{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:43:42Z","timestamp":1755222222456,"version":"3.43.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,10]]},"DOI":"10.7759\/cureus.89721","type":"journal-article","created":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T09:20:41Z","timestamp":1754817641000},"source":"Crossref","is-referenced-by-count":0,"title":["Oral Manifestations in Children With Neutropenia: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Esther","family":"Kirubakaran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushmita","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"K","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selvakumar","family":"Haridoss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavitha","family":"Swaminathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkPediatriArs.2015.2295","article-title":"Approach to the patient with neutropenia in childhood","volume":"50","author":"Celkan T","year":"2015","unstructured":"Celkan T, Ko\u00e7 B\u015e. Approach to the patient with neutropenia in childhood. Turk Pediatri Ars. 2015, 50:136-44. 10.5152\/TurkPediatriArs.2015.2295","journal-title":"Turk Pediatri Ars"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13210","article-title":"How I investigate neutropenia","volume":"42 Suppl 1","author":"Frater JL","year":"2020","unstructured":"Frater JL. How I investigate neutropenia. Int J Lab Hematol. 2020, 42 Suppl 1:121-32. 10.1111\/ijlh.13210","journal-title":"Int J Lab Hematol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2018.10.003","article-title":"Congenital neutropenia and primary immunodeficiency diseases","volume":"133","author":"Spoor J","year":"2019","unstructured":"Spoor J, Farajifard H, Rezaei N. Congenital neutropenia and primary immunodeficiency diseases. Crit Rev Oncol Hematol. 2019, 133:149-62. 10.1016\/j.critrevonc.2018.10.003","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.17796\/1053-4625-43.1.9","article-title":"Oral manifestations of autoimmune neutropenia: a case report","volume":"43","author":"Dixon CC","year":"2019","unstructured":"Dixon CC, Thomson FJ, Barry SM. Oral manifestations of autoimmune neutropenia: a case report. J Clin Pediatr Dent. 2019, 43:46-50. 10.17796\/1053-4625-43.1.9","journal-title":"J Clin Pediatr Dent"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2023.125312","article-title":"Manifestation of severe congenital neutropenia in the oral cavity. Case report","volume":"48","author":"Krasuska-S\u0142awi\u0144ska E","year":"2013","unstructured":"Krasuska-S\u0142awi\u0144ska E, Klaudel-Dreszler M, Minota M, Po\u017cyczka-Fedor M, Olczak-Kowalczyk D, Minko-Chojnowska I. Manifestation of severe congenital neutropenia in the oral cavity. Case report. Cent Eur J Immunol. 2013, 48:70-4. 10.5114\/ceji.2023.125312","journal-title":"Cent Eur J Immunol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2012.10.004","article-title":"ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology","volume":"27","author":"Horwitz MS","year":"2013","unstructured":"Horwitz MS, Corey SJ, Grimes HL, Tidwell T. ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology. Hematol Oncol Clin North Am. 2013, 27:19-41, vii. 10.1016\/j.hoc.2012.10.004","journal-title":"Hematol Oncol Clin North Am"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1978.tb01908.x","article-title":"Gingivo-periodontal manifestations in chronic benign neutropenia","volume":"5","author":"Reichart PA","year":"1978","unstructured":"Reichart PA, Dornow H. Gingivo-periodontal manifestations in chronic benign neutropenia. J Clin Periodontol. 1978, 5:74-80. 10.1111\/j.1600-051x.1978.tb01908.x","journal-title":"J Clin Periodontol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.1998.tb00144.x","article-title":"A case of chronic severe neutropenia: oral findings and consequences of short-term granulocyte colony-stimulating factor treatment","volume":"43","author":"Hast\u00fcrk H","year":"1998","unstructured":"Hast\u00fcrk H, Tezcan I, Yel L, Ersoy F, Sanal O, Yamalik N, Berker E. A case of chronic severe neutropenia: oral findings and consequences of short-term granulocyte colony-stimulating factor treatment. Aust Dent J. 1998, 43:9-13. 10.1111\/j.1834-7819.1998.tb00144.x","journal-title":"Aust Dent J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.37.3.n8k0111177074828","article-title":"Cyclic neutropenia presenting as recurrent oral ulcers and periodontitis","volume":"37","author":"Chen Y","year":"2013","unstructured":"Chen Y, Fang L, Yang X. Cyclic neutropenia presenting as recurrent oral ulcers and periodontitis. J Clin Pediatr Dent. 2013, 37:307-8. 10.17796\/jcpd.37.3.n8k0111177074828","journal-title":"J Clin Pediatr Dent"},{"key":"ref10","unstructured":"World Health Organization. Adolescent health. (2022). Accessed. July 23, 2025: https:\/\/www.who.int\/health-topics\/adolescent-health."},{"key":"ref11","article-title":"Interrater reliability: the kappa statistic","volume":"22","author":"McHugh ML","year":"2012","unstructured":"McHugh ML. Interrater reliability: the kappa statistic. Biochem Med (Zagreb). 