{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:37:10Z","timestamp":1790563030706,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,20]]},"DOI":"10.7759\/cureus.90573","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:21:23Z","timestamp":1755696083000},"source":"Crossref","is-referenced-by-count":2,"title":["Burden of Helicobacter pylori in Duodenal Ulcer Disease: Evidence From a Tertiary Hospital in Chennai, India"],"prefix":"10.7759","author":[{"given":"Arunima","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"C","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaykanthan","family":"N","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velvizhi","family":"Ravi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suganya","family":"P","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl20288","article-title":"Evidence-based guidelines for the treatment of Helicobacter pylori infection in Korea 2020","volume":"15","author":"Jung HK","year":"2021","unstructured":"Jung HK, Kang SJ, Lee YC, et al.. Evidence-based guidelines for the treatment of Helicobacter pylori infection in Korea 2020. Gut Liver. 2021, 15:168-95. 10.5009\/gnl20288","journal-title":"Gut Liver"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2018.09.040","article-title":"Prevalence of Helicobacter pylori in asymptomatic patients at surgical outpatient department: Harare hospitals","volume":"35","author":"Mungazi SG","year":"2018","unstructured":"Mungazi SG, Chihaka OB, Muguti GI. Prevalence of Helicobacter pylori in asymptomatic patients at surgical outpatient department: Harare hospitals. Ann Med Surg (Lond). 2018, 35:153-7. 10.1016\/j.amsu.2018.09.040","journal-title":"Ann Med Surg (Lond)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000517","article-title":"Low prevalence of Helicobacter pylori-positive peptic ulcers in private outpatient endoscopy centers in the United States","volume":"115","author":"Sonnenberg A","year":"2020","unstructured":"Sonnenberg A, Turner KO, Genta RM. Low prevalence of Helicobacter pylori-positive peptic ulcers in private outpatient endoscopy centers in the United States. Am J Gastroenterol. 2020, 115:244-50. 10.14309\/ajg.0000000000000517","journal-title":"Am J Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i46.10118","article-title":"Role of dupA in virulence of Helicobacter pylori","volume":"22","author":"Talebi Bezmin Abadi A","year":"2016","unstructured":"Talebi Bezmin Abadi A, Perez-Perez G. Role of dupA in virulence of Helicobacter pylori. World J Gastroenterol. 2016, 22:10118-23. 10.3748\/wjg.v22.i46.10118","journal-title":"World J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.680","article-title":"Long-term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers","volume":"5","author":"S\u00f8gaard KK","year":"2016","unstructured":"S\u00f8gaard KK, Farkas DK, Pedersen L, Lund JL, Thomsen RW, S\u00f8rensen HT. Long-term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers. Cancer Med. 2016, 5:1341-51. 10.1002\/cam4.680","journal-title":"Cancer Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.938608","article-title":"Relationship between Helicobacter pylori infection and gastrointestinal microecology","volume":"12","author":"Xu W","year":"2022","unstructured":"Xu W, Xu L, Xu C. Relationship between Helicobacter pylori infection and gastrointestinal microecology. Front Cell Infect Microbiol. 2022, 12:938608. 10.3389\/fcimb.2022.938608","journal-title":"Front Cell Infect Microbiol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0775-1","article-title":"Dietary habits and Helicobacter pylori infection: a cross sectional study at a Lebanese hospital","volume":"18","author":"Assaad S","year":"2018","unstructured":"Assaad S, Chaaban R, Tannous F, Costanian C. Dietary habits and Helicobacter pylori infection: a cross sectional study at a Lebanese hospital. BMC Gastroenterol. 2018, 18:48. 10.1186\/s12876-018-0775-1","journal-title":"BMC Gastroenterol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72400-0","article-title":"Clinical factors associated with initial Helicobacter pylori eradication therapy: a retrospective study in China","volume":"10","author":"Tang Y","year":"2020","unstructured":"Tang Y, Tang G, Pan L, Zhu H, Zhou S, Wei Z. Clinical factors associated with initial Helicobacter pylori eradication therapy: a retrospective study in China. Sci Rep. 2020, 10:15403. 