{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:24:02Z","timestamp":1791786242552,"version":"4.3.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,18]]},"DOI":"10.7759\/cureus.90445","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:58:56Z","timestamp":1755583136000},"source":"Crossref","is-referenced-by-count":1,"title":["Hip Fractures and Hypogonadism in Young Males: A Missed Opportunity for Secondary Prevention?"],"prefix":"10.7759","author":[{"given":"Chan","family":"Khin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olive","family":"Kyaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shri","family":"Thangaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriade","family":"Akinsolu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Elfiky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanth","family":"D'Sa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedict","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell O","year":"2006","unstructured":"Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006, 17:1726-33. 10.1007\/s00198-006-0172-4","journal-title":"Osteoporos Int"},{"key":"ref2","unstructured":"Osteoporosis. assessing the risk of fragility fracture. (2017). Accessed: August 14, 2025: https:\/\/www.nice.org.uk\/guidance\/cg146."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4704-5","article-title":"European guidance for the diagnosis and management of osteoporosis in postmenopausal women","volume":"30","author":"Kanis JA","year":"2019","unstructured":"Kanis JA, Cooper C, Rizzoli R, Reginster JY. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2019, 30:3-44. 10.1007\/s00198-018-4704-5","journal-title":"Osteoporos Int"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3045","article-title":"Osteoporosis in men: an Endocrine Society clinical practice guideline","volume":"97","author":"Watts NB","year":"2012","unstructured":"Watts NB, Adler RA, Bilezikian JP, Drake MT, Eastell R, Orwoll ES, Finkelstein JS. Osteoporosis in men: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012, 97:1802-22. 10.1210\/jc.2011-3045","journal-title":"J Clin Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afp221","article-title":"Excess mortality in men compared with women following a hip fracture. National analysis of comedications, comorbidity and survival","volume":"39","author":"Kannegaard PN","year":"2010","unstructured":"Kannegaard PN, van der Mark S, Eiken P, Abrahamsen B. Excess mortality in men compared with women following a hip fracture. National analysis of comedications, comorbidity and survival. Age Ageing. 2010, 39:203-9. 10.1093\/ageing\/afp221","journal-title":"Age Ageing"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-15-362","article-title":"Mortality and complications of hip fracture in young adults: a nationwide population-based cohort study","volume":"15","author":"Lin JC","year":"2014","unstructured":"Lin JC, Wu CC, Lo C, et al.. Mortality and complications of hip fracture in young adults: a nationwide population-based cohort study. BMC Musculoskelet Disord. 2014, 15:362. 10.1186\/1471-2474-15-362","journal-title":"BMC Musculoskelet Disord"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413640","article-title":"Management of osteoporosis in men: a narrative review","volume":"22","author":"Vescini F","year":"2021","unstructured":"Vescini F, Chiodini I, Falchetti A, et al.. Management of osteoporosis in men: a narrative review. Int J Mol Sci. 2021, 22:13640. 10.3390\/ijms222413640","journal-title":"Int J Mol Sci"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa115","article-title":"U-shaped association of plasma testosterone, and no association of plasma estradiol, with incidence of fractures in men","volume":"105","author":"Yeap BB","year":"2020","unstructured":"Yeap BB, Alfonso H, Chubb SA, et al.. U-shaped association of plasma testosterone, and no association of plasma estradiol, with incidence of fractures in men. J Clin Endocrinol Metab. 2020, 105:115. 10.1210\/clinem\/dgaa115","journal-title":"J Clin Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.acuroe.2012.06.005","article-title":"Testosterone-deficiency as a risk factor for hip fracture in elderly men","volume":"37","author":"Torremad\u00e9-Barreda J","year":"2013","unstructured":"Torremad\u00e9-Barreda J, Rodr\u00edguez-Tolr\u00e0 J, Rom\u00e1n-Romera I, Padr\u00f3-Miquel A, Rius-Moreno J, Franco-Miranda E. Testosterone-deficiency as a risk factor for hip fracture in elderly men. Actas Urol Esp (Engl Ed). 2013, 37:142-6. 10.1016\/j.acuroe.2012.06.005","journal-title":"Actas Urol Esp (Engl Ed)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/smrj.63","article-title":"Osteoporosis and low bone mineral density in men with testosterone deficiency syndrome","volume":"3","author":"Gaffney CD","year":"2015","unstructured":"Gaffney CD, Pagano MJ, Kuker AP, Stember DS, Stahl PJ. Osteoporosis and low bone mineral density in men with testosterone deficiency syndrome. Sex Med Rev. 2015, 3:298-315. 10.1002\/smrj.63","journal-title":"Sex Med Rev"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-837652","article-title":"Low serum levels of testosterone in men with minimal traumatic hip fractures","volume":"113","author":"Leifke E","year":"2005","unstructured":"Leifke E, Wichers C, Gorenoi V, Lucke P, von zur M\u00fchlen A, Brabant G. Low serum levels of testosterone in men with minimal traumatic hip fractures. Exp Clin Endocrinol Diabetes. 