{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:18:18Z","timestamp":1762255098545,"version":"3.44.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,18]]},"DOI":"10.7759\/cureus.90436","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T03:48:56Z","timestamp":1755575336000},"source":"Crossref","is-referenced-by-count":1,"title":["Effect of Negative Pressure Therapy on Skin Blood Flow Responses in Scar Tissue"],"prefix":"10.7759","author":[{"given":"Wei-Cheng","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsu-Tang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yih-Kuen","family":"Jan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben-Yi","family":"Liau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Ming","family":"Lien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Guo","family":"Bau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hung","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congo T","family":"Ching","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Wen","family":"Lung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: a cellular perspective","volume":"99","author":"Rodrigues M","year":"2019","unstructured":"Rodrigues M, Kosaric N, Bonham CA, Gurtner GC. Wound healing: a cellular perspective. Physiol Rev. 2019, 99:665-706. 10.1152\/physrev.00067.2017","journal-title":"Physiol Rev"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0039","article-title":"From chronic wounds to scarring: the growing health care burden of under- and over-healing wounds","volume":"11","author":"desJardins-Park HE","year":"2022","unstructured":"desJardins-Park HE, Gurtner GC, Wan DC, Longaker MT. From chronic wounds to scarring: the growing health care burden of under- and over-healing wounds. Adv Wound Care (New Rochelle). 2022, 11:496-510. 10.1089\/wound.2021.0039","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2016.0696","article-title":"Cutaneous scarring: basic science, current treatments, and future directions","volume":"7","author":"Marshall CD","year":"2018","unstructured":"Marshall CD, Hu MS, Leavitt T, Barnes LA, Lorenz HP, Longaker MT. Cutaneous scarring: basic science, current treatments, and future directions. Adv Wound Care (New Rochelle). 2018, 7:29-45. 10.1089\/wound.2016.0696","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S218134","article-title":"Skin care management for medical and aesthetic procedures to prevent scarring","volume":"12","author":"Jourdan M","year":"2019","unstructured":"Jourdan M, Madfes DC, Lima E, Tian Y, Seit\u00e9 S. Skin care management for medical and aesthetic procedures to prevent scarring. Clin Cosmet Investig Dermatol. 2019, 12:799-804. 10.2147\/CCID.S218134","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr2107204","article-title":"To scar or not to scar","volume":"385","author":"Clark RA","year":"2021","unstructured":"Clark RA. To scar or not to scar. N Engl J Med. 2021, 385:469-71. 10.1056\/NEJMcibr2107204","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102715","article-title":"Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation","volume":"54","author":"Feng Y","year":"2020","unstructured":"Feng Y, Wu JJ, Sun ZL, et al.. Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation. EBioMedicine. 2020, 54:102715. 10.1016\/j.ebiom.2020.102715","journal-title":"EBioMedicine"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S1431927615000707","article-title":"Phase and texture characterizations of scar collagen second-harmonic generation images varied with scar duration","volume":"21","author":"Chen G","year":"2015","unstructured":"Chen G, Liu Y, Zhu X, et al.. Phase and texture characterizations of scar collagen second-harmonic generation images varied with scar duration. Microsc Microanal. 2015, 21:855-62. 10.1017\/S1431927615000707","journal-title":"Microsc Microanal"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.00943.x","article-title":"Healing process of venous ulcers: the role of microcirculation","volume":"10","author":"Ambr\u00f3zy E","year":"2013","unstructured":"Ambr\u00f3zy E, Waczul\u00edkov\u00e1 I, Willfort A, et al.. Healing process of venous ulcers: the role of microcirculation. Int Wound J. 2013, 10:57-64. 