{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:04:53Z","timestamp":1756166693285,"version":"3.44.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,25]]},"DOI":"10.7759\/cureus.90930","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T10:00:23Z","timestamp":1756116023000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of GSTT1, GSTM1, and NQO1 Gene Polymorphisms With Susceptibility, Clinical Severity, and Treatment Response in Aplastic Anemia"],"prefix":"10.7759","author":[{"given":"Vijayta","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anam","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alka","family":"Diwedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayank","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil Kumar","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saurabh","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-020-01281-0","article-title":"Association of interleukin-1\u03b2-31C\/T, -511T\/C and -3954C\/T single nucleotide polymorphism and their blood plasma level in acquired aplastic anemia","volume":"37","author":"Shukla S","year":"2021","unstructured":"Shukla S, Tripathi AK, Verma SP, Yadav DK, Tripathi RK, Maurya S, Awasthi N. Association of interleukin-1\u03b2-31C\/T, -511T\/C and -3954C\/T single nucleotide polymorphism and their blood plasma level in acquired aplastic anemia. Indian J Hematol Blood Transfus. 2021, 37:210-9. 10.1007\/s12288-020-01281-0","journal-title":"Indian J Hematol Blood Transfus"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5045\/br.2020.2020009","article-title":"Prognostic value of TNF-a-308 and IFN-g-874 single nucleotide polymorphisms and their plasma levels in patients with aplastic anemia","volume":"55","author":"Shukla S","year":"2020","unstructured":"Shukla S, Tripathi AK, Verma SP, Awasthi N. Prognostic value of TNF-a-308 and IFN-g-874 single nucleotide polymorphisms and their plasma levels in patients with aplastic anemia. Blood Res. 2020, 55:193-9. 10.5045\/br.2020.2020009","journal-title":"Blood Res"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0903373","article-title":"Telomere diseases","volume":"361","author":"Calado RT","year":"2009","unstructured":"Calado RT, Young NS. Telomere diseases. N Engl J Med. 2009, 361:2353-65. 10.1056\/NEJMra0903373","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07842.x","article-title":"Guidelines for the diagnosis and management of aplastic anaemia","volume":"147","author":"Marsh JC","year":"2009","unstructured":"Marsh JC, Ball SE, Cavenagh J, et al.. Guidelines for the diagnosis and management of aplastic anaemia. Br J Haematol. 2009, 147:43-70. 10.1111\/j.1365-2141.2009.07842.x","journal-title":"Br J Haematol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/njms.njms_62_22","article-title":"Immunotherapeutic and their immunological aspects: current treatment strategies and agents","volume":"13","author":"Jain M","year":"2022","unstructured":"Jain M, Mishra A, Singh MK, Shyam H, Kumar S, Shankar P, Singh S. Immunotherapeutic and their immunological aspects: current treatment strategies and agents. Natl J Maxillofac Surg. 2022, 13:322-9. 10.4103\/njms.njms_62_22","journal-title":"Natl J Maxillofac Surg"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13471","article-title":"EACR 2023: Innovative Cancer Science, 12-15 June 2023, Torino, Italy","volume":"17 Suppl 1","year":"2023","unstructured":"EACR 2023. Innovative Cancer Science, 12-15 June 2023, Torino, Italy. Mol Oncol. 2023, 17 Suppl 1:1-597. 10.1002\/1878-0261.13471","journal-title":"Mol Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.10.357","article-title":"221P Genetic polymorphism of genes encoding cytokines interleukin1 1-alpha and TNF-alpha in non-muscle invasive bladder cancer","volume":"34","author":"Kumar A","year":"2023","unstructured":"Kumar A, Singh V, Singh MK. 221P Genetic polymorphism of genes encoding cytokines interleukin1 1-alpha and TNF-alpha in non-muscle invasive bladder cancer. Annals of Oncology. 2023, 34:1561. 10.1016\/j.annonc.2023.10.357","journal-title":"Annals of Oncology"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.10.305","article-title":"285P Genetic variation of the inflammatory cytokine Interleukin 17 in non-muscle invasive bladder cancer","volume":"35","author":"Singh MK","year":"2024","unstructured":"Singh MK, Singh V, Kumar A. 285P Genetic variation of the inflammatory cytokine Interleukin 17 in non-muscle invasive bladder cancer. Annals of Oncology. 2024, 35:1515. 