{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:36:14Z","timestamp":1788021374511,"version":"build-2784847793"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,6]]},"DOI":"10.7759\/cureus.89485","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T15:57:56Z","timestamp":1754495876000},"source":"Crossref","is-referenced-by-count":2,"title":["Outcomes, Predictors of Retreatment, and Complications After Repeat Gamma Knife Radiosurgery for Trigeminal Neuralgia: A Single-Center Retrospective Cohort Study"],"prefix":"10.7759","author":[{"given":"Biljana","family":"Seha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vojislav","family":"Bogosavljevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danica","family":"Grujicic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuk","family":"Djulejic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihailo","family":"Mili\u0107evi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanda","family":"Ilic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koca","family":"Cicarevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Jovanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slobodan","family":"Kapor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.12.2347","article-title":"Trigeminal neuralgia: pathology and pathogenesis","volume":"124","author":"Love S","year":"2001","unstructured":"Love S, Coakham HB. Trigeminal neuralgia: pathology and pathogenesis. Brain. 2001, 124:2347-60. 10.1093\/brain\/124.12.2347","journal-title":"Brain"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1967.26.1part2.0159","article-title":"Arterial compression of the trigeminal nerve at the pons in patients with trigeminal neuralgia","volume":"26","author":"Jannetta PJ","year":"1967","unstructured":"Jannetta PJ. Arterial compression of the trigeminal nerve at the pons in patients with trigeminal neuralgia. J Neurosurg. 1967, 26:Suppl:159-62. 10.3171\/jns.1967.26.1part2.0159","journal-title":"J Neurosurg"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.1.117","article-title":"Trigeminal neuralgia--pathophysiology, diagnosis and current treatment","volume":"87","author":"Nurmikko TJ","year":"2001","unstructured":"Nurmikko TJ, Eldridge PR. Trigeminal neuralgia--pathophysiology, diagnosis and current treatment. Br J Anaesth. 2001, 87:117-32. 10.1093\/bja\/87.1.117","journal-title":"Br J Anaesth"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416687280","article-title":"Trigeminal neuralgia - diagnosis and treatment","volume":"37","author":"Maarbjerg S","year":"2017","unstructured":"Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G. Trigeminal neuralgia - diagnosis and treatment. Cephalalgia. 2017, 37:648-57. 10.1177\/0333102416687280","journal-title":"Cephalalgia"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/head.12441","article-title":"Trigeminal neuralgia--a prospective systematic study of clinical characteristics in 158 patients","volume":"54","author":"Maarbjerg S","year":"2014","unstructured":"Maarbjerg S, Gozalov A, Olesen J, Bendtsen L. Trigeminal neuralgia--a prospective systematic study of clinical characteristics in 158 patients. Headache. 2014, 54:1574-82. 10.1111\/head.12441","journal-title":"Headache"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g474","article-title":"Trigeminal neuralgia","volume":"348","author":"Zakrzewska JM","year":"2014","unstructured":"Zakrzewska JM, Linskey ME. Trigeminal neuralgia. BMJ. 2014, 348:g474. 10.1136\/bmj.g474","journal-title":"BMJ"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000326598.83183.04","article-title":"Practice parameter: the diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies","volume":"71","author":"Gronseth G","year":"2008","unstructured":"Gronseth G, Cruccu G, Alksne J, et al.. Practice parameter: the diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies. Neurology. 2008, 71:1183-90. 10.1212\/01.wnl.0000326598.83183.04","journal-title":"Neurology"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.57.663.16","article-title":"Long-term treatment of trigeminal neuralgia with carbamazepine","volume":"57","author":"Taylor JC","year":"1981","unstructured":"Taylor JC, Brauer S, Espir ML. Long-term treatment of trigeminal neuralgia with carbamazepine. Postgrad Med J. 1981, 57:16-8. 10.1136\/pgmj.57.663.16","journal-title":"Postgrad Med J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200201000-00007","article-title":"Stereotactic radiosurgery for the treatment of trigeminal neuralgia","volume":"18","author":"Kondziolka D","year":"2002","unstructured":"Kondziolka D, Lunsford LD, Flickinger JC. Stereotactic radiosurgery for the treatment of trigeminal neuralgia. Clin J Pain. 2002, 18:42-7. 