{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:39:32Z","timestamp":1764333572590,"version":"3.41.2"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,27]]},"DOI":"10.7759\/cureus.88838","type":"journal-article","created":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T08:18:18Z","timestamp":1753604298000},"source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of Three-Dimensional Printing in the Management of Orthopedic Sarcoma Patients: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Mohamed","family":"Elgamal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Elnewishy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohaib","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Hassanin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Noureldin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muawia Yousif","family":"Fadlelmola Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatem","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayden","family":"Chahal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.03.002","article-title":"Burden of soft-tissue and bone sarcoma in routine care: Estimation of incidence, prevalence and survival for health services research","volume":"39","author":"Trautmann F","year":"2015","unstructured":"Trautmann F, Schuler M, Schmitt J. Burden of soft-tissue and bone sarcoma in routine care: Estimation of incidence, prevalence and survival for health services research. Cancer Epidemiol. 2015, 39:440-6. 10.1016\/j.canep.2015.03.002","journal-title":"Cancer Epidemiol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/GO.21.00387","article-title":"Overview of adult sarcoma burden and clinical pathways in Brazil","volume":"8","author":"David BB","year":"2022","unstructured":"David BB, Abdon Mello C, Santos Thuler LC, de Melo AC. Overview of adult sarcoma burden and clinical pathways in Brazil. JCO Glob Oncol. 2022, 8:e2100387. 10.1200\/GO.21.00387","journal-title":"JCO Glob Oncol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal-D-23-00176","article-title":"Unplanned sarcoma excisions: Understanding how they happen","volume":"8","author":"Belzarena AC","year":"2024","unstructured":"Belzarena AC, Binitie O, Letson GD, Joyce DM. Unplanned sarcoma excisions: Understanding how they happen. J Am Acad Orthop Surg Glob Res Rev. 2024, 8:e23.00176. 10.5435\/JAAOSGlobal-D-23-00176","journal-title":"J Am Acad Orthop Surg Glob Res Rev"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2533-4","article-title":"Symptom burden and medication use in adult sarcoma patients","volume":"23","author":"Chan A","year":"2015","unstructured":"Chan A, Lim E, Ng T, Shih V, Quek R, Cheung YT. Symptom burden and medication use in adult sarcoma patients. Support Care Cancer. 2015, 23:1709-17. 10.1007\/s00520-014-2533-4","journal-title":"Support Care Cancer"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.mporth.2017.03.006","article-title":"Surgical management of primary bone sarcomas","volume":"31","author":"Cosker T","year":"2017","unstructured":"Cosker T, Gibbons CLMH. Surgical management of primary bone sarcomas. Orthop Trauma. 2017, 31:173-9. 10.1016\/j.mporth.2017.03.006","journal-title":"Orthop Trauma"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-5194-5_12","article-title":"Perioperative management of patients with bone sarcomas","author":"Rutledge J","year":"2012","unstructured":"Rutledge J, Pilarczyk MS, Yasko AW. Perioperative management of patients with bone sarcomas.  Bone Sarcoma. Lin P, Patel S (ed): Springer, Boston, MA; 2012. 203-14. 10.1007\/978-1-4614-5194-5_12"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30010084","article-title":"A planned multidisciplinary surgical approach to treat primary pelvic malignancies","volume":"30","author":"Sambri A","year":"2023","unstructured":"Sambri A, Fiore M, Rottoli M, et al.. A planned multidisciplinary surgical approach to treat primary pelvic malignancies. Curr Oncol. 2023, 30:1106-15. 