{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:31:50Z","timestamp":1754152310733,"version":"3.41.2"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,21]]},"DOI":"10.7759\/cureus.88468","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:33:27Z","timestamp":1753144407000},"source":"Crossref","is-referenced-by-count":0,"title":["A Case of Primary Malignant Mixed Mesonephric Tumor of the Vagina"],"prefix":"10.7759","author":[{"given":"Shinichiro","family":"Maeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiyasu","family":"Miki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2017.11.084","article-title":"Mesonephric proliferations of the female genital tract","volume":"50","author":"Howitt BE","year":"2018","unstructured":"Howitt BE, Nucci MR. Mesonephric proliferations of the female genital tract. Pathology. 2018, 50:141-50. 10.1016\/j.pathol.2017.11.084","journal-title":"Pathology"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001142","article-title":"A comparison of GATA3, TTF1, CD10, and calretinin in identifying mesonephric and mesonephric-like carcinomas of the Gynecologic tract","volume":"42","author":"Pors J","year":"2018","unstructured":"Pors J, Cheng A, Leo JM, Kinloch MA, Gilks B, Hoang L. A comparison of GATA3, TTF1, CD10, and calretinin in identifying mesonephric and mesonephric-like carcinomas of the Gynecologic tract. Am J Surg Pathol. 2018, 42:1596-606. 10.1097\/PAS.0000000000001142","journal-title":"Am J Surg Pathol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2015.58.3.251","article-title":"Carcinosarcoma of the uterine cervix arising from M\u00fcllerian ducts","volume":"58","author":"Kim M","year":"2015","unstructured":"Kim M, Lee C, Choi H, Ko JK, Kang G, Chun KC. Carcinosarcoma of the uterine cervix arising from M\u00fcllerian ducts. Obstet Gynecol Sci. 2015, 58:251-5. 10.5468\/ogs.2015.58.3.251","journal-title":"Obstet Gynecol Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200405000-00006","article-title":"Malignant mesonephric tumors of the female genital tract: a clinicopathologic study of 9 cases","volume":"28","author":"Bagu\u00e9 S","year":"2004","unstructured":"Bagu\u00e9 S, Rodr\u00edguez IM, Prat J. Malignant mesonephric tumors of the female genital tract: a clinicopathologic study of 9 cases. Am J Surg Pathol. 2004, 28:601-7. 10.1097\/00000478-200405000-00006","journal-title":"Am J Surg Pathol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000088","article-title":"Mesonephric carcinosarcoma involving uterine cervix and vagina: report of 2 cases with immunohistochemical positivity For PAX2, PAX8, and GATA-3","volume":"33","author":"Roma AA","year":"2014","unstructured":"Roma AA. Mesonephric carcinosarcoma involving uterine cervix and vagina: report of 2 cases with immunohistochemical positivity For PAX2, PAX8, and GATA-3. Int J Gynecol Pathol. 2014, 33:624-9. 10.1097\/PGP.0000000000000088","journal-title":"Int J Gynecol Pathol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2021-002517","article-title":"Updates in the treatment of vaginal cancer","volume":"32","author":"Jhingran A","year":"2022","unstructured":"Jhingran A. Updates in the treatment of vaginal cancer. Int J Gynecol Cancer. 2022, 32:344-51. 10.1136\/ijgc-2021-002517","journal-title":"Int J Gynecol Cancer"},{"key":"ref7","unstructured":"NCCN Clinical Practice Guidelines in Oncology. caginal cancer. (2024). Accessed: July 20, 2025: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/vaginal.pdf."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199510000-00006","article-title":"Malignant mesonephric neoplasms of the uterine cervix. A report of eight cases, including four with a malignant spindle cell component","volume":"19","author":"Clement PB","year":"1995","unstructured":"Clement PB, Young RH, Keh P, Ost\u00f6r AG, Scully RE. Malignant mesonephric neoplasms of the uterine cervix. A report of eight cases, including four with a malignant spindle cell component. Am J Surg Pathol. 1995, 19:1158-71. 