{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T03:09:47Z","timestamp":1787540987189,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,25]]},"DOI":"10.7759\/cureus.90997","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T05:15:58Z","timestamp":1756185358000},"source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Seed Cycling as an Integrative Therapy for Premenstrual Syndrome and Polycystic Ovary Syndrome in Reproductive-Aged Women: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Divyashri  R","family":"Nagarajan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daya","family":"Mani Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Munir Mufti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smiruti","family":"Rajesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajani","family":"Dube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.54393\/pbmj.v4i2.100","article-title":"Nutraceutical intervention of seeds in the treatment of poly cystic ovarian syndrome; a systematic review: nutraceutical intervention; seed cycling","volume":"4","author":"Aslam M","year":"2021","unstructured":"Aslam M, Shauket R. Nutraceutical intervention of seeds in the treatment of poly cystic ovarian syndrome; a systematic review: nutraceutical intervention; seed cycling. Pakistan BioMedical Journal. 2021, 4:281-286. 10.54393\/pbmj.v4i2.100","journal-title":"Pakistan BioMedical Journal"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph21091165","article-title":"Prevalence of polycystic ovary syndrome (PCOS) and its associated risk factors among medical students in two countries","volume":"21","author":"Begum GS","year":"2024","unstructured":"Begum GS, Almashaikhi NA, Albalushi MY, Alsalehi HM, Alazawi RS, Goud BK, Dube R. Prevalence of polycystic ovary syndrome (PCOS) and its associated risk factors among medical students in two countries. Int J Environ Res Public Health. 2024, 21:1165. 10.3390\/ijerph21091165","journal-title":"Int J Environ Res Public Health"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/diabetology5040032","article-title":"The prevalence of gestational diabetes mellitus in polycystic ovary disease\u2014a systematic review, meta-analysis, and exploration of associated risk factors","volume":"5","author":"Dube R","unstructured":"Dube R, Bambani T, Saif S, Hashmi N, Patni MAMF, Kedia NR. The prevalence of gestational diabetes mellitus in polycystic ovary disease\u2014a systematic review, meta-analysis, and exploration of associated risk factors. Diabetology. 5:430-46. 10.3390\/diabetology5040032","journal-title":"Diabetology"},{"key":"ref4","article-title":"Effects of flax seeds supplementation in polycystic ovarian syndrome","volume":"31","author":"Farzana F K","year":"2015","unstructured":"Farzana F K, Sulaiman AF, Ruckmani A, et al.. Effects of flax seeds supplementation in polycystic ovarian syndrome. International Journal of Pharmaceutical Sciences Review and Research. 2015, 31:113-9.","journal-title":"International Journal of Pharmaceutical Sciences Review and Research"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3328","article-title":"Effectiveness of combined seeds (pumpkin, sunflower, sesame, flaxseed): As adjacent therapy to treat polycystic ovary syndrome in females","volume":"11","author":"Rasheed N","year":"2023","unstructured":"Rasheed N, Ahmed A, Nosheen F, et al.. Effectiveness of combined seeds (pumpkin, sunflower, sesame, flaxseed): As adjacent therapy to treat polycystic ovary syndrome in females. Food Sci Nutr. 2023, 11:3385-93. 10.1002\/fsn3.3328","journal-title":"Food Sci Nutr"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","unstructured":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004, 19.41-7. 10.1093\/humrep\/deh098","journal-title":"Hum Reprod"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26125575","article-title":"Exploring hirsutism: Epidemiology, associated endocrinal abnormalities, and societal challenges in GCC-a narrative review","volume":"26","author":"Patni MA","year":"2025","unstructured":"Patni MA, Dube R, Kar SS, George BT, Kuruba MG, Srinivasamurthy SK, Elamin AA. Exploring hirsutism: Epidemiology, associated endocrinal abnormalities, and societal challenges in GCC-a narrative review. Int J Mol Sci. 2025, 26:5575. 10.3390\/ijms26125575","journal-title":"Int J Mol Sci"},{"key":"ref8","article-title":"Diagnostic criteria and management in premenstrual syndrome","volume":"4","author":"Czajkowska M","year":"2016","unstructured":"Czajkowska M, Hanzel I, S\u0142omska A, Skrzypulec-Plinta V. Diagnostic criteria and management in premenstrual syndrome. GinPolMedProject. 2016, 4:49-53.","journal-title":"GinPolMedProject"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-4102500\/v1","article-title":"Effect of seed cycling on polycystic ovary syndrome [PREPRINT]","author":"Ajith K","year":"2024","unstructured":"Ajith K, Meera R. Effect of seed cycling on polycystic ovary syndrome [PREPRINT]. ResearchSquare. 