{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T10:40:04Z","timestamp":1756550404562,"version":"3.44.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,30]]},"DOI":"10.7759\/cureus.91279","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T10:01:21Z","timestamp":1756548081000},"source":"Crossref","is-referenced-by-count":0,"title":["Severe Neutropenia and Vitamin B12 Deficiency in a Patient With Recreational Nitrous Oxide Use and History of Polysubstance Use: A Case Report"],"prefix":"10.7759","author":[{"given":"Lindsay A","family":"Turmelle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Chotas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12372","article-title":"Neurologic, psychiatric, and other medical manifestations of nitrous oxide abuse: A systematic review of the case literature","volume":"25","author":"Garakani A","year":"2016","unstructured":"Garakani A, Jaffe RJ, Savla D, Welch AK, Protin CA, Bryson EO, McDowell DM. Neurologic, psychiatric, and other medical manifestations of nitrous oxide abuse: A systematic review of the case literature. Am J Addict. 2016, 25:358-69. 10.1111\/ajad.12372","journal-title":"Am J Addict"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.73807","article-title":"Nitrous oxide-induced vitamin B12 deficiency and myelopathy in whippets abusers: A report of two cases","volume":"16","author":"Barmak F","year":"2024","unstructured":"Barmak F, Numan J, Shabih M, Nolte J, Adams J, Ferguson P, Inam SH. Nitrous oxide-induced vitamin B12 deficiency and myelopathy in whippets abusers: A report of two cases. Cureus. 2024, 16:e73807. 10.7759\/cureus.73807","journal-title":"Cureus"},{"key":"ref3","unstructured":"Nitrous oxide - Alcohol and Drug Foundation. Accessed. June 6, 2025: https:\/\/adf.org.au\/drug-facts\/nitrous-oxide\/."},{"key":"ref4","unstructured":"ToxTalks. Substances of Use and Misuse \r\nNitrous Oxide. (2023). https:\/\/med.virginia.edu\/toxicology\/wp-content\/uploads\/sites\/268\/2023\/08\/Aug23-SAM-NitrousOxide.pdf."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp-rj.2023.190201","article-title":"Let\u2019s \u201cWhippit\" away: Nitrous oxide misuse and its complications","volume":"19","author":"Sedore S","year":"2023","unstructured":"Sedore S. Let\u2019s \u201cWhippit\" away: Nitrous oxide misuse and its complications. Am J Psychiatry Resid J. 2023, 19:2-4. 10.1176\/appi.ajp-rj.2023.190201","journal-title":"Am J Psychiatry Resid J"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(24)00298-6","article-title":"Tackling the growing burden of nitrous oxide-induced public health harms","volume":"10","author":"Zaloum SA","year":"2025","unstructured":"Zaloum SA, Mair D, Paris A, Smith LJ, Patyjewicz M, Onen BL, Noyce AJ. Tackling the growing burden of nitrous oxide-induced public health harms. Lancet Public Health. 2025, 10:e257-63. 10.1016\/S2468-2667(24)00298-6","journal-title":"Lancet Public Health"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2023-254727","article-title":"Subacute combined degeneration of the spinal cord in a patient with nitrous oxide use and autoimmune atrophic gastritis","volume":"16","author":"Gardin TM","year":"2023","unstructured":"Gardin TM, Yang A, Moeller JJ, Quraishi IH. Subacute combined degeneration of the spinal cord in a patient with nitrous oxide use and autoimmune atrophic gastritis. BMJ Case Rep. 2023, 16:e254727. 10.1136\/bcr-2023-254727","journal-title":"BMJ Case Rep"},{"key":"ref8","unstructured":"Nitrous Oxide Misuse and Abuse | Toxicology Section. (2021). Accessed. March 30, 2025: https:\/\/www.acep.org\/toxicology\/newsroom\/jun2021\/nitrous-oxide-misuse-and-abuse."},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Dharaiya D, Silverstone L, Sharma R, et al. Nitrous Oxide Toxicity. Reference Article. (2014). Accessed. August 28, 2025: https:\/\/radiopaedia.org\/articles\/30559.","DOI":"10.53347\/rID-30559"},{"key":"ref10","unstructured":"Nitrous Oxide Abuse. Side Effects & Treatment for Whippets. American Addiction Centers. Accessed: March 29, 2025: https:\/\/americanaddictioncenters.org\/inhalant-abuse\/nitrous-oxide-whippets."},{"key":"ref11","article-title":"Vitamin B12 deficiency","author":"Ankar A","year":"2025","unstructured":"Ankar A, Kumar A. Vitamin B12 deficiency. StatPearls [Internet]. StatPearls Publishing, Treasure Island, FL; 2025."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.98.18_supplement.2476","article-title":"A unique case of whippets-induced B12 deficiency manifesting as a subacute Brown-Sequard spinal syndrome (P1-1.Virtual)","volume":"98","author":"Kao A","year":"2022","unstructured":"Kao A, Malik S. A unique case of whippets-induced B12 deficiency manifesting as a subacute Brown-Sequard spinal syndrome (P1-1.Virtual). Neurology. 2022, 98:2476. 10.1212\/WNL.98.18_supplement.2476","journal-title":"Neurology"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000642","article-title":"The hematological effects of nitrous oxide anesthesia in pediatric patients","volume":"120","author":"Duma A","year":"2015","unstructured":"Duma A, Cartmill C, Blood J, Sharma A, Kharasch ED, Nagele P. The hematological effects of nitrous oxide anesthesia in pediatric patients. Anesth Analg. 2015, 120:1325-30. 10.1213\/ANE.0000000000000642","journal-title":"Anesth Analg"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/378957-severe-neutropenia-and-vitamin-b12-deficiency-in-a-patient-with-recreational-nitrous-oxide-use-and-history-of-polysubstance-use-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T10:01:22Z","timestamp":1756548082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/378957-severe-neutropenia-and-vitamin-b12-deficiency-in-a-patient-with-recreational-nitrous-oxide-use-and-history-of-polysubstance-use-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,30]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.91279","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,30]]}}}