10.1111\/j.1742-481X.2012.00943.x","journal-title":"Int Wound J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394307-1.00003-5","article-title":"Hypoxia and hypoxia signaling in tissue repair and fibrosis","volume":"296","author":"Lokmic Z","year":"2012","unstructured":"Lokmic Z, Musyoka J, Hewitson TD, Darby IA. Hypoxia and hypoxia signaling in tissue repair and fibrosis. Int Rev Cell Mol Biol. 2012, 296:139-85. 10.1016\/B978-0-12-394307-1.00003-5","journal-title":"Int Rev Cell Mol Biol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/nm1075","article-title":"Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1","volume":"10","author":"Ceradini DJ","year":"2004","unstructured":"Ceradini DJ, Kulkarni AR, Callaghan MJ, et al.. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med. 2004, 10:858-64. 10.1038\/nm1075","journal-title":"Nat Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20170033","article-title":"Recent advances in bedside microcirculation assessment in critically ill patients","volume":"29","author":"Tafner PF","year":"2017","unstructured":"Tafner PF, Chen FK, Rabello R Filho, Corr\u00eaa TD, Chaves RC, Serpa A Neto. Recent advances in bedside microcirculation assessment in critically ill patients. Rev Bras Ter Intensiva. 2017, 29:238-47. 10.5935\/0103-507X.20170033","journal-title":"Rev Bras Ter Intensiva"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2022.894901","article-title":"Quantitative assessment of angiogenesis in skin wound healing by multi-optical imaging techniques","volume":"10","author":"Li L","year":"2022","unstructured":"Li L, Sun Y, He H, He G, Ma S, Yang W, Wang Y. Quantitative assessment of angiogenesis in skin wound healing by multi-optical imaging techniques. Front Phys. 2022, 10:894901. 10.3389\/fphy.2022.894901","journal-title":"Front Phys"},{"key":"ref13","article-title":"The role of macrophages in thermal injury","volume":"12","author":"Penatzer JA","year":"2022","unstructured":"Penatzer JA, Srinivas S, Thakkar RK. The role of macrophages in thermal injury. Int J Burns Trauma. 2022, 12:1-12.","journal-title":"Int J Burns Trauma"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2014.01.025","article-title":"Reliability of scar assessments performed with an integrated skin testing device: the DermaLab Combo(\u00ae)","volume":"40","author":"Gankande TU","year":"2014","unstructured":"Gankande TU, Duke JM, Danielsen PL, DeJong HM, Wood FM, Wallace HJ. Reliability of scar assessments performed with an integrated skin testing device: the DermaLab Combo(\u00ae). Burns. 2014, 40:1521-9. 10.1016\/j.burns.2014.01.025","journal-title":"Burns"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2014.11.036","article-title":"Cupping therapy: a prudent remedy for a plethora of medical ailments","volume":"5","author":"Mehta P","year":"2015","unstructured":"Mehta P, Dhapte V. Cupping therapy: a prudent remedy for a plethora of medical ailments. J Tradit Complement Med. 2015, 5:127-34. 10.1016\/j.jtcme.2014.11.036","journal-title":"J Tradit Complement Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23201","article-title":"Laser treatment of traumatic scars and contractures: 2020 International Consensus Recommendations","volume":"52","author":"Seago M","year":"2020","unstructured":"Seago M, Shumaker PR, Spring LK, et al.. Laser treatment of traumatic scars and contractures: 2020 International Consensus Recommendations. Lasers Surg Med. 2020, 52:96-116. 10.1002\/lsm.23201","journal-title":"Lasers Surg Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.18293.1","article-title":"Toward understanding scarless skin wound healing and pathological scarring","volume":"8","author":"Karppinen SM","year":"2019","unstructured":"Karppinen SM, Heljasvaara R, Gullberg D, Tasanen K, Pihlajaniemi T. Toward understanding scarless skin wound healing and pathological scarring. F1000Res. 2019, 8:787. 10.12688\/f1000research.18293.1","journal-title":"F1000Res"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202200342","article-title":"Using near-infrared spectroscopy to investigate the effects of pressures and durations of cupping therapy on muscle blood volume and oxygenation","volume":"16","author":"Li Y","year":"2023","unstructured":"Li Y, Mo PC, Lin CF, Pauly S, Kundal N, Hernandez ME, Jan YK. Using near-infrared spectroscopy to investigate the effects of pressures and durations of cupping therapy on muscle blood volume and oxygenation. J Biophotonics. 2023, 16:e202200342. 