10.1038\/s41598-020-72400-0","journal-title":"Sci Rep"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11111658","article-title":"Helicobacter pylori infection and peptic ulcer disease in symptomatic children in southern Vietnam: a prospective multicenter study","volume":"11","author":"Nguyen TC","year":"2023","unstructured":"Nguyen TC, Tang NL, Le GK, et al.. Helicobacter pylori infection and peptic ulcer disease in symptomatic children in southern Vietnam: a prospective multicenter study. Healthcare (Basel). 2023, 11:1658. 10.3390\/healthcare11111658","journal-title":"Healthcare (Basel)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000538079","article-title":"Helicobacter pylori infection: a 40-year journey through shifting the paradigm to transforming the management","volume":"42","author":"Malfertheiner P","year":"2024","unstructured":"Malfertheiner P, Schulz C, Hunt RH. Helicobacter pylori infection: a 40-year journey through shifting the paradigm to transforming the management. Dig Dis. 2024, 42:299-308. 10.1159\/000538079","journal-title":"Dig Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12251","article-title":"Pathogenesis of Helicobacter pylori infection","volume":"20","author":"Sgouras DN","year":"2015","unstructured":"Sgouras DN, Trang TT, Yamaoka Y. Pathogenesis of Helicobacter pylori infection. Helicobacter. 2015, 20:8-16. 10.1111\/hel.12251","journal-title":"Helicobacter"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.713955","article-title":"Helicobacter pylori in human stomach: the inconsistencies in clinical outcomes and the probable causes","volume":"12","author":"Alexander SM","year":"2021","unstructured":"Alexander SM, Retnakumar RJ, Chouhan D, et al.. Helicobacter pylori in human stomach: the inconsistencies in clinical outcomes and the probable causes. Front Microbiol. 2021, 12:713955. 10.3389\/fmicb.2021.713955","journal-title":"Front Microbiol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1302-3_1","article-title":"An overview of Helicobacter pylori infection","author":"FitzGerald R","year":"2021","unstructured":"FitzGerald R, Smith SM. An overview of Helicobacter pylori infection. Helicobacter Pylori: Methods and Protocols. Smith SM (ed): Humana, New York, NY; 2021. 2283:10.1007\/978-1-0716-1302-3_1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c05374","article-title":"Rapid detection of Helicobacter pylori by the naked eye using DNA aptamers","volume":"6","author":"Wu H","year":"2021","unstructured":"Wu H, Gu L, Ma X, et al.. Rapid detection of Helicobacter pylori by the naked eye using DNA aptamers. ACS Omega. 2021, 6:3771-9. 10.1021\/acsomega.0c05374","journal-title":"ACS Omega"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9064952","article-title":"Diagnosis of Helicobacter pylori using invasive and noninvasive approaches","volume":"2018","author":"Talebi Bezmin Abadi A","year":"2018","unstructured":"Talebi Bezmin Abadi A. Diagnosis of Helicobacter pylori using invasive and noninvasive approaches. J Pathog. 2018, 2018:9064952. 10.1155\/2018\/9064952","journal-title":"J Pathog"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v7.i4.187","article-title":"Helicobacter pylori vs coronary heart disease - searching for connections","volume":"7","author":"Chmiela M","year":"2015","unstructured":"Chmiela M, Gajewski A, Rudnicka K. Helicobacter pylori vs coronary heart disease - searching for connections. World J Cardiol. 2015, 7:187-203. 10.4330\/wjc.v7.i4.187","journal-title":"World J Cardiol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4103\/jwas.jwas_51_22","article-title":"Epidemiology of surgical site infection following abdominal surgeries at a reference hospital in north-west Cameroon","volume":"11","author":"Ebogo Titus NT","year":"2021","unstructured":"Ebogo Titus NT, Nzinga JR, Nchufor NR, Njuma TE, Ntih LM, Sena GR, Pisoh CT. Epidemiology of surgical site infection following abdominal surgeries at a reference hospital in north-west Cameroon. J West Afr Coll Surg. 2021, 11:1-6. 