2012, 22:276-82.","journal-title":"Biochem Med (Zagreb)"},{"key":"ref12","article-title":"Critical appraisal tools","author":"Moola S","year":"2020","unstructured":"Moola S, Munn Z, Tufanaru C, et al.. Critical appraisal tools. JBI Manual for Evidence Synthesis. Aromataris E, Lockwood C, Porritt K, Pilla B, Jordan Z (ed): Joanna Briggs Institute, Adelaide, Australia; 2020."},{"key":"ref13","article-title":"The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses","author":"Wells GA","year":"2014","unstructured":"Wells GA, Shea B, O\u2019Connell D, et al.. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Ottawa Hospital Research Institute, Ottawa, Canada; 2014."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2012.00299.x","article-title":"Oral health comparison between children with neutropenia and healthy controls","volume":"34","author":"Park MS","year":"2014","unstructured":"Park MS, Tenenbaum HC, Dror Y, Gloguaer M. Oral health comparison between children with neutropenia and healthy controls. Spec Care Dentist. 2014, 34:12-8. 10.1111\/j.1754-4505.2012.00299.x","journal-title":"Spec Care Dentist"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9572-0","article-title":"Mutations in the ELANE gene are associated with development of periodontitis in patients with severe congenital neutropenia","volume":"31","author":"Ye Y","year":"2011","unstructured":"Ye Y, Carlsson G, Wondimu B, et al.. Mutations in the ELANE gene are associated with development of periodontitis in patients with severe congenital neutropenia. J Clin Immunol. 2011, 31:936-45. 10.1007\/s10875-011-9572-0","journal-title":"J Clin Immunol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-007-9106-y","article-title":"The clinical, immunohematological, and molecular study of Iranian patients with severe congenital neutropenia","volume":"27","author":"Rezaei N","year":"2007","unstructured":"Rezaei N, Moin M, Pourpak Z, et al.. The clinical, immunohematological, and molecular study of Iranian patients with severe congenital neutropenia. J Clin Immunol. 2007, 27:525-33. 10.1007\/s10875-007-9106-y","journal-title":"J Clin Immunol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2011.38.2.106","article-title":"Case report of a family with benign familial neutropenia and the implications for the general dental practitioner","volume":"38","author":"Casey C","year":"2011","unstructured":"Casey C, Brooke T, Davies R, Franklin D. Case report of a family with benign familial neutropenia and the implications for the general dental practitioner. Dent Update. 2011, 38:106-8, 110. 10.12968\/denu.2011.38.2.106","journal-title":"Dent Update"},{"key":"ref18","article-title":"Severe congenital neutropenia in 2 siblings of consanguineous parents. The role of HAX1 deficiency","volume":"19","author":"Mamishi S","year":"2009","unstructured":"Mamishi S, Esfahani SA, Parvaneh N, Diestelhorst J, Rezaei N. Severe congenital neutropenia in 2 siblings of consanguineous parents. The role of HAX1 deficiency. J Investig Allergol Clin Immunol. 2009, 19:500-3.","journal-title":"J Investig Allergol Clin Immunol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050191","article-title":"Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia","volume":"77","author":"Carlsson G","year":"2006","unstructured":"Carlsson G, Wahlin YB, Johansson A, et al.. Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. J Periodontol. 2006, 77:744-51. 10.1902\/jop.2006.050191","journal-title":"J Periodontol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.31.2.x78245364736262k","article-title":"Dental findings and treatment in consanguinity associated congenital chronic familial neutropenia","volume":"31","author":"Buduneli N","year":"2006","unstructured":"Buduneli N, Cogulu D, Kardesler L, K\u00fct\u00fck\u00e7\u00fcler N. Dental findings and treatment in consanguinity associated congenital chronic familial neutropenia. J Clin Pediatr Dent. 2006, 31:123-6. 10.17796\/jcpd.31.2.x78245364736262k","journal-title":"J Clin Pediatr Dent"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.5.837","article-title":"Periodontal status in two siblings with severe congenital neutropenia: diagnosis and mutational analysis of the cases","volume":"76","author":"Hakki SS","year":"2005","unstructured":"Hakki SS, Aprikyan AA, Yildirim S, et al.. Periodontal status in two siblings with severe congenital neutropenia: diagnosis and mutational analysis of the cases. J Periodontol. 2005, 76:837-44. 10.1902\/jop.2005.76.5.837","journal-title":"J Periodontol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.6.566","article-title":"Periodontal disease in three siblings with familial neutropenia","volume":"64","author":"Kirstil\u00e4 V","year":"1993","unstructured":"Kirstil\u00e4 V, Sew\u00f3n L, Laine J. Periodontal disease in three siblings with familial neutropenia. J Periodontol. 1993, 64:566-70. 