10.1002\/jbio.202200342","journal-title":"J Biophotonics"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s41038-016-0053-9","article-title":"The physical and physiological effects of vacuum massage on the different skin layers: a current status of the literature","volume":"4","author":"Moortgat P","year":"2016","unstructured":"Moortgat P, Anthonissen M, Meirte J, Van Daele U, Maertens K. The physical and physiological effects of vacuum massage on the different skin layers: a current status of the literature. Burns Trauma. 2016, 4:34. 10.1186\/s41038-016-0053-9","journal-title":"Burns Trauma"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1009-2587.2015.02.001","article-title":"Lay emphasis on the application of negative pressure wound therapy technique in burn surgery. (Article in Chinese)","volume":"31","author":"Chai J","year":"2015","unstructured":"Chai J, Shen C. Lay emphasis on the application of negative pressure wound therapy technique in burn surgery. (Article in Chinese). Zhonghua Shao Shang Za Zhi. 2015, 31:81-3. 10.3760\/cma.j.issn.1009-2587.2015.02.001","journal-title":"Zhonghua Shao Shang Za Zhi"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2017.09.008","article-title":"Cupping therapy: an analysis of the effects of suction on skin and the possible influence on human health","volume":"29","author":"Lowe DT","year":"2017","unstructured":"Lowe DT. Cupping therapy: an analysis of the effects of suction on skin and the possible influence on human health. Complement Ther Clin Pract. 2017, 29:162-8. 10.1016\/j.ctcp.2017.09.008","journal-title":"Complement Ther Clin Pract"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.17816\/PTORS5325-36","article-title":"Clinical and morphological characteristics of the vascular bed of hypertrophic scar tissue in different periods of its formation","volume":"5","author":"Filippova OV","year":"2017","unstructured":"Filippova OV, Afonichev KA, Krasnogorskiy IN, Vashetko RVJPT, Orthopaedics, Surgery R. Clinical and morphological characteristics of the vascular bed of hypertrophic scar tissue in different periods of its formation. Pediatr Traumatol Orthop Reconstr Surg. 2017, 5:25-35. 10.17816\/PTORS5325-36","journal-title":"Pediatr Traumatol Orthop Reconstr Surg"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.35086","article-title":"A review of current advancements for wound healing: biomaterial applications and medical devices","volume":"110","author":"Deng X","year":"2022","unstructured":"Deng X, Gould M, Ali MA. A review of current advancements for wound healing: biomaterial applications and medical devices. J Biomed Mater Res B Appl Biomater. 2022, 110:2542-73. 10.1002\/jbm.b.35086","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2017.05.006","article-title":"Scar massage for hypertrophic burns scarring: a systematic review","volume":"44","author":"Ault P","year":"2018","unstructured":"Ault P, Plaza A, Paratz J. Scar massage for hypertrophic burns scarring: a systematic review. Burns. 2018, 44:24-38. 10.1016\/j.burns.2017.05.006","journal-title":"Burns"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1353418","article-title":"Effect of negative pressure therapy on the treatment response to scar thickness and viscoelasticity","volume":"12","author":"Shen WC","year":"2024","unstructured":"Shen WC, Cheng HT, Jan YK, et al.. Effect of negative pressure therapy on the treatment response to scar thickness and viscoelasticity. Front Bioeng Biotechnol. 2024, 12:1353418. 10.3389\/fbioe.2024.1353418","journal-title":"Front Bioeng Biotechnol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.06.081","article-title":"The tumor microenvironment","volume":"30","author":"Anderson NM","year":"2020","unstructured":"Anderson NM, Simon MC. The tumor microenvironment. Curr Biol. 2020, 30:R921-5. 10.1016\/j.cub.2020.06.081","journal-title":"Curr Biol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8824737","article-title":"The combined use of negative-pressure wound therapy and dermal substitutes for tissue repair and regeneration","volume":"2020","author":"Zhang L","year":"2020","unstructured":"Zhang L, Weng T, Wu P, Li Q, Han C, Wang X. The combined use of negative-pressure wound therapy and dermal substitutes for tissue repair and regeneration. Biomed Res Int. 2020, 2020:8824737. 