{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T02:11:14Z","timestamp":1755828674583,"version":"3.44.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,21]]},"DOI":"10.7759\/cureus.90659","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T12:43:23Z","timestamp":1755780203000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardiac Amyloidosis Mimicking Heart Failure With Preserved Ejection Fraction: Evaluating Self-Reported Red Flags in Routine Clinical Practice"],"prefix":"10.7759","author":[{"given":"Adil","family":"Mushtaq","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anum","family":"Faiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayyar Iqbal","family":"Tiwana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankit","family":"Wadhwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Zubair Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azmir Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roukaya Lamine","family":"Hamadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Sabah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafsa","family":"Aslam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Maher","family":"Husni Abdelkhalik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saifullah","family":"Syed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zainab","family":"Salahuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.83","article-title":"The pathophysiology of heart failure with preserved ejection fraction","volume":"11","author":"Borlaug BA","year":"2014","unstructured":"Borlaug BA. The pathophysiology of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2014, 11:507-15. 10.1038\/nrcardio.2014.83","journal-title":"Nat Rev Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12153","article-title":"\"Red-flag\" symptom clusters in transthyretin familial amyloid polyneuropathy","volume":"21","author":"Concei\u00e7\u00e3o I","year":"2016","unstructured":"Concei\u00e7\u00e3o I, Gonz\u00e1lez-Duarte A, Obici L, Schmidt HH, Simoneau D, Ong ML, Amass L. \"Red-flag\" symptom clusters in transthyretin familial amyloid polyneuropathy. J Peripher Nerv Syst. 2016, 21:5-9. 10.1111\/jns.12153","journal-title":"J Peripher Nerv Syst"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.313572","article-title":"Heart failure with preserved ejection fraction in perspective","volume":"124","author":"Pfeffer MA","year":"2019","unstructured":"Pfeffer MA, Shah AM, Borlaug BA. Heart failure with preserved ejection fraction in perspective. Circ Res. 2019, 124:1598-617. 10.1161\/CIRCRESAHA.119.313572","journal-title":"Circ Res"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft062","article-title":"How do patients with heart failure with preserved ejection fraction die?","volume":"15","author":"Chan MM","year":"2013","unstructured":"Chan MM, Lam CS. How do patients with heart failure with preserved ejection fraction die?. Eur J Heart Fail. 2013, 15:604-13. 10.1093\/eurjhf\/hft062","journal-title":"Eur J Heart Fail"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.2020","article-title":"Heart failure with preserved ejection fraction: a review","volume":"329","author":"Redfield MM","year":"2023","unstructured":"Redfield MM, Borlaug BA. Heart failure with preserved ejection fraction: a review. JAMA. 2023, 329:827-38. 10.1001\/jama.2023.2020","journal-title":"JAMA"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051530","article-title":"Outcome of heart failure with preserved ejection fraction in a population-based study","volume":"355","author":"Bhatia RS","year":"2006","unstructured":"Bhatia RS, Tu JV, Lee DS, et al.. Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med. 2006, 355:260-9. 10.1056\/NEJMoa051530","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.18-2-s30","article-title":"Cardiac amyloidosis","volume":"18","author":"Martinez-Naharro A","year":"2018","unstructured":"Martinez-Naharro A, Hawkins PN, Fontana M. Cardiac amyloidosis. Clin Med (Lond). 2018, 18:s30-5. 10.7861\/clinmedicine.18-2-s30","journal-title":"Clin Med (Lond)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.12.005","article-title":"The impact of patients with cardiac\u00a0amyloidosis in HFpEF trials","volume":"9","author":"Oghina S","year":"2021","unstructured":"Oghina S, Bougouin W, B\u00e9zard M, et al.. The impact of patients with cardiac\u00a0amyloidosis in HFpEF trials. JACC Heart Fail. 2021, 9:169-78. 10.1016\/j.jchf.2020.12.005","journal-title":"JACC Heart Fail"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111519","article-title":"Heart failure with preserved ejection fraction and cardiac amyloidosis in the aging heart","volume":"25","author":"Tana M","year":"2024","unstructured":"Tana M, Piccinini R, Moffa L, Tana C. Heart failure with preserved ejection fraction and cardiac amyloidosis in the aging heart. Int J Mol Sci. 2024, 25:11519. 