10.4103\/jwas.jwas_51_22","journal-title":"J West Afr Coll Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14561","article-title":"Systematic review with meta-analysis: the worldwide prevalence of Helicobacter pylori infection","volume":"47","author":"Zamani M","year":"2018","unstructured":"Zamani M, Ebrahimtabar F, Zamani V, Miller WH, Alizadeh-Navaei R, Shokri-Shirvani J, Derakhshan MH. Systematic review with meta-analysis: the worldwide prevalence of Helicobacter pylori infection. Aliment Pharmacol Ther. 2018, 47:868-76. 10.1111\/apt.14561","journal-title":"Aliment Pharmacol Ther"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022","article-title":"Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis","volume":"153","author":"Hooi JK","year":"2017","unstructured":"Hooi JK, Lai WY, Ng WK, et al.. Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology. 2017, 153:420-9. 10.1053\/j.gastro.2017.04.022","journal-title":"Gastroenterology"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10018-1208","article-title":"Epidemiology, diagnosis, and risk factors of Helicobacter pylori infection in children","volume":"7","author":"Ozbey G","year":"2017","unstructured":"Ozbey G, Hanafiah A. Epidemiology, diagnosis, and risk factors of Helicobacter pylori infection in children. Euroasian J Hepatogastroenterol. 2017, 7:34-9. 10.5005\/jp-journals-10018-1208","journal-title":"Euroasian J Hepatogastroenterol"},{"key":"ref21","article-title":"Helicobacter pylori: a contemporary perspective on pathogenesis, diagnosis and treatment strategies","volume":"12","author":"Ali A","year":"2024","unstructured":"Ali A, AlHussaini KI. Helicobacter pylori: a contemporary perspective on pathogenesis, diagnosis and treatment strategies. Microorganisms. 2024, 12:222.","journal-title":"Microorganisms"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-017-0028-8","article-title":"Helicobacter pylori infection and prevalence of high blood pressure among Chinese adults","volume":"32","author":"Wan Z","year":"2018","unstructured":"Wan Z, Hu L, Hu M, Lei X, Huang Y, Lv Y. Helicobacter pylori infection and prevalence of high blood pressure among Chinese adults. J Hum Hypertens. 2018, 32:158-64. 10.1038\/s41371-017-0028-8","journal-title":"J Hum Hypertens"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197430","article-title":"Helicobacter pylori virulence factor cytotoxin-associated gene A (CagA)-mediated gastric pathogenicity","volume":"21","author":"Ansari S","year":"2020","unstructured":"Ansari S, Yamaoka Y. Helicobacter pylori virulence factor cytotoxin-associated gene A (CagA)-mediated gastric pathogenicity. Int J Mol Sci. 2020, 21:7430. 10.3390\/ijms21197430","journal-title":"Int J Mol Sci"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i40.11221","article-title":"Diagnosis of Helicobacter pylori infection: current options and developments","volume":"21","author":"Wang YK","year":"2015","unstructured":"Wang YK, Kuo FC, Liu CJ, et al.. Diagnosis of Helicobacter pylori infection: current options and developments. World J Gastroenterol. 2015, 21:11221-35. 10.3748\/wjg.v21.i40.11221","journal-title":"World J Gastroenterol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2023.10.021","article-title":"Berberine-loaded mannosylerythritol lipid-B nanomicelles as drug delivery carriers for the treatment of Helicobacter pylori biofilms in vivo","volume":"193","author":"Cheng X","year":"2023","unstructured":"Cheng X, Geng J, Wang L, Ma X, Su Y, Arif M, Liu C. Berberine-loaded mannosylerythritol lipid-B nanomicelles as drug delivery carriers for the treatment of Helicobacter pylori biofilms in vivo. Eur J Pharm Biopharm. 2023, 193:105-18. 10.1016\/j.ejpb.2023.10.021","journal-title":"Eur J Pharm Biopharm"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-50266-2","article-title":"A pilot study of non-invasive diagnostic tools to detect Helicobacter pylori infection and peptic ulcer disease","volume":"13","author":"Liao EC","year":"2023","unstructured":"Liao EC, Yu CH, Lai JH, Lin CC, Chen CJ, Chang WH, Chien DK. A pilot study of non-invasive diagnostic tools to detect Helicobacter pylori infection and peptic ulcer disease. Sci Rep. 2023, 13:22800. 