10.3390\/curroncol30010084","journal-title":"Curr Oncol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v9.i9.173","article-title":"Is there consensus regarding surgical treatment of bone sarcomas?","volume":"9","author":"Baad-Hansen T","year":"2018","unstructured":"Baad-Hansen T, Freund SS, Bech BH, Keller J. Is there consensus regarding surgical treatment of bone sarcomas?. World J Orthop. 2018, 9:173-9. 10.5312\/wjo.v9.i9.173","journal-title":"World J Orthop"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1302\/1358-992X.98BSUPP_13.IOSUK2015-009","article-title":"Sarcoma awareness amongst orthopaedic and surgical trainees","volume":"98-B","author":"Neal S","year":"2016","unstructured":"Neal S, Sargazi N, Harrison W, Chandrasekar C. Sarcoma awareness amongst orthopaedic and surgical trainees. Orthop Procs. 2016, 98-B:9. 10.1302\/1358-992X.98BSUPP_13.IOSUK2015-009","journal-title":"Orthop Procs"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-66164-5.00010-6","article-title":"3D printing in orthopedic surgery","author":"Tzavellas AN","year":"2020","unstructured":"Tzavellas AN, Kenanidis E, Potoupnis M, Tsiridis E. 3D printing in orthopedic surgery. 3D Printing: Applications in Medicine and Surgery. Volume 1. Tsoulfas G, Bangeas PI, Suri JS (ed): Elsevier, Amsterdam, Netherlands; 2020. 133-141. 10.1016\/B978-0-323-66164-5.00010-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-15089-1_26","article-title":"3D printing in orthopedics","author":"Vaishya R","year":"2019","unstructured":"Vaishya R, Vaish A. 3D printing in orthopedics. General Principles of Orthopedics and Trauma. Iyer K, Khan W (ed): Springer, Cham; 2019. 391-399. 10.1007\/978-3-030-15089-1_26"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1542179","article-title":"Innovative 3D printing technologies and advanced materials revolutionizing orthopedic surgery: Current applications and future directions","volume":"13","author":"Cong B","year":"2025","unstructured":"Cong B, Zhang H. Innovative 3D printing technologies and advanced materials revolutionizing orthopedic surgery: Current applications and future directions. Front Bioeng Biotechnol. 2025, 13:1542179. 10.3389\/fbioe.2025.1542179","journal-title":"Front Bioeng Biotechnol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-023-09847-x","article-title":"3D printing technology in pediatric orthopedics: A primer for the clinician","volume":"16","author":"Wu W","year":"2023","unstructured":"Wu W, Sabharwal S, Bunker M, Sabharwal S. 3D printing technology in pediatric orthopedics: A primer for the clinician. Curr Rev Musculoskelet Med. 2023, 16:398-409. 10.1007\/s12178-023-09847-x","journal-title":"Curr Rev Musculoskelet Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1109\/EHB50910.2020.9280113","article-title":"3D prints are not a panacea, but definitely support orthopedic surgery","author":"Marinescu R","year":"2020","unstructured":"Marinescu R, Popescu D. 3D prints are not a panacea, but definitely support orthopedic surgery. 2020 International Conference on e-Health and Bioengineering (EHB), Iasi, Romania. 2020. 1-4. 10.1109\/EHB50910.2020.9280113"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2217\/3dp-2022-0001","article-title":"A review of 3D printing in orthopedic oncology","volume":"6","author":"Benady A","year":"2022","unstructured":"Benady A, Meyer JS, Freidin D, Ran Y, Golden E, Wong KC, Dadia S. A review of 3D printing in orthopedic oncology. J 3D Print Med. 2022, 6:147-61. 10.2217\/3dp-2022-0001","journal-title":"J 3D Print Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2011.02.018","article-title":"Clinical effectiveness of hemipelvic reconstruction using computer-aided custom-made prostheses after resection of malignant pelvic tumors","volume":"26","author":"Sun W","year":"2011","unstructured":"Sun W, Li J, Li Q, Li G, Cai Z. Clinical effectiveness of hemipelvic reconstruction using computer-aided custom-made prostheses after resection of malignant pelvic tumors. J Arthroplasty. 2011, 26:1508-13. 