10.3390\/ijms252111519","journal-title":"Int J Mol Sci"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20170079","article-title":"Cardiac amyloidosis and its new clinical phenotype: heart failure with preserved ejection fraction","volume":"109","author":"Mesquita ET","year":"2017","unstructured":"Mesquita ET, Jorge AJ, Souza CV Junior, Andrade TR. Cardiac amyloidosis and its new clinical phenotype: heart failure with preserved ejection fraction. Arq Bras Cardiol. 2017, 109:71-80. 10.5935\/abc.20170079","journal-title":"Arq Bras Cardiol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.04.007","article-title":"Endomyocardial biopsy characterization of heart\u00a0failure with preserved ejection\u00a0fraction and prevalence of cardiac amyloidosis","volume":"8","author":"Hahn VS","year":"2020","unstructured":"Hahn VS, Yanek LR, Vaishnav J, et al.. Endomyocardial biopsy characterization of heart\u00a0failure with preserved ejection\u00a0fraction and prevalence of cardiac amyloidosis. JACC Heart Fail. 2020, 8:712-24. 10.1016\/j.jchf.2020.04.007","journal-title":"JACC Heart Fail"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-019-09880-4","article-title":"Myocardial phenotypes and dysfunction in HFpEF and HFrEF assessed by echocardiography and cardiac magnetic resonance","volume":"25","author":"Berlot B","year":"2020","unstructured":"Berlot B, Bucciarelli-Ducci C, Palazzuoli A, Marino P. Myocardial phenotypes and dysfunction in HFpEF and HFrEF assessed by echocardiography and cardiac magnetic resonance. Heart Fail Rev. 2020, 25:75-84. 10.1007\/s10741-019-09880-4","journal-title":"Heart Fail Rev"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-022-01694-7","article-title":"Sample size calculation for prevalence studies using Scalex and ScalaR calculators","volume":"22","author":"Naing L","year":"2022","unstructured":"Naing L, Nordin RB, Abdul Rahman H, Naing YT. Sample size calculation for prevalence studies using Scalex and ScalaR calculators. BMC Med Res Methodol. 2022, 22:209. 10.1186\/s12874-022-01694-7","journal-title":"BMC Med Res Methodol"},{"key":"ref14","unstructured":"Classification of functional capacity and objective assessment. (1994). Accessed. June 23, 2025: https:\/\/professional.heart.org\/en\/guidelines-and-statements\/classification."},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(00)00531-3","article-title":"Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure","volume":"35","author":"Green CP","year":"2000","unstructured":"Green CP, Porter CB, Bresnahan DR, Spertus JA. Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure. J Am Coll Cardiol. 2000, 35:1245-55. 10.1016\/s0735-1097(00)00531-3","journal-title":"J Am Coll Cardiol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319877708","article-title":"Keys to early diagnosis of cardiac amyloidosis: red flags from clinical, laboratory and imaging findings","volume":"27","author":"Vergaro G","year":"2020","unstructured":"Vergaro G, Aimo A, Barison A, Genovesi D, Buda G, Passino C, Emdin M. Keys to early diagnosis of cardiac amyloidosis: red flags from clinical, laboratory and imaging findings. Eur J Prev Cardiol. 2020, 27:1806-15. 10.1177\/2047487319877708","journal-title":"Eur J Prev Cardiol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2004.01.009","article-title":"Age, functional capacity, and health-related quality of life in patients with heart failure","volume":"10","author":"Masoudi FA","year":"2004","unstructured":"Masoudi FA, Rumsfeld JS, Havranek EP, House JA, Peterson ED, Krumholz HM, Spertus JA. Age, functional capacity, and health-related quality of life in patients with heart failure. J Card Fail. 2004, 10:368-73. 10.1016\/j.cardfail.2004.01.009","journal-title":"J Card Fail"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046680","article-title":"Complexities and pitfalls in cardiac amyloidosis","volume":"142","author":"Cuddy SA","year":"2020","unstructured":"Cuddy SA, Dorbala S, Falk RH. Complexities and pitfalls in cardiac amyloidosis. Circulation. 2020, 142:409-15. 10.1161\/CIRCULATIONAHA.120.046680","journal-title":"Circulation"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5146\/tjpath.2023.12923","article-title":"Cardiac amyloidosis: clinical features, pathogenesis, diagnosis, and treatment","volume":"40","author":"Argon A","year":"2024","unstructured":"Argon A, Nart D, Yilmazbarbet F. Cardiac amyloidosis: clinical features, pathogenesis, diagnosis, and treatment. Turk Patoloji Derg. 2024, 40:1-9. 10.5146\/tjpath.2023.12923","journal-title":"Turk Patoloji Derg"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2025.07.011","article-title":"Transthyretin amyloid cardiomyopathy: evolving therapies, expanding hope [in press]","author":"Costabel JP","year":"2025","unstructured":"Costabel JP, Suarez LL, Rochlani Y, Masri A, Slipczuk L, Berrios E. Transthyretin amyloid cardiomyopathy: evolving therapies, expanding hope [in press]. Prog Cardiovasc Dis. 2025, 10.1016\/j.pcad.2025.07.011","journal-title":"Prog Cardiovasc Dis"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038169","article-title":"Natural history, quality of life, and outcome in cardiac transthyretin amyloidosis","volume":"140","author":"Lane T","year":"2019","unstructured":"Lane T, Fontana M, Martinez-Naharro A, et al.. Natural history, quality of life, and outcome in cardiac transthyretin amyloidosis. Circulation. 