{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:42:55Z","timestamp":1759542175591,"version":"3.41.2"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"DOI":"10.7759\/cureus.89189","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:24:55Z","timestamp":1754033095000},"source":"Crossref","is-referenced-by-count":1,"title":["Carfilzomib-Associated Thrombotic Microangiopathy in a Multiple Myeloma Patient: Complement Genetic Alterations Impact and Eculizumab Therapy"],"prefix":"10.7759","author":[{"given":"Joana","family":"Lopes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edtor","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Paulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Lisboa Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Faria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Bergantim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Fraz\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/20406207211019612","article-title":"The role of carfilzomib in relapsed\/refractory multiple myeloma","volume":"12","author":"Yee AJ","year":"2021","unstructured":"Yee AJ. The role of carfilzomib in relapsed\/refractory multiple myeloma. Ther Adv Hematol. 2021, 12:20406207211019612. 10.1177\/20406207211019612","journal-title":"Ther Adv Hematol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.20344\/amp.19037","article-title":"Multiple myeloma treatment guidelines by the Portuguese group of multiple myeloma (Article in Portugese)","volume":"36","author":"Jo\u00e3o C","year":"2023","unstructured":"Jo\u00e3o C, Bergantim R, Santos J, et al.. Multiple myeloma treatment guidelines by the Portuguese group of multiple myeloma (Article in Portugese). Acta Med Port. 2023, 36:517-26. 10.20344\/amp.19037","journal-title":"Acta Med Port"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24447","article-title":"Proteasome inhibitor associated thrombotic microangiopathy","volume":"91","author":"Yui JC","year":"2016","unstructured":"Yui JC, Van Keer J, Weiss BM, et al.. Proteasome inhibitor associated thrombotic microangiopathy. Am J Hematol. 2016, 91:E348-52. 10.1002\/ajh.24447","journal-title":"Am J Hematol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfae096","article-title":"Carfilzomib-associated thrombotic microangiopathy: clinical features and outcomes","volume":"39","author":"Joseph A","year":"2024","unstructured":"Joseph A, Harel S, Mesnard L, et al.. Carfilzomib-associated thrombotic microangiopathy: clinical features and outcomes. Nephrol Dial Transplant. 2024, 39:2067-78. 10.1093\/ndt\/gfae096","journal-title":"Nephrol Dial Transplant"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-023-03228-9","article-title":"Microangiopathy in multiple myeloma: a case of carfilzomib-induced secondary thrombotic microangiopathy successfully treated with plasma exchange and complement inhibition","volume":"24","author":"Catanese L","year":"2023","unstructured":"Catanese L, Link K, Rupprecht H. Microangiopathy in multiple myeloma: a case of carfilzomib-induced secondary thrombotic microangiopathy successfully treated with plasma exchange and complement inhibition. BMC Nephrol. 2023, 24:179. 10.1186\/s12882-023-03228-9","journal-title":"BMC Nephrol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1312353","article-title":"Syndromes of thrombotic microangiopathy","volume":"371","author":"George JN","year":"2014","unstructured":"George JN, Nester CM. Syndromes of thrombotic microangiopathy. N Engl J Med. 2014, 371:654-66. 10.1056\/NEJMra1312353","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00337","article-title":"Complement in thrombotic microangiopathies: unraveling Ariadne's thread into the labyrinth of complement Therapeutics","volume":"10","author":"Gavriilaki E","year":"2019","unstructured":"Gavriilaki E, Anagnostopoulos A, Mastellos DC. Complement in thrombotic microangiopathies: unraveling Ariadne's thread into the labyrinth of complement Therapeutics. Front Immunol. 2019, 10:337. 10.3389\/fimmu.2019.00337","journal-title":"Front Immunol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.10.014","article-title":"Renal thrombotic microangiopathy: a review","volume":"81","author":"Genest DS","year":"2023","unstructured":"Genest DS, Patriquin CJ, Licht C, John R, Reich HN. Renal thrombotic microangiopathy: a review. Am J Kidney Dis. 2023, 81:591-605. 10.1053\/j.ajkd.2022.10.014","journal-title":"Am J Kidney Dis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2019.106195","article-title":"A review of thrombotic microangiopathies in multiple myeloma","volume":"85","author":"Portuguese AJ","year":"2019","unstructured":"Portuguese AJ, Gleber C, Passero FC Jr, Lipe B. A review of thrombotic microangiopathies in multiple myeloma. Leuk Res. 2019, 85:106195. 10.1016\/j.leukres.2019.106195","journal-title":"Leuk Res"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30062-4","article-title":"Haemolytic uraemic syndrome","volume":"390","author":"Fakhouri F","year":"2017","unstructured":"Fakhouri F, Zuber J, Fr\u00e9meaux-Bacchi V, et al.. Haemolytic uraemic syndrome. Lancet. 2017, 390:681-96. 10.1016\/S0140-6736(17)30062-4","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23960","article-title":"Drug-induced thrombotic microangiopathy: experience of the Oklahoma Registry and the BloodCenter of Wisconsin","volume":"90","author":"Reese JA","year":"2015","unstructured":"Reese JA, Bougie DW, Curtis BR, Terrell DR, Vesely SK, Aster RH, George JN. Drug-induced thrombotic microangiopathy: experience of the Oklahoma Registry and the BloodCenter of Wisconsin. Am J Hematol. 2015, 90:406-10. 10.1002\/ajh.23960","journal-title":"Am J Hematol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05830519","article-title":"Complement activation and thrombotic microangiopathies","volume":"14","author":"Palomo M","year":"2019","unstructured":"Palomo M, Blasco M, Molina P, et al.. Complement activation and thrombotic microangiopathies. Clin J Am Soc Nephrol. 2019, 14:1719-32. 10.2215\/CJN.05830519","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/kidneydial2040056","article-title":"Carfilzomib-induced thrombotic microangiopathy treated with eculizumab: a case report and rapid literature review","volume":"2","author":"Pallotti F","year":"2022","unstructured":"Pallotti F, Queffeulou C, Bellal M, et al.. Carfilzomib-induced thrombotic microangiopathy treated with eculizumab: a case report and rapid literature review. Kidney Dial. 2022, 2:625-37. 10.3390\/kidneydial2040056","journal-title":"Kidney Dial"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/377276-carfilzomib-associated-thrombotic-microangiopathy-in-a-multiple-myeloma-patient-complement-genetic-alterations-impact-and-eculizumab-therapy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:24:56Z","timestamp":1754033096000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/377276-carfilzomib-associated-thrombotic-microangiopathy-in-a-multiple-myeloma-patient-complement-genetic-alterations-impact-and-eculizumab-therapy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.89189","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,1]]}}}