{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:10:21Z","timestamp":1755216621378,"version":"3.43.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,4]]},"DOI":"10.7759\/cureus.89341","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T14:41:13Z","timestamp":1754318473000},"source":"Crossref","is-referenced-by-count":0,"title":["When Carcinoembryonic Antigen Misleads: A Benign Cause of Tumor Marker Elevation"],"prefix":"10.7759","author":[{"given":"Samer","family":"Alhasan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azeez","family":"Alzafiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisham","family":"Tharwat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramia","family":"Alhasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Alrashidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000338393","article-title":"Tumor markers in clinical practice: a review focusing on common solid cancers","volume":"22","author":"Duffy MJ","year":"2013","unstructured":"Duffy MJ. Tumor markers in clinical practice: a review focusing on common solid cancers. Med Princ Pract. 2013, 22:4-11. 10.1159\/000338393","journal-title":"Med Princ Pract"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.2644","article-title":"ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer","volume":"24","author":"Locker GY","year":"2006","unstructured":"Locker GY, Hamilton S, Harris J, et al.. ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J Clin Oncol. 2006, 24:5313-27. 10.1200\/JCO.2006.08.2644","journal-title":"J Clin Oncol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-1-66","article-title":"Carcinoembryonic antigen","volume":"104","author":"Fletcher RH","year":"1986","unstructured":"Fletcher RH. Carcinoembryonic antigen. Ann Intern Med. 1986, 104:66-73. 10.7326\/0003-4819-104-1-66","journal-title":"Ann Intern Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.121.3.439","article-title":"Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques","volume":"121","author":"Gold P","year":"1965","unstructured":"Gold P, Freedman SO. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med. 1965, 121:439-62. 10.1084\/jem.121.3.439","journal-title":"J Exp Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.105601","article-title":"National Academy of Clinical Biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers","volume":"54","author":"Sturgeon CM","year":"2008","unstructured":"Sturgeon CM, Duffy MJ, Stenman UH, et al.. National Academy of Clinical Biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers. Clin Chem. 2008, 54:e11-79. 10.1373\/clinchem.2008.105601","journal-title":"Clin Chem"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1001\/jama.1975.03260040020016","article-title":"Elevated carcinoembryonic antigen levels and biliary tract obstruction","volume":"233","author":"Lurie BB","year":"1975","unstructured":"Lurie BB, Loewenstein MS, Zamcheck N. Elevated carcinoembryonic antigen levels and biliary tract obstruction. JAMA. 1975, 233:326-30.","journal-title":"JAMA"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197809)42:3+%3C1412::AID-CNCR2820420805%3E3.0.CO;2-8","article-title":"Carcinoembryonic antigen (CEA) levels in benign gastrointestinal disease states","volume":"42","author":"Loewenstein MS","year":"1978","unstructured":"Loewenstein MS, Zamcheck N. Carcinoembryonic antigen (CEA) levels in benign gastrointestinal disease states. Cancer . 1978, 42:1412-8. 10.1002\/1097-0142(197809)42:3+%3C1412::AID-CNCR2820420805%3E3.0.CO;2-8","journal-title":"Cancer"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.23.092101.134534","article-title":"Cascade effects of medical technology","volume":"23","author":"Deyo RA","year":"2002","unstructured":"Deyo RA. Cascade effects of medical technology. Annu Rev Public Health. 2002, 23:23-44. 10.1146\/annurev.publhealth.23.092101.134534","journal-title":"Annu Rev Public Health"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2012.01.010","article-title":"Cancer biomarkers","volume":"6","author":"Henry NL","year":"2012","unstructured":"Henry NL, Hayes DF. Cancer biomarkers. Mol Oncol. 2012, 6:140-6. 10.1016\/j.molonc.2012.01.010","journal-title":"Mol Oncol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.6238","article-title":"Screening for colorectal cancer: US Preventive Services Task Force recommendation statement","volume":"325","author":"Davidson KW","year":"2021","unstructured":"Davidson KW, Barry MJ, Mangione CM, et al.. Screening for colorectal cancer: US Preventive Services Task Force recommendation statement. JAMA. 2021, 325:1965-77. 10.1001\/jama.2021.6238","journal-title":"JAMA"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21457","article-title":"Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society","volume":"68","author":"Wolf AM","year":"2018","unstructured":"Wolf AM, Fontham ET, Church TR, et al.. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. CA Cancer J Clin. 2018, 68:250-81. 10.3322\/caac.21457","journal-title":"CA Cancer J Clin"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/393145-when-carcinoembryonic-antigen-misleads-a-benign-cause-of-tumor-marker-elevation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T14:41:13Z","timestamp":1754318473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/393145-when-carcinoembryonic-antigen-misleads-a-benign-cause-of-tumor-marker-elevation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":11,"URL":"https:\/\/doi.org\/10.7759\/cureus.89341","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,8,4]]}}}