10.1016\/j.arth.2011.02.018","journal-title":"J Arthroplasty"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.58542\/jbota.v60i02.90","article-title":"A rare case of Ewing\u2019s sarcoma in a 4-year-old child treated by tumor endoprosthetics using 3D printing","volume":"60","author":"Stavrev V","year":"2023","unstructured":"Stavrev V, Stokov L, Ganev P, Georgiev G. A rare case of Ewing\u2019s sarcoma in a 4-year-old child treated by tumor endoprosthetics using 3D printing. J Bulg Orthop Trauma Assoc. 2023, 60:97-108. 10.58542\/jbota.v60i02.90","journal-title":"J Bulg Orthop Trauma Assoc"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-025-02205-y","article-title":"3D printing in orthopedic oncology \u2014 Workflow and outcomes of 59 cases","author":"Kamat A","year":"2025","unstructured":"Kamat A, Chinder P, Gopurathingal A, Hindiskere S\r\n. 3D printing in orthopedic oncology \u2014 Workflow and outcomes of 59 cases. Indian J Surg Oncol. 2025, 10.1007\/s13193-025-02205-y","journal-title":"Indian J Surg Oncol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3345\/cep.2022.00080","article-title":"Three-dimensional printing technology in orthopedic oncology","volume":"65","author":"Kim Y","year":"2022","unstructured":"Kim Y. Three-dimensional printing technology in orthopedic oncology. Clin Exp Pediatr. 2022, 65:496-7. 10.3345\/cep.2022.00080","journal-title":"Clin Exp Pediatr"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-020-04787-4","article-title":"Implementation of the three-dimensional printing technology in treatment of bone tumours: A case series","volume":"45","author":"Jovi\u010di\u0107 M\u0160","year":"2021","unstructured":"Jovi\u010di\u0107 M\u0160, Vuleti\u0107 F, Ribi\u010di\u0107 T, \u0160imuni\u0107 S, Petrovi\u0107 T, Kolund\u017ei\u0107 R. Implementation of the three-dimensional printing technology in treatment of bone tumours: A case series. Int Orthop. 2021, 45:1079-85. 10.1007\/s00264-020-04787-4","journal-title":"Int Orthop"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000001179","article-title":"Reconstruction of the upper cervical spine using a personalized 3D-printed vertebral body in an adolescent with Ewing sarcoma","volume":"41","author":"Xu N","year":"2016","unstructured":"Xu N, Wei F, Liu X, et al.. Reconstruction of the upper cervical spine using a personalized 3D-printed vertebral body in an adolescent with Ewing sarcoma. Spine (Phila Pa 1976). 2016, 41:E50-4. 10.1097\/BRS.0000000000001179","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/app11188584","article-title":"Computer assisted surgery and 3D printing in orthopaedic oncology: A lesson learned by cranio-maxillo-facial surgery","volume":"11","author":"Bianchi G","year":"2021","unstructured":"Bianchi G, Frisoni T, Spazzoli B, Lucchese A, Donati D. Computer assisted surgery and 3D printing in orthopaedic oncology: A lesson learned by cranio-maxillo-facial surgery. Appl Sci. 2021, 11:8584. 10.3390\/app11188584","journal-title":"Appl Sci"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20211124-07","article-title":"3D-printed cutting guides for resection of long bone sarcoma and intercalary allograft reconstruction","volume":"45","author":"Gasparro MA","year":"2022","unstructured":"Gasparro MA, Gusho CA, Obioha OA, Colman MW, Gitelis S, Blank AT. 3D-printed cutting guides for resection of long bone sarcoma and intercalary allograft reconstruction. Orthopedics. 2022, 45:e35-41. 10.3928\/01477447-20211124-07","journal-title":"Orthopedics"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2020.12.006","article-title":"Reconstruction with customized, 3D-printed prosthesis after resection of periacetabular Ewing's sarcoma in children using \"triradiate cartilage-based\" surgical strategy: A technical note","volume":"28","author":"Zhu D","year":"2021","unstructured":"Zhu D, Fu J, Wang L, Guo Z, Wang Z, Fan H. Reconstruction with customized, 3D-printed prosthesis after resection of periacetabular Ewing's sarcoma in children using \"triradiate cartilage-based\" surgical strategy: A technical note. J Orthop Translat. 