{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:03:59Z","timestamp":1756512239600,"version":"3.44.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,29]]},"DOI":"10.7759\/cureus.91220","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T08:48:46Z","timestamp":1756457326000},"source":"Crossref","is-referenced-by-count":0,"title":["Distribution of Oncological Diagnoses in Pediatric Patients With Febrile Neutropenia and Sepsis: Is There an Association?"],"prefix":"10.7759","author":[{"given":"Florin-Mihai","family":"Radulescu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Ionela","family":"Nedea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina-Magdalena","family":"Dumitru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s005200100277","article-title":"Fever and neutropenia in children with solid tumors is similar in severity and outcome to that in children with leukemia","volume":"10","author":"Ko\u00e7ak U","year":"2002","unstructured":"Ko\u00e7ak U, Rolston KV, Mullen CA. Fever and neutropenia in children with solid tumors is similar in severity and outcome to that in children with leukemia. Support Care Cancer. 2002, 10:58-64. 10.1007\/s005200100277","journal-title":"Support Care Cancer"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-64-2-328","article-title":"Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia","volume":"64","author":"Bodey GP","year":"1966","unstructured":"Bodey GP, Buckley M, Sathe YS, Freireich EJ. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med. 1966, 64:328-40. 10.7326\/0003-4819-64-2-328","journal-title":"Ann Intern Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4274\/jbuch.galenos.2024.88310","article-title":"Evaluation of infectious complications and their causative agents in pediatric cancer patients: a prospective single-center cohort study","volume":"14","author":"Besin D","year":"2024","unstructured":"Besin D, \u00c7a\u011flar \u0130, K\u0131ymet E, et al.. Evaluation of infectious complications and their causative agents in pediatric cancer patients: a prospective single-center cohort study. J Dr Behcet Uz Child Hosp. 2024, 14:20-7. 10.4274\/jbuch.galenos.2024.88310","journal-title":"J Dr Behcet Uz Child Hosp"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02224","article-title":"Guideline for the management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients: 2023 update","volume":"41","author":"Lehrnbecher T","year":"2023","unstructured":"Lehrnbecher T, Robinson PD, Ammann RA, et al.. Guideline for the management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients: 2023 update. J Clin Oncol. 2023, 41:1774-85. 10.1200\/JCO.22.02224","journal-title":"J Clin Oncol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1086\/522533","article-title":"A prospective study on the epidemiology of febrile episodes during chemotherapy-induced neutropenia in children with cancer or after hemopoietic stem cell transplantation","volume":"45","author":"Castagnola E","year":"2007","unstructured":"Castagnola E, Fontana V, Caviglia I, et al.. A prospective study on the epidemiology of febrile episodes during chemotherapy-induced neutropenia in children with cancer or after hemopoietic stem cell transplantation. Clin Infect Dis. 2007, 45:1296-304. 10.1086\/522533","journal-title":"Clin Infect Dis"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq196","article-title":"Management of febrile neutropenia: ESMO clinical practice guidelines","volume":"21","author":"de Naurois J","year":"2010","unstructured":"de Naurois J, Novitzky-Basso I, Gill MJ, Marti FM, Cullen MH, Roila F. Management of febrile neutropenia: ESMO clinical practice guidelines. Ann Oncol. 2010, 21:v252-6. 10.1093\/annonc\/mdq196","journal-title":"Ann Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir073","article-title":"Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America","volume":"52","author":"Freifeld AG","year":"2011","unstructured":"Freifeld AG, Bow EJ, Sepkowitz KA, et al.. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis. 2011, 52:e56-93. 10.1093\/cid\/cir073","journal-title":"Clin Infect Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.1.7","article-title":"Neutrophil disorders and their management","volume":"54","author":"Lakshman R","year":"2001","unstructured":"Lakshman R, Finn A. Neutrophil disorders and their management. J Clin Pathol. 2001, 54:7-19. 10.1136\/jcp.54.1.7","journal-title":"J Clin Pathol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14020130","article-title":"Antimicrobial stewardship programs in pediatric intensive care units: a systematic scoping review","volume":"14","author":"Liberati C","year":"2025","unstructured":"Liberati C, Brigadoi G, Barbieri E, Giaquinto C, Don\u00e0 D. Antimicrobial stewardship programs in pediatric intensive care units: a systematic scoping review. Antibiotics (Basel). 2025, 14:130. 