2019, 140:16-26. 10.1161\/CIRCULATIONAHA.118.038169","journal-title":"Circulation"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-016-0564-2","article-title":"The burden of amyloid light chain amyloidosis on health-related quality of life","volume":"12","author":"Bayliss M","year":"2017","unstructured":"Bayliss M, McCausland KL, Guthrie SD, White MK. The burden of amyloid light chain amyloidosis on health-related quality of life. Orphanet J Rare Dis. 2017, 12:15. 10.1186\/s13023-016-0564-2","journal-title":"Orphanet J Rare Dis"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-021-00219-5","article-title":"Impact of delayed diagnosis and misdiagnosis for patients with transthyretin amyloid cardiomyopathy (ATTR-CM): a targeted literature review","volume":"10","author":"Rozenbaum MH","year":"2021","unstructured":"Rozenbaum MH, Large S, Bhambri R, et al.. Impact of delayed diagnosis and misdiagnosis for patients with transthyretin amyloid cardiomyopathy (ATTR-CM): a targeted literature review. Cardiol Ther. 2021, 10:141-59. 10.1007\/s40119-021-00219-5","journal-title":"Cardiol Ther"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.858281","article-title":"Red flags, prognostic impact, and management of patients with cardiac amyloidosis and aortic valve stenosis: a systematic review and meta-analysis","volume":"9","author":"Myasoedova VA","year":"2022","unstructured":"Myasoedova VA, Conte M, Valerio V, et al.. Red flags, prognostic impact, and management of patients with cardiac amyloidosis and aortic valve stenosis: a systematic review and meta-analysis. Front Med (Lausanne). 2022, 9:858281. 10.3389\/fmed.2022.858281","journal-title":"Front Med (Lausanne)"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2001.49082.x","article-title":"The relationship between body mass index and self-reported functional limitation among older adults: a gender difference","volume":"49","author":"Friedmann JM","year":"2001","unstructured":"Friedmann JM, Elasy T, Jensen GL. The relationship between body mass index and self-reported functional limitation among older adults: a gender difference. J Am Geriatr Soc. 2001, 49:398-403. 10.1046\/j.1532-5415.2001.49082.x","journal-title":"J Am Geriatr Soc"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.59663","article-title":"Gender disparities in cardiovascular disease and their management: a review","volume":"16","author":"Betai D","year":"2024","unstructured":"Betai D, Ahmed AS, Saxena P, et al.. Gender disparities in cardiovascular disease and their management: a review. Cureus. 2024, 16:e59663. 10.7759\/cureus.59663","journal-title":"Cureus"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-014-0166-4","article-title":"Aging, Gender and Quality of Life (AGEQOL) study: factors associated with good quality of life in older Brazilian community-dwelling adults","volume":"12","author":"Campos AC","year":"2014","unstructured":"Campos AC, Ferreira e Ferreira E, Vargas AM, Albala C. Aging, Gender and Quality of Life (AGEQOL) study: factors associated with good quality of life in older Brazilian community-dwelling adults. Health Qual Life Outcomes. 2014, 12:166. 10.1186\/s12955-014-0166-4","journal-title":"Health Qual Life Outcomes"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1590\/2237-6089-2018-0057","article-title":"Relationship between sexual hormones, quality of life and postmenopausal sexual function","volume":"41","author":"Peixoto C","year":"2019","unstructured":"Peixoto C, Carrilho CG, Ribeiro TT, et al.. Relationship between sexual hormones, quality of life and postmenopausal sexual function. Trends Psychiatry Psychother. 2019, 41:136-43. 10.1590\/2237-6089-2018-0057","journal-title":"Trends Psychiatry Psychother"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2021.1976450","article-title":"Trends in diagnosis, referral, red flag onset, patient profiles and natural outcome of de novo cardiac amyloidosis and their multidisciplinary implications","volume":"77","author":"Debonnaire P","year":"2022","unstructured":"Debonnaire P, Claeys M, De Smet M, et al.. Trends in diagnosis, referral, red flag onset, patient profiles and natural outcome of de novo cardiac amyloidosis and their multidisciplinary implications. Acta Cardiol. 2022, 77:791-804. 10.1080\/00015385.2021.1976450","journal-title":"Acta Cardiol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-311x2005000400020","article-title":"Functional limitations of Brazilian elderly by age and gender differences: data from SABE Survey","volume":"21","author":"Barbosa AR","year":"2005","unstructured":"Barbosa AR, Souza JM, Lebr\u00e3o ML, Laurenti R, Marucci Mde F. Functional limitations of Brazilian elderly by age and gender differences: data from SABE Survey. Cad Saude Publica. 