{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:04:04Z","timestamp":1770455044890,"version":"3.49.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,14]]},"DOI":"10.7759\/cureus.90081","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T16:05:16Z","timestamp":1755187516000},"source":"Crossref","is-referenced-by-count":0,"title":["Congenital Inferior Vena Cava Atresia Unmasked by Pyrexia and Extensive Bilateral Deep Vein Thrombosis in a Young Adult With MTHFR Mutation"],"prefix":"10.7759","author":[{"given":"Daya","family":"Mani Jacob","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divyashri","family":"Ramanathan Nagarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawan","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niyas Khalid","family":"Ottu Para","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.18-2-170","article-title":"Pyrexia of unknown origin","volume":"18","author":"Fernandez C","year":"2018","unstructured":"Fernandez C, Beeching NJ. Pyrexia of unknown origin. Clin Med (Lond). 2018, 18:170-4. 10.7861\/clinmedicine.18-2-170","journal-title":"Clin Med (Lond)"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4965458","article-title":"The typical presentation spectrum of deep vein thrombosis associated with Inferior Vena Cava malformations","volume":"2016","author":"Pozzi A","year":"2016","unstructured":"Pozzi A, El Lakis MA, Chamieh J, Carbonell BB, Villa F. The typical presentation spectrum of deep vein thrombosis associated with Inferior Vena Cava malformations. Thrombosis. 2016, 2016:4965458. 10.1155\/2016\/4965458","journal-title":"Thrombosis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1278377","article-title":"A rare cause of venous thrombosis: Congenital absence (agenesis) of the inferior vena cava","volume":"19","author":"Singh K","year":"2010","unstructured":"Singh K, Poliquin J, Syversten G, Kohler DO. A rare cause of venous thrombosis: Congenital absence (agenesis) of the inferior vena cava. Int J Angiol. 2010, 19:e110-2. 10.1055\/s-0031-1278377","journal-title":"Int J Angiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.75385","article-title":"The impact of inferior vena cava anomalies on deep vein thrombosis: a case report","volume":"16","author":"Mansha WM","year":"2024","unstructured":"Mansha WM, Eftekharzadeh P, Ahmed S. The impact of inferior vena cava anomalies on deep vein thrombosis: a case report. Cureus. 2024, 16:e75385. 10.7759\/cureus.75385","journal-title":"Cureus"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2023.07.002","article-title":"Systematic review of inferior vena cava atresia","volume":"11","author":"Saab K","year":"2023","unstructured":"Saab K, Brahmandam AS, Brackett AL, Desai MM, Dardik A, Guzman RJ, Chaar CI. Systematic review of inferior vena cava atresia. J Vasc Surg Venous Lymphat Disord. 2023, 11:1253-64. 10.1016\/j.jvsv.2023.07.002","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.180.3.1800729","article-title":"Congenital anomalies of the inferior vena cava revealed on CT in patients with deep vein thrombosis","volume":"180","author":"Gayer G","year":"2003","unstructured":"Gayer G, Luboshitz J, Hertz M, et al.. Congenital anomalies of the inferior vena cava revealed on CT in patients with deep vein thrombosis. AJR Am J Roentgenol. 2003, 180:729-32. 10.2214\/ajr.180.3.1800729","journal-title":"AJR Am J Roentgenol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-1-200201010-00009","article-title":"Anomalies of the inferior vena cava in patients with iliac venous thrombosis","volume":"136","author":"Obernosterer A","year":"2002","unstructured":"Obernosterer A, Aschauer M, Schnedl W, Lipp RW. Anomalies of the inferior vena cava in patients with iliac venous thrombosis. Ann Intern Med. 2002, 136:37-41. 10.7326\/0003-4819-136-1-200201010-00009","journal-title":"Ann Intern Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.001","article-title":"Thrombophilia and pregnancy complications","volume":"191","author":"Kujovich JL","year":"2004","unstructured":"Kujovich JL. Thrombophilia and pregnancy complications. Am J Obstet Gynecol. 2004, 191:412-24. 10.1016\/j.ajog.2004.03.001","journal-title":"Am J Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.16.2023","article-title":"MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis","volume":"288","author":"Klerk M","year":"2002","unstructured":"Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG. MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA. 2002, 288:2023-31. 10.1001\/jama.288.16.2023","journal-title":"JAMA"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20200860","article-title":"Meta-analysis of the relationship between methylenetetrahydrofolate reductase C677T and A1298C polymorphism and venous thromboembolism in the Caucasian and Asian","volume":"40","author":"Gao M","year":"2020","unstructured":"Gao M, Feng N, Zhang M, Ti X, Zuo X. Meta-analysis of the relationship between methylenetetrahydrofolate reductase C677T and A1298C polymorphism and venous thromboembolism in the Caucasian and Asian. Biosci Rep. 2020, 40:10.1042\/BSR20200860","journal-title":"Biosci Rep"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2021.1920404","article-title":"Mediastinal lymphadenopathy: a practical approach","volume":"15","author":"Iyer H","year":"2021","unstructured":"Iyer H, Anand A, Sryma PB, et al.. Mediastinal lymphadenopathy: a practical approach. Expert Rev Respir Med. 2021, 15:1317-34. 10.1080\/17476348.2021.1920404","journal-title":"Expert Rev Respir Med"},{"key":"ref12","article-title":"Thrombosis","author":"Ashorobi D","year":"2024","unstructured":"Ashorobi D, Ameer MA, Fernandez R. Thrombosis. StatPearls. StatPearls Publishing, Treasure Island, FL; 2024."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000288","article-title":"Patients with inferior vena cava thrombosis frequently present with lower back pain and bilateral lower-extremity deep vein thrombosis","volume":"42","author":"Kraft C","year":"2013","unstructured":"Kraft C, Hecking C, Schwonberg J, Schindewolf M, Lindhoff-Last E, Linnemann B. Patients with inferior vena cava thrombosis frequently present with lower back pain and bilateral lower-extremity deep vein thrombosis. Vasa. 2013, 42:275-83. 10.1024\/0301-1526\/a000288","journal-title":"Vasa"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/396546-congenital-inferior-vena-cava-atresia-unmasked-by-pyrexia-and-extensive-bilateral-deep-vein-thrombosis-in-a-young-adult-with-mthfr-mutation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T16:05:16Z","timestamp":1755187516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/396546-congenital-inferior-vena-cava-atresia-unmasked-by-pyrexia-and-extensive-bilateral-deep-vein-thrombosis-in-a-young-adult-with-mthfr-mutation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.90081","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,14]]}}}