10.1097\/00000478-199510000-00006","journal-title":"Am J Surg Pathol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001612","article-title":"Clinicopathologic characteristics of mesonephric adenocarcinomas and mesonephric-like adenocarcinomas in the gynecologic tract: a multi-institutional study","volume":"45","author":"Pors J","year":"2021","unstructured":"Pors J, Segura S, Chiu DS, et al.. Clinicopathologic characteristics of mesonephric adenocarcinomas and mesonephric-like adenocarcinomas in the gynecologic tract: a multi-institutional study. Am J Surg Pathol. 2021, 45:498-506. 10.1097\/PAS.0000000000001612","journal-title":"Am J Surg Pathol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12144846","article-title":"Diagnosis, treatment and prognosis of mesonephric adenocarcinoma of the vagina: a literature review and a case report","volume":"12","author":"Ferrari F","year":"2023","unstructured":"Ferrari F, Omodei AS, Ferrari FA, et al.. Diagnosis, treatment and prognosis of mesonephric adenocarcinoma of the vagina: a literature review and a case report. J Clin Med. 2023, 12:4846. 10.3390\/jcm12144846","journal-title":"J Clin Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12010119","article-title":"Mesonephric adenocarcinoma of the vagina harboring TP53 mutation","volume":"12","author":"Lee H","year":"2022","unstructured":"Lee H, Kim H, Kim HS. Mesonephric adenocarcinoma of the vagina harboring TP53 mutation. Diagnostics (Basel). 2022, 12:119. 10.3390\/diagnostics12010119","journal-title":"Diagnostics (Basel)"},{"article-title":"Female Genital Tumours: WHO Classification of Tumours, 5th Edition, Volume 4","year":"2020","key":"ref12","unstructured":"Female Genital Tumours. WHO Classification of Tumours, 5th Edition, Volume 4. WHO Classification of Tumours Editorial Board (ed): International Agency for Research on Cancer, Lyon, France; 2020."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/his.12895","article-title":"Hormone receptor-negative, thyroid transcription factor 1-positive uterine and ovarian adenocarcinomas: report of a series of mesonephric-like adenocarcinomas","volume":"68","author":"McFarland M","year":"2016","unstructured":"McFarland M, Quick CM, McCluggage WG. Hormone receptor-negative, thyroid transcription factor 1-positive uterine and ovarian adenocarcinomas: report of a series of mesonephric-like adenocarcinomas. Histopathology. 2016, 68:1013-20. 10.1111\/his.12895","journal-title":"Histopathology"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000958","article-title":"Targeted genomic profiling reveals recurrent KRAS mutations in mesonephric-like adenocarcinomas of the female genital tract","volume":"42","author":"Mirkovic J","year":"2018","unstructured":"Mirkovic J, McFarland M, Garcia E, et al.. Targeted genomic profiling reveals recurrent KRAS mutations in mesonephric-like adenocarcinomas of the female genital tract. Am J Surg Pathol. 2018, 42:227-33. 10.1097\/PAS.0000000000000958","journal-title":"Am J Surg Pathol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12985-x","article-title":"Clinically relevant molecular subtypes and genomic alteration-independent differentiation in gynecologic carcinosarcoma","volume":"10","author":"Gotoh O","year":"2019","unstructured":"Gotoh O, Sugiyama Y, Takazawa Y, et al.. Clinically relevant molecular subtypes and genomic alteration-independent differentiation in gynecologic carcinosarcoma. Nat Commun. 2019, 10:4965. 10.1038\/s41467-019-12985-x","journal-title":"Nat Commun"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000861","article-title":"Comparing mortality of vaginal sarcoma, squamous cell carcinoma, and adenocarcinoma in the surveillance, epidemiology, and end results database","volume":"125","author":"Ghezelayagh T","year":"2015","unstructured":"Ghezelayagh T, Rauh-Hain JA, Growdon WB. Comparing mortality of vaginal sarcoma, squamous cell carcinoma, and adenocarcinoma in the surveillance, epidemiology, and end results database. Obstet Gynecol. 2015, 125:1353-61. 10.1097\/AOG.0000000000000861","journal-title":"Obstet Gynecol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/364399-a-case-of-primary-malignant-mixed-mesonephric-tumor-of-the-vagina","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:33:30Z","timestamp":1753144410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/364399-a-case-of-primary-malignant-mixed-mesonephric-tumor-of-the-vagina"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.88468","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,7,21]]}}}