10.1038\/s41598-023-50266-2","journal-title":"Sci Rep"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12081260","article-title":"Biofilm of Helicobacter pylori: life cycle, features, and treatment options","volume":"12","author":"Elshenawi Y","year":"2023","unstructured":"Elshenawi Y, Hu S, Hathroubi S. Biofilm of Helicobacter pylori: life cycle, features, and treatment options. Antibiotics (Basel). 2023, 12:1260. 10.3390\/antibiotics12081260","journal-title":"Antibiotics (Basel)"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26196078","article-title":"Revisiting therapeutic strategies for H. pylori treatment in the context of antibiotic resistance: focus on alternative and complementary therapies","volume":"26","author":"Cardos IA","year":"2021","unstructured":"Cardos IA, Zaha DC, Sindhu RK, Cavalu S. Revisiting therapeutic strategies for H. pylori treatment in the context of antibiotic resistance: focus on alternative and complementary therapies. Molecules. 2021, 26:6078. 10.3390\/molecules26196078","journal-title":"Molecules"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000618","article-title":"Recent progress in Helicobacter pylori treatment","volume":"133","author":"Hu Y","year":"2020","unstructured":"Hu Y, Zhu Y, Lu NH. Recent progress in Helicobacter pylori treatment. Chin Med J (Engl). 2020, 133:335-43. 10.1097\/CM9.0000000000000618","journal-title":"Chin Med J (Engl)"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-022-01322-8","article-title":"Comparison of the efficacies of triple, quadruple and sequential antibiotic therapy in eradicating Helicobacter pylori infection: a randomized controlled trial","volume":"42","author":"Panigrahi MK","year":"2023","unstructured":"Panigrahi MK, Chouhan MI, Hallur VK, et al.. Comparison of the efficacies of triple, quadruple and sequential antibiotic therapy in eradicating Helicobacter pylori infection: a randomized controlled trial. Indian J Gastroenterol. 2023, 42:517-24. 10.1007\/s12664-022-01322-8","journal-title":"Indian J Gastroenterol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000146","article-title":"Recurrence of Helicobacter pylori infection: incidence and influential factors","volume":"132","author":"Xue Y","year":"2019","unstructured":"Xue Y, Zhou LY, Lu HP, Liu JZ. Recurrence of Helicobacter pylori infection: incidence and influential factors. Chin Med J (Engl). 2019, 132:765-71. 10.1097\/CM9.0000000000000146","journal-title":"Chin Med J (Engl)"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.11.035","article-title":"Time latencies of Helicobacter pylori eradication after peptic ulcer and risk of recurrent ulcer, ulcer adverse events, and gastric cancer: a population-based cohort study","volume":"88","author":"Sverd\u00e9n E","year":"2018","unstructured":"Sverd\u00e9n E, Brusselaers N, Wahlin K, Lagergren J. Time latencies of Helicobacter pylori eradication after peptic ulcer and risk of recurrent ulcer, ulcer adverse events, and gastric cancer: a population-based cohort study. Gastrointest Endosc. 2018, 88:242-50.e1. 10.1016\/j.gie.2017.11.035","journal-title":"Gastrointest Endosc"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000497","article-title":"Helicobacter pylori resistance to current therapies","volume":"35","author":"Smith SM","year":"2019","unstructured":"Smith SM, O'Morain C, McNamara D. Helicobacter pylori resistance to current therapies. Curr Opin Gastroenterol. 2019, 35:6-13. 10.1097\/MOG.0000000000000497","journal-title":"Curr Opin Gastroenterol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/392387-burden-of-helicobacter-pylori-in-duodenal-ulcer-disease-evidence-from-a-tertiary-hospital-in-chennai-india","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:21:23Z","timestamp":1755696083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/392387-burden-of-helicobacter-pylori-in-duodenal-ulcer-disease-evidence-from-a-tertiary-hospital-in-chennai-india"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":33,"URL":"https:\/\/doi.org\/10.7759\/cureus.90573","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,20]]}}}