2024, 10.21203\/rs.3.rs-4102500\/v1","journal-title":"ResearchSquare"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-020-0524-5","article-title":"The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial","volume":"19","author":"Haidari F","year":"2020","unstructured":"Haidari F, Banaei-Jahromi N, Zakerkish M, Ahmadi K. The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial. Nutr J. 2020, 19:8. 10.1186\/s12937-020-0524-5","journal-title":"Nutr J"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.22271\/tpi.2023.v12.i4k.19683","article-title":"Advantages of seed cycling diet in menstrual dysfunctions: A review based explanation","volume":"12","author":"Mahapatra D","year":"2023","unstructured":"Mahapatra D, Jwngsar B, Das M, et al.. Advantages of seed cycling diet in menstrual dysfunctions: A review based explanation. Pharma Innov. 2023, 12:931-9. 10.22271\/tpi.2023.v12.i4k.19683","journal-title":"Pharma Innov"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/cl2.1230","article-title":"PRISMA2020: An R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis","volume":"18","author":"Haddaway NR","year":"2022","unstructured":"Haddaway NR, Page MJ, Pritchard CC, McGuinness LA. PRISMA2020: An R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis. Campbell Syst Rev. 2022, 18:e1230. 10.1002\/cl2.1230","journal-title":"Campbell Syst Rev"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-021-06122-y","article-title":"Quality assessment with diverse studies (QuADS): an appraisal tool for methodological and reporting quality in systematic reviews of mixed- or multi-method studies","volume":"21","author":"Harrison R","year":"2021","unstructured":"Harrison R, Jones B, Gardner P, Lawton R. Quality assessment with diverse studies (QuADS): an appraisal tool for methodological and reporting quality in systematic reviews of mixed- or multi-method studies. BMC Health Serv Res. 2021, 21:144. 10.1186\/s12913-021-06122-y","journal-title":"BMC Health Serv Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.18311\/jnr\/2024\/36489","article-title":"Evaluation of effect of seed cycling on anthropometric, biochemical, hormonal and nutritional parameters in the women diagnosed with polycystic ovarian syndrome - a cohort interventional study design","volume":"24","author":"Kaur H","year":"2024","unstructured":"Kaur H, Anitha C, Ghatnatti V, Patil S, Kadeangadi D. Evaluation of effect of seed cycling on anthropometric, biochemical, hormonal and nutritional parameters in the women diagnosed with polycystic ovarian syndrome - a cohort interventional study design. Journal of Natural Remedies. 2024, 24:1547-59. 10.18311\/jnr\/2024\/36489","journal-title":"Journal of Natural Remedies"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.jpbs_164_25","article-title":"Seed cycling and hormonal balance: a case study of successful fertility intervention in polycystic ovarian syndrome","volume":"17","author":"Dhamija P","year":"2025","unstructured":"Dhamija P, More A, Choudhary N, Wadhe T, Barai J, Shah D. Seed cycling and hormonal balance: a case study of successful fertility intervention in polycystic ovarian syndrome. J Pharm Bioallied Sci. 2025, 17:S1030-3. 10.4103\/jpbs.jpbs_164_25","journal-title":"J Pharm Bioallied Sci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.31661\/gmj.v5i3.613","article-title":"Herbal treatment of oligomenorrhea with Sesamum indicum L.: a randomized controlled trial","volume":"5","author":"Yavari M","year":"2016","unstructured":"Yavari M, Rouholamin S, Tansaz M, Esmaeili S. Herbal treatment of oligomenorrhea with Sesamum indicum L.: a randomized controlled trial. Galen Medical Journal. 2016, 5:613-10. 10.31661\/gmj.v5i3.613","journal-title":"Galen Medical Journal"},{"key":"ref17","article-title":"The effect of consuming sesame (Sesamum indicum) on primary dysmenorrhea in students at Rafsanjan University of Medical Sciences (RUMS)","volume":"8","author":"Mohammadian F","year":"2017","unstructured":"Mohammadian F, Ghoreishi A, Sheikh Fathollali M, et al.. The effect of consuming sesame (Sesamum indicum) on primary dysmenorrhea in students at Rafsanjan University of Medical Sciences (RUMS). Community Health Journal. 2017, 8:1-9.","journal-title":"Community Health Journal"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.21608\/enj.2021.209919","article-title":"The bioactive effect of flaxseed on women with the polycystic ovarian syndrome","volume":"36","author":"Matar SS","year":"2021","unstructured":"Matar SS, Farrag AA, Hafez SM, Fahmy RM. The bioactive effect of flaxseed on women with the polycystic ovarian syndrome. Egyptian Journal of Nutrition. 2021, 36:49-77. 