{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:52:45Z","timestamp":1755798765999,"version":"3.44.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,19]]},"DOI":"10.7759\/cureus.90481","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T13:02:43Z","timestamp":1755608563000},"source":"Crossref","is-referenced-by-count":0,"title":["Vaccinated Toddler With 15B\/15C Serotype Switch Pneumococcal Meningitis"],"prefix":"10.7759","author":[{"given":"Richard","family":"Kevorkian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milene T","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory M","family":"Mcfadden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan T","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason R","family":"Smedberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14913","article-title":"Review on pneumococcal infection in children","volume":"13","author":"Thadchanamoorthy V","year":"2021","unstructured":"Thadchanamoorthy V, Dayasiri K. Review on pneumococcal infection in children. Cureus. 2021, 13:e14913. 10.7759\/cureus.14913","journal-title":"Cureus"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2020-0062","article-title":"Streptococcus pneumoniae","volume":"42","author":"Olarte L","year":"2021","unstructured":"Olarte L, Jackson MA. Streptococcus pneumoniae. Pediatr Rev. 2021, 42:349-59. 10.1542\/pir.2020-0062","journal-title":"Pediatr Rev"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03183.x","article-title":"Streptococcus pneumoniae: virulence factors and variation","volume":"16","author":"Mitchell AM","year":"2010","unstructured":"Mitchell AM, Mitchell TJ. Streptococcus pneumoniae: virulence factors and variation. Clin Microbiol Infect. 2010, 16:411-8. 10.1111\/j.1469-0691.2010.03183.x","journal-title":"Clin Microbiol Infect"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00024-15","article-title":"Pneumococcal capsules and their types: past, present, and future","volume":"28","author":"Geno KA","year":"2015","unstructured":"Geno KA, Gilbert GL, Song JY, et al.. Pneumococcal capsules and their types: past, present, and future. Clin Microbiol Rev. 2015, 28:871-99. 10.1128\/CMR.00024-15","journal-title":"Clin Microbiol Rev"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2196\/50678","article-title":"Estimating the global and regional burden of Streptococcus pneumoniae meningitis in children: protocol for a systematic review and meta-analysis","volume":"13","author":"Park JJ","year":"2024","unstructured":"Park JJ, Tiefenbach J, Anwar MM, et al.. Estimating the global and regional burden of Streptococcus pneumoniae meningitis in children: protocol for a systematic review and meta-analysis. JMIR Res Protoc. 2024, 13:e50678. 10.2196\/50678","journal-title":"JMIR Res Protoc"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-024-00977-4","article-title":"Cost-effectiveness of PCV20 to prevent pneumococcal disease in the pediatric population: a German societal perspective analysis","volume":"13","author":"Ta A","year":"2024","unstructured":"Ta A, K\u00fchne F, Laurenz M, von Eiff C, Warren S, Perdrizet J. Cost-effectiveness of PCV20 to prevent pneumococcal disease in the pediatric population: a German societal perspective analysis. Infect Dis Ther. 2024, 13:1333-58. 10.1007\/s40121-024-00977-4","journal-title":"Infect Dis Ther"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.11.6192-6198.2003","article-title":"Genetic basis for the structural difference between Streptococcus pneumoniae serotype 15B and 15C capsular polysaccharides","volume":"71","author":"van Selm S","year":"2003","unstructured":"van Selm S, van Cann LM, Kolkman MA, van der Zeijst BA, van Putten JP. Genetic basis for the structural difference between Streptococcus pneumoniae serotype 15B and 15C capsular polysaccharides. Infect Immun. 2003, 71:6192-8. 10.1128\/IAI.71.11.6192-6198.2003","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/147.6.1041","article-title":"Type variation of strains of Streptococcus pneumoniae in capsular serogroup 15","volume":"147","author":"Venkateswaran PS","year":"1983","unstructured":"Venkateswaran PS, Stanton N, Austrian R. Type variation of strains of Streptococcus pneumoniae in capsular serogroup 15. J Infect Dis. 1983, 147:1041-54. 10.1093\/infdis\/147.6.1041","journal-title":"J Infect Dis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/srep15843","article-title":"Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization","volume":"5","author":"Su LH","year":"2015","unstructured":"Su LH, Kuo AJ, Chia JH, Li HC, Wu TL, Feng Y, Chiu CH. Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization. Sci Rep. 2015, 5:15843. 10.1038\/srep15843","journal-title":"Sci Rep"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177113","article-title":"Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: a systematic review and meta-analysis","volume":"12","author":"Balsells E","year":"2017","unstructured":"Balsells E, Guillot L, Nair H, Kyaw MH. Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: a systematic review and meta-analysis. PLoS One. 2017, 12:e0177113. 