2021, 28:108-17. 10.1016\/j.jot.2020.12.006","journal-title":"J Orthop Translat"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02374-w","article-title":"3D printing guide plate for accurate hemicortical bone tumor resection in metaphysis of distal femoral: A technical note","volume":"16","author":"Wu H","year":"2021","unstructured":"Wu H, Yang S, Liu J, et al.. 3D printing guide plate for accurate hemicortical bone tumor resection in metaphysis of distal femoral: A technical note. J Orthop Surg Res. 2021, 16:343. 10.1186\/s13018-021-02374-w","journal-title":"J Orthop Surg Res"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.935059","article-title":"Reconstruction of tumor-induced pelvic defects with customized, three-dimensional printed prostheses","volume":"12","author":"Xu S","year":"2022","unstructured":"Xu S, Guo Z, Shen Q, et al.. Reconstruction of tumor-induced pelvic defects with customized, three-dimensional printed prostheses. Front Oncol. 2022, 12:935059. 10.3389\/fonc.2022.935059","journal-title":"Front Oncol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/os.14279","article-title":"3D-printed talus-calcaneus prosthesis in treating Ewing's sarcoma: A case report","volume":"17","author":"Wang W","year":"2025","unstructured":"Wang W, An J, Lu M, et al.. 3D-printed talus-calcaneus prosthesis in treating Ewing's sarcoma: A case report. Orthop Surg. 2025, 17:288-94. 10.1111\/os.14279","journal-title":"Orthop Surg"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/srep23335","article-title":"3D-printed guiding templates for improved osteosarcoma resection","volume":"6","author":"Ma L","year":"2016","unstructured":"Ma L, Zhou Y, Zhu Y, et al.. 3D-printed guiding templates for improved osteosarcoma resection. Sci Rep. 2016, 6:23335. 10.1038\/srep23335","journal-title":"Sci Rep"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-022-05918-1","article-title":"Internal hemipelvectomy for primary bone sarcomas using intraoperative patient specific instruments - The next step in limb salvage concept","volume":"23","author":"Benady A","year":"2022","unstructured":"Benady A, Gortzak Y, Sofer S, et al.. Internal hemipelvectomy for primary bone sarcomas using intraoperative patient specific instruments - The next step in limb salvage concept. BMC Musculoskelet Disord. 2022, 23:1012. 10.1186\/s12891-022-05918-1","journal-title":"BMC Musculoskelet Disord"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2020.01.012","article-title":"Treatment of osteosarcoma of the talus with a 3D-printed talar prosthesis","volume":"60","author":"Huang J","year":"2021","unstructured":"Huang J, Xie F, Tan X, Xing W, Zheng Y, Zeng C. Treatment of osteosarcoma of the talus with a 3D-printed talar prosthesis. J Foot Ankle Surg. 2021, 60:194-8. 10.1053\/j.jfas.2020.01.012","journal-title":"J Foot Ankle Surg"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3390\/medicina61030476","article-title":"Knee-sparing resection and reconstruction surgery for bone sarcoma using 3D-surgical approach: Average of 5-year follow-up","volume":"61","author":"Benady A","year":"2025","unstructured":"Benady A, Yehiel N, Segal O, et al.. Knee-sparing resection and reconstruction surgery for bone sarcoma using 3D-surgical approach: Average of 5-year follow-up. Medicina (Kaunas). 2025, 61:476. 10.3390\/medicina61030476","journal-title":"Medicina (Kaunas)"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11050351","article-title":"Highly cancellous titanium alloy (TiAl(6)V(4)) surfaces on three-dimensionally printed, custom-made intercalary tibia prostheses: Promising short- to intermediate-term results","volume":"11","author":"Guder WK","year":"2021","unstructured":"Guder WK, Hardes J, Nottrott M, Podleska LE, Streitb\u00fcrger A. Highly cancellous titanium alloy (TiAl(6)V(4)) surfaces on three-dimensionally printed, custom-made intercalary tibia prostheses: Promising short- to intermediate-term results. J Pers Med. 2021, 11:351. 