10.1902\/jop.1993.64.6.566","journal-title":"J Periodontol"},{"key":"ref23","article-title":"Cyclic neutropenia: case report of two siblings","volume":"5","author":"Long LM Jr","year":"1983","unstructured":"Long LM Jr, Jacoway JR, Bawden JW. Cyclic neutropenia: case report of two siblings. Pediatr Dent. 1983, 5:142-4.","journal-title":"Pediatr Dent"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.62347\/OLFS3168","article-title":"Cyclic neutropenia: a case report and literature review","volume":"17","author":"Li JL","year":"2025","unstructured":"Li JL, Zhao JJ, Li RJ, Zhao L, Ma Y, Liu JP, Wang YM. Cyclic neutropenia: a case report and literature review. Am J Transl Res. 2025, 17:1153-61. 10.62347\/OLFS3168","journal-title":"Am J Transl Res"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000039086","article-title":"Oral health management in children with severe congenital neutropenia with periodontitis: case report","volume":"103","author":"Tao SY","year":"2024","unstructured":"Tao SY, Yao M, Dong YL, Lin XJ, Sunchuri D, Guo ZL. Oral health management in children with severe congenital neutropenia with periodontitis: case report. Medicine (Baltimore). 2024, 103:e39086. 10.1097\/MD.0000000000039086","journal-title":"Medicine (Baltimore)"},{"key":"ref26","article-title":"Severe periodontitis in a patient with cyclic neutropenia: a case report of long-term follow-up","volume":"15","author":"Lu RF","year":"2012","unstructured":"Lu RF, Meng HX. Severe periodontitis in a patient with cyclic neutropenia: a case report of long-term follow-up. Chin J Dent Res. 2012, 15:159-63.","journal-title":"Chin J Dent Res"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.060076","article-title":"Periodontitis as a manifestation of chronic benign neutropenia","volume":"77","author":"Zaromb A","year":"2006","unstructured":"Zaromb A, Chamberlain D, Schoor R, Almas K, Blei F. Periodontitis as a manifestation of chronic benign neutropenia. J Periodontol. 2006, 77:1921-6. 10.1902\/jop.2006.060076","journal-title":"J Periodontol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1998.tb02518.x","article-title":"Subgingival microflora and treatment in prepubertal periodontitis associated with chronic idiopathic neutropenia","volume":"25","author":"Kamma JJ","year":"1998","unstructured":"Kamma JJ, Lygidakis NA, Nakou M. Subgingival microflora and treatment in prepubertal periodontitis associated with chronic idiopathic neutropenia. J Clin Periodontol. 1998, 25:759-65. 10.1111\/j.1600-051x.1998.tb02518.x","journal-title":"J Clin Periodontol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1983.tb02209.x","article-title":"Periodontal status associated with chronic neutropenia","volume":"10","author":"Baehni PC","year":"1983","unstructured":"Baehni PC, Payot P, Tsai CC, Cimasoni G. Periodontal status associated with chronic neutropenia. J Clin Periodontol. 1983, 10:222-30. 10.1111\/j.1600-051x.1983.tb02209.x","journal-title":"J Clin Periodontol"},{"key":"ref30","article-title":"Periodontal changes associated with chronic idiopathic neutropenia","volume":"3","author":"Kalkwarf KL","year":"1981","unstructured":"Kalkwarf KL, Gutz DP. Periodontal changes associated with chronic idiopathic neutropenia. Pediatr Dent. 1981, 3:189-95.","journal-title":"Pediatr Dent"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-015-0352-5","article-title":"Cyclic neutropenia with a novel gene mutation presenting with a necrotizing soft tissue infection and severe sepsis: case report","volume":"15","author":"Boo YJ","year":"2015","unstructured":"Boo YJ, Nam MH, Lee EH, Lee KC. Cyclic neutropenia with a novel gene mutation presenting with a necrotizing soft tissue infection and severe sepsis: case report. BMC Pediatr. 2015, 15:34. 10.1186\/s12887-015-0352-5","journal-title":"BMC Pediatr"},{"key":"ref32","article-title":"Periodontal disease as a manifestation of cyclic neutropenia: case report with a 34-year follow-up","volume":"3","author":"Costello L","year":"2020","unstructured":"Costello L, McNamara C, MacCarthy D. Periodontal disease as a manifestation of cyclic neutropenia: case report with a 34-year follow-up. J Ir Dent Assoc. 2020, 3:66.","journal-title":"J Ir Dent Assoc"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201900058","article-title":"Dysbiosis of the oral ecosystem in severe congenital neutropenia patients","volume":"14","author":"Zaura E","year":"2020","unstructured":"Zaura E, Brandt BW, Buijs MJ, et al.. Dysbiosis of the oral ecosystem in severe congenital neutropenia patients. Proteomics Clin Appl. 2020, 14:e1900058. 10.1002\/prca.201900058","journal-title":"Proteomics Clin Appl"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/399256-oral-manifestations-in-children-with-neutropenia-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T09:20:43Z","timestamp":1754817643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/399256-oral-manifestations-in-children-with-neutropenia-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,10]]},"references-count":33,"URL":"https:\/\/doi.org\/10.7759\/cureus.89721","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,10]]}}}