10.1371\/journal.pone.0177113","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12090974","article-title":"Implications of cross-reactivity and cross-protection for pneumococcal vaccine development","volume":"12","author":"Feemster K","year":"2024","unstructured":"Feemster K, Hausdorff WP, Banniettis N, et al.. Implications of cross-reactivity and cross-protection for pneumococcal vaccine development. Vaccines (Basel). 2024, 12:974. 10.3390\/vaccines12090974","journal-title":"Vaccines (Basel)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00099-17","article-title":"The pneumococcal serotype 15C capsule is partially O-acetylated and allows for limited evasion of 23-valent pneumococcal polysaccharide vaccine-elicited anti-serotype 15B antibodies","volume":"24","author":"Spencer BL","year":"2017","unstructured":"Spencer BL, Shenoy AT, Orihuela CJ, Nahm MH. The pneumococcal serotype 15C capsule is partially O-acetylated and allows for limited evasion of 23-valent pneumococcal polysaccharide vaccine-elicited anti-serotype 15B antibodies. Clin Vaccine Immunol. 2017, 24:10.1128\/CVI.00099-17","journal-title":"Clin Vaccine Immunol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad068","article-title":"Comparison of PCV10, PCV13, PCV15, PCV20 and PPSV23 vaccine coverage of invasive Streptococcus pneumoniae isolate serotypes in Canada: the SAVE study, 2011-20","volume":"78","author":"Schellenberg JJ","year":"2023","unstructured":"Schellenberg JJ, Adam HJ, Baxter MR, et al.. Comparison of PCV10, PCV13, PCV15, PCV20 and PPSV23 vaccine coverage of invasive Streptococcus pneumoniae isolate serotypes in Canada: the SAVE study, 2011-20. J Antimicrob Chemother. 2023, 78:i37-47. 10.1093\/jac\/dkad068","journal-title":"J Antimicrob Chemother"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.14745\/ccdr.v50i12a04","article-title":"PCV13, PCV15 or PCV20: which vaccine is best for children in terms of immunogenicity?","volume":"50","author":"De Wals P","year":"2024","unstructured":"De Wals P. PCV13, PCV15 or PCV20: which vaccine is best for children in terms of immunogenicity?. Can Commun Dis Rep. 2024, 50:35-9. 10.14745\/ccdr.v50i12a04","journal-title":"Can Commun Dis Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2025.126931","article-title":"A phase 3 study of 20-valent pneumococcal conjugate vaccine in healthy toddlers previously vaccinated in infancy with 13-valent pneumococcal conjugate vaccine","volume":"53","author":"Martin\u00f3n-Torres F","year":"2025","unstructured":"Martin\u00f3n-Torres F, Martinez SN, Kline MJ, et al.. A phase 3 study of 20-valent pneumococcal conjugate vaccine in healthy toddlers previously vaccinated in infancy with 13-valent pneumococcal conjugate vaccine. Vaccine. 2025, 53:126931. 10.1016\/j.vaccine.2025.126931","journal-title":"Vaccine"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2023.12.057","article-title":"Cost-effectiveness of 20-valent pneumococcal conjugate vaccine in US infants","volume":"42","author":"Rozenbaum MH","year":"2024","unstructured":"Rozenbaum MH, Huang L, Perdrizet J, et al.. Cost-effectiveness of 20-valent pneumococcal conjugate vaccine in US infants. Vaccine. 2024, 42:573-82. 10.1016\/j.vaccine.2023.12.057","journal-title":"Vaccine"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2024.126656","article-title":"Systematic literature review of cost-effectiveness analyses of adult 15- and 20-valent pneumococcal vaccines","volume":"46","author":"Cho JY","year":"2025","unstructured":"Cho JY, Lee H, Wannaadisai W, Vietri J, Chaiyakunapruk N. Systematic literature review of cost-effectiveness analyses of adult 15- and 20-valent pneumococcal vaccines. Vaccine. 2025, 46:126656. 10.1016\/j.vaccine.2024.126656","journal-title":"Vaccine"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(06)69637-2","article-title":"Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study","volume":"368","author":"Whitney CG","year":"2006","unstructured":"Whitney CG, Pilishvili T, Farley M, et al.. Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study. Lancet. 2006, 368:1495-502. 10.1016\/s0140-6736(06)69637-2","journal-title":"Lancet"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.35482","article-title":"Complicated invasive pneumococcal meningitis: highlighting the value of implementing new pneumococcal vaccines","volume":"15","author":"Thacker SA","year":"2023","unstructured":"Thacker SA. Complicated invasive pneumococcal meningitis: highlighting the value of implementing new pneumococcal vaccines. Cureus. 2023, 15:e35482. 10.7759\/cureus.35482","journal-title":"Cureus"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/396955-vaccinated-toddler-with-15b15c-serotype-switch-pneumococcal-meningitis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T13:02:43Z","timestamp":1755608563000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/396955-vaccinated-toddler-with-15b15c-serotype-switch-pneumococcal-meningitis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.90481","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,8,19]]}}}