{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:04:20Z","timestamp":1791389060902,"version":"4.3.3"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,24]]},"DOI":"10.7759\/cureus.88696","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T02:44:47Z","timestamp":1753411487000},"source":"Crossref","is-referenced-by-count":1,"title":["Reactivation of Latent Varicella-Zoster Virus Leading to Meningitis in a Patient With Malignant Pleural Mesothelioma Undergoing Immune Checkpoint Inhibitor Therapy: A Case Report"],"prefix":"10.7759","author":[{"given":"Risako","family":"Shionoya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Ishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Sugeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Ebina-Shibuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisatoshi","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.02.033","article-title":"Varicella zoster virus encephalitis mimicking nivolumab-induced autoimmune neuropathy in a patient with lung cancer","volume":"14","author":"Watanabe Y","year":"2019","unstructured":"Watanabe Y, Kikuchi R, Iwai Y, et al.. Varicella zoster virus encephalitis mimicking nivolumab-induced autoimmune neuropathy in a patient with lung cancer. J Thorac Oncol. 2019, 14:e163-5. 10.1016\/j.jtho.2019.02.033","journal-title":"J Thorac Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16081499","article-title":"Reactivation of varicella-zoster virus in patients with lung cancer receiving immune checkpoint inhibitors: retrospective nationwide population-based cohort study from South Korea","volume":"16","author":"Jung J","year":"2024","unstructured":"Jung J, Park SY, Park JY, Kim D, Lee K, Choi S. Reactivation of varicella-zoster virus in patients with lung cancer receiving immune checkpoint inhibitors: retrospective nationwide population-based cohort study from South Korea. Cancers (Basel). 2024, 16:1499. 10.3390\/cancers16081499","journal-title":"Cancers (Basel)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2021-217260","article-title":"Infections due to dysregulated immunity: an emerging complication of cancer immunotherapy","volume":"77","author":"Morelli T","year":"2022","unstructured":"Morelli T, Fujita K, Redelman-Sidi G, Elkington PT. Infections due to dysregulated immunity: an emerging complication of cancer immunotherapy. Thorax. 2022, 77:304-11. 10.1136\/thoraxjnl-2021-217260","journal-title":"Thorax"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200405210-00021","article-title":"Compartmentalization of the immune response in varicella zoster virus immune restoration disease causing transverse myelitis","volume":"18","author":"Clark BM","year":"2004","unstructured":"Clark BM, Krueger RG, Price P, French MA. Compartmentalization of the immune response in varicella zoster virus immune restoration disease causing transverse myelitis. AIDS. 2004, 18:1218-21. 10.1097\/00002030-200405210-00021","journal-title":"AIDS"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00015-09","article-title":"Immune restoration diseases reflect diverse immunopathological mechanisms","volume":"22","author":"Price P","year":"2009","unstructured":"Price P, Murdoch DM, Agarwal U, Lewin SR, Elliott JH, French MA. Immune restoration diseases reflect diverse immunopathological mechanisms. Clin Microbiol Rev. 2009, 22:651-63. 10.1128\/CMR.00015-09","journal-title":"Clin Microbiol Rev"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02512-2021","article-title":"The paradox of immune checkpoint inhibition re-activating tuberculosis","volume":"60","author":"Ahmed M","year":"2022","unstructured":"Ahmed M, Tezera LB, Elkington PT, Leslie AJ. The paradox of immune checkpoint inhibition re-activating tuberculosis. Eur Respir J. 2022, 60:2102512. 10.1183\/13993003.02512-2021","journal-title":"Eur Respir J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2024.02.002","article-title":"Cancer immunotherapy with immune checkpoint inhibitors and infections: a particular focus on mycobacterial infections","volume":"62","author":"Fujita K","year":"2024","unstructured":"Fujita K, Elkington PT. Cancer immunotherapy with immune checkpoint inhibitors and infections: a particular focus on mycobacterial infections. Respir Investig. 2024, 62:339-47. 10.1016\/j.resinv.2024.02.002","journal-title":"Respir Investig"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000239","article-title":"CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition","volume":"39","author":"Buchbinder EI","year":"2016","unstructured":"Buchbinder EI, Desai A. CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition. Am J Clin Oncol. 2016, 39:98-106. 10.1097\/COC.0000000000000239","journal-title":"Am J Clin Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-021-09976-0","article-title":"Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new challenge for internists and general practitioners","volume":"40","author":"Wojtukiewicz MZ","year":"2021","unstructured":"Wojtukiewicz MZ, Rek MM, Karpowicz K, et al.. Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new challenge for internists and general practitioners. Cancer Metastasis Rev. 2021, 40:949-82. 10.1007\/s10555-021-09976-0","journal-title":"Cancer Metastasis Rev"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-04-712612","article-title":"CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency","volume":"128","author":"Lo B","year":"2016","unstructured":"Lo B, Fritz JM, Su HC, Uzel G, Jordan MB, Lenardo MJ. CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency. Blood. 2016, 128:1037-42. 10.1182\/blood-2016-04-712612","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0042-2016","article-title":"Immune reconstitution inflammatory syndrome associated with pulmonary pathogens","volume":"26","author":"Gopal R","year":"2017","unstructured":"Gopal R, Rapaka RR, Kolls JK. Immune reconstitution inflammatory syndrome associated with pulmonary pathogens. Eur Respir Rev. 2017, 26:160042. 10.1183\/16000617.0042-2016","journal-title":"Eur Respir Rev"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0218-0","article-title":"Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance","volume":"16","author":"Martins F","year":"2019","unstructured":"Martins F, Sofiya L, Sykiotis GP, et al.. Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance. Nat Rev Clin Oncol. 2019, 16:563-80. 10.1038\/s41571-019-0218-0","journal-title":"Nat Rev Clin Oncol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1447021","article-title":"Toxicity in the era of immune checkpoint inhibitor therapy","volume":"15","author":"Keam S","year":"2024","unstructured":"Keam S, Turner N, Kugeratski FG, et al.. Toxicity in the era of immune checkpoint inhibitor therapy. Front Immunol. 2024, 15:1447021. 10.3389\/fimmu.2024.1447021","journal-title":"Front Immunol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-008591","article-title":"Chronic immune-related adverse events arising from immune checkpoint inhibitors: an update","volume":"12","author":"Fletcher K","year":"2024","unstructured":"Fletcher K, Johnson DB. Chronic immune-related adverse events arising from immune checkpoint inhibitors: an update. J Immunother Cancer. 2024, 12:e008591. 10.1136\/jitc-2023-008591","journal-title":"J Immunother Cancer"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104595","article-title":"Central nervous system complications of immune checkpoint inhibitors: a comprehensive review","volume":"206","author":"Lopes S","year":"2025","unstructured":"Lopes S, Pabst L, Bahougne T, et al.. Central nervous system complications of immune checkpoint inhibitors: a comprehensive review. Crit Rev Oncol Hematol. 2025, 206:104595. 10.1016\/j.critrevonc.2024.104595","journal-title":"Crit Rev Oncol Hematol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/390359-reactivation-of-latent-varicella-zoster-virus-leading-to-meningitis-in-a-patient-with-malignant-pleural-mesothelioma-undergoing-immune-checkpoint-inhibitor-therapy-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T02:44:48Z","timestamp":1753411488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/390359-reactivation-of-latent-varicella-zoster-virus-leading-to-meningitis-in-a-patient-with-malignant-pleural-mesothelioma-undergoing-immune-checkpoint-inhibitor-therapy-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.88696","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,24]]}}}