10.1155\/2020\/8824737","journal-title":"Biomed Res Int"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181c82e1f","article-title":"Wound edge microvascular blood flow during negative-pressure wound therapy: examining the effects of pressures from -10 to -175 mmHg","volume":"125","author":"Borgquist O","year":"2010","unstructured":"Borgquist O, Ingemansson R, Malmsj\u00f6 M. Wound edge microvascular blood flow during negative-pressure wound therapy: examining the effects of pressures from -10 to -175 mmHg. Plast Reconstr Surg. 2010, 125:502-9. 10.1097\/PRS.0b013e3181c82e1f","journal-title":"Plast Reconstr Surg"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9905","article-title":"Negative pressure wound therapy enhances bone regeneration compared with conventional therapy in a rabbit radius gap-healing model","volume":"21","author":"Zhu J","year":"2021","unstructured":"Zhu J, Wang F, Yan L, Wang J, Wu M, Hu R, An Y. Negative pressure wound therapy enhances bone regeneration compared with conventional therapy in a rabbit radius gap-healing model. Exp Ther Med. 2021, 21:474. 10.3892\/etm.2021.9905","journal-title":"Exp Ther Med"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1177\/1553350611414920","article-title":"Closed incision management with negative pressure wound therapy (CIM): biomechanics","volume":"19","author":"Wilkes RP","year":"2012","unstructured":"Wilkes RP, Kilpad DV, Zhao Y, Kazala R, McNulty A. Closed incision management with negative pressure wound therapy (CIM): biomechanics. Surg Innov. 2012, 19:67-75. 10.1177\/1553350611414920","journal-title":"Surg Innov"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2018.03.003","article-title":"The medical perspective of cupping therapy: effects and mechanisms of action","volume":"9","author":"Al-Bedah AM","year":"2019","unstructured":"Al-Bedah AM, Elsubai IS, Qureshi NA, et al.. The medical perspective of cupping therapy: effects and mechanisms of action. J Tradit Complement Med. 2019, 9:90-7. 10.1016\/j.jtcme.2018.03.003","journal-title":"J Tradit Complement Med"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159\/000454919","article-title":"Skin wound healing: an update on the current knowledge and concepts","volume":"58","author":"Sorg H","year":"2017","unstructured":"Sorg H, Tilkorn DJ, Hager S, Hauser J, Mirastschijski U. Skin wound healing: an update on the current knowledge and concepts. Eur Surg Res. 2017, 58:81-94. 10.1159\/000454919","journal-title":"Eur Surg Res"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2020.1348","article-title":"Vascular and collagen target: a rational approach to hypertrophic scar management","volume":"12","author":"Yuan B","year":"2023","unstructured":"Yuan B, Upton Z, Leavesley D, Fan C, Wang XQ. Vascular and collagen target: a rational approach to hypertrophic scar management. Adv Wound Care (New Rochelle). 2023, 12:38-55. 10.1089\/wound.2020.1348","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14752","article-title":"Drug-induced peripheral oedema: an aetiology-based review","volume":"87","author":"Largeau B","year":"2021","unstructured":"Largeau B, Cracowski JL, Lengell\u00e9 C, Sautenet B, Jonville-B\u00e9ra AP. Drug-induced peripheral oedema: an aetiology-based review. Br J Clin Pharmacol. 2021, 87:3043-55. 10.1111\/bcp.14752","journal-title":"Br J Clin Pharmacol"},{"key":"ref35","article-title":"Effect of time and pressure factors on the cupping mark color. (Article in Chinese)","volume":"29","author":"Zhao XX","year":"2009","unstructured":"Zhao XX, Tong BY, Wang XX, Sun GL. Effect of time and pressure factors on the cupping mark color. (Article in Chinese). Zhongguo Zhen Jiu. 2009, 29:385-8.","journal-title":"Zhongguo Zhen Jiu"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2011.00790.x","article-title":"The influence of different sizes and types of wound fillers on wound contraction and tissue pressure during negative pressure wound therapy","volume":"8","author":"Anes\u00e4ter E","year":"2011","unstructured":"Anes\u00e4ter E, Borgquist O, Hedstr\u00f6m E, Waga J, Ingemansson R, Malmsj\u00f6 M. The influence of different sizes and types of wound fillers on wound contraction and tissue pressure during negative pressure wound therapy. Int Wound J. 2011, 8:336-42. 10.1111\/j.1742-481X.2011.00790.x","journal-title":"Int Wound J"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.608509","article-title":"Effect of pressures and durations of cupping therapy on skin blood flow responses","volume":"8","author":"Wang X","year":"2020","unstructured":"Wang X, Zhang X, Elliott J, Liao F, Tao J, Jan YK. Effect of pressures and durations of cupping therapy on skin blood flow responses. Front Bioeng Biotechnol. 