{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:59:23Z","timestamp":1777543163438,"version":"3.51.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,3]]},"DOI":"10.7759\/cureus.89309","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T05:53:59Z","timestamp":1754286839000},"source":"Crossref","is-referenced-by-count":1,"title":["A Randomized, Double-Blind, Placebo and Active Controlled Phase II Study to Evaluate the Safety and Efficacy of Novel Dutasteride Topical Solution (0.01%, 0.02%, and 0.05% w\/v) in Male Subjects With Androgenetic Alopecia"],"prefix":"10.7759","author":[{"given":"Veerendra Kumar","family":"Panuganti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavan","family":"Kumar Madala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkata","family":"Ramalingayya Grandhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandrasekhar","family":"Varma Alluri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javeed","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanyasi","family":"Rao KSSVV","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamatha","family":"Reddy Dundigalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_24_19","article-title":"Expert consensus on the management of androgenetic alopecia in India","volume":"11","author":"Mysore V","year":"2019","unstructured":"Mysore V, Parthasaradhi A, Kharkar RD, et al.. Expert consensus on the management of androgenetic alopecia in India. Int J Trichology. 2019, 11:101-6. 10.4103\/ijt.ijt_24_19","journal-title":"Int J Trichology"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14041195","article-title":"A three-step diagnostic algorithm for alopecia: pattern analysis in trichoscopy","volume":"14","author":"Katoulis AC","year":"2025","unstructured":"Katoulis AC, Pappa G, Sgouros D, et al.. A three-step diagnostic algorithm for alopecia: pattern analysis in trichoscopy. J Clin Med. 2025, 14:1195. 10.3390\/jcm14041195","journal-title":"J Clin Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1741037","article-title":"Psychology of hair loss patients and importance of counseling","volume":"54","author":"Dhami L","year":"2021","unstructured":"Dhami L. Psychology of hair loss patients and importance of counseling. Indian J Plast Surg. 2021, 54:411-5. 10.1055\/s-0041-1741037","journal-title":"Indian J Plast Surg"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12030893","article-title":"Integrative and mechanistic approach to the hair growth cycle and hair loss","volume":"12","author":"Natarelli N","year":"2023","unstructured":"Natarelli N, Gahoonia N, Sivamani RK. Integrative and mechanistic approach to the hair growth cycle and hair loss. J Clin Med. 2023, 12:893. 10.3390\/jcm12030893","journal-title":"J Clin Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-023-00974-4","article-title":"Use of 5-alpha reductase inhibitors in dermatology: a narrative review","volume":"13","author":"Escamilla-Cruz M","year":"2023","unstructured":"Escamilla-Cruz M, Maga\u00f1a M, Escand\u00f3n-Perez S, Bello-Chavolla OY. Use of 5-alpha reductase inhibitors in dermatology: a narrative review. Dermatol Ther (Heidelb). 2023, 13:1721-31. 10.1007\/s13555-023-00974-4","journal-title":"Dermatol Ther (Heidelb)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01378.x","article-title":"Evaluation of efficacy and safety of finasteride 1 mg in 3177 Japanese men with androgenetic alopecia","volume":"39","author":"Sato A","year":"2012","unstructured":"Sato A, Takeda A. Evaluation of efficacy and safety of finasteride 1 mg in 3177 Japanese men with androgenetic alopecia. J Dermatol. 2012, 39:27-32. 10.1111\/j.1346-8138.2011.01378.x","journal-title":"J Dermatol"},{"key":"ref7","article-title":"Finasteride in the treatment of Japanese men with male pattern hair loss","volume":"14","author":"Kawashima M","year":"2004","unstructured":"Kawashima M, Hayashi N, Igarashi A, et al.. Finasteride in the treatment of Japanese men with male pattern hair loss. Eur J Dermatol. 2004, 14:247-54.","journal-title":"Eur J Dermatol"},{"key":"ref8","article-title":"Long-term (5-year) multinational experience with finasteride 1 mg in the treatment of men with androgenetic alopecia","volume":"12","year":"2002","unstructured":"Long-term (5-year) multinational experience with finasteride 1 mg in the treatment of men with androgenetic alopecia. Eur J Dermatol. 