10.3390\/jpm11050351","journal-title":"J Pers Med"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.recot.2024.11.014","article-title":"[Can 3D-printed patient-specific instruments improve local control and overall survival in pelvic sarcoma? A clinical validation study]","volume":"69","author":"Fern\u00e1ndez-Fern\u00e1ndez T","year":"2025","unstructured":"Fern\u00e1ndez-Fern\u00e1ndez T, Mediavilla-Santos L, Cuervo-Dehesa M, G\u00f3mez-Larr\u00e9n E, P\u00e9rez-Ma\u00f1anes R, Calvo-Haro J. [Can 3D-printed patient-specific instruments improve local control and overall survival in pelvic sarcoma? A clinical validation study]. Rev Esp Cir Ortop Traumatol. 2025, 69:T83-90. 10.1016\/j.recot.2024.11.014","journal-title":"Rev Esp Cir Ortop Traumatol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-04697-w","article-title":"Biomechanical and clinical outcomes of 3D-printed versus modular hemipelvic prostheses for limb-salvage reconstruction following periacetabular tumor resection: A mid-term retrospective cohort study","volume":"19","author":"Hu X","year":"2024","unstructured":"Hu X, Wen Y, Lu M, et al.. Biomechanical and clinical outcomes of 3D-printed versus modular hemipelvic prostheses for limb-salvage reconstruction following periacetabular tumor resection: A mid-term retrospective cohort study. J Orthop Surg Res. 2024, 19:258. 10.1186\/s13018-024-04697-w","journal-title":"J Orthop Surg Res"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1153801","article-title":"A novel three dimensional-printed biomechanically evaluated patient-specific sacral implant in spinopelvic reconstruction after total en bloc sacrectomy","volume":"11","author":"Lv Z","year":"2023","unstructured":"Lv Z, Li J, Yang Z, Li X, Yang Q, Li Z. A novel three dimensional-printed biomechanically evaluated patient-specific sacral implant in spinopelvic reconstruction after total en bloc sacrectomy. Front Bioeng Biotechnol. 2023, 11:1153801. 10.3389\/fbioe.2023.1153801","journal-title":"Front Bioeng Biotechnol"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1233960","article-title":"A 3D-printed patient-specific modular implants for pelvic reconstruction of bone tumors involving the sacroiliac joint","volume":"11","author":"Lv Z","year":"2023","unstructured":"Lv Z, Li Z, Yang Q, Li J. A 3D-printed patient-specific modular implants for pelvic reconstruction of bone tumors involving the sacroiliac joint. Front Bioeng Biotechnol. 2023, 11:1233960. 10.3389\/fbioe.2023.1233960","journal-title":"Front Bioeng Biotechnol"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6749","article-title":"The application of 3D printed surgical guides in resection and reconstruction of malignant bone tumor","volume":"14","author":"Wang F","year":"2017","unstructured":"Wang F, Zhu J, Peng X, Su J. The application of 3D printed surgical guides in resection and reconstruction of malignant bone tumor. Oncol Lett. 2017, 14:4581-4. 10.3892\/ol.2017.6749","journal-title":"Oncol Lett"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2022.101733","article-title":"Personalized 3D-printed guide in malignant bone tumor resection and following reconstruction - 17 cases in pelvic and extremities","volume":"42","author":"Dong C","year":"2022","unstructured":"Dong C, Beglinger I, Krieg AH. Personalized 3D-printed guide in malignant bone tumor resection and following reconstruction - 17 cases in pelvic and extremities. Surg Oncol. 2022, 42:101733. 10.1016\/j.suronc.2022.101733","journal-title":"Surg Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/385077-effectiveness-of-three-dimensional-printing-in-the-management-of-orthopedic-sarcoma-patients-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T08:18:19Z","timestamp":1753604299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/385077-effectiveness-of-three-dimensional-printing-in-the-management-of-orthopedic-sarcoma-patients-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,27]]},"references-count":38,"URL":"https:\/\/doi.org\/10.7759\/cureus.88838","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,7,27]]}}}