10.3390\/antibiotics14020130","journal-title":"Antibiotics (Basel)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00274-X","article-title":"Incidence of septicaemias and invasive mycoses in children undergoing treatment for solid tumours: a 12-year experience at a single Italian institution","volume":"37","author":"Haupt R","year":"2001","unstructured":"Haupt R, Romanengo M, Fears T, Viscoli C, Castagnola E. Incidence of septicaemias and invasive mycoses in children undergoing treatment for solid tumours: a 12-year experience at a single Italian institution. Eur J Cancer. 2001, 37:2413-9. 10.1016\/S0959-8049(01)00274-X","journal-title":"Eur J Cancer"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0884-6","article-title":"Infections in a pediatric patient cohort with acute lymphoblastic leukemia during the entire course of treatment","volume":"14","author":"Katsimpardi K","year":"2006","unstructured":"Katsimpardi K, Papadakis V, Pangalis A, et al.. Infections in a pediatric patient cohort with acute lymphoblastic leukemia during the entire course of treatment. Support Care Cancer. 2006, 14:277-84. 10.1007\/s00520-005-0884-6","journal-title":"Support Care Cancer"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00052-0","article-title":"Bloodstream infections in children with cancer: a multicentre surveillance study of the Italian Association of Paediatric Haematology and Oncology","volume":"35","author":"Viscoli C","year":"1999","unstructured":"Viscoli C, Castagnola E, Giacchino M, et al.. Bloodstream infections in children with cancer: a multicentre surveillance study of the Italian Association of Paediatric Haematology and Oncology. Eur J Cancer. 1999, 35:770-7. 10.1016\/S0959-8049(99)00052-0","journal-title":"Eur J Cancer"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24995","article-title":"Invasive bacterial and fungal infections in paediatric patients with cancer: incidence, risk factors, aetiology and outcomes in a UK regional cohort 2009-2011","volume":"61","author":"Calton EA","year":"2014","unstructured":"Calton EA, Le Doar\u00e9 K, Appleby G, Chisholm JC, Sharland M, Ladhani SN. Invasive bacterial and fungal infections in paediatric patients with cancer: incidence, risk factors, aetiology and outcomes in a UK regional cohort 2009-2011. Pediatr Blood Cancer. 2014, 61:1239-45. 10.1002\/pbc.24995","journal-title":"Pediatr Blood Cancer"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268819001845","article-title":"Comparison of epidemiological, clinical and microbiological characteristics of bloodstream infection in children with solid tumours and haematological malignancies","volume":"147","author":"Garrido MM","year":"2019","unstructured":"Garrido MM, Garrido RQ, Cunha TN, Ehrlich S, Martins IS. Comparison of epidemiological, clinical and microbiological characteristics of bloodstream infection in children with solid tumours and haematological malignancies. Epidemiol Infect. 2019, 147:e298. 10.1017\/S0950268819001845","journal-title":"Epidemiol Infect"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S199657","article-title":"Infectious complications in children with malignant bone tumors: a multicenter nationwide study","volume":"12","author":"Czy\u017cewski K","year":"2019","unstructured":"Czy\u017cewski K, Ga\u0142\u0105zka P, Zalas-Wi\u0119cek P, et al.. Infectious complications in children with malignant bone tumors: a multicenter nationwide study. Infect Drug Resist. 2019, 12:1471-80. 10.2147\/IDR.S199657","journal-title":"Infect Drug Resist"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328351d199","article-title":"Rationalizing the approach to children with fever in neutropenia","volume":"25","author":"Ammann RA","year":"2012","unstructured":"Ammann RA, Tissing WJ, Phillips B. Rationalizing the approach to children with fever in neutropenia. Curr Opin Infect Dis. 2012, 25:258-65. 10.1097\/QCO.0b013e328351d199","journal-title":"Curr Opin Infect Dis"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/children8121086","article-title":"Update on febrile neutropenia in pediatric oncological patients undergoing chemotherapy","volume":"8","author":"Cennamo F","year":"2021","unstructured":"Cennamo F, Masetti R, Largo P, Argentiero A, Pession A, Esposito S. Update on febrile neutropenia in pediatric oncological patients undergoing chemotherapy. Children (Basel). 2021, 8:1086. 10.3390\/children8121086","journal-title":"Children (Basel)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246654","article-title":"Pediatric fever in neutropenia with bacteremia\u2014pathogen distribution and in vitro antibiotic susceptibility patterns over time in a retrospective single-center cohort study","volume":"16","author":"Stergiotis M","year":"2021","unstructured":"Stergiotis M, Ammann RA, Droz S, Koenig C, Agyeman PKA. Pediatric fever in neutropenia with bacteremia\u2014pathogen distribution and in vitro antibiotic susceptibility patterns over time in a retrospective single-center cohort study. PLoS One. 2021, 16:e0246654. 10.1371\/journal.pone.0246654","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11576-z","article-title":"A prediction model for bacteremia and transfer to intensive care in pediatric and adolescent cancer patients with febrile neutropenia","volume":"12","author":"Alali M","year":"2022","unstructured":"Alali M, Mayampurath A, Dai Y, Bartlett AH. A prediction model for bacteremia and transfer to intensive care in pediatric and adolescent cancer patients with febrile neutropenia. Sci Rep. 2022, 12:7429. 