2020, 8:608509. 10.3389\/fbioe.2020.608509","journal-title":"Front Bioeng Biotechnol"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-007-0524-0","article-title":"Review of methodological developments in laser Doppler flowmetry","volume":"24","author":"Rajan V","year":"2009","unstructured":"Rajan V, Varghese B, van Leeuwen TG, Steenbergen W. Review of methodological developments in laser Doppler flowmetry. Lasers Med Sci. 2009, 24:269-83. 10.1007\/s10103-007-0524-0","journal-title":"Lasers Med Sci"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.996589","article-title":"Effect of durations and pressures of cupping therapy on muscle stiffness of triceps","volume":"10","author":"Li Y","year":"2022","unstructured":"Li Y, Mo PC, Jain S, Elliott J, Bleakney A, Lyu S, Jan YK. Effect of durations and pressures of cupping therapy on muscle stiffness of triceps. Front Bioeng Biotechnol. 2022, 10:996589. 10.3389\/fbioe.2022.996589","journal-title":"Front Bioeng Biotechnol"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2018.06.005","article-title":"The response of peripheral microcirculation to gravity-induced changes","volume":"57","author":"Ovadia-Blechman Z","year":"2018","unstructured":"Ovadia-Blechman Z, Gritzman A, Shuvi M, Gavish B, Aharonson V, Rabin N. The response of peripheral microcirculation to gravity-induced changes. Clin Biomech (Bristol). 2018, 57:19-25. 10.1016\/j.clinbiomech.2018.06.005","journal-title":"Clin Biomech (Bristol)"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/S2005-2901(11)60004-6","article-title":"Violet laser acupuncture: part 2: effects on peripheral microcirculation","volume":"4","author":"Wang L","year":"2011","unstructured":"Wang L, Huang T, Zhang W, Litscher G. Violet laser acupuncture: part 2: effects on peripheral microcirculation. J Acupunct Meridian Stud. 2011, 4:24-8. 10.1016\/S2005-2901(11)60004-6","journal-title":"J Acupunct Meridian Stud"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1515\/dmpt-2022-0111","article-title":"The efficacy and safety of dry cupping in cervical spondylosis with optimization of cup application time: a randomized clinical trial","volume":"38","author":"Tehseen A","year":"2023","unstructured":"Tehseen A, Ali H, Husain N, Varda HK. The efficacy and safety of dry cupping in cervical spondylosis with optimization of cup application time: a randomized clinical trial. Drug Metab Pers Ther. 2023, 38:113-9. 10.1515\/dmpt-2022-0111","journal-title":"Drug Metab Pers Ther"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12970","article-title":"Using laser Doppler flowmetry with wavelet analysis to study skin blood flow regulations after cupping therapy","volume":"27","author":"Hou X","year":"2021","unstructured":"Hou X, He X, Zhang X, Liao F, Hung YJ, Jan YK. Using laser Doppler flowmetry with wavelet analysis to study skin blood flow regulations after cupping therapy. Skin Res Technol. 2021, 27:393-9. 10.1111\/srt.12970","journal-title":"Skin Res Technol"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00798.2001","article-title":"Blood extraction from lancet wounds using vacuum combined with skin stretching","volume":"92","author":"Cunningham DD","year":"2002","unstructured":"Cunningham DD, Henning TP, Shain EB, Young DF, Hannig J, Barua E, Lee RC. Blood extraction from lancet wounds using vacuum combined with skin stretching. J Appl Physiol (1985). 2002, 92:1089-96. 10.1152\/japplphysiol.00798.2001","journal-title":"J Appl Physiol (1985)"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-71226-5_15","article-title":"Initial results of intracutaneous measurements of PO2 profiles","author":"Baumg\u00e4rtl H","year":"1987","unstructured":"Baumg\u00e4rtl H, Ehrly A, Saeger-Lorenz K, L\u00fcbbers D. Initial results of intracutaneous measurements of PO2 profiles. Clinical Oxygen Pressure Measurement. Ehrly AM, Hauss J, Huch R (ed): Springer, Berlin, Heidelberg; 1987. 121-8. 10.1007\/978-3-642-71226-5_15"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-007-9124-3","article-title":"In vitro wounding: effects of hypoxia and transforming growth factor beta1 on proliferation, migration and myofibroblastic differentiation in an endothelial cell-fibroblast co-culture model","volume":"39","author":"Oberringer M","year":"2008","unstructured":"Oberringer M, Meins C, Bubel M, Pohlemann T. In vitro wounding: effects of hypoxia and transforming growth factor beta1 on proliferation, migration and myofibroblastic differentiation in an endothelial cell-fibroblast co-culture model. J Mol Histol. 