. 2014, 9:e105238. 10.1371\/journal.pone.0105238","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.5114\/dr.2020.99876","article-title":"Interleukins-6, -8 and-12p40 and C-reactive protein levels in patients with acne vulgaris with various severity of skin changes","volume":"107","author":"Sta\u0144kowska A","year":"2020","unstructured":"Sta\u0144kowska A, Bergler-Czop B, Brzezi\u0144ska-Wcis\u0142o L. Interleukins-6, -8 and-12p40 and C-reactive protein levels in patients with acne vulgaris with various severity of skin changes. Dermatology Review\/Przegl\u0105d Dermatologiczny. 2020, 107:308-22. 10.5114\/dr.2020.99876","journal-title":"Dermatology Review\/Przegl\u0105d Dermatologiczny"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.12.029","article-title":"Long-term effects of systemic cancer treatment on DNA oxidative damage: the potential for targeted therapies","volume":"327","author":"Vera-Ramirez L","year":"2012","unstructured":"Vera-Ramirez L, Ramirez-Tortosa M, Perez-Lopez P, Granados-Principal S, Battino M, Quiles JL. Long-term effects of systemic cancer treatment on DNA oxidative damage: the potential for targeted therapies. Cancer Lett. 2012, 327:134-41. 10.1016\/j.canlet.2011.12.029","journal-title":"Cancer Lett"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1684\/abc.2008.0283","article-title":"Biomarkers of lipid peroxidation: analytical aspects (in French)","volume":"66","author":"Michel F","year":"2008","unstructured":"Michel F, Bonnefont-Rousselot D, Mas E, Drai J, Th\u00e9rond P. Biomarkers of lipid peroxidation: analytical aspects (in French). Ann Biol Clin (Paris). 2008, 66:605-20. 10.1684\/abc.2008.0283","journal-title":"Ann Biol Clin (Paris)"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1179\/1351000215Y.0000000015","article-title":"Oxidative stress and antioxidant strategies in dermatology","volume":"21","author":"Baek J","year":"2016","unstructured":"Baek J, Lee MG. Oxidative stress and antioxidant strategies in dermatology. Redox Rep. 2016, 21:164-9. 10.1179\/1351000215Y.0000000015","journal-title":"Redox Rep"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.05.032","article-title":"Lipid peroxidation: physiological levels and dual biological effects","volume":"47","author":"Niki E","year":"2009","unstructured":"Niki E. Lipid peroxidation: physiological levels and dual biological effects. Free Radic Biol Med. 2009, 47:469-84. 10.1016\/j.freeradbiomed.2009.05.032","journal-title":"Free Radic Biol Med"},{"key":"ref29","article-title":"Gluthathione peroxidase and malondialdehyde in skin lesion of acne vulgaris","volume":"8","author":"Moftah NH","year":"2009","unstructured":"Moftah NH, Hamad WAM, Salam FMAA, Marzouk SA, Said M. Gluthathione peroxidase and malondialdehyde in skin lesion of acne vulgaris. J Egypt Women Dermatol Soc. 2009, 8:25-9.","journal-title":"J Egypt Women Dermatol Soc"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.13181\/mji.v22i3.586","article-title":"Efficacy of Garcinia mangostana (mangosteen rind extract) to reduce acne severity","volume":"22","author":"Sutono T","year":"2013","unstructured":"Sutono T. Efficacy of Garcinia mangostana (mangosteen rind extract) to reduce acne severity. Medical Journal of Indonesia. 2013, 22:167-72. 10.13181\/mji.v22i3.586","journal-title":"Medical Journal of Indonesia"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/382452-serum-high-sensitive-c-reactive-protein-interleukin-6-and-malondialdehyde-levels-in-acne-vulgaris-and-their-correlation-with-disease-severity-a-cross-sectional-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T08:45:53Z","timestamp":1753087553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/382452-serum-high-sensitive-c-reactive-protein-interleukin-6-and-malondialdehyde-levels-in-acne-vulgaris-and-their-correlation-with-disease-severity-a-cross-sectional-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.88405","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,7,21]]}}}