2005, 113:208-13. 10.1055\/s-2005-837652","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-3-200802050-00198","article-title":"Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis","volume":"148","author":"MacLean C","year":"2008","unstructured":"MacLean C, Newberry S, Maglione M, et al.. Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. Ann Intern Med. 2008, 148:197-213. 10.7326\/0003-4819-148-3-200802050-00198","journal-title":"Ann Intern Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.150033","article-title":"Diagnosis and management of testosterone deficiency syndrome in men: clinical practice guideline","volume":"187","author":"Morales A","year":"2015","unstructured":"Morales A, Bebb RA, Manjoo P, et al.. Diagnosis and management of testosterone deficiency syndrome in men: clinical practice guideline. CMAJ. 2015, 187:1369-77. 10.1503\/cmaj.150033","journal-title":"CMAJ"},{"key":"ref14","article-title":"Hip fracture overview","author":"Emmerson BR","year":"2023","unstructured":"Emmerson BR, Varacallo MA, Inman D. Hip fracture overview. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2023."},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum","volume":"84","author":"Vermeulen A","year":"1999","unstructured":"Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 1999, 84:3666-72. 10.1210\/jcem.84.10.6079","journal-title":"J Clin Endocrinol Metab"},{"key":"ref16","unstructured":"Free and bioavailable testosterone calculator. (2025). Accessed. August 14, 2025: https:\/\/www.issam.ch\/freetesto.htm."},{"key":"ref17","unstructured":"Is my study research?. (2025). Accessed. August 11, 2025: https:\/\/www.hra-decisiontools.org.uk\/research\/."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecns.2017.11.009","article-title":"Learning high-energy trauma care through simulation","volume":"17","author":"Abelsson A","year":"2018","unstructured":"Abelsson A, Rystedt I, Suserud B-O, Lindwall L. Learning high-energy trauma care through simulation. Clin Simul Nurs. 2018, 17:1-6. 10.1016\/j.ecns.2017.11.009","journal-title":"Clin Simul Nurs"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210\/er.2014-1024","article-title":"Sex steroid actions in male bone","volume":"35","author":"Vanderschueren D","year":"2014","unstructured":"Vanderschueren D, Laurent MR, Claessens F, et al.. Sex steroid actions in male bone. Endocr Rev. 2014, 35:906-60. 10.1210\/er.2014-1024","journal-title":"Endocr Rev"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506119","article-title":"Effects of testosterone treatment in older men","volume":"374","author":"Snyder PJ","year":"2016","unstructured":"Snyder PJ, Bhasin S, Cunningham GR, et al.. Effects of testosterone treatment in older men. N Engl J Med. 2016, 374:611-24. 10.1056\/NEJMoa1506119","journal-title":"N Engl J Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1972","article-title":"Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study","volume":"93","author":"Wu FC","year":"2008","unstructured":"Wu FC, Tajar A, Pye SR, et al.. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab. 2008, 93:2737-45. 10.1210\/jc.2007-1972","journal-title":"J Clin Endocrinol Metab"},{"key":"ref22","article-title":"Alcohol and the male reproductive system","volume":"25","author":"Emanuele MA","year":"2001","unstructured":"Emanuele MA, Emanuele N. Alcohol and the male reproductive system. Alcohol Res Health. 2001, 25:282-7.","journal-title":"Alcohol Res Health"},{"key":"ref23","article-title":"Pathophysiology of the effects of alcohol abuse on the endocrine system","volume":"38","author":"Rachdaoui N","year":"2017","unstructured":"Rachdaoui N, Sarkar DK. Pathophysiology of the effects of alcohol abuse on the endocrine system. Alcohol Res. 2017, 38:255-76.","journal-title":"Alcohol Res"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(75)90094-3","article-title":"Plasma estrone, prolactin, neurophysin, and sex steroid-binding globulin in chronic alcoholic men","volume":"24","author":"Van Thiel DH","year":"1975","unstructured":"Van Thiel DH, Gavaler JS, Lester R, Loriaux DL, Braunstein GD. Plasma estrone, prolactin, neurophysin, and sex steroid-binding globulin in chronic alcoholic men. Metabolism. 1975, 24:1015-9. 10.1016\/0026-0495(75)90094-3","journal-title":"Metabolism"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-025-07446-9","article-title":"Sex-specific associations of vitamin D and bone biomarkers with bone density and physical function during recovery from hip fracture: the Baltimore Hip Studies","volume":"36","author":"Cappola AR","year":"2025","unstructured":"Cappola AR, Abraham DS, Kroopnick JM, et al.. Sex-specific associations of vitamin D and bone biomarkers with bone density and physical function during recovery from hip fracture: the Baltimore Hip Studies. Osteoporos Int. 2025, 36:855-63. 10.1007\/s00198-025-07446-9","journal-title":"Osteoporos Int"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/401917-hip-fractures-and-hypogonadism-in-young-males-a-missed-opportunity-for-secondary-prevention","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:58:58Z","timestamp":1755583138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/401917-hip-fractures-and-hypogonadism-in-young-males-a-missed-opportunity-for-secondary-prevention"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,18]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.90445","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,18]]}}}