10.21608\/enj.2021.209919","journal-title":"Egyptian Journal of Nutrition"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1531762","article-title":"Flaxseed intervention and reproductive endocrine profiles in patients with polycystic ovary syndrome: an open-labeled randomized controlled clinical trial","volume":"16","author":"Najdgholami Z","year":"2025","unstructured":"Najdgholami Z, Sedgi FM, Ghalishourani SS, Feyzpour M, Rahimlou M. Flaxseed intervention and reproductive endocrine profiles in patients with polycystic ovary syndrome: an open-labeled randomized controlled clinical trial. Front Endocrinol (Lausanne). 2025, 16:1531762. 10.3389\/fendo.2025.1531762","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080\/10408360701612942","article-title":"Lignans and human health","volume":"44","author":"Adlercreutz H","year":"2007","unstructured":"Adlercreutz H. Lignans and human health. Crit Rev Clin Lab Sci. 2007, 44:483-525. 10.1080\/10408360701612942","journal-title":"Crit Rev Clin Lab Sci"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1222584","article-title":"The effect of flaxseed supplementation on sex hormone profile in adults: a systematic review and meta-analysis","volume":"10","author":"Musazadeh V","unstructured":"Musazadeh V, Nazari A, Natami M, et al.. The effect of flaxseed supplementation on sex hormone profile in adults: a systematic review and meta-analysis. Front Nutr. 10:1222584. 10.3389\/fnut.2023.1222584","journal-title":"Front Nutr"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-014-1293-y","article-title":"Flaxseed: a potential functional food source","volume":"52","author":"Kajla P","year":"2015","unstructured":"Kajla P, Sharma A, Sood DR. Flaxseed: a potential functional food source. J Food Sci Technol. 2015, 52:1857-71. 10.1007\/s13197-014-1293-y","journal-title":"J Food Sci Technol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioab023","article-title":"Role of zinc in female reproduction","volume":"104","author":"Garner TB","year":"2021","unstructured":"Garner TB, Hester JM, Carothers A, Diaz FJ. Role of zinc in female reproduction. Biol Reprod. 2021, 104:976-94. 10.1093\/biolre\/ioab023","journal-title":"Biol Reprod"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.26717\/BJSTR.2019.21.003586","article-title":"Nutritional and therapeutic effects of the pumpkin seeds","volume":"21","author":"Syed QA","year":"2019","unstructured":"Syed QA, Akram M, Shukat R. Nutritional and therapeutic effects of the pumpkin seeds. Biomed J Sci Tech Res. 2019, 21: 15798-803. 10.26717\/BJSTR.2019.21.003586","journal-title":"Biomed J Sci Tech Res"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3945\/an.112.003210","article-title":"Discovery of human zinc deficiency: its impact on human health and disease","volume":"4","author":"Prasad AS","year":"2013","unstructured":"Prasad AS. Discovery of human zinc deficiency: its impact on human health and disease. Adv Nutr. 2013, 4:176-90. 10.3945\/an.112.003210","journal-title":"Adv Nutr"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.54393\/pbmj.v4i2.122","article-title":"Role of seed cycling in polycystic ovarian syndrome: seed cycling in PCOS","volume":"4","author":"Irfan T","year":"2021","unstructured":"Irfan T, Seher K, Rizwan B, et al.. Role of seed cycling in polycystic ovarian syndrome: seed cycling in PCOS. Pakistan BioMedical Journal. 2021, 4:21-5. 10.54393\/pbmj.v4i2.122","journal-title":"Pakistan BioMedical Journal"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.455","article-title":"The role of selenium in thyroid autoimmunity and cancer","volume":"16","author":"Duntas LH","year":"2006","unstructured":"Duntas LH. The role of selenium in thyroid autoimmunity and cancer. Thyroid. 2006, 16:455-60. 10.1089\/thy.2006.16.455","journal-title":"Thyroid"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2236749","article-title":"Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism","volume":"15","author":"Hu S","year":"2023","unstructured":"Hu S, Ding Q, Zhang W, Kang M, Ma J, Zhao L. Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism. Gut Microbes. 2023, 15:2236749. 10.1080\/19490976.2023.2236749","journal-title":"Gut Microbes"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/399861-efficacy-of-seed-cycling-as-an-integrative-therapy-for-premenstrual-syndrome-and-polycystic-ovary-syndrome-in-reproductive-aged-women-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T05:16:01Z","timestamp":1756185361000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/399861-efficacy-of-seed-cycling-as-an-integrative-therapy-for-premenstrual-syndrome-and-polycystic-ovary-syndrome-in-reproductive-aged-women-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":28,"URL":"https:\/\/doi.org\/10.7759\/cureus.90997","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,25]]}}}