10.1038\/s41598-022-11576-z","journal-title":"Sci Rep"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.86413","article-title":"Monitoring hematologic parameters in pediatric oncology patients diagnosed with sepsis or febrile neutropenia: a tertiary center experience","volume":"17","author":"Radulescu FM","year":"2025","unstructured":"Radulescu FM, Nedea Ilie MI, Dumitru IM. Monitoring hematologic parameters in pediatric oncology patients diagnosed with sepsis or febrile neutropenia: a tertiary center experience. Cureus. 2025, 17:e86413. 10.7759\/cureus.86413","journal-title":"Cureus"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.31925\/farmacia.2025.3.15","article-title":"Antibiotherapy in pediatric oncological patients with positive bacterial infection post-treatment","volume":"73","author":"R\u0103dulescu FM","year":"2025","unstructured":"R\u0103dulescu FM, Nedea MI, Dasc\u0103lu AM, Tar\u021ba E, N\u0103st\u0103sescu TI, V\u0103lean D, Dumitru IM. Antibiotherapy in pediatric oncological patients with positive bacterial infection post-treatment. Farmacia. 2025, 73:686-95. 10.31925\/farmacia.2025.3.15","journal-title":"Farmacia"},{"key":"ref22","unstructured":"CDC. Bloodstream infection (BSI) events. (2025). https.\/\/www.cdc.gov\/nhsn\/psc\/bsi\/index.html."},{"key":"ref23","unstructured":"POGO. Management of fever and neutropenia. (2023). https.\/\/www.pogo.ca\/wp-content\/uploads\/2023\/01\/4.1-Management-of-Fever-and-Neutropenia-1.pdf."},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0287233","article-title":"Outcome prediction in pediatric fever in neutropenia: development of clinical decision rules and external validation of published rules based on data from the prospective multicenter SPOG 2015 FN definition study","volume":"18","author":"Santschi M","year":"2023","unstructured":"Santschi M, Ammann RA, Agyeman PKA, Ansari M, Bodmer N, Brack E, Koenig C. Outcome prediction in pediatric fever in neutropenia: development of clinical decision rules and external validation of published rules based on data from the prospective multicenter SPOG 2015 FN definition study. PLoS One. 2023, 18:e0287233. 10.1371\/journal.pone.0287233","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22246","article-title":"Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management","volume":"87","author":"Estey EH","year":"2012","unstructured":"Estey EH. Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management. Am J Hematol. 2012, 87:89-99. 10.1002\/ajh.22246","journal-title":"Am J Hematol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw325","article-title":"Management of febrile neutropaenia: ESMO clinical practice guidelines","volume":"27","author":"Klastersky J","year":"2016","unstructured":"Klastersky J, de Naurois J, Rolston K, Rapoport B, Maschmeyer G, Aapro M, Herrstedt J. Management of febrile neutropaenia: ESMO clinical practice guidelines. Ann Oncol. 2016, 27:v111-8. 10.1093\/annonc\/mdw325","journal-title":"Ann Oncol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01968","article-title":"Assessment of neutrophil chemotaxis upon G-CSF treatment of healthy stem cell donors and in allogeneic transplant recipients","volume":"9","author":"Thunstr\u00f6m Salzer A","year":"2018","unstructured":"Thunstr\u00f6m Salzer A, Niemiec MJ, Hosseinzadeh A, et al.. Assessment of neutrophil chemotaxis upon G-CSF treatment of healthy stem cell donors and in allogeneic transplant recipients. Front Immunol. 2018, 9:1968. 10.3389\/fimmu.2018.01968","journal-title":"Front Immunol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-07103-5","article-title":"Current state and future opportunities in granulocyte colony-stimulating factor (G-CSF)","volume":"30","author":"Link H","year":"2022","unstructured":"Link H. Current state and future opportunities in granulocyte colony-stimulating factor (G-CSF). Support Care Cancer. 2022, 30:7067-77. 10.1007\/s00520-022-07103-5","journal-title":"Support Care Cancer"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00031-6","article-title":"Global effect of the COVID-19 pandemic on paediatric cancer care: a cross-sectional study","volume":"5","author":"Graetz D","year":"2021","unstructured":"Graetz D, Agulnik A, Ranadive R, et al.. Global effect of the COVID-19 pandemic on paediatric cancer care: a cross-sectional study. Lancet Child Adolesc Health. 2021, 5:332-40. 10.1016\/S2352-4642(21)00031-6","journal-title":"Lancet Child Adolesc Health"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/389014-distribution-of-oncological-diagnoses-in-pediatric-patients-with-febrile-neutropenia-and-sepsis-is-there-an-association","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T08:48:49Z","timestamp":1756457329000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/389014-distribution-of-oncological-diagnoses-in-pediatric-patients-with-febrile-neutropenia-and-sepsis-is-there-an-association"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.91220","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,29]]}}}