10.1097\/00002508-200201000-00007","journal-title":"Clin J Pain"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3171\/2014.8.GKS141487","article-title":"Repeat Gamma Knife surgery for recurrent trigeminal neuralgia: long-term outcomes and systematic review","volume":"121 Suppl","author":"Tuleasca C","year":"2014","unstructured":"Tuleasca C, Carron R, Resseguier N, et al.. Repeat Gamma Knife surgery for recurrent trigeminal neuralgia: long-term outcomes and systematic review. J Neurosurg. 2014, 121 Suppl:210-21. 10.3171\/2014.8.GKS141487","journal-title":"J Neurosurg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3171\/2009.2.JNS08977","article-title":"Long-term outcomes of Gamma Knife radiosurgery for classic trigeminal neuralgia: implications of treatment and critical review of the literature. Clinical article","volume":"111","author":"Dhople AA","year":"2009","unstructured":"Dhople AA, Adams JR, Maggio WW, Naqvi SA, Regine WF, Kwok Y. Long-term outcomes of Gamma Knife radiosurgery for classic trigeminal neuralgia: implications of treatment and critical review of the literature. Clinical article. J Neurosurg. 2009, 111:351-8. 10.3171\/2009.2.JNS08977","journal-title":"J Neurosurg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.141272","article-title":"Effect of radiation dose on the outcomes of gamma knife treatment for trigeminal neuralgia: a multi-factor analysis","volume":"62","author":"Zhang X","year":"2014","unstructured":"Zhang X, Li P, Zhang S, Gong F, Yang S, Wang W. Effect of radiation dose on the outcomes of gamma knife treatment for trigeminal neuralgia: a multi-factor analysis. Neurol India. 2014, 62:400-5. 10.4103\/0028-3886.141272","journal-title":"Neurol India"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318230218e","article-title":"Repeat gamma knife radiosurgery for trigeminal neuralgia","volume":"70","author":"Park KJ","year":"2012","unstructured":"Park KJ, Kondziolka D, Berkowitz O, et al.. Repeat gamma knife radiosurgery for trigeminal neuralgia. Neurosurgery. 2012, 70:295-305. 10.1227\/NEU.0b013e318230218e","journal-title":"Neurosurgery"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2025.100969","article-title":"Outcomes and predictive factors after second stereotactic radiosurgery for refractory trigeminal neuralgia","volume":"53","author":"Loving BA","year":"2025","unstructured":"Loving BA, Oyeniyi JF, Ramanathan S, et al.. Outcomes and predictive factors after second stereotactic radiosurgery for refractory trigeminal neuralgia. Clin Transl Radiat Oncol. 2025, 53:100969. 10.1016\/j.ctro.2025.100969","journal-title":"Clin Transl Radiat Oncol"},{"key":"ref15","article-title":"Predictors of trigeminal nerve dysfunction following stereotactic radiosurgery for trigeminal neuralgia","volume":"4","author":"Lucas JT Jr","year":"2016","unstructured":"Lucas JT Jr, Huang AJ, Bourland JD, Laxton AW, Tatter SB, Chan MD. Predictors of trigeminal nerve dysfunction following stereotactic radiosurgery for trigeminal neuralgia. J Radiosurg SBRT. 2016, 4:117-23.","journal-title":"J Radiosurg SBRT"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3171\/2017.9.JNS17545","article-title":"Stereotactic radiosurgery for trigeminal neuralgia: a systematic review","volume":"130","author":"Tuleasca C","year":"2019","unstructured":"Tuleasca C, R\u00e9gis J, Sahgal A, et al.. Stereotactic radiosurgery for trigeminal neuralgia: a systematic review. J Neurosurg. 2019, 130:733-57. 10.3171\/2017.9.JNS17545","journal-title":"J Neurosurg"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.11.046","article-title":"Long-term outcome of gamma knife radiosurgery for treatment of typical trigeminal neuralgia","volume":"75","author":"Han JH","year":"2009","unstructured":"Han JH, Kim DG, Chung HT, et al.. Long-term outcome of gamma knife radiosurgery for treatment of typical trigeminal neuralgia. Int J Radiat Oncol Biol Phys. 2009, 75:822-7. 10.1016\/j.ijrobp.2008.11.046","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2021.0303","article-title":"Gamma Knife radiosurgery for trigeminal neuralgia : review and update","volume":"65","author":"Lee S","year":"2022","unstructured":"Lee S, Lee JI. Gamma Knife radiosurgery for trigeminal neuralgia : review and update. J Korean Neurosurg Soc. 2022, 65:633-9. 10.3340\/jkns.2021.0303","journal-title":"J Korean Neurosurg Soc"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3171\/2009.7.JNS09694","article-title":"Gamma Knife stereotactic radiosurgery for idiopathic trigeminal neuralgia","volume":"112","author":"Kondziolka D","year":"2010","unstructured":"Kondziolka D, Zorro O, Lobato-Polo J, Kano H, Flannery TJ, Flickinger JC, Lunsford LD. Gamma Knife stereotactic radiosurgery for idiopathic trigeminal neuralgia. J Neurosurg. 2010, 112:758-65. 