2002, 12.38-49.","journal-title":"Eur J Dermatol"},{"key":"ref9","article-title":"Finasteride in the treatment of Taiwanese men with androgenetic alopecia: a 12-month open-label study","volume":"18","author":"Lin JH","year":"2002","unstructured":"Lin JH, Chen WC. Finasteride in the treatment of Taiwanese men with androgenetic alopecia: a 12-month open-label study. Kaohsiung J Med Sciens. 2002, 18:379-85.","journal-title":"Kaohsiung J Med Sciens"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03780.x","article-title":"Finasteride increases anagen hair in men with androgenetic alopecia","volume":"143","author":"Van Neste D","year":"2000","unstructured":"Van Neste D, Fuh V, Sanchez-Pedreno P, et al.. Finasteride increases anagen hair in men with androgenetic alopecia. Br J Dermatol. 2000, 143:804-10. 10.1046\/j.1365-2133.2000.03780.x","journal-title":"Br J Dermatol"},{"key":"ref11","article-title":"Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss","volume":"13","author":"Whiting DA","year":"2003","unstructured":"Whiting DA, Olsen EA, Savin R, et al.. Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss. Eur J Dermatol. 2003, 13:150-60.","journal-title":"Eur J Dermatol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.07.001","article-title":"Changes in hair weight in men with androgenetic alopecia after treatment with finasteride (1 mg daily): three- and 4-year results","volume":"55","author":"Price VH","year":"2006","unstructured":"Price VH, Menefee E, Sanchez M, Kaufman KD. Changes in hair weight in men with androgenetic alopecia after treatment with finasteride (1 mg daily): three- and 4-year results. J Am Acad Dermatol. 2006, 55:71-4. 10.1016\/j.jaad.2005.07.001","journal-title":"J Am Acad Dermatol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7162.865","article-title":"Male pattern androgenetic alopecia","volume":"317","author":"Sinclair R","year":"1998","unstructured":"Sinclair R. Male pattern androgenetic alopecia. BMJ. 1998, 317:865-9. 10.1136\/bmj.317.7162.865","journal-title":"BMJ"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.10.049","article-title":"A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia","volume":"70","author":"Gubelin Harcha W","year":"2014","unstructured":"Gubelin Harcha W, Barboza Mart\u00ednez J, Tsai TF, et al.. A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. J Am Acad Dermatol. 2014, 70:489-498.e3. 10.1016\/j.jaad.2013.10.049","journal-title":"J Am Acad Dermatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.188652","article-title":"Superiority of dutasteride over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: a randomized controlled open-label, evaluator-blinded study","volume":"83","author":"Shanshanwal SJ","year":"2017","unstructured":"Shanshanwal SJ, Dhurat RS. Superiority of dutasteride over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: a randomized controlled open-label, evaluator-blinded study. Indian J Dermatol Venereol Leprol. 2017, 83:47-54. 10.4103\/0378-6323.188652","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.05.007","article-title":"The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride","volume":"55","author":"Olsen EA","year":"2006","unstructured":"Olsen EA, Hordinsky M, Whiting D, et al.. The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride. J Am Acad Dermatol. 2006, 55:1014-23. 10.1016\/j.jaad.2006.05.007","journal-title":"J Am Acad Dermatol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.018","article-title":"Efficacy, safety, and tolerability of dutasteride 0.5 mg once daily in male patients with male pattern hair loss: a randomized, double-blind, placebo-controlled, phase III study","volume":"63","author":"Eun HC","year":"2010","unstructured":"Eun HC, Kwon OS, Yeon JH, et al.. Efficacy, safety, and tolerability of dutasteride 0.5 mg once daily in male patients with male pattern hair loss: a randomized, double-blind, placebo-controlled, phase III study. J Am Acad Dermatol. 2010, 63:252-8. 