2008, 39:37-47. 10.1007\/s10735-007-9124-3","journal-title":"J Mol Histol"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(95)00166-2","article-title":"The hypertrophic scar and microcirculation properties","volume":"22","author":"Clark J","year":"1996","unstructured":"Clark J, Leung K, Cheng J, Leung PJ. The hypertrophic scar and microcirculation properties. Burns. 1996, 22:447-50. 10.1016\/0305-4179(95)00166-2","journal-title":"Burns"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000187182.90907.3d","article-title":"The effects of varying degrees of pressure delivered by negative-pressure wound therapy on skin perfusion","volume":"55","author":"Timmers MS","year":"2005","unstructured":"Timmers MS, Le Cessie S, Banwell P, Jukema GN. The effects of varying degrees of pressure delivered by negative-pressure wound therapy on skin perfusion. Ann Plast Surg. 2005, 55:665-71. 10.1097\/01.sap.0000187182.90907.3d","journal-title":"Ann Plast Surg"},{"key":"ref49","article-title":"Hemorheological factors can be informative in comparing treatment possibilities of\u00a0abdominal compartment syndrome","volume":"64","author":"Nemeth N","year":"2016","unstructured":"Nemeth N, Peto K, Deak A, et al.. Hemorheological factors can be informative in comparing treatment possibilities of\u00a0abdominal compartment syndrome. Clin Hemorheol Microcirc. 2016, 64:765-75.","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2005.06.027","article-title":"Cupping: from a biomechanical perspective","volume":"39","author":"Tham LM","year":"2006","unstructured":"Tham LM, Lee HP, Lu C. Cupping: from a biomechanical perspective. J Biomech. 2006, 39:2183-93. 10.1016\/j.jbiomech.2005.06.027","journal-title":"J Biomech"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2010.02244.x","article-title":"Regulation of blood flow in the microcirculation: role of conducted vasodilation","volume":"202","author":"Bagher P","year":"2011","unstructured":"Bagher P, Segal SS. Regulation of blood flow in the microcirculation: role of conducted vasodilation. Acta Physiol (Oxf). 2011, 202:271-84. 10.1111\/j.1748-1716.2010.02244.x","journal-title":"Acta Physiol (Oxf)"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2005.10.025","article-title":"Equibiaxial cyclic stretch stimulates fibroblasts to rapidly remodel fibrin","volume":"39","author":"Balestrini JL","year":"2006","unstructured":"Balestrini JL, Billiar KL. Equibiaxial cyclic stretch stimulates fibroblasts to rapidly remodel fibrin. J Biomech. 2006, 39:2983-90. 10.1016\/j.jbiomech.2005.10.025","journal-title":"J Biomech"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2005.07.001","article-title":"The relative contributions of different skin layers to the mechanical behavior of human skin in vivo using suction experiments","volume":"28","author":"Hendriks FM","year":"2006","unstructured":"Hendriks FM, Brokken D, Oomens CW, Bader DL, Baaijens FP. The relative contributions of different skin layers to the mechanical behavior of human skin in vivo using suction experiments. Med Eng Phys. 2006, 28:259-66. 10.1016\/j.medengphy.2005.07.001","journal-title":"Med Eng Phys"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1556\/2060.2020.00013","article-title":"Stable laser-Doppler flow-motion patterns in the human cutaneous microcirculation: implications for prospective geroscience studies","volume":"107","author":"T\u00f3th-Sz\u0171ki V","year":"2020","unstructured":"T\u00f3th-Sz\u0171ki V, Bari F, Domoki F. Stable laser-Doppler flow-motion patterns in the human cutaneous microcirculation: implications for prospective geroscience studies. Physiol Int. 2020, 107:134-44. 10.1556\/2060.2020.00013","journal-title":"Physiol Int"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/383427-effect-of-negative-pressure-therapy-on-skin-blood-flow-responses-in-scar-tissue","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T03:48:58Z","timestamp":1755575338000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/383427-effect-of-negative-pressure-therapy-on-skin-blood-flow-responses-in-scar-tissue"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,18]]},"references-count":54,"URL":"https:\/\/doi.org\/10.7759\/cureus.90436","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,8,18]]}}}