{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:04:45Z","timestamp":1785535485638,"version":"3.56.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,10]]},"DOI":"10.7759\/cureus.89760","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T05:20:16Z","timestamp":1754889616000},"source":"Crossref","is-referenced-by-count":1,"title":["A Rare Cause of Primary Amenorrhea in Adolescence: A Case Report"],"prefix":"10.7759","author":[{"given":"Alexandra","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Salgueiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita S","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-1487","article-title":"Management of endocrine disease: Diagnosis and management of primary amenorrhea and female delayed puberty","volume":"184","author":"Sepp\u00e4 S","year":"2021","unstructured":"Sepp\u00e4 S, Kuiri-H\u00e4nninen T, Holopainen E, Voutilainen R. Management of endocrine disease: Diagnosis and management of primary amenorrhea and female delayed puberty. Eur J Endocrinol. 2021, 184:R225-42. 10.1530\/EJE-20-1487","journal-title":"Eur J Endocrinol"},{"key":"ref2","article-title":"Amenorrhea: a systematic approach to diagnosis and management","volume":"100","author":"Klein DA","year":"2019","unstructured":"Klein DA, Paradise SL, Reeder RM. Amenorrhea: a systematic approach to diagnosis and management. Am Acad Fam Phys. 2019, 100:","journal-title":"Am Acad Fam Phys"},{"key":"ref3","unstructured":"Congenital anomalies of the hymen and vagina. (2025). https.\/\/www.uptodate.com\/contents\/congenital-anomalies-of-the-hymen-and-vagina?search=rokitansky+mayer+hauser+syndrom...."},{"key":"ref4","doi-asserted-by":"crossref","DOI":"10.3390\/endocrines4030038","article-title":"Primary amenorrhea in adolescents: approach to diagnosis and management","volume":"4","author":"Gaspari L","year":"2023","unstructured":"Gaspari L, Paris F, Kalfa N, Sultan C. Primary amenorrhea in adolescents: approach to diagnosis and management. Endocrines. 2023, 4:536-47.","journal-title":"Endocrines"},{"key":"ref5","article-title":"Primary Amenorrhea","author":"Gasner A","year":"2020","unstructured":"Gasner A, Rehman A. Primary Amenorrhea. StatPearls, Treasure Island, FL; 2020."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12883","article-title":"Genetics of Mayer-Rokitansky-K\u00fcster-Hauser (MRKH) syndrome","volume":"91","author":"Fontana L","year":"2017","unstructured":"Fontana L, Gentilin B, Fedele L, Gervasini C, Miozzo M. Genetics of Mayer-Rokitansky-K\u00fcster-Hauser (MRKH) syndrome. Clin Genet. 2017, 91:233-46. 10.1111\/cge.12883","journal-title":"Clin Genet"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01491-9","article-title":"Mayer-Rokitansky-K\u00fcster-Hauser (MRKH) syndrome: a comprehensive update","volume":"15","author":"Herlin MK","year":"2020","unstructured":"Herlin MK, Petersen MB, Br\u00e4nnstr\u00f6m M. Mayer-Rokitansky-K\u00fcster-Hauser (MRKH) syndrome: a comprehensive update. Orphanet J Rare Dis. 2020, 15:214. 10.1186\/s13023-020-01491-9","journal-title":"Orphanet J Rare Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-022-0969-3","article-title":"Update on Mayer-Rokitansky-K\u00fcster-Hauser syndrome","volume":"16","author":"Chen N","year":"2022","unstructured":"Chen N, Song S, Bao X, Zhu L. Update on Mayer-Rokitansky-K\u00fcster-Hauser syndrome. Front Med. 2022, 16:859-72. 10.1007\/s11684-022-0969-3","journal-title":"Front Med"},{"key":"ref9","unstructured":"Mayer-Rokitansky-K\u00fcster-Hauser syndrome. (2015). https.\/\/www.orpha.net\/en\/disease\/detail\/3109."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-024-07830-6","article-title":"Davydov-Moore vaginoplasty in Mayer-Rokitansky-K\u00fcster-Hauser syndrome: sexual and surgical outcomes","volume":"312","author":"Pir\u00f3g M","year":"2025","unstructured":"Pir\u00f3g M, Bednarczyk M, Barabasz K, Kacalska-Janssen O, Jach R. Davydov-Moore vaginoplasty in Mayer-Rokitansky-K\u00fcster-Hauser syndrome: sexual and surgical outcomes. Arch Gynecol Obstet. 2025, 312:119-24. 10.1007\/s00404-024-07830-6","journal-title":"Arch Gynecol Obstet"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/399510-a-rare-cause-of-primary-amenorrhea-in-adolescence-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T05:20:17Z","timestamp":1754889617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/399510-a-rare-cause-of-primary-amenorrhea-in-adolescence-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,10]]},"references-count":10,"URL":"https:\/\/doi.org\/10.7759\/cureus.89760","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,10]]}}}