2005, 21:1177-85. 10.1590\/s0102-311x2005000400020","journal-title":"Cad Saude Publica"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2022.1109","article-title":"Age-related hormones changes and its impact on health status and lifespan","volume":"14","author":"Biagetti B","year":"2023","unstructured":"Biagetti B, Puig-Domingo M. Age-related hormones changes and its impact on health status and lifespan. Aging Dis. 2023, 14:605-20. 10.14336\/AD.2022.1109","journal-title":"Aging Dis"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldn003","article-title":"Quality of life in older ages","volume":"85","author":"Netuveli G","year":"2008","unstructured":"Netuveli G, Blane D. Quality of life in older ages. Br Med Bull. 2008, 85:113-26. 10.1093\/bmb\/ldn003","journal-title":"Br Med Bull"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0195-4","article-title":"Self-awareness of heart failure in the oldest old-an observational study of participants, \u2265 80 years old, with an objectively verified heart failure","volume":"16","author":"Selan S","year":"2016","unstructured":"Selan S, Siennicki-Lantz A, Berglund J, Fagerstr\u00f6m C. Self-awareness of heart failure in the oldest old-an observational study of participants, \u2265 80 years old, with an objectively verified heart failure. BMC Geriatr. 2016, 16:23. 10.1186\/s12877-016-0195-4","journal-title":"BMC Geriatr"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.029284","article-title":"Patient awareness of heart failure diagnosis: a community study","volume":"12","author":"Shropshire SJ","year":"2023","unstructured":"Shropshire SJ, Fabbri M, Manemann SM, Roger VL, Killian JM, Weston SA, Chamberlain AM. Patient awareness of heart failure diagnosis: a community study. J Am Heart Assoc. 2023, 12:e029284. 10.1161\/JAHA.122.029284","journal-title":"J Am Heart Assoc"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8287.2011.02047.x","article-title":"Newly diagnosed heart failure: change in quality of life, mood, and illness beliefs in the first 6 months after diagnosis","volume":"17","author":"Mulligan K","year":"2012","unstructured":"Mulligan K, Mehta PA, Fteropoulli T, et al.. Newly diagnosed heart failure: change in quality of life, mood, and illness beliefs in the first 6 months after diagnosis. Br J Health Psychol. 2012, 17:447-62. 10.1111\/j.2044-8287.2011.02047.x","journal-title":"Br J Health Psychol"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2024.07.007","article-title":"Functional status and quality of life in light-chain amyloidosis: advanced imaging, longitudinal changes, and outcomes","volume":"12","author":"Clerc OF","year":"2024","unstructured":"Clerc OF, Vijayakumar S, Cuddy SA, et al.. Functional status and quality of life in light-chain amyloidosis: advanced imaging, longitudinal changes, and outcomes. JACC Heart Fail. 2024, 12:1994-2006. 10.1016\/j.jchf.2024.07.007","journal-title":"JACC Heart Fail"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb04571.x","article-title":"Age-related differences in management of heart disease: a study of cardiac medication use in an older cohort. Pacemaker Selection in the Elderly (PASE) Investigators","volume":"47","author":"Ganz DA","year":"1999","unstructured":"Ganz DA, Lamas GA, Orav EJ, Goldman L, Gutierrez PR, Mangione CM. Age-related differences in management of heart disease: a study of cardiac medication use in an older cohort. Pacemaker Selection in the Elderly (PASE) Investigators. J Am Geriatr Soc. 1999, 47:145-50. 10.1111\/j.1532-5415.1999.tb04571.x","journal-title":"J Am Geriatr Soc"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1177\/1090198112473110","article-title":"Family health history communication networks of older adults: importance of social relationships and disease perceptions","volume":"40","author":"Ashida S","year":"2013","unstructured":"Ashida S, Kaphingst KA, Goodman M, Schafer EJ. Family health history communication networks of older adults: importance of social relationships and disease perceptions. Health Educ Behav. 2013, 40:612-9. 10.1177\/1090198112473110","journal-title":"Health Educ Behav"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/395723-cardiac-amyloidosis-mimicking-heart-failure-with-preserved-ejection-fraction-evaluating-self-reported-red-flags-in-routine-clinical-practice","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T12:43:24Z","timestamp":1755780204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/395723-cardiac-amyloidosis-mimicking-heart-failure-with-preserved-ejection-fraction-evaluating-self-reported-red-flags-in-routine-clinical-practice"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":38,"URL":"https:\/\/doi.org\/10.7759\/cureus.90659","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,8,21]]}}}