10.1016\/j.jaad.2009.09.018","journal-title":"J Am Acad Dermatol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S192435","article-title":"The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis","volume":"14","author":"Zhou Z","year":"2019","unstructured":"Zhou Z, Song S, Gao Z, Wu J, Ma J, Cui Y. The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis. Clin Interv Aging. 2019, 14:399-406. 10.2147\/CIA.S192435","journal-title":"Clin Interv Aging"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030330","article-title":"Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor","volume":"89","author":"Clark RV","year":"2004","unstructured":"Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB, Hobbs S. Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor. J Clin Endocrinol Metab. 2004, 89:2179-84. 10.1210\/jc.2003-030330","journal-title":"J Clin Endocrinol Metab"},{"key":"ref20","article-title":"","author":"Norwood OT","year":"1973","unstructured":"Norwood OT. Hair Transplant Surgery. Charles. C Thomas, Springfield IL; 1973."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17738","article-title":"Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial","volume":"36","author":"Piraccini BM","year":"2022","unstructured":"Piraccini BM, Blume-Peytavi U, Scarci F, et al.. Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial. J Eur Acad Dermatol Venereol. 2022, 36:286-94. 10.1111\/jdv.17738","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.10.027","article-title":"Global photographic assessment of men aged 18 to 60 years with male pattern hair loss receiving finasteride 1 mg or placebo","volume":"67","author":"Olsen EA","year":"2012","unstructured":"Olsen EA, Whiting DA, Savin R, et al.. Global photographic assessment of men aged 18 to 60 years with male pattern hair loss receiving finasteride 1 mg or placebo. J Am Acad Dermatol. 2012, 67:379-86. 10.1016\/j.jaad.2011.10.027","journal-title":"J Am Acad Dermatol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(98)70007-6","article-title":"Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group","volume":"39","author":"Kaufman KD","year":"1998","unstructured":"Kaufman KD, Olsen EA, Whiting D, et al.. Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. J Am Acad Dermatol. 1998, 39:578-89. 10.1016\/s0190-9622(98)70007-6","journal-title":"J Am Acad Dermatol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12060","article-title":"Effect of dutasteride 0.5\u00a0mg\/d in men with androgenetic alopecia recalcitrant to finasteride","volume":"53","author":"Jung JY","year":"2014","unstructured":"Jung JY, Yeon JH, Choi JW, et al.. Effect of dutasteride 0.5\u00a0mg\/d in men with androgenetic alopecia recalcitrant to finasteride. Int J Dermatol. 2014, 53:1351-7. 10.1111\/ijd.12060","journal-title":"Int J Dermatol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_262_17","article-title":"Genetic and molecular aspects of androgenetic alopecia","volume":"84","author":"Martinez-Jacobo L","year":"2018","unstructured":"Martinez-Jacobo L, Villarreal-Villarreal CD, Ortiz-L\u00f3pez R, Ocampo-Candiani J, Rojas-Mart\u00ednez A. Genetic and molecular aspects of androgenetic alopecia. Indian J Dermatol Venereol Leprol. 2018, 84:263-8. 10.4103\/ijdvl.IJDVL_262_17","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref26","article-title":"The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia","volume":"41","author":"Drake L","year":"1999","unstructured":"Drake L, Hordinsky M, Fiedler V, et al.. The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. J Am Acad Dermatol. 1999, 41:550-4.","journal-title":"J Am Acad Dermatol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/375228-a-randomized-double-blind-placebo-and-active-controlled-phase-ii-study-to-evaluate-the-safety-and-efficacy-of-novel-dutasteride-topical-solution-001-002-and-005-wv-in-male-subjects-with-androgenetic-alopecia","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T05:54:01Z","timestamp":1754286841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/375228-a-randomized-double-blind-placebo-and-active-controlled-phase-ii-study-to-evaluate-the-safety-and-efficacy-of-novel-dutasteride-topical-solution-001-002-and-005-wv-in-male-subjects-with-androgenetic-alopecia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,3]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.89309","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,3]]}}}