10.3171\/2009.7.JNS09694","journal-title":"J Neurosurg"},{"key":"ref20","article-title":"Gamma Knife radiosurgery for trigeminal neuralgia provides greater pain relief at higher dose rates","volume":"8","author":"Yang AI","year":"2022","unstructured":"Yang AI, Mensah-Brown KG, Shekhtman EF, et al.. Gamma Knife radiosurgery for trigeminal neuralgia provides greater pain relief at higher dose rates. J Radiosurg SBRT. 2022, 8:117-25.","journal-title":"J Radiosurg SBRT"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.07.010","article-title":"Repeat gamma knife radiosurgery for trigeminal neuralgia","volume":"81","author":"Aubuchon AC","year":"2011","unstructured":"Aubuchon AC, Chan MD, Lovato JF, et al.. Repeat gamma knife radiosurgery for trigeminal neuralgia. Int J Radiat Oncol Biol Phys. 2011, 81:1059-65. 10.1016\/j.ijrobp.2010.07.010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.52662\/nf.2024.00115","article-title":"The role of Gamma Knife radiosurgery in trigeminal neuralgia management and technical considerations","volume":"20","author":"Kim J","year":"2024","unstructured":"Kim J, Yu JW, Rim J, Chang WS, Jung HH. The role of Gamma Knife radiosurgery in trigeminal neuralgia management and technical considerations. Neurofunction. 2024, 20:1-8. 10.52662\/nf.2024.00115","journal-title":"Neurofunction"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.125463","article-title":"Histopathological effects of radiosurgery on a human trigeminal nerve","volume":"4","author":"Al-Otaibi F","year":"2013","unstructured":"Al-Otaibi F, Alhindi H, Alhebshi A, Albloushi M, Baeesa S, Hodaie M. Histopathological effects of radiosurgery on a human trigeminal nerve. Surg Neurol Int. 2013, 4:S462-7. 10.4103\/2152-7806.125463","journal-title":"Surg Neurol Int"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.84.6.0940","article-title":"Stereotactic radiosurgery for trigeminal neuralgia: a multiinstitutional study using the gamma unit","volume":"84","author":"Kondziolka D","year":"1996","unstructured":"Kondziolka D, Lunsford LD, Flickinger JC, et al.. Stereotactic radiosurgery for trigeminal neuralgia: a multiinstitutional study using the gamma unit. J Neurosurg. 1996, 84:940-5. 10.3171\/jns.1996.84.6.0940","journal-title":"J Neurosurg"},{"key":"ref25","article-title":"Gamma knife radiosurgery for trigeminal neuralgia: dose-volume histograms of the brainstem and trigeminal nerve","volume":"93","author":"Brisman R","year":"2000","unstructured":"Brisman R, Mooij R. Gamma knife radiosurgery for trigeminal neuralgia: dose-volume histograms of the brainstem and trigeminal nerve. J Neurosurg. 2000, 93:155-8.","journal-title":"J Neurosurg"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-021-01474-9","article-title":"Factors affecting long-lasting pain relief after Gamma Knife radiosurgery for trigeminal neuralgia: a single institutional analysis and literature review","volume":"44","author":"Barzaghi LR","year":"2021","unstructured":"Barzaghi LR, Albano L, Scudieri C, Gigliotti CR, Del Vecchio A, Mortini P. Factors affecting long-lasting pain relief after Gamma Knife radiosurgery for trigeminal neuralgia: a single institutional analysis and literature review. Neurosurg Rev. 2021, 44:2797-808. 10.1007\/s10143-021-01474-9","journal-title":"Neurosurg Rev"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3171\/2015.2.JNS142144","article-title":"Long-term safety and efficacy of Gamma Knife surgery in classical trigeminal neuralgia: a 497-patient historical cohort study","volume":"124","author":"R\u00e9gis J","year":"2016","unstructured":"R\u00e9gis J, Tuleasca C, Resseguier N, Carron R, Donnet A, Gaudart J, Levivier M. Long-term safety and efficacy of Gamma Knife surgery in classical trigeminal neuralgia: a 497-patient historical cohort study. J Neurosurg. 2016, 124:1079-87. 10.3171\/2015.2.JNS142144","journal-title":"J Neurosurg"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.12.1524","article-title":"Gamma knife radiosurgery for trigeminal neuralgia: results and expectations","volume":"55","author":"Kondziolka D","year":"1998","unstructured":"Kondziolka D, Perez B, Flickinger JC, Habeck M, Lunsford LD. Gamma knife radiosurgery for trigeminal neuralgia: results and expectations. Arch Neurol. 1998, 55:1524-9. 10.1001\/archneur.55.12.1524","journal-title":"Arch Neurol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/395269-outcomes-predictors-of-retreatment-and-complications-after-repeat-gamma-knife-radiosurgery-for-trigeminal-neuralgia-a-single-center-retrospective-cohort-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T15:57:57Z","timestamp":1754495877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/395269-outcomes-predictors-of-retreatment-and-complications-after-repeat-gamma-knife-radiosurgery-for-trigeminal-neuralgia-a-single-center-retrospective-cohort-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":28,"URL":"https:\/\/doi.org\/10.7759\/cureus.89485","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,6]]}}}