10.1016\/j.annonc.2024.10.305","journal-title":"Annals of Oncology"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12020","article-title":"Epidemiology of aplastic anemia: a prospective multicenter study","volume":"93","author":"Montan\u00e9 E","year":"2008","unstructured":"Montan\u00e9 E, Ib\u00e1\u00f1ez L, Vidal X, Ballar\u00edn E, Puig R, Garc\u00eda N, Laporte JR. Epidemiology of aplastic anemia: a prospective multicenter study. Haematologica. 2008, 93:518-23. 10.3324\/haematol.12020","journal-title":"Haematologica"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(04)82008-1","article-title":"NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics","volume":"382","author":"Ross D","year":"2004","unstructured":"Ross D, Siegel D. NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics. Elsevier. 2004, 382:115-44. 10.1016\/S0076-6879(04)82008-1","journal-title":"Elsevier"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2023.09.008","article-title":"The relationship between BCG immunotherapy and oxidative stress parameters in patients with nonmuscle invasive bladder cancer","volume":"41","author":"Singh V","year":"2023","unstructured":"Singh V, Singh MK, Jain M, Pandey AK, Kumar A, Sahu DK. The relationship between BCG immunotherapy and oxidative stress parameters in patients with nonmuscle invasive bladder cancer. Urol Oncol. 2023, 41:486.e25-32. 10.1016\/j.urolonc.2023.09.008","journal-title":"Urol Oncol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2023.04.022","article-title":"CYP1A1 gene polymorphism and heavy metal analyses in benign prostatic hyperplasia and prostate cancer: an explorative case-control study","volume":"41","author":"Singh V","year":"2023","unstructured":"Singh V, Madeshiya AK, Ansari NG, Singh MK, Abhishek A. CYP1A1 gene polymorphism and heavy metal analyses in benign prostatic hyperplasia and prostate cancer: an explorative case-control study. Urol Oncol. 2023, 41:355.e9-355.e17. 10.1016\/j.urolonc.2023.04.022","journal-title":"Urol Oncol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2174\/138920006778017786","article-title":"Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology","volume":"7","author":"Bolt HM","year":"2006","unstructured":"Bolt HM, Thier R. Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology. Curr Drug Metab. 2006, 7:613-28. 10.2174\/138920006778017786","journal-title":"Curr Drug Metab"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199902000-00015","article-title":"Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1","volume":"9","author":"Siegel D","year":"1999","unstructured":"Siegel D, McGuinness SM, Winski SL, Ross D. Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1. Pharmacogenetics. 1999, 9:113-21. 10.1097\/00008571-199902000-00015","journal-title":"Pharmacogenetics"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-024-01187-y","article-title":"Metabolomic biomarkers for prognosis in non-muscle invasive bladder cancer: a comprehensive systematic review and meta-analysis","volume":"40","author":"Singh V","year":"2025","unstructured":"Singh V, Singh MK, Kumar A, et al.. Metabolomic biomarkers for prognosis in non-muscle invasive bladder cancer: a comprehensive systematic review and meta-analysis. Indian J Clin Biochem. 2025, 40:176-90. 10.1007\/s12291-024-01187-y","journal-title":"Indian J Clin Biochem"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/gim.0b013e3180654ccd","article-title":"The NAD(P)H:quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma","volume":"9","author":"di Martino E","year":"2007","unstructured":"di Martino E, Hardie LJ, Wild CP, Gong YY, Olliver JR, Gough MD, Bird NC. The NAD(P)H:quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma. Genet Med. 2007, 9:341-7. 10.1097\/gim.0b013e3180654ccd","journal-title":"Genet Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb02460.x","article-title":"Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT* SAA Working Party","volume":"70","author":"Bacigalupo A","year":"1988","unstructured":"Bacigalupo A, Hows J, Gluckman E, et al.. Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT* SAA Working Party. Br J Haematol. 1988, 70:177-82. 10.1111\/j.1365-2141.1988.tb02460.x","journal-title":"Br J Haematol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.7.2191","article-title":"Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia: a report from the European Blood and Marrow Transplant (EBMT) Severe Aplastic Anaemia Working Party","volume":"93","author":"Marsh J","year":"1999","unstructured":"Marsh J, Schrezenmeier H, Marin P, et al.. Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia: a report from the European Blood and Marrow Transplant (EBMT) Severe Aplastic Anaemia Working Party. Blood. 1999, 93:2191-5. 10.1182\/blood.V93.7.2191","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013145","article-title":"Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm","volume":"5","author":"Ji G","year":"2010","unstructured":"Ji G, Gu A, Zhou Y, et al.. Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm. PLoS ONE. 2010, 5:10.1371\/journal.pone.0013145","journal-title":"PLoS ONE"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000324066","article-title":"Glutathione S-transferase gene polymorphism as a susceptibility factor for acute myocardial infarction and smoking in the North Indian population","volume":"118","author":"Singh N","year":"2011","unstructured":"Singh N, Sinha N, Kumar S, Pandey CM, Agrawal S. Glutathione S-transferase gene polymorphism as a susceptibility factor for acute myocardial infarction and smoking in the North Indian population. Cardiology. 2011, 118:16-21. 10.1159\/000324066","journal-title":"Cardiology"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-636381","article-title":"Clonal hematopoiesis in acquired aplastic anemia","volume":"128","author":"Ogawa S","year":"2016","unstructured":"Ogawa S. Clonal hematopoiesis in acquired aplastic anemia. Blood. 2016, 128:337-47. 10.1182\/blood-2016-01-636381","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2013.08.005","article-title":"Association between virulence factors of helicobacter pylori and gastric mucosal interleukin-18 mRNA expression in dyspeptic patients","volume":"65","author":"Bagheri N","year":"2013","unstructured":"Bagheri N, Taghikhani A, Rahimian G, et al.. Association between virulence factors of helicobacter pylori and gastric mucosal interleukin-18 mRNA expression in dyspeptic patients. Microb Pathog. 2013, 65:7-13. 10.1016\/j.micpath.2013.08.005","journal-title":"Microb Pathog"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12855","article-title":"The epidemiology of acquired aplastic anemia","volume":"93","author":"Young NS","year":"2008","unstructured":"Young NS, Kaufman DW. The epidemiology of acquired aplastic anemia. Haematologica. 2008, 93:489-92. 10.3324\/haematol.12855","journal-title":"Haematologica"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000041000","article-title":"Current results of bone marrow transplantation in patients with acquired severe aplastic anemia: report of the European Group for Blood and Marrow Transplantation","volume":"103","author":"Bacigalupo A","year":"2000","unstructured":"Bacigalupo A, Oneto R, Bruno B, et al.. Current results of bone marrow transplantation in patients with acquired severe aplastic anemia: report of the European Group for Blood and Marrow Transplantation. Acta Haematol. 2000, 103:19-25. 10.1159\/000041000","journal-title":"Acta Haematol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.46505\/ijbi.2024.6206","article-title":"NAD (P) H: quinone oxidoreductase 1 gene C609t polymorphism and Alzheimer's disease risk","volume":"6","author":"Kumar P","year":"2024","unstructured":"Kumar P, Kannojiya A, Rai V. NAD (P) H: quinone oxidoreductase 1 gene C609t polymorphism and Alzheimer's disease risk. International Journal of Biological Innovations. 2024, 6:135-42. 10.46505\/ijbi.2024.6206","journal-title":"International Journal of Biological Innovations"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1992-x","article-title":"Immunoregulatory cytokines gene polymorphisms in Egyptian patients affected with acquired aplastic anemia","volume":"93","author":"El Mahgoub IR","year":"2014","unstructured":"El Mahgoub IR, Afify RA, Botros SK, Fawzy R. Immunoregulatory cytokines gene polymorphisms in Egyptian patients affected with acquired aplastic anemia. Ann Hematol. 2014, 93:923-9. 10.1007\/s00277-013-1992-x","journal-title":"Ann Hematol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/397084-association-of-gstt1-gstm1-and-nqo1-gene-polymorphisms-with-susceptibility-clinical-severity-and-treatment-response-in-aplastic-anemia","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T10:00:24Z","timestamp":1756116024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/397084-association-of-gstt1-gstm1-and-nqo1-gene-polymorphisms-with-susceptibility-clinical-severity-and-